Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways

European Journal of Pharmacology

Volumn 795, Issue , 2017, Pages 84-93

  Wu, Jing ^a   Xu, Linlin ^a   Sun, Chao ^a   Zhang, Bin ^a   Li, Juan ^a   Sun, Jing ^a   Zhang, Ying ^a   Sun, Deqing ^a  

^a THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

Author keywords

Epirubicin; Nephrotoxicity; NF B; Nrf2; Paeonol

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; EPIRUBICIN; HEME OXYGENASE 1; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEONOL; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR NRF2; ACETOPHENONE DERIVATIVE; ANTIOXIDANT; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; HISTOLOGY; INFLAMMATION; KIDNEY FUNCTION; KIDNEY INJURY; MOUSE; NEPHROTOXICITY; NITRATIVE STRESS; NONHUMAN; NUCLEAR TRANSLOCATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT; REGULATORY MECHANISM; RENAL PROTECTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL PROTECTION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; INJURIES; KIDNEY; METABOLISM;

ACETOPHENONES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CYTOPROTECTION; EPIRUBICIN; FEMALE; GENE EXPRESSION REGULATION; KIDNEY; MICE; NF-E2-RELATED FACTOR 2; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 85006323924     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.12.005     Document Type: Article

References (32)

1. Abdelraouf, K., Braggs, K.H., Yin, T., et al. Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design. Antimicrob. Agents Chemother. 56:9 (2012), 4625–4629.
2. Ozkok, Abdullah, Ravichandran, Kameswaran, Wang, Qian, et al. NF-kB transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI). Toxicol. Lett. 240 (2016), 105–113.
3. Baldini, E., Prochilo, T., Salvadori, B., et al. Multicenter randomized phase III trial of epirubicin plus paclitaxel vs epirubicin followed by paclitaxel in metastatic breast cancer patients: focus on cardiac safety. Br. J. Cancer 91:1 (2004), 45–49.
4. Sahu, Bidya Dhar, Kumar, Jerald Mahesh, Sistla, Ramakrishna, Baicalein, a bioflavonoid, prevents cisplatin-induced acute kidney injury by up-regulating antioxidant defenses and down-regulating the MAPKs and NF-κB pathways. PLoS One, 10(7), 2015, e0134139.
5. Chen, B., Ning, M., Yang, G., Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats. Molecules 17 (2012), 4672–4683.
6. El-Sheikh, A.A., Morsy, M.A., Mahmoud, M.M., et al. Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats. Adv. Pharmacol. Sci., 2012, 2012, 981461.
7. Gan, Fei-Fei, Ling, Hui, Ang, Xiaohui, et al. A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-kB and Nrf2-Keap1 signaling pathways. Toxicol. Appl. Pharmacol. 272 (2013), 852–862.
8. Fountzilas, George, Valavanis, Christos, Kotoula, Vassiliki, et al. HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy. J. Transl. Med., 10, 2012, 10.
9. Ichioka, D., Miyazaki, J., Inoue, T., et al. Impact of renal function of patients with advanced urothelial cancer on eligibility for first-line chemotherapy and treatment outcomes. Jpn. J. Clin. Oncol. 45:9 (2015), 867–873.
10. Wu, Jing, Xue, Xia, Zhang, Bin, et al. The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway. Chem.-Biol. Interact. 244 (2016), 1–8.
11. Kebieche, M., Lakroun, Z., Lahouel, M., et al. Evaluation of epirubicin-induced acute oxidative stress toxicity in rat liver cells and mitochondria, and the prevention of toxicity through quercetin administration. Exp. Toxicol. Pathol. 61:2 (2009), 161–167.
12. Lee, H., Lee, G., Kim, H., Bae, H., Paeonol, a major compound of moutan cortex, attenuates cisplatin-induced nephrotoxicity in mice. Evid. Based Complement. Altern. Med. 310, 989 (2013), 1–7.
13. Lee, I.-C., Kim, S.-H., Baek, H.-S., et al. The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats. Food Chem. Toxicol. 63 (2014), 174–185.
14. Li, H., Xie, Y.H., Yang, Q., et al. Cardioprotective effect of paeonol and danshensu combination on isoproterenol-induced myocardial injury in rats. PloS One, 7, 2012, e48872.
15. Lin, H., Sue, Y.M., Chou, Y., et al. Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis. Br. J. Pharmacol. 161:7 (2010), 1661–1676.
16. Liu, Q., Si, T., Xu, X., et al. Electromagnetic radiation at 900MHz induces sperm apoptosis through bcl-2, bax and caspase-3 signaling pathways in rats. Reprod. Health, 4(12), 2015, 65.
17. Marullo, R., Werner, E., Degtyareva, N., et al. Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS One, 8, 2013, e81162.
18. Liu, Meng-Han, Lin, An-Hsuan, Lee, Hung-Fu, et al. Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Mediat. Inflamm., 8(3), 2014, 651890.
19. Mitazaki, S., Hashimoto, M., Matsuhashi, Y., et al. Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity. Life Sci. 92 (2013), 694–700.
20. Mukhopadhyay, P., Pan, H., Rajesh, M., et al. CB1 cannabinoid receptors promote oxidative stress/nitrosative stress, inflammation and cell death in a murine nephropathy model. Br. J. Pharmacol. 160 (2010), 657–668.
21. Pan, H., Mukhopadhyay, P., Rajesh, M., Patel, V., Mukhopadhyay, B., et al. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/ nitrosative stress, inflammation, and cell death. J. Pharmacol. Exp. Ther. 328 (2009), 708–714.
22. Pan, H., Shen, K., Wang, X., et al. Protective effect of metalloporphyrins against cisplatin-induced kidney injury in mice. PLoS One, 9(1), 2014, e86057.
23. Park, H.M., Cho, J.M., Lee, H.R., et al. Renal protection by 3H-1, 2-dithiole-3- thione against cisplatin through the Nrf2-antioxidant pathway. Biochem. Pharmacol. 76 (2008), 597–607.
24. Pasello, G., Carli, P., Canova, F., Bonanno, L., et al. Epirubicin plus paclitaxel regimen as second-line treatment of patients with small-cell lung cancer. Anticancer Res. 35:4 (2015), 2183–2189.
25. Sahin, K., Tuzcu, M., Gencoglu, H., et al. Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. Life Sci. 87 (2010), 240–245.
26. Sahu, B.D., Kalvala, A.K., Koneru, M., et al. Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-kB activation and antioxidant defence. PLoS One, 9(9), 2014, e105070.
27. NAGD, Santos, Rodrigues, M.A.C., Martins, N.M., et al. Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update. Arch. Toxicol. 86 (2012), 1233–1250.
28. Shelton, L.M., Park, B.K., Copple, I.M., Role of Nrf2 in protection against acute kidney injury. Kidney Int. 84 (2013), 1090–1095.
29. Li, Wenge, Khor, Tin Oo, Xu, Changjiang, et al. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem. Pharmacol. 76 (2008), 1485–1489.
30. Zha, L., Chen, J., Sun, S., et al. Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway. PLoS One, 9(9), 2014, e107655 (1-9).
31. Zhang, Z., Cui, W., Li, G., et al. Baicalein protects against 6-OHDA002D induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways. J. Agric. Food Chem. 60 (2012), 8171–8182.
32. Zirak, M.R., Rahimian, R., Ghazi-Khansari, M., et al. Tropisetron attenuates cisplatin- induced nephrotoxicity in mice. Eur. J. Pharmacol. 738 (2014), 222–229.