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Volumn 6, Issue FEB, 2016, Pages

Hemorrhagic fever with renal syndrome: Pathogenesis and clinical picture

Author keywords

Bunyavirus; Hantaan virus; Hantavirus; Hemorrhagic fever with renal syndrome; Pathogenesis

Indexed keywords

BETA INTERFERON; BETA3 INTEGRIN; CREATININE; CXCL1 CHEMOKINE; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERFERON REGULATORY FACTOR; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; MYXOVIRUS RESISTANCE PROTEIN A; NUCLEOCAPSID PROTEIN; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PROTEIN ZO1; RANTES; RETINOIC ACID INDUCIBLE PROTEIN I; RIBAVIRIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ANTIVIRUS AGENT; VIRUS ANTIBODY;

EID: 85006216338     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2016.00001     Document Type: Review
Times cited : (172)

References (97)
  • 1
    • 0028145126 scopus 로고
    • Prevalence of serum IgG antibodies to Puumala virus (hemorrhagic fever with renal syndrome) in norther Sweden
    • Ahlm, C., Linderholm, M., Juto, P., Stegmyr, B., and Settergren, B. (1994). Prevalence of serum IgG antibodies to Puumala virus (hemorrhagic fever with renal syndrome) in norther Sweden. Epidemiol. Infect. 113, 129-136. doi: 10.1017/S0950268800051542
    • (1994) Epidemiol. Infect , vol.113 , pp. 129-136
    • Ahlm, C.1    Linderholm, M.2    Juto, P.3    Stegmyr, B.4    Settergren, B.5
  • 2
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., Uematsu, S., and Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell 124, 783-801. doi: 10.1016/j.cell.2006.02.015
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 0028430954 scopus 로고
    • Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome
    • Alexeyev, O. A., Ahlm, C., Billheden, J., Settergran, B., Wadell, G., and Juto, P. (1994). Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome. Clin. Diagn. Lab. Immunol. 1, 269-272.
    • (1994) Clin. Diagn. Lab. Immunol , vol.1 , pp. 269-272
    • Alexeyev, O.A.1    Ahlm, C.2    Billheden, J.3    Settergran, B.4    Wadell, G.5    Juto, P.6
  • 4
    • 0034959844 scopus 로고    scopus 로고
    • Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections
    • Araki, K., Yoshimatsu, K., Ogino, M., Ebihara, H., Lundkvist, Å., Kariwa, H., et al. (2001). Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections. J. Clin. Microbiol. 39, 2397-2404. doi: 10.1128/JCM.39.7.2397-2404.2001
    • (2001) J. Clin. Microbiol , vol.39 , pp. 2397-2404
    • Araki, K.1    Yoshimatsu, K.2    Ogino, M.3    Ebihara, H.4    Lundkvist, Å.5    Kariwa, H.6
  • 5
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid, Y., and Rouse, B. T. (2005). Natural regulatory T cells in infectious disease. Nat. Immunol. 6, 353-360. doi: 10.1038/ni1181
    • (2005) Nat. Immunol , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 6
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • Beutler, B. A. (2009). TLRs and innate immunity. Blood 113, 1399-1407. doi: 10.1182/blood-2008-07-019307
    • (2009) Blood , vol.113 , pp. 1399-1407
    • Beutler, B.A.1
  • 7
    • 78651492046 scopus 로고    scopus 로고
    • Rapid expansion and long term persistence of elevated NK cell numbers in humans infected with hantavirus
    • Björkström, N. K., Lindgren, T., Stoltz, M., Fauriat, C., Braun, M., Evander, M., et al. (2011). Rapid expansion and long term persistence of elevated NK cell numbers in humans infected with hantavirus. J. Exp. Med. 208, 13-21. doi: 10.1084/jem.20100762
    • (2011) J. Exp. Med , vol.208 , pp. 13-21
    • Björkström, N.K.1    Lindgren, T.2    Stoltz, M.3    Fauriat, C.4    Braun, M.5    Evander, M.6
  • 8
    • 9144246217 scopus 로고    scopus 로고
    • Platelet-activationg factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex
    • Bossi, F., Fischetti, F., Pellis, V., Bulla, R., Ferrero, E., and Mollnes, T. E. (2004). Platelet-activationg factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. J. Immunol. 173, 6921-6927. doi: 10.4049/jimmunol.173.11.6921
    • (2004) J. Immunol , vol.173 , pp. 6921-6927
    • Bossi, F.1    Fischetti, F.2    Pellis, V.3    Bulla, R.4    Ferrero, E.5    Mollnes, T.E.6
  • 9
    • 0033636606 scopus 로고    scopus 로고
    • A mechanism for modulation of cellular responses to VEGF: activation of the integrins
    • Byzova, T. V., Goldman, C. K., Pampori, N., Thomas, K. A., Bett, A., Shattil, S. J., et al. (2000). A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol. Cell. 6, 851-860. doi: 10.1016/s1097-2765(00)00083-6
    • (2000) Mol. Cell , vol.6 , pp. 851-860
    • Byzova, T.V.1    Goldman, C.K.2    Pampori, N.3    Thomas, K.A.4    Bett, A.5    Shattil, S.J.6
  • 10
    • 17544365081 scopus 로고    scopus 로고
    • Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience
    • Chapman, L. E., Mertz, G. J., Peters, C. J., Jolson, H. M., Khan, A. S., Ksiazek, T. G., et al. (1999). Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Antivir. Ther. (Lond). 4, 211-219.
    • (1999) Antivir. Ther. (Lond) , vol.4 , pp. 211-219
    • Chapman, L.E.1    Mertz, G.J.2    Peters, C.J.3    Jolson, H.M.4    Khan, A.S.5    Ksiazek, T.G.6
  • 11
    • 78149331671 scopus 로고    scopus 로고
    • Hantavirus infection: a neglected diagnosis in thrombocytopenia and fever?
