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Volumn 5, Issue 1, 2016, Pages

Pharmacological interventions for delirium in intensive care patients: A protocol for an overview of reviews

Author keywords

Antipsychotics; Critically ill; Delirium; Intensive care unit; Management; Pharmacological interventions; Prevention; Sedatives; Systematic review

Indexed keywords

CHOLINESTERASE INHIBITOR; DEXMEDETOMIDINE; DIAZEPAM; HALOPERIDOL; LORAZEPAM; MIDAZOLAM; MORPHINE; OLANZAPINE; OPIATE; PROPOFOL; QUETIAPINE; RAMELTEON; RISPERIDONE; RIVASTIGMINE; ZIPRASIDONE; HYPNOTIC SEDATIVE AGENT; MELATONIN;

EID: 85002712935     PISSN: None     EISSN: 20464053     Source Type: Journal    
DOI: 10.1186/s13643-016-0391-5     Document Type: Article
Times cited : (18)

References (105)
  • 1
    • 33847349467 scopus 로고    scopus 로고
    • Practice Guidelines for the treatment of psychiatric disorders
    • compendium
    • Association AP. Practice Guidelines for the treatment of psychiatric disorders, compendium. 2006.
    • (2006)
  • 2
    • 38649126579 scopus 로고    scopus 로고
    • Pathophysiology of delirium in the intensive care unit
    • Gunther ML, Morandi A, Ely EW. Pathophysiology of delirium in the intensive care unit. Crit Care Clin. 2008;24(1):45-65.
    • (2008) Crit Care Clin , vol.24 , Issue.1 , pp. 45-65
    • Gunther, M.L.1    Morandi, A.2    Ely, E.W.3
  • 3
    • 84893032098 scopus 로고    scopus 로고
    • Sedation and delirium in the intensive care unit
    • Reade MC, Finfer S. Sedation and delirium in the intensive care unit. N Engl J Med. 2014;370(5):444-54.
    • (2014) N Engl J Med , vol.370 , Issue.5 , pp. 444-454
    • Reade, M.C.1    Finfer, S.2
  • 5
    • 33644988306 scopus 로고    scopus 로고
    • Delirium in older persons
    • Inouye SK. Delirium in older persons. N Engl J Med. 2006;354(11):1157-65.
    • (2006) N Engl J Med , vol.354 , Issue.11 , pp. 1157-1165
    • Inouye, S.K.1
  • 6
    • 84862215583 scopus 로고    scopus 로고
    • The prevalence, incidence and risk factors for delirium in Dutch nursing homes and residential care homes
    • Boorsma M, et al. The prevalence, incidence and risk factors for delirium in Dutch nursing homes and residential care homes. Int J Geriatr Psychiatry. 2012;27(7):709-15.
    • (2012) Int J Geriatr Psychiatry , vol.27 , Issue.7 , pp. 709-715
    • Boorsma, M.1
  • 7
    • 0031727578 scopus 로고    scopus 로고
    • Delirium in hospitalized older patients
    • Inouye SK. Delirium in hospitalized older patients. Clin Geriatr Med. 1998;14(4):745-64.
    • (1998) Clin Geriatr Med , vol.14 , Issue.4 , pp. 745-764
    • Inouye, S.K.1
  • 9
    • 84856579294 scopus 로고    scopus 로고
    • Pharmacological and nonpharmacological management of delirium in critically ill patients
    • Hipp DM, Ely EW. Pharmacological and nonpharmacological management of delirium in critically ill patients. Neurotherapeutics. 2012;9(1):158-75.
    • (2012) Neurotherapeutics , vol.9 , Issue.1 , pp. 158-175
    • Hipp, D.M.1    Ely, E.W.2
  • 10
    • 0035800052 scopus 로고    scopus 로고
    • American College of Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel
    • Diagnosis and management of delirium near the end of life. Ann Intern Med
    • Casarett DJ, Inouye SK, American College of Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel. Diagnosis and management of delirium near the end of life. Ann Intern Med. 2001;135(1):32-40.
    • (2001) , vol.135 , Issue.1 , pp. 32-40
    • Casarett, D.J.1    Inouye, S.K.2
  • 11
    • 84884950975 scopus 로고    scopus 로고
    • Long-term cognitive impairment after critical illness
    • Pandharipande PP, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306-16.
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1306-1316
    • Pandharipande, P.P.1
  • 12
    • 1842867052 scopus 로고    scopus 로고
    • Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    • Ely EW, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753-62.
    • (2004) JAMA , vol.291 , Issue.14 , pp. 1753-1762
    • Ely, E.W.1
  • 13
    • 84913597409 scopus 로고    scopus 로고
    • The attributable mortality of delirium in critically ill patients: prospective cohort study
    • Klein Klouwenberg PM, et al. The attributable mortality of delirium in critically ill patients: prospective cohort study. BMJ. 2014;349:g6652. doi: 10.1136/bmj.g6652.
    • (2014) BMJ , vol.349 , pp. g6652
    • Klein Klouwenberg, P.M.1
  • 14
    • 11144358457 scopus 로고    scopus 로고
    • Costs associated with delirium in mechanically ventilated patients
    • Milbrandt EB, et al. Costs associated with delirium in mechanically ventilated patients. Crit Care Med. 2004;32(4):955-62.
    • (2004) Crit Care Med , vol.32 , Issue.4 , pp. 955-962
    • Milbrandt, E.B.1
  • 15
    • 84863224781 scopus 로고    scopus 로고
    • The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies
    • Gusmao-Flores D, et al. The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care. 2012;16(4):R115.
    • (2012) Crit Care , vol.16 , Issue.4 , pp. R115
    • Gusmao-Flores, D.1
  • 16
