Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs

Current Opinion in Pharmacology

Volumn 5, Issue 5 SPEC.ISS., 2005, Pages 495-499

  Brunner, Martin ^a,b   Derendorf, Hartmut ^b   Müller, Markus ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CEFIXIME; CEFPIROME; CEFPODOXIME; CIPROFLOXACIN; FOSFOMYCIN; GEMIFLOXACIN; GENTAMICIN; LEVOFLOXACIN; METRONIDAZOLE; PIPERACILLIN; TELITHROMYCIN;

ANALYTIC METHOD; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; BIOPSY TECHNIQUE; CATHETER; CENTRAL NERVOUS SYSTEM INFECTION; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; DRUG TARGETING; DRUG TISSUE LEVEL; HUMAN; IN VIVO STUDY; MEASUREMENT; MICRODIALYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; SAMPLING; SEPSIS; SEPTIC SHOCK; TISSUE DISTRIBUTION;

EID: 24344458982     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2005.04.010     Document Type: Review

References (48)

1. P. Liu M. Müller H. Derendorf Rational dosing of antibiotics: The use of plasma concentrations versus tissue concentrations Int J Antimicrob Agents 19 2002 285-290
2. M. Müller A. dela Pena H. Derendorf Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: Distribution in tissue Antimicrob Agents Chemother 48 2004 1441-1453
3. A.J. Fischman J.W. Babich A.A. Bonab N.M. Alpert J. Vincent R.J. Callahan J.A. Correia R.H. Rubin Pharmacokinetics of [18F]trovafloxacin in healthy human subjects studied with positron emission tomography Antimicrob Agents Chemother 42 1998 2048-2054
4. R.K. Jain The next frontier of molecular medicine: Delivery of therapeutics Nat Med 4 1998 655-657
5. C.A. Presant W. Wolf V. Waluch C. Wiseman P. Kennedy D. Blayney R.R. Brechner Association of intratumoral pharmacokinetics of fluorouracil with clinical response Lancet 343 1994 1184-1187
6. M. Brunner T. Pernerstorfer B.X. Mayer H.G. Eichler M. Müller Surgery and intensive care procedures affect the target site distribution of piperacillin Crit Care Med 28 2000 1754-1759
7. C. Joukhadar M. Frossard B.X. Mayer M. Brunner N. Klein P. Siostrzonek H.G. Eichler M. Müller Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock Crit Care Med 29 2001 385-391
8. J.M. Hyatt P.S. McKinnon G.S. Zimmer J.J. Schentag The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agents Clin Pharmacokinet 28 1995 143-160
9. C.M. Kunin W.A. Craig M. Kornguth R. Monson Influence of binding on the pharmacologic activity of antibiotics Ann NY Acad Sci 226 1973 214-224
10. D.J. Merrikin J. Briant G.N. Rolinson Effect of protein binding on antibiotic activity in vivo J Antimicrob Chemother 11 1983 233-238
11. P. Liu H. Derendorf Antimicrobial tissue concentrations Infect Dis Clin North Am 17 2003 599-613
12. O. Langer M. Müller Methods to assess tissue-specific distribution and metabolism of drugs Curr Drug Metab 5 2004 463-481
13. M. Müller R. Schmid A. Georgopoulos A. Buxbaum C. Wasicek H.G. Eichler Application of microdialysis to clinical pharmacokinetics in humans Clin Pharmacol Ther 57 1995 371-380
14. M. Müller Microdialysis in clinical drug delivery studies Adv Drug Deliv Rev 45 2000 255-269
15. A. de la Pena P. Liu H. Derendorf Microdialysis in peripheral tissues Adv Drug Deliv Rev 45 2000 189-216
16. C. Joukhadar H. Derendorf M. Müller Microdialysis: A novel tool for clinical studies of anti-infective agents Eur J Clin Pharmacol 57 2001 211-219
17. M. Müller Science, medicine, and the future: Microdialysis BMJ 324 2002 588-591
18. N. Borg E. Gotharson E. Benfeldt L. Groth L. Stahle Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers: Comparison of the suction blister technique and cutaneous microdialysis Acta Derm Venereol 79 1999 274-277
19. L. Sasongko K.M. Williams R.O. Day A.J. McLachlan Human subcutaneous tissue distribution of fluconazole: Comparison of microdialysis and suction blister techniques Br J Clin Pharmacol 56 2003 551-561
20. J. Karjagin R. Pahkla T. Karki J. Starkopf Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro J Antimicrob Chemother 55 2005 341-346
21. J. Karjagin R. Pahkla J. Starkopf Perioperative penetration of metronidazole into muscle tissue: A microdialysis study Eur J Clin Pharmacol 59 2004 809-813
22. P. Liu M. Müller M. Grant B. Obermann H. Derendorf Tissue penetration of cefpodoxime and cefixime in healthy subjects J Clin Pharmacol 45 2005 564-569
23. U. Hollenstein M. Brunner B.X. Mayer S. Delacher B. Erovic H.G. Eichler M. Müller Target site concentrations after continuous infusion and bolus injection of cefpirome to healthy volunteers Clin Pharmacol Ther 67 2000 229-236
24. P.A. de M. Brunner H.G. Eichler E. Rehak J. Gross U. Thyroff-Friesinger M. Müller H. Derendorf Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans J Clin Pharmacol 42 2002 403-411
25. P. Liu K.H. Rand B. Obermann H. Derendorf Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models Int J Antimicrob Agents 25 2005 120-129