    • Denecke, B., Bigalke, B., Haap, M., Overkamp, D., Lehnert, H., and Haas, C. S. (2010). Hantavirus infection: a neglected diagnosis in thrombocytopenia and fever? Mayo Clin. Proc. 85, 1016-1020. doi: 10.4065/mcp.2009.0040
    • (2010) Mayo Clin. Proc , vol.85 , pp. 1016-1020
    • Denecke, B.1    Bigalke, B.2    Haap, M.3    Overkamp, D.4    Lehnert, H.5    Haas, C.S.6
  • 12
    • 39749194869 scopus 로고    scopus 로고
    • Kinship, dispersal and hantavirus transmission in bank and common voles
    • Deter, J., Chaval, Y., Galan, M., Gauffre, B., Morand, S., Henttonen, H., et al. (2008). Kinship, dispersal and hantavirus transmission in bank and common voles. Arch. Virol. 153, 435-444. doi: 10.1007/s00705-007-0005-6
    • (2008) Arch. Virol , vol.153 , pp. 435-444
    • Deter, J.1    Chaval, Y.2    Galan, M.3    Gauffre, B.4    Morand, S.5    Henttonen, H.6
  • 13
    • 84896086305 scopus 로고    scopus 로고
    • Clinical study of critical patients with hemorrhagic fever with renal syndrome complicated by acute respiratory distress syndrome
    • Du, H., Li, J., Jiang, W., Yu, H., Zhang, Y., Wang, J., et al. (2014a). Clinical study of critical patients with hemorrhagic fever with renal syndrome complicated by acute respiratory distress syndrome. PLoS ONE 9:e89740. doi: 10.1371/journal.pone.0089740
    • (2014) PLoS ONE , vol.9
    • Du, H.1    Li, J.2    Jiang, W.3    Yu, H.4    Zhang, Y.5    Wang, J.6
  • 14
    • 84908115355 scopus 로고    scopus 로고
    • Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome
    • Du, H., Li, J., Yu, H. T., Jiang, W., Zhang, Y., Wang, J. N., et al. (2014b). Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome. Clin. Chem. Lab. Med. 52, 1667-1675. doi: 10.1515/cclm-2014-0016
    • (2014) Clin. Chem. Lab. Med , vol.52 , pp. 1667-1675
    • Du, H.1    Li, J.2    Yu, H.T.3    Jiang, W.4    Zhang, Y.5    Wang, J.N.6
  • 15
    • 33344463349 scopus 로고    scopus 로고
    • Discovery of vascular permeability factor (VPF)
    • Dvorak, H. F. (2006). Discovery of vascular permeability factor (VPF). Exp. Cell Res. 312, 522-526. doi: 10.1016/j.yexcr.2005.11.026
    • (2006) Exp. Cell Res , vol.312 , pp. 522-526
    • Dvorak, H.F.1
  • 16
    • 34848897210 scopus 로고    scopus 로고
    • Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host
    • Easterbrook, J. D., Zink, M. C., and Klein, S. L. (2007). Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Proc. Natl. Acad. Sci. U.S.A. 104, 15502-15507. doi: 10.1073/pnas.0707453104
    • (2007) Proc. Natl. Acad. Sci. U.S.A , vol.104 , pp. 15502-15507
    • Easterbrook, J.D.1    Zink, M.C.2    Klein, S.L.3
  • 17
    • 0029671215 scopus 로고    scopus 로고
    • Inhibition of Bunyaviruses, Phleboviruses, and Hantaviruses by Human MxA Protein
    • Frese, M., Kochs, G., Feldmann, H., Hertkorn, C., and Haller, O. (1996). Inhibition of Bunyaviruses, Phleboviruses, and Hantaviruses by Human MxA Protein. J. Virol. 70, 915-923.
    • (1996) J. Virol , vol.70 , pp. 915-923
    • Frese, M.1    Kochs, G.2    Feldmann, H.3    Hertkorn, C.4    Haller, O.5
  • 18
    • 77950813111 scopus 로고    scopus 로고
    • Pathogenic Hantaviruses direct the adherence of quiescent platelets to infected endothelial cell
    • Gavrilovskaya, I. N., Gorbunova, E. E., and Mackow, E. R. (2010). Pathogenic Hantaviruses direct the adherence of quiescent platelets to infected endothelial cell. J. Virol. 84, 4832-4839. doi: 10.1128/JVI.02405-09
    • (2010) J. Virol , vol.84 , pp. 4832-4839
    • Gavrilovskaya, I.N.1    Gorbunova, E.E.2    Mackow, E.R.3
  • 19
    • 44949117721 scopus 로고    scopus 로고
    • Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability
    • Gavrilovskaya, I. N., Gorbunova, E. E., Mackow, N. A., and Mackow, E. R. (2008). Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability. J. Virol. 82, 5797-5806. doi: 10.1128/JVI.02397-07
    • (2008) J. Virol , vol.82 , pp. 5797-5806
    • Gavrilovskaya, I.N.1    Gorbunova, E.E.2    Mackow, N.A.3    Mackow, E.R.4
  • 20
    • 0036402322 scopus 로고    scopus 로고
    • Pathogenic hantaviruses selectively inhibit beta 3 integrin directed endothelial cell migration
    • Gavrilovskaya, I. N., Peresleni, T., Geimonen, E., and Mackow, E. R. (2002). Pathogenic hantaviruses selectively inhibit beta 3 integrin directed endothelial cell migration. Arch. Virol. 147, 1913-1931. doi: 10.1007/s00705-002-0852-0
    • (2002) Arch. Virol , vol.147 , pp. 1913-1931
    • Gavrilovskaya, I.N.1    Peresleni, T.2    Geimonen, E.3    Mackow, E.R.4
  • 21
    • 0032499532 scopus 로고    scopus 로고
    • Beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure
    • Gavrilovskaya, I. N., Shepley, M., Shaw, R., Ginsberg, M. H., and Mackon, E. R. (1998). Beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc. Natl. Acad. Sci. U.S.A. 95, 7074-7079. doi: 10.1073/pnas.95.12.7074
    • (1998) Proc. Natl. Acad. Sci. U.S.A , vol.95 , pp. 7074-7079
    • Gavrilovskaya, I.N.1    Shepley, M.2    Shaw, R.3    Ginsberg, M.H.4    Mackon, E.R.5
  • 22
    • 77953763318 scopus 로고    scopus 로고
    • Pathogenic Hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells
    • Gorbunova, E., Gavrilovskaya, I. N., and Mackow, E. R. (2010). Pathogenic Hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. J. Virol. 84, 7405-7411. doi: 10.1128/JVI.00576-10
    • (2010) J. Virol , vol.84 , pp. 7405-7411
    • Gorbunova, E.1    Gavrilovskaya, I.N.2    Mackow, E.R.3
  • 23
    • 79551692297 scopus 로고    scopus 로고
    • VEGFR2 and Src kinase inhibitors suppress Andes Virus-induced endothelial cell permeability
