Application of a LC–MS/MS method for evaluating lung penetration of tobramycin in rats by microdialysis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 134, Issue , 2017, Pages 340-345

  Bernardi, P M ^a   Barreto, F ^b   Dalla Costa, T ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Laboratório Nacional Agropecuário Do Rio Grande Do sul LANAGRO RS   (Brazil)

Author keywords

Bioanalytical method validation; LC MS MS; Microdialysis; Pre clinical pharmacokinetics; Tissue penetration; Tobramycin

Indexed keywords

ACETONITRILE; APRAMYCIN; BUTYRIC ACID DERIVATIVE; RINGER SOLUTION; TOBRAMYCIN; WATER; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG PENETRATION; DRUG STABILITY; DRUG TISSUE LEVEL; ELECTROSPRAY; ELIMINATION HALF-LIFE; ELUTION; FLOW RATE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LUNG; MALE; MICRODIALYSIS; NONHUMAN; PLASMA CLEARANCE; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT; VOLUME OF DISTRIBUTION; ANIMAL; BLOOD; LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; TANDEM MASS SPECTROMETRY; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, LIQUID; LUNG; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY; TOBRAMYCIN;

EID: 85006092469     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2016.10.023     Document Type: Article

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