Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

Journal of Clinical Investigation

Volumn 126, Issue 12, 2016, Pages 4527-4536

  Wang, Sheng Peng ^a   Chennupati, Ramesh ^a   Kaur, Harmandeep ^a   Iring, Andras ^a   Wettschureck, Nina ^a,b   Offermanns, Stefan ^a,b,c  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c Instituto de Investigación en Biomedicina de Buenos Aires   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; NITRIC OXIDE; PIEZO1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; CALCIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ION CHANNEL; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, MOUSE; PIEZO1 PROTEIN, HUMAN; PIEZO1 PROTEIN, MOUSE; PROTEIN KINASE B; PURINERGIC P2Y RECEPTOR;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; HYPERTENSION; IMMUNOPRECIPITATION; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PURIFICATION; REGULATORY MECHANISM; SHEAR STRESS; UMBILICAL VEIN ENDOTHELIAL CELL; VASODILATATION; WESTERN BLOTTING; ANIMAL; BLOOD PRESSURE; BOVINE; CALCIUM SIGNALING; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; CALCIUM; CALCIUM SIGNALING; CATTLE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ION CHANNELS; MICE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, PURINERGIC P2Y; VASODILATION;

EID: 85002770961     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI87343     Document Type: Article

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