    • Gorbunova, E. E., Gavrilovskaya, I. N., Pepini, T., and Mackow, E. R. (2011). VEGFR2 and Src kinase inhibitors suppress Andes Virus-induced endothelial cell permeability. J. Virol. 85, 2296-2303. doi: 10.1128/JVI.02319-10
    • (2011) J. Virol , vol.85 , pp. 2296-2303
    • Gorbunova, E.E.1    Gavrilovskaya, I.N.2    Pepini, T.3    Mackow, E.R.4
  • 24
    • 35948957769 scopus 로고    scopus 로고
    • In vitro and in vivo activities of T-705 against arenavirus and Bunyavirus infectious
    • Gowen, B. B., Wong, M. H., Jung, K. H., Sanders, A. B., Mendenhall, M., Bailey, K. W., et al. (2007). In vitro and in vivo activities of T-705 against arenavirus and Bunyavirus infectious. Antimicrob. Agents Chemother. 51, 3168-3176. doi: 10.1128/AAC.00356-07
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 3168-3176
    • Gowen, B.B.1    Wong, M.H.2    Jung, K.H.3    Sanders, A.B.4    Mendenhall, M.5    Bailey, K.W.6
  • 25
    • 44949117721 scopus 로고    scopus 로고
    • Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit Hantavirus-directed permeability
    • Grvrilovskaya, I. N., Gorbunova, E. E., Mackow, N. A., and Mackow, E. R. (2008). Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit Hantavirus-directed permeability. J. Virol. 82, 5797-5806. doi: 10.1128/JVI.02397-07
    • (2008) J. Virol , vol.82 , pp. 5797-5806
    • Grvrilovskaya, I.N.1    Gorbunova, E.E.2    Mackow, N.A.3    Mackow, E.R.4
  • 26
    • 77951068772 scopus 로고    scopus 로고
    • Infection of in vivo differentiated human mast cells with hantaviruses
    • Guhl, S., Franke, R., Schielke, A., Johne, R., Krüger, D. H., Babina, M., et al. (2010). Infection of in vivo differentiated human mast cells with hantaviruses. J. Gen. Virol. 91, 1256-1261. doi: 10.1099/vir.0.019505-0
    • (2010) J. Gen. Virol , vol.91 , pp. 1256-1261
    • Guhl, S.1    Franke, R.2    Schielke, A.3    Johne, R.4    Krüger, D.H.5    Babina, M.6
  • 28
    • 64849104899 scopus 로고    scopus 로고
    • Hantaan virus triggers TLR3-dependent innate immune responses
    • Handke, W., Oelschlegel, R., Franke, R., Krüger, D. H., and Rang, A. (2009). Hantaan virus triggers TLR3-dependent innate immune responses. J. Immunol. 182, 2849-2858. doi: 10.4049/jimmunol.0802893
    • (2009) J. Immunol , vol.182 , pp. 2849-2858
    • Handke, W.1    Oelschlegel, R.2    Franke, R.3    Krüger, D.H.4    Rang, A.5
  • 29
    • 41349100684 scopus 로고    scopus 로고
    • Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats
    • Hannah, M. F., Bajic, V. B., and Klein, S. L. (2008). Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats. Brain Behav. Immun. 22, 503-516. doi: 10.1016/j.bbi.2007.10.005
    • (2008) Brain Behav. Immun , vol.22 , pp. 503-516
    • Hannah, M.F.1    Bajic, V.B.2    Klein, S.L.3
  • 30
    • 33846027112 scopus 로고    scopus 로고
    • Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes
    • Hayasaka, D., Maeda, K., Ennis, F. A., and Terajima, M. (2007). Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes. Virus Res. 123, 120-127. doi: 10.1016/j.virusres.2006.08.006
    • (2007) Virus Res , vol.123 , pp. 120-127
    • Hayasaka, D.1    Maeda, K.2    Ennis, F.A.3    Terajima, M.4
  • 31
    • 77958599053 scopus 로고    scopus 로고
    • Mortality rate patterns for hemorrhagic fever with renal syndrome caused by Puumala virus
    • Hjertqvist, M., Klein, S. L., Ahlm, C., and Klingström, J. (2010). Mortality rate patterns for hemorrhagic fever with renal syndrome caused by Puumala virus. Emerg infec Dis. 16, 1584-1586. doi: 10.3201/eid1610.100242
    • (2010) Emerg infec Dis , vol.16 , pp. 1584-1586
    • Hjertqvist, M.1    Klein, S.L.2    Ahlm, C.3    Klingström, J.4
  • 32
    • 0025838388 scopus 로고
    • Prospective, double-bind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome
    • Huggins, J. W., Hsiang, C. M., Cosgriff, T. M., Guang, M. Y., Smith, J. I., Wu, Z. O., et al. (1991). Prospective, double-bind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J. Infect. Dis. 164, 1119-1127. doi: 10.1093/infdis/164.6.1119
    • (1991) J. Infect. Dis , vol.164 , pp. 1119-1127
    • Huggins, J.W.1    Hsiang, C.M.2    Cosgriff, T.M.3    Guang, M.Y.4    Smith, J.I.5    Wu, Z.O.6
  • 33
    • 52049099840 scopus 로고    scopus 로고
    • Hantaan virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon, interleukin-6 and tumor necrosis factor-alpha
    • Jiang, H., Wang, P. Z., Zhang, Y., Xu, Z., Sun, L., Wang, L. M., et al. (2008). Hantaan virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon, interleukin-6 and tumor necrosis factor-alpha. Virology 380, 52-59. doi: 10.1016/j.virol.2008.07.002
    • (2008) Virology , vol.380 , pp. 52-59
    • Jiang, H.1    Wang, P.Z.2    Zhang, Y.3    Xu, Z.4    Sun, L.5    Wang, L.M.6
  • 34
    • 84888775962 scopus 로고    scopus 로고
    • Development of a SYBR Green I based one-step real-time PCR assay for the detection of Hantaan virus
    • Jiang, W., Wang, P. Z., Yu, H. T., Zhang, Y., Zhao, K., Du, H., et al. (2014). Development of a SYBR Green I based one-step real-time PCR assay for the detection of Hantaan virus. J. Virol. Methods. 196, 145-151. doi: 10.1016/j.jviromet.2013.11.004
    • (2014) J. Virol. Methods , vol.196 , pp. 145-151
    • Jiang, W.1    Wang, P.Z.2    Yu, H.T.3    Zhang, Y.4    Zhao, K.5    Du, H.6
  • 35
    • 77950651664 scopus 로고    scopus 로고
    • A global perspective on hantavirus ecology, epidemiology, and disease
    • Jonsson, C. B., Figueiredo, L. T., and Vapalahti, O. (2010). A global perspective on hantavirus ecology, epidemiology, and disease. Clin. Microbiol. Rev. 23, 412-441. doi: 10.1128/CMR.00062-09
