Human metabolome-derived cofactors are required for the antibacterial activity of siderocalin in urine

Journal of Biological Chemistry

Volumn 291, Issue 50, 2016, Pages 25901-25910

  Shields Cutler, Robin R ^a   Crowley, Jan R ^a   Miller, Connelly D ^a   Stapleton, Ann E ^b   Cui, Weidong ^c   Henderson, Jeffrey P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; BIOCHEMISTRY; BODY FLUIDS; ESCHERICHIA COLI; IRON; IRON COMPOUNDS; MASS SPECTROMETRY; PHENOLS; PHYSIOLOGY; PROTEINS;

ANTI-BACTERIAL ACTIVITY; ANTIMICROBIAL PROTEINS; BACTERIAL PATHOGENS; GROWTH-LIMITING NUTRIENTS; NATIVE MASS SPECTROMETRIES; NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN; URINARY METABOLOME; URINARY TRACT INFECTIONS;

LIGANDS;

3 HYDROXYBENZOIC ACID; 3 HYDROXYPHENYLACETIC ACID; 4 HYDROXYPHENYLACETIC ACID; 4 METHYLCATECHOL; 5 HYDROXYINDOLE; CAFFEIC ACID; CATECHOL; DIHYDROCAFFEIC ACID; ENTEROCHELIN; FERULIC ACID; GALLIC ACID PROPYL ESTER; INDOLEACETIC ACID; IRON; MANDELIC ACID; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PYROGALLOL; ANTIINFECTIVE AGENT; CARRIER PROTEIN; CATECHOL DERIVATIVE; SIDEROCALIN PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; CYSTITIS; ESCHERICHIA COLI; FEMALE; HUMAN; IN VIVO STUDY; INNATE IMMUNITY; LIGAND BINDING; METABOLOME; NONHUMAN; PRIORITY JOURNAL; URINALYSIS; URINARY TRACT INFECTION; ADOLESCENT; ESCHERICHIA COLI INFECTION; IMMUNOLOGY; MIDDLE AGED; URINE;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; CARRIER PROTEINS; CATECHOLS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; HUMANS; IMMUNITY, INNATE; METABOLOME; MIDDLE AGED; URINARY TRACT INFECTIONS;

EID: 85002835024     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.759183     Document Type: Article

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