26. S. Delacher H. Derendorf U. Hollenstein M. Brunner C. Joukhadar S. Hofmann A. Georgopoulos H.G. Eichler M. Müller A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans J Antimicrob Chemother 46 2000 733-739
27. M. Brunner U. Hollenstein S. Delacher D. Jäger R. Schmid E. Lackner A. Georgopoulos H.G. Eichler M. Müller Distribution and antimicrobial activity of ciprofloxacin in human soft tissues Antimicrob Agents Chemother 43 1999 1307-1309
28. R. Gattringer E. Urbauer F. Traunmuller M. Zeitlinger P. Dehghanyar P. Zeleny W. Graninger M. Müller C. Joukhadar Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers Antimicrob Agents Chemother 48 2004 4650-4653
29. F. Islinger R. Bouw M. Stahl E. Lackner P. Zeleny M. Brunner M. Müller H.G. Eichler C. Joukhadar Concentrations of gemifloxacin at the target site in healthy volunteers after a single oral dose Antimicrob Agents Chemother 48 2004 4246-4249
30. R. Sauermann G. Delle-Karth C. Marsik I. Steiner M. Zeitlinger B.X. Mayer-Helm A. Georgopoulos M. Müller C. Joukhadar Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients Antimicrob Agents Chemother 49 2005 650-655
31. M.A. Zeitlinger P. Dehghanyar B.X. Mayer B.S. Schenk U. Neckel G. Heinz A. Georgopoulos M. Müller C. Joukhadar Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis Antimicrob Agents Chemother 47 2003 3548-3553
32. M.A. Zeitlinger C. Marsik A. Georgopoulos M. Müller G. Heinz C. Joukhadar Target site bacterial killing of cefpirome and fosfomycin in critically ill patients Int J Antimicrob Agents 21 2003 562-567
33. C. Joukhadar N. Klein B.X. Mayer N. Kreischitz G. Delle-Karth P. Palkovits G. Heinz M. Müller Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis Crit Care Med 30 2002 1478-1482
34. I. Tegeder A. Schmidtko L. Brautigam A. Kirschbaum G. Geisslinger J. Lotsch Tissue distribution of imipenem in critically ill patients Clin Pharmacol Ther 71 2002 325-333
35. R. Sauermann M. Zeitlinger B.M. Erovic C. Marsik A. Georgopoulos M. Müller M. Brunner C. Joukhadar Pharmacodynamics of piperacillin in severely ill patients evaluated by using a PK/PD model Int J Antimicrob Agents 22 2003 574-578
36. U.M. Hollenstein M. Brunner R. Schmid M. Müller Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing Int J Obes Relat Metab Disord 25 2001 354-358
37. M. Müller M. Brunner U. Hollenstein C. Joukhadar R. Schmid E. Minar H. Ehringer H.G. Eichler Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients Antimicrob Agents Chemother 43 1999 2056-2058
38. R. Bellmann G. Kuchling P. Dehghanyar M. Zeitlinger E. Minar B.X. Mayer M. Müller C. Joukhadar Tissue pharmacokinetics of levofloxacin in human soft tissue infections Br J Clin Pharmacol 57 2004 563-568
39. F.J. Legat A. Maier P. Dittrich P. Zenahlik T. Kern S. Nuhsbaumer M. Frossard W. Salmhofer H. Kerl M. Müller Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome Antimicrob Agents Chemother 47 2003 371-374
40. C. Joukhadar N. Klein M. Frossard E. Minar H. Stass E. Lackner M. Herrmann E. Riedmuller M. Müller Angioplasty increases target site concentrations of ciprofloxacin in patients with peripheral arterial occlusive disease Clin Pharmacol Ther 70 2001 532-539
41. J.J. Schentag C.H. Ballow Tissue-directed pharmacokinetics Am J Med 91 1991 5S-11S
42. F. Tomaselli A. Maier V. Matzi F.M. Smolle-Juttner P. Dittrich Penetration of meropenem into pneumonic human lung tissue as measured by in vivo microdialysis Antimicrob Agents Chemother 48 2004 2228-2232
43. F. Tomaselli P. Dittrich A. Maier M. Woltsche V. Matzi J. Pinter S. Nuhsbaumer H. Pinter J. Smolle F.M. Smolle-Juttner Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis Br J Clin Pharmacol 55 2003 620-624
44. H. Herkner M.R. Muller N. Kreischitz B.X. Mayer M. Frossard C. Joukhadar N. Klein E. Lackner M. Müller Closed-chest microdialysis to measure antibiotic penetration into human lung tissue Am J Respir Crit Care Med 165 2002 273-276
45. T. Mindermann W. Zimmerli O. Gratzl Rifampin concentrations in various compartments of the human brain: A novel method for determining drug levels in the cerebral extracellular space Antimicrob Agents Chemother 42 1998 2626-2629
46. M. Brunner A. Reinprecht U. Illievich C.K. Spiss P. Dittrich M. van Houte M. Müller Penetration of fosfomycin into the parenchyma of human brain: A case study in three patients Br J Clin Pharmacol 54 2002 548-550
47. H. Derendorf L.J. Lesko P. Chaikin W.A. Colburn P. Lee R. Miller R. Powell G. Rhodes D. Stanski J. Venitz Pharmacokinetic/pharmacodynamic modeling in drug research and development J Clin Pharmacol 40 2000 1399-1418
48. A. de la Pena A. Grabe K.H. Rand E. Rehak J. Gross U. Thyroff-Friesinger M. Müller H. Derendorf PK-PD modelling of the effect of cefaclor on four different bacterial strains Int J Antimicrob Agents 23 2004 218-225