    • (2010) Clin. Microbiol. Rev , vol.23 , pp. 412-441
    • Jonsson, C.B.1    Figueiredo, L.T.2    Vapalahti, O.3
  • 37
    • 0030273055 scopus 로고    scopus 로고
    • Inhibition of Puumala and Tula Hantaviruses in Vero Cells by MxA Protein
    • Kanerva, M., Melén, K., Vaheri, A., and Ulkunen, I. (1996). Inhibition of Puumala and Tula Hantaviruses in Vero Cells by MxA Protein. Virology 224, 55-62. doi: 10.1006/viro.1996.0506
    • (1996) Virology , vol.224 , pp. 55-62
    • Kanerva, M.1    Melén, K.2    Vaheri, A.3    Ulkunen, I.4
  • 38
    • 42549101917 scopus 로고    scopus 로고
    • The role of regulatory T cells in chronic and acute viral infections
    • Keynan, Y., Card, C. M., McLaren, P. J., Dawood, M. R., Kasper, K., and Fowke, K. R. (2008). The role of regulatory T cells in chronic and acute viral infections. Clin. Infect. Dis. 46, 1046-1052. doi: 10.1086/529379
    • (2008) Clin. Infect. Dis , vol.46 , pp. 1046-1052
    • Keynan, Y.1    Card, C.M.2    McLaren, P.J.3    Dawood, M.R.4    Kasper, K.5    Fowke, K.R.6
  • 39
    • 0034469162 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor alpha on sin nombre virus infection in vitro
    • Khaiboullina, S. F., Netski, D. M., Krumpe, P., and St. Jeor, S. C. (2000). Effects of tumor necrosis factor alpha on sin nombre virus infection in vitro. J. Virol. 74, 11966-11971. doi: 10.1128/JVI.74.24.11966-11971.2000
    • (2000) J. Virol , vol.74 , pp. 11966-11971
    • Khaiboullina, S.F.1    Netski, D.M.2    Krumpe, P.3    St Jeor, S.C.4
  • 40
    • 29444437300 scopus 로고    scopus 로고
    • Hantavirus: molecular biology, evolution and pathogenesis
    • Khaiboullina, S. F., Morzunov, S. P., and St. Jeor, S. C. (2005a). Hantavirus: molecular biology, evolution and pathogenesis. Curr. Mol. Med. 5, 773-790. doi: 10.2174/156652405774962317
    • (2005) Curr. Mol. Med , vol.5 , pp. 773-790
    • Khaiboullina, S.F.1    Morzunov, S.P.2    St Jeor, S.C.3
  • 41
    • 11144230448 scopus 로고    scopus 로고
    • Andes virus stimulates interferon-inducible MxA protein expression in endothelial cells
    • Khaiboullina, S. F., Rizvanov, A. A., Deyde, V. M., and St. Jeor, S. C. (2005b). Andes virus stimulates interferon-inducible MxA protein expression in endothelial cells. J. Med. Virol. 75, 267-275. doi: 10.1002/jmv.20266
    • (2005) J. Med. Virol , vol.75 , pp. 267-275
    • Khaiboullina, S.F.1    Rizvanov, A.A.2    Deyde, V.M.3    St Jeor, S.C.4
  • 43
    • 77954813894 scopus 로고    scopus 로고
    • A case report of crescentic glomerulonephritis associated with hantaan virus infection
    • Kim, S., Sung, S. H., An, H. R., Jun, Y. H., Yu, M., Ryu, D. R., et al. (2010). A case report of crescentic glomerulonephritis associated with hantaan virus infection. Nephrol. Dial. Transplant. 25, 2790-2792. doi: 10.1093/ndt/gfq253
    • (2010) Nephrol. Dial. Transplant , vol.25 , pp. 2790-2792
    • Kim, S.1    Sung, S.H.2    An, H.R.3    Jun, Y.H.4    Yu, M.5    Ryu, D.R.6
  • 44
    • 79958099812 scopus 로고    scopus 로고
    • Sex differences in the incidence and case fataltity rates from hemorrhagic fever with renal syndrome in China, 2004-2008
    • Klein, S. L., Marks, M. A., Li, W., Glass, G. E., Fang, L. Q., Ma, J. Q., et al. (2011). Sex differences in the incidence and case fataltity rates from hemorrhagic fever with renal syndrome in China, 2004-2008. Clin. Infec. Dis. 52, 1414-1421. doi: 10.1093/cid/cir232
    • (2011) Clin. Infec. Dis , vol.52 , pp. 1414-1421
    • Klein, S.L.1    Marks, M.A.2    Li, W.3    Glass, G.E.4    Fang, L.Q.5    Ma, J.Q.6
  • 45
    • 80054006066 scopus 로고    scopus 로고
    • Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts
    • Krautkrämer, E., Grouls, S., Stein, N., Reiser, J., and Zeier, M. (2011). Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts. J. Virol. 85, 9811-9823. doi: 10.1128/JVI.00568-11
    • (2011) J. Virol , vol.85 , pp. 9811-9823
    • Krautkrämer, E.1    Grouls, S.2    Stein, N.3    Reiser, J.4    Zeier, M.5
  • 46
    • 84895924155 scopus 로고    scopus 로고
    • Regulatory T cell response correlates with the severity of human hantavirus infection
    • Koivula, T. T., Tuulasvaara, A., Hetemäki, L., Mäkelä, S. M., Mustonen, J., Sironen, T. Y., et al. (2014). Regulatory T cell response correlates with the severity of human hantavirus infection. J. Infec. 68, 387-394. doi: 10.1016/j.jinf.2013.11.007
    • (2014) J. Infec , vol.68 , pp. 387-394
    • Koivula, T.T.1    Tuulasvaara, A.2    Hetemäki, L.3    Mäkelä, S.M.4    Mustonen, J.5    Sironen, T.Y.6
  • 47
    • 84880283406 scopus 로고    scopus 로고
    • The detection of vascular endothelial growth factor in serum of patients with hemorrhagic fever with renal syndrome
    • Li, M., Ji, Y., Dong, Y., Zhou, Y., Ren, H., Xie, M., et al. (2013). The detection of vascular endothelial growth factor in serum of patients with hemorrhagic fever with renal syndrome. Inflamatory 36, 962-967. doi: 10.1007/s10753-013-9627-x
    • (2013) Inflamatory , vol.36 , pp. 962-967
    • Li, M.1    Ji, Y.2    Dong, Y.3    Zhou, Y.4    Ren, H.5    Xie, M.6
  • 48
    • 34347209905 scopus 로고    scopus 로고
    • Key differentiating features between scrub typhus and hemorrhagic fever with renal syndrome in northern China
    • Liu, Y. X., Feng, D., Zhang, Q., Jia, N., Zhao, Z. T., De Vlas, S. J., et al. (2007). Key differentiating features between scrub typhus and hemorrhagic fever with renal syndrome in northern China. Am. J. Trop. Med. Hyg. 76, 801-805. Available online at: http://www.ajtmh.org/content/76/5/801.full.pdf+html