    • 67649312057 scopus 로고    scopus 로고
    • Occurrence of delirium is severely underestimated in the ICU during daily care
    • Spronk PE, et al. Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med. 2009;35(7):1276-80.
    • (2009) Intensive Care Med , vol.35 , Issue.7 , pp. 1276-1280
    • Spronk, P.E.1
  • 17
    • 66449120873 scopus 로고    scopus 로고
    • Comparison of delirium assessment tools in a mixed intensive care unit
    • van Eijk MM, et al. Comparison of delirium assessment tools in a mixed intensive care unit. Crit Care Med. 2009;37(6):1881-5.
    • (2009) Crit Care Med , vol.37 , Issue.6 , pp. 1881-1885
    • Eijk, M.M.1
  • 18
    • 33644652127 scopus 로고    scopus 로고
    • Delirium and its motoric subtypes: a study of 614 critically ill patients
    • Peterson JF, et al. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc. 2006;54(3):479-84.
    • (2006) J Am Geriatr Soc , vol.54 , Issue.3 , pp. 479-484
    • Peterson, J.F.1
  • 19
    • 34748892931 scopus 로고    scopus 로고
    • Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients
    • Pandharipande P, et al. Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Intensive Care Med. 2007;33(10):1726-31.
    • (2007) Intensive Care Med , vol.33 , Issue.10 , pp. 1726-1731
    • Pandharipande, P.1
  • 20
    • 85040124141 scopus 로고    scopus 로고
    • Pharmacological interventions for the treatment of delirium in critically ill patients
    • Burry L, et al. Pharmacological interventions for the treatment of delirium in critically ill patients. Cochrane Database Syst Rev. 2015. doi: 10.1002/14651858.CD011749.
    • (2015) Cochrane Database Syst Rev
    • Burry, L.1
  • 21
    • 84872087535 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit
    • Barr J, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263-306.
    • (2013) Crit Care Med , vol.41 , Issue.1 , pp. 263-306
    • Barr, J.1
  • 22
    • 70450207439 scopus 로고    scopus 로고
    • Detection, prevention and treatment of delirium in critically ill patients
    • Intensive Care Society 2006. Available from:Accessed Dec 2016
    • Borthwick M, B.R., Craig M, Egan A, Oxley J. Detection, prevention and treatment of delirium in critically ill patients. Intensive Care Society 2006. Available from: http://members.ics.ac.uk/AsiCommon/Controls/BSA/Downloader.aspx?iDocumentStorageKey=d616cece-070a-48a4-bfaa-18da5a546634&iFileTypeCode=PDF&iFileName=Detection,%20Prevention%20and%20Treatment%20of%20Delirium. Accessed Dec 2016.
    • Borthwick, M.B.R.1    Craig, M.2    Egan, A.3    Oxley, J.4
  • 23
    • 84856961636 scopus 로고    scopus 로고
    • Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version
    • Doc02
    • Martin J, et al. Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci. 2010;8:Doc02.
    • (2010) Ger Med Sci , vol.8
    • Martin, J.1
  • 24
    • 85002758986 scopus 로고    scopus 로고
    • Sedationsstrategi - Målrette behandling af gener forbundet med kritisk sygdom
    • Available from:Accessed Dec 2016.
    • Dansk Selskab for Anæstesi og Intensiv Medicin (DASAIM), Sedationsstrategi - Målrette behandling af gener forbundet med kritisk sygdom. 2014. Available from: https://www.google.dk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjSjMmimdPQAhWwbZoKHanCpsQFggaMAA&url=http%3A%2F%2Fwww.dasaim.dk%2Fwp-content%2Fuploads%2F2015%2F09%2FSedationsstrategisept15.pdf&usg=AFQjCNF9xGfr3aoeEBMTTPHrDpBm2BqMSw&bvm=bv.139782543,d.bGs. Accessed Dec 2016.
    • (2014)
  • 25
    • 79959563165 scopus 로고    scopus 로고
    • Delirium: diagnosis, prevention and management
    • Available from:Accessed Dec 2016.
    • National Clinical Guideline Centre, Delirium: diagnosis, prevention and management. 2010. Available from: https://www.nice.org.uk/guidance/cg103/evidence/full-guideline-134653069. Accessed Dec 2016.
    • (2010)
  • 26
    • 85002880407 scopus 로고    scopus 로고
    • Delirium and acute confusional states: Prevention, treatment, and prognosis
    • UpToDate Accessed Oct 2015.
    • Francis J, Delirium and acute confusional states: Prevention, treatment, and prognosis. UpToDate 2014. Accessed Oct 2015.
    • (2014)
    • Francis, J.1
  • 27
    • 85002616459 scopus 로고    scopus 로고
    • diagnosis and management of delirium in older people - National guideline. 2006. Available from: https://www.rcplondon.ac.uk/file/1619/download?token=YNbPLdOo. Accessed Dec 2016.
    • British Geriatrics Society, The prevention, diagnosis and management of delirium in older people - National guideline. 2006. Available from: https://www.rcplondon.ac.uk/file/1619/download?token=YNbPLdOo. Accessed Dec 2016.
  • 28
    • 84888645458 scopus 로고    scopus 로고
    • What do we really know about the treatment of delirium with antipsychotics? Ten key issues for delirium pharmacotherapy
    • Meagher DJ, et al. What do we really know about the treatment of delirium with antipsychotics? Ten key issues for delirium pharmacotherapy. Am J Geriatr Psychiatry. 2013;21(12):1223-38.
    • (2013) Am J Geriatr Psychiatry , vol.21 , Issue.12 , pp. 1223-1238
    • Meagher, D.J.1
  • 29
    • