Pathophysiology of a severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant

Antiviral Research

Volumn 111, Issue , 2014, Pages 23-25

  Vaheri, Antti ^a,b   Strandin, Tomas ^a   Jääskeläinen, Anne J ^a,b   Vapalahti, Olli ^a,b   Jarva, Hanna ^a   Lokki, Marja Liisa ^a   Antonen, Jaakko ^c   Leppänen, Ilona ^c   Mäkelä, Satu ^c,d   Meri, Seppo ^a   Mustonen, Jukka ^c,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Bradykinin; Capillary leakage; Complement activation; Hantavirus; Icatibant; Pathophysiology

Indexed keywords

BRADYKININ; CEFTRIAXONE; CORTICOSTEROID; HISTONE; ICATIBANT; NITRIC OXIDE; VASOACTIVE AGENT; BRADYKININ ANTAGONIST; BRADYKININ RECEPTOR;

ADULT; ANGIONEUROTIC EDEMA; ARTICLE; ARTIFICIAL VENTILATION; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; CASE REPORT; CLINICAL CHEMISTRY; COMPLEMENT ACTIVATION; CONTINUOUS RENAL REPLACEMENT THERAPY; DISEASE SEVERITY; FIBRINOLYSIS; HANTAVIRUS INFECTION; HEMATOLOGICAL PARAMETERS; HLA SYSTEM; HOSPITAL ADMISSION; HOST; HUMAN; INTENSIVE CARE UNIT; KIDNEY FAILURE; LEUKOCYTOSIS; LIVER DISEASE; LIVER FAILURE; LIVER FUNCTION; MALE; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PUUMALA VIRUS; RESPIRATORY FAILURE; SHOCK; SPHEROCYTOSIS; SPLENECTOMY; VIROLOGY; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENETICS; HEMORRHAGIC FEVER WITH RENAL SYNDROME; METABOLISM; PATHOLOGY; PHYSIOLOGY;

HANTAVIRUS; PUUMALA VIRUS;

ADULT; BRADYKININ; BRADYKININ RECEPTOR ANTAGONISTS; HEMORRHAGIC FEVER WITH RENAL SYNDROME; HUMANS; MALE; PUUMALA VIRUS; RECEPTORS, BRADYKININ;

EID: 84907494075     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.08.007     Document Type: Article

References (16)

1. J. Antonen, I. Leppänen, J. Tenhunen, P. Arvola, S. Mäkelä, A. Vaheri, and J. Mustonen A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant Scand. J. Infect. Dis. 45 2013 494 496
2. A. Di Sabatino, R. Carsetti, and G.R. Corazza Post-splenectomy and hyposplenic states Lancet 378 2011 86 97
3. X.Y. Han, B.A. Hellerstedt, and C.A. Koller Postsplenectomy cytomegalovirus mononucleosis is a distinct clinicopathologic syndrome Am. J. Med. Sci. 33 2010 395 399
4. T. Jaatinen, M. Eholuoto, T. Laitinen, and M.L. Lokki Characterization of a de novo conversion in human complement C4 gene producing a C4B5-like protein J. Immunol. 168 2002 5652 5658
5. Koskela, S.M., Laine, O.K., Paakkala, A.S., Mäkelä, S.M., Mustonen, J.T., 2014. Spleen enlargement is a common finding in acute Puumala hantavirus infection and it does not associate with thrombocytopenia. Scand. J. Infect. Dis. (in press).
6. O. Laine, S. Mäkelä, J. Mustonen, H. Huhtala, T. Szanto, A. Vaheri, R. Lassila, and L. Joutsi-Korhonen Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection Thromb. Res. 126 2010 154 158
7. S. Mäkelä, J. Mustonen, I. Ala-Houhala, M. Hurme, J. Partanen, O. Vapalahti, A. Vaheri, and A. Pasternack Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-a(-308 G/A polymorphism J. Infect. Dis. 186 2002 843 846
8. S. Meri Complement activation in diseases presenting with thrombotic microangiopathy Eur. J. Int. Med. 24 2013 496 502
9. J. Mustonen, S. Mäkelä, T. Outinen, T. Laine, J. Jylhävä, P.T. Arstila, M. Hurme, and A. Vaheri The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions Antiviral Res. 100 2013 589 604
10. J. Mustonen, J. Partanen, M. Kanerva, K. Pietilä, O. Vapalahti, A. Pasternack, and A. Vaheri Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus Kidney Int. 49 1996 217 221
11. R. Paakkanen, H. Vauhkonen, K.T. Eronen, A. Järvinen, M. Seppänen, and M.L. Lokki Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction PLoS One 7 6 2012 e38813 10.1371/journal.pone.0038813
12. Raftery, M.J., Lalwani, P., Krautkrämer, E., Peters, T., Scharffetter-Kochanek, K., Krüger, R., Hofmann, J., Seeger, K., Krüger, D.H., Schönrich, G., 2014. β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps, J. Exp. Med.
13. J. Sane, O. Laine, S. Mäkelä, A. Paakkala, H. Jarva, J. Mustonen, O. Vapalahti, S. Meri, and A. Vaheri Complement activation in Puumala hantavirus infection correlates with disease severity Ann. Med. 44 2012 468 475
14. A. Vaheri, O. Vapalahti, and A. Plyusnin How to diagnose hantavirus infections and detect them in rodents and insectivores Rev. Med. Virol. 8 2008 277 288
15. A. Wennerström, E. Vlachopoulou, L.E. Lahtela, R. Paakkanen, K.T. Eronen, M. Seppänen, and M.L. Lokki Diversity of extended HLA-DRB1 haplotypes in the Finnish population PLoS One 8 11 2013 e79690 10.1371/journal.pone.0079690
16. J. Xu, X. Zhang, R. Pelayo, M. Monestier, C.T. Ammollo, F. Semeraro, F.B. Taylor, N.L. Esmon, F. Lupu, and C.T. Esmon Extracellular histones are major mediators of death in sepsis Nat. Med. 15 2009 1318 1321