    • (2007) Am. J. Trop. Med. Hyg , vol.76 , pp. 801-805
    • Liu, Y.X.1    Feng, D.2    Zhang, Q.3    Jia, N.4    Zhao, Z.T.5    De Vlas, S.J.6
  • 49
    • 33744952536 scopus 로고    scopus 로고
    • Characterization of Truncated Hantavirus Nucleocapsid proteins and their application for serotyping
    • Li, G., Pan, L., Mou, D., Chen, Y., Zhang, Y., Li, X., et al. (2006). Characterization of Truncated Hantavirus Nucleocapsid proteins and their application for serotyping. J. Med. Virol. 78, 926-932. doi: 10.1002/jmv.20643
    • (2006) J. Med. Virol , vol.78 , pp. 926-932
    • Li, G.1    Pan, L.2    Mou, D.3    Chen, Y.4    Zhang, Y.5    Li, X.6
  • 50
    • 0036201324 scopus 로고    scopus 로고
    • Serologic diagnosis of Hantaan Virus infection based on a peptide antigen
    • Li, Z., Bai, X., and Bian, H. (2002). Serologic diagnosis of Hantaan Virus infection based on a peptide antigen. Clin. Chem. 48, 645-647. Available online at: http://www.clinchem.org/content/48/4/645.full.pdf+html
    • (2002) Clin. Chem , vol.48 , pp. 645-647
    • Li, Z.1    Bai, X.2    Bian, H.3
  • 51
    • 0030051430 scopus 로고    scopus 로고
    • Elevated plasma levels of tumor necrosis factor (TNF)-a, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome
    • Linderholm, M., Ahlm, C., Settergren, B., Waage, A., and Tärnvik, A. (1996). Elevated plasma levels of tumor necrosis factor (TNF)-a, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome. J. Infect. Dis. 173, 38-43. doi: 10.1093/infdis/173.1.38
    • (1996) J. Infect. Dis , vol.173 , pp. 38-43
    • Linderholm, M.1    Ahlm, C.2    Settergren, B.3    Waage, A.4    Tärnvik, A.5
  • 52
    • 80054002068 scopus 로고    scopus 로고
    • Longitudinal analysis of the human T cell response during acute hantavirus infection
    • Lindgern, T., Ahlm, C., Mohamed, N., Evander, M., Ljunggren, H. G., and Björkström, N. K. (2011). Longitudinal analysis of the human T cell response during acute hantavirus infection. J. Virol. 85, 10252-10260. doi: 10.1128/JVI.05548-11
    • (2011) J. Virol , vol.85 , pp. 10252-10260
    • Lindgern, T.1    Ahlm, C.2    Mohamed, N.3    Evander, M.4    Ljunggren, H.G.5    Björkström, N.K.6
  • 53
    • 13444283466 scopus 로고    scopus 로고
    • Roles of interferon-regulatory factors in T-helper-cell differentiation
    • Lohoff, M., and Mark, T. W. (2005). Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat. Rev. Immunol. 5, 125-135. doi: 10.1038/nri1552
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 125-135
    • Lohoff, M.1    Mark, T.W.2
  • 54
    • 0027448354 scopus 로고
    • Immunoglobulin G subclass against the structural components of Puumala virus
    • Lundkvist, Å., Björsten, S., and Niklasson, B. (1993). Immunoglobulin G subclass against the structural components of Puumala virus. J. Clin. Microbiol. 31, 368-372.
    • (1993) J. Clin. Microbiol , vol.31 , pp. 368-372
    • Lundkvist, Å.1    Björsten, S.2    Niklasson, B.3
  • 55
    • 33750949421 scopus 로고    scopus 로고
    • Tumor necrosis factor-a genetic predisposing factors can influence clinical severity in nephropathia epidemica
    • Maes, P., Clement, J., Groeneveld, P. H., Colson, P., Huizinga, T. W., and Van Ranst, M. (2006). Tumor necrosis factor-a genetic predisposing factors can influence clinical severity in nephropathia epidemica. Viral Immunol. 19, 558-564. doi: 10.1089/vim.2006.19.558
    • (2006) Viral Immunol , vol.19 , pp. 558-564
    • Maes, P.1    Clement, J.2    Groeneveld, P.H.3    Colson, P.4    Huizinga, T.W.5    Van Ranst, M.6
  • 56
    • 84941059621 scopus 로고    scopus 로고
    • Effectiveness of the ribavirin in treatment of hantavirus infections in the Americas and Eurasia: a meta-analysis
    • Moreli, M. L., Marques-Silva, A. C., Pimentel, V. A., and da Costa, V. G. (2014). Effectiveness of the ribavirin in treatment of hantavirus infections in the Americas and Eurasia: a meta-analysis. Virusdisease 25, 385-389. doi: 10.1007/s13337-014-0219-7
    • (2014) Virusdisease , vol.25 , pp. 385-389
    • Moreli, M.L.1    Marques-Silva, A.C.2    Pimentel, V.A.3    da Costa, V.G.4
  • 57
    • 28444438203 scopus 로고    scopus 로고
    • Cellular entry of Hantaan virus A9 strain: specific interactions with β3 integrins and a novel 70 kDa protein
    • Mou, D. L., Wang, Y. P., Huang, C. X., Li, G. Y., Pan, L., Yang, W. S., et al. (2006). Cellular entry of Hantaan virus A9 strain: specific interactions with β3 integrins and a novel 70 kDa protein. Biochem. Biophy. Res. Commun. 339, 611-617. doi: 10.1016/j.bbrc.2005.11.049
    • (2006) Biochem. Biophy. Res. Commun , vol.339 , pp. 611-617
    • Mou, D.L.1    Wang, Y.P.2    Huang, C.X.3    Li, G.Y.4    Pan, L.5    Yang, W.S.6
  • 58
    • 84886730432 scopus 로고    scopus 로고
    • The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions
    • Mustonen, J., Mäkelä, S., Outinen, T., Laine, O., Jylhävä, J., Arstila, P. T., et al. (2013). The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions. Antiviral Res. 100, 589-604. doi: 10.1016/j.antiviral.2013.10.001
    • (2013) Antiviral Res , vol.100 , pp. 589-604
    • Mustonen, J.1    Mäkelä, S.2    Outinen, T.3    Laine, O.4    Jylhävä, J.5    Arstila, P.T.6
  • 59
    • 19244377678 scopus 로고    scopus 로고
    • Interferon in patients with hemorrhagic fever with renal syndrome
    • Murzabaeva, R. T. (2002). Interferon in patients with hemorrhagic fever with renal syndrome. Zh. Mikrobiol. Epidemiol. Immunobiol. 5, 74-76.
    • (2002) Zh. Mikrobiol. Epidemiol. Immunobiol , vol.5 , pp. 74-76
    • Murzabaeva, R.T.1
  • 60
    • 0030021593 scopus 로고    scopus 로고
    • Genetic susptibility to severe course of nephropathia epidemica caused by Puumala hantavirus
    • Mustonen, J., Partanen, K., Kanerva, M., Ptetilä, K., Vapalahti, O., Pasternack, A., et al. (1996). Genetic susptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int. 49, 217-221. doi: 10.1038/ki.1996.29
    • (1996) Kidney Int , vol.49 , pp. 217-221
    • Mustonen, J.1    Partanen, K.2    Kanerva, M.3    Ptetilä, K.4    Vapalahti, O.5    Pasternack, A.6
  • 61
    • 0342748418 scopus 로고    scopus 로고
    • Immunoglobulin A response to Puumala Hantavirus
    • Nicacio, C. C., Björling, E., and Lundkvist, Å. (2000). Immunoglobulin A response to Puumala Hantavirus. J. Gen. Virol. 81, 1453-1461. doi: 10.1099/0022-1317-81-6-1453
    • (2000) J. Gen. Virol , vol.81 , pp. 1453-1461
    • Nicacio, C.C.1    Björling, E.2    Lundkvist, Å.3
  • 62
    • 34249017376 scopus 로고    scopus 로고
    • MxA-independent inhibition of Hantaan virus replication induced by type I and type II interferon in vitro
    • Oelschlegel, R., Krüger, D. H., and Rang, A. (2007). MxA-independent inhibition of Hantaan virus replication induced by type I and type II interferon in vitro. Vir Res. 127, 100-105. doi: 10.1016/j.virusres.2007.03.027
    • (2007) Vir Res , vol.127 , pp. 100-105
    • Oelschlegel, R.1    Krüger, D.H.2    Rang, A.3
  • 63
    • 77952506401 scopus 로고    scopus 로고
    • The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations
    • Outinen, T. K., Mäkelä, S. M., Ala-Houhala, I. O., Huhtala, H. A. S., Hurme, M., Paakkala, A. S., et al. (2010). The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations. BMC Infect. Dis. 10:132. doi: 10.1186/1471-2334-10-132
    • (2010) BMC Infect. Dis , vol.10 , pp. 132
    • Outinen, T.K.1    Mäkelä, S.M.2    Ala-Houhala, I.O.3    Huhtala, H.A.S.4    Hurme, M.5    Paakkala, A.S.6
  • 64
    • 84863838792 scopus 로고    scopus 로고
    • High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica
    • Outinen, T. K., Mäkelä, S., Huhtala, H., Hurme, M., Meri, S., Pörsti, I., et al. (2012). High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica. Eur. J. Clin. Microbiol. Infect. Dis. 31, 957-963. doi: 10.1007/s10096-011-1392-x
    • (2012) Eur. J. Clin. Microbiol. Infect. Dis , vol.31 , pp. 957-963
    • Outinen, T.K.1    Mäkelä, S.2    Huhtala, H.3    Hurme, M.4    Meri, S.5    Pörsti, I.6
  • 65
    • 0036570359 scopus 로고    scopus 로고
    • Hantavirus pulmonary syndrome: the new American hemorrhagic fever
    • Peters, C. J., and Khan, A. S. (2002). Hantavirus pulmonary syndrome: the new American hemorrhagic fever. Clin. Infect. Dis. 34, 1224-1231. doi: 10.1086/339864
    • (2002) Clin. Infect. Dis , vol.34 , pp. 1224-1231
    • Peters, C.J.1    Khan, A.S.2
  • 66
    • 0026731010 scopus 로고
    • Hantaan virus infection of human endothelial cells
    • Pensiero, M. N., Sharefkin, J. B., Dieffenbach, C. W., and Hay, J. (1992). Hantaan virus infection of human endothelial cells. J. Virol. 66, 5929-5936.
    • (1992) J. Virol , vol.66 , pp. 5929-5936
    • Pensiero, M.N.1    Sharefkin, J.B.2    Dieffenbach, C.W.3    Hay, J.4
  • 67
    • 78650046006 scopus 로고    scopus 로고
    • Modulation of innate immune response by Hantaviruses
    • Rang, A. (2010). Modulation of innate immune response by Hantaviruses. Crit. Rev. Immunol. 30, 515-527. doi: 10.1615/CritRevImmunol.v30.i6.20
    • (2010) Crit. Rev. Immunol , vol.30 , pp. 515-527
    • Rang, A.1
  • 68
    • 77954097645 scopus 로고    scopus 로고
    • Immunity and immunopathology to viruses: what decides the outcome?
    • Rouse, B. T., and Sehrawat, S. (2010). Immunity and immunopathology to viruses: what decides the outcome? Nat. Rev. Immunol. 10, 514-526. doi: 10.1038/nri2802
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 514-526
    • Rouse, B.T.1    Sehrawat, S.2
  • 69
    • 57149094212 scopus 로고    scopus 로고
    • Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea
    • Rusnak, J. M., Byrne, W. R., Chung, K. N., Gibbs, P. H., Kim, T. T., Boudreau, E. F., et al. (2009). Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea. Antiviral Res. 81, 68-76. doi: 10.1016/j.antiviral.2008.09.007
    • (2009) Antiviral Res , vol.81 , pp. 68-76
    • Rusnak, J.M.1    Byrne, W.R.2    Chung, K.N.3    Gibbs, P.H.4    Kim, T.T.5    Boudreau, E.F.6
  • 70
    • 40549087926 scopus 로고    scopus 로고
    • Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome
    • Saksida, A., Duh, D., Korva, M., and Avsic-Zupanc, T. (2008). Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome. J. Infect. Dis. 197, 681-685. doi: 10.1086/527485
    • (2008) J. Infect. Dis , vol.197 , pp. 681-685
    • Saksida, A.1    Duh, D.2    Korva, M.3    Avsic-Zupanc, T.4
  • 71
    • 79956206897 scopus 로고    scopus 로고
    • Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome
    • Saksida, A., Wraber, B., and Avšic-Županc, T. (2011). Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome. BMC Infect. Dis. 11:142. doi: 10.1186/1471-2334-11-142
    • (2011) BMC Infect. Dis , vol.11 , pp. 142
    • Saksida, A.1    Wraber, B.2    Avšic-Županc, T.3
  • 72
    • 84864058294 scopus 로고    scopus 로고
    • Complement activation in Puumala hantavirus infection correlates with disease severity
    • Sane, J., Laine, O., Mäkelä, S., Paakkala, A., Jarva, H., Mustonen, J., et al. (2012). Complement activation in Puumala hantavirus infection correlates with disease severity. Ann. Med. 44, 468-475. doi: 10.3109/07853890.2011.573500
    • (2012) Ann. Med , vol.44 , pp. 468-475
    • Sane, J.1    Laine, O.2    Mäkelä, S.3    Paakkala, A.4    Jarva, H.5    Mustonen, J.6
  • 73
    • 84884268745 scopus 로고    scopus 로고
    • Antiviral efficacy of Favipiravir against two prominent etiological agents of Hantaviruses pulmonary syndrome
    • Safronetz, D., Falzarano, D., Scott, D. P., Furuta, Y., Feldmann, H., and Gowen, B. B. (2013). Antiviral efficacy of Favipiravir against two prominent etiological agents of Hantaviruses pulmonary syndrome. Antimicrob. Agents Chemother. 57, 4673-4680. doi: 10.1128/AAC.00886-13
    • (2013) Antimicrob. Agents Chemother , vol.57 , pp. 4673-4680
    • Safronetz, D.1    Falzarano, D.2    Scott, D.P.3    Furuta, Y.4    Feldmann, H.5    Gowen, B.B.6
  • 74
    • 0031113395 scopus 로고    scopus 로고
    • Hantaviruses: a global disease problem
    • Schmaljohn, C., and Hjelle, B. (1997). Hantaviruses: a global disease problem. Emerg. Infect. Dis. 3, 95-103. doi: 10.3201/eid0302.970202
    • (1997) Emerg. Infect. Dis , vol.3 , pp. 95-103
    • Schmaljohn, C.1    Hjelle, B.2
  • 75
  • 76
    • 77957940689 scopus 로고    scopus 로고
    • Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin
    • Shrivastava-Ranjan, P., Rollin, P. E., and Spiropoulou, C. F. (2010). Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin. J. Virol. 84, 11227-11234. doi: 10.1128/JVI.01405-10
    • (2010) J. Virol , vol.84 , pp. 11227-11234
    • Shrivastava-Ranjan, P.1    Rollin, P.E.2    Spiropoulou, C.F.3
  • 77
    • 34547654176 scopus 로고    scopus 로고
    • Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice
    • Taruishi, M., Yoshimatsu, K., Araki, K., Okumura, M., Nakamura, I., Kajino, K., et al. (2007). Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice. Virology 365, 292-301. doi: 10.1016/j.virol.2007.02.039
    • (2007) Virology , vol.365 , pp. 292-301
    • Taruishi, M.1    Yoshimatsu, K.2    Araki, K.3    Okumura, M.4    Nakamura, I.5    Kajino, K.6
  • 78
    • 79960781684 scopus 로고    scopus 로고
    • T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever renal syndrome
    • Terajima, M., and Ennis, F. A. (2011). T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever renal syndrome. Viruses 3, 1059-1073. doi: 10.3390/v3071059
    • (2011) Viruses , vol.3 , pp. 1059-1073
    • Terajima, M.1    Ennis, F.A.2
  • 80
    • 84907494075 scopus 로고    scopus 로고
    • Pathophysiology of a serve case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant
    • Vaheri, A., Strandin, T., Jääskeläinen, A. J., Vapalahti, O., Jarva, H., Lokki, M. L., et al. (2014). Pathophysiology of a serve case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant. Antiviral Res. 111, 23-25. doi: 10.1016/j.antiviral.2014.08.007
    • (2014) Antiviral Res , vol.111 , pp. 23-25
    • Vaheri, A.1    Strandin, T.2    Jääskeläinen, A.J.3    Vapalahti, O.4    Jarva, H.5    Lokki, M.L.6
  • 81
    • 67650751396 scopus 로고    scopus 로고
    • Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population
    • Wang, M. L., Lai, J. H., Zhu, Y., Zhang, H. B., Li, C., Wang, J. P., et al. (2009a). Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population. Int. J. Immun. 36, 227-229. doi: 10.1111/j.1744-313X.2009.00848.x
    • (2009) Int. J. Immun , vol.36 , pp. 227-229
    • Wang, M.L.1    Lai, J.H.2    Zhu, Y.3    Zhang, H.B.4    Li, C.5    Wang, J.P.6
  • 82
    • 84871809432 scopus 로고    scopus 로고
    • Thrombcytopenia as a predictor of severe acute kidney injury in patients with Hantaan virus infections
    • Wang, M., Wang, J., Wang, T., Li, J., Hui, L., and Ha, X. (2013). Thrombcytopenia as a predictor of severe acute kidney injury in patients with Hantaan virus infections. PLoS ONE 8:e53236. doi: 10.1371/journal.pone.0053236
    • (2013) PLoS ONE , vol.8
    • Wang, M.1    Wang, J.2    Wang, T.3    Li, J.4    Hui, L.5    Ha, X.6
  • 83
    • 83255184406 scopus 로고    scopus 로고
    • Identification of three novel CTL Epitopes within nucleocapsid protein of hantaan virus
    • Wang, M., Zhu, Y., Wang, J., Lv, T., and Jin, B. (2011). Identification of three novel CTL Epitopes within nucleocapsid protein of hantaan virus. Virl. Immunol. 24, 449-454. doi: 10.1089/vim.2011.0026
    • (2011) Virl. Immunol , vol.24 , pp. 449-454
    • Wang, M.1    Zhu, Y.2    Wang, J.3    Lv, T.4    Jin, B.5
  • 84
    • 67849097073 scopus 로고    scopus 로고
    • Analysis of the immune response to Hantaan virus nucleocapsid protein C-terminal-specific CD8+ T cells in patients with Hemorrhagic fever with renal syndrome
    • Wang, P. Z., Huang, C. X., Zhang, Y., Li, Z. D., Yu, H. T., Zhang, Y., et al. (2009b). Analysis of the immune response to Hantaan virus nucleocapsid protein C-terminal-specific CD8+ T cells in patients with Hemorrhagic fever with renal syndrome. Viral Immunol. 22, 253-260. doi: 10.1089/vim.2008.0097
    • (2009) Viral Immunol , vol.22 , pp. 253-260
    • Wang, P.Z.1    Huang, C.X.2    Zhang, Y.3    Li, Z.D.4    Yu, H.T.5    Zhang, Y.6
  • 85
    • 84860435268 scopus 로고    scopus 로고
    • Elevated serum concentrations of inflammatory cytokines and chemokines in patients with haemorrhagic fever with renal syndrome
    • Wang, P. Z., Li, Z. D., Yu, H. T., Zhang, Y., Wang, W., Jiang, W., et al. (2012a). Elevated serum concentrations of inflammatory cytokines and chemokines in patients with haemorrhagic fever with renal syndrome. J. Int. Med. Res. 40, 648-656. doi: 10.1177/147323001204000227
    • (2012) J. Int. Med. Res , vol.40 , pp. 648-656
    • Wang, P.Z.1    Li, Z.D.2    Yu, H.T.3    Zhang, Y.4    Wang, W.5    Jiang, W.6
  • 86
    • 84862798115 scopus 로고    scopus 로고
    • Dysregulation of the β3 integrin-VEGFR2 complex in Hantaan virus-directed hyperpermeability upon treatment with VEGF
    • Wang, W., Zhang, Y., Li, Y., Pan, L., Bai, L., Zhuang, Y., et al. (2012b). Dysregulation of the β3 integrin-VEGFR2 complex in Hantaan virus-directed hyperpermeability upon treatment with VEGF. Arch. Virol. 157, 1051-1061. doi: 10.1007/s00705-012-1245-7
    • (2012) Arch. Virol , vol.157 , pp. 1051-1061
    • Wang, W.1    Zhang, Y.2    Li, Y.3    Pan, L.4    Bai, L.5    Zhuang, Y.6
  • 87
    • 33750721011 scopus 로고    scopus 로고
    • Sin Nombre viral RNA load in patients with hantavirus cardiopulmonary syndrome
    • Xiao, R., Yang, S., Koster, F., Ye, C., Stidley, C., and Hjelle, B. (2006). Sin Nombre viral RNA load in patients with hantavirus cardiopulmonary syndrome. J. Infect. Dis. 194, 1403-1409. doi: 10.1086/508494
    • (2006) J. Infect. Dis , vol.194 , pp. 1403-1409
    • Xiao, R.1    Yang, S.2    Koster, F.3    Ye, C.4    Stidley, C.5    Hjelle, B.6
  • 88
    • 84883656381 scopus 로고    scopus 로고
    • Levels of HTNV-specific CD8+T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome
    • Xie, M., Dong, Y., Zhou, Y., Ren, H., Ji, Y., and Lv, S. (2013). Levels of HTNV-specific CD8+T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome. Intern. Emerg. Med. 8, 503-508. doi: 10.1007/s11739-011-0633-4
    • (2013) Intern. Emerg. Med , vol.8 , pp. 503-508
    • Xie, M.1    Dong, Y.2    Zhou, Y.3    Ren, H.4    Ji, Y.5    Lv, S.6
  • 89
    • 71249110581 scopus 로고    scopus 로고
    • Phase I Evaluation of the safety and pharmacokinetics of a single-dose intravenous injection of a mruine monoclonal antibody against Hantaan Virus in healthy volunteers
    • Xu, R., Yang, X. Y., Yang, D. F., Zou, C. Y., Gong, P. L., and Zeng, F. D. (2009). Phase I Evaluation of the safety and pharmacokinetics of a single-dose intravenous injection of a mruine monoclonal antibody against Hantaan Virus in healthy volunteers. Antimicrob. Agents Ch. 53, 5055-5059. doi: 10.1128/AAC.00728-09
    • (2009) Antimicrob. Agents Ch , vol.53 , pp. 5055-5059
    • Xu, R.1    Yang, X.Y.2    Yang, D.F.3    Zou, C.Y.4    Gong, P.L.5    Zeng, F.D.6
  • 90
    • 0036431834 scopus 로고    scopus 로고
    • The in vitro and in vivo protective activity of monoclonal antibodies directed against Hantaan virus: potential application for immunotherapy and passive immunization
    • Xu, Z., Wei, L., Wang, L., Wang, H., and Jiang, S. (2002). The in vitro and in vivo protective activity of monoclonal antibodies directed against Hantaan virus: potential application for immunotherapy and passive immunization. Biochem. Biophys. Res. Commun. 298, 552-558. doi: 10.1016/S0006-291X(02)02491-9
    • (2002) Biochem. Biophys. Res. Commun , vol.298 , pp. 552-558
    • Xu, Z.1    Wei, L.2    Wang, L.3    Wang, H.4    Jiang, S.5
  • 91
    • 84876011261 scopus 로고    scopus 로고
    • Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity
    • Yi, J., Xu, Z., Zhuang, R., Wang, J., Zhang, Y., Ma, Y., et al. (2013). Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity. J. Infect. Dis. 207, 1457-1461. doi: 10.1093/infdis/jis475
    • (2013) J. Infect. Dis , vol.207 , pp. 1457-1461
    • Yi, J.1    Xu, Z.2    Zhuang, R.3    Wang, J.4    Zhang, Y.5    Ma, Y.6
  • 92
    • 84899531922 scopus 로고    scopus 로고
    • Involvement of the Akt/NF-κB pathways in the HTNV-Medicated increase of IL-6, CCL5, ICAM-1, and VCAM-1 in HUVECs
    • Yu, H. T., Jiang, W., Du, H., Xing, Y., Bai, G. Z., Zhang, Y., et al. (2014). Involvement of the Akt/NF-κB pathways in the HTNV-Medicated increase of IL-6, CCL5, ICAM-1, and VCAM-1 in HUVECs. PLoS ONE 9:e93810. doi: 10.1371/journal.pone.0093810
    • (2014) PLoS ONE , vol.9
    • Yu, H.T.1    Jiang, W.2    Du, H.3    Xing, Y.4    Bai, G.Z.5    Zhang, Y.6
  • 93
    • 58149196517 scopus 로고    scopus 로고
    • Expression of L protein of Hantaan virus 84FLi strain and its application for recovery of minigenomes
    • Zhang, Y., Li, X. H., Jiang, H., Huang, C. X., Wang, P. Z., Mou, D. L., et al. (2008). Expression of L protein of Hantaan virus 84FLi strain and its application for recovery of minigenomes. APMIS 116, 1089-1096. doi: 10.1111/j.1600-0463.2008.01011.x
    • (2008) APMIS , vol.116 , pp. 1089-1096
    • Zhang, Y.1    Li, X.H.2    Jiang, H.3    Huang, C.X.4    Wang, P.Z.5    Mou, D.L.6
  • 94
    • 77956023499 scopus 로고    scopus 로고
    • Hantavirus infections in humans and animals, China
    • Zhang, Y. Z., Zou, Y., Fu, Z. F., and Plyusnin, A. (2010). Hantavirus infections in humans and animals, China. Emerging Infect. Dis. 16, 1195-1203. doi: 10.3201/eid1608.090470
    • (2010) Emerging Infect. Dis , vol.16 , pp. 1195-1203
    • Zhang, Y.Z.1    Zou, Y.2    Fu, Z.F.3    Plyusnin, A.4
  • 95
    • 84904079889 scopus 로고    scopus 로고
    • Epidemic characteristics of hemorrhagic fever with renal syndrome in China, 2006-2012
    • Zhang, S., Wang, S., Yin, W., Liang, M., Li, J., Zhang, Q., et al. (2014a). Epidemic characteristics of hemorrhagic fever with renal syndrome in China, 2006-2012. BMC Infect. Dis. 14:384. doi: 10.1186/1471-2334-14-384
    • (2014) BMC Infect. Dis , vol.14 , pp. 384
    • Zhang, S.1    Wang, S.2    Yin, W.3    Liang, M.4    Li, J.5    Zhang, Q.6
  • 96
    • 84896954337 scopus 로고    scopus 로고
    • Hantaan virus infection induces CXCL10 expression through TLR3, RIG-I, and MDA-5 pathways correlated with the disease severity
    • Zhang, Y., Liu, B., Ma, Y., Yi, J., Zhang, C., Zhang, Y., et al. (2014b). Hantaan virus infection induces CXCL10 expression through TLR3, RIG-I, and MDA-5 pathways correlated with the disease severity. Med. Inflamm. 2014:697837. doi: 10.1155/2014/697837
    • (2014) Med. Inflamm , vol.2014
    • Zhang, Y.1    Liu, B.2    Ma, Y.3    Yi, J.4    Zhang, C.5    Zhang, Y.6
  • 97
    • 61849158287 scopus 로고    scopus 로고
    • + cell populations in haemorrhagic fever with renal syndrome
    • + cell populations in haemorrhagic fever with renal syndrome. Clin. Exp. Immunol. 156, 88-96. doi: 10.1111/j.1365-2249.2008.03858.x
    • (2009) Clin. Exp. Immunol , vol.156 , pp. 88-96
    • Zhu, L.Y.1    Chi, L.J.2    Wang, X.3    Zhou, H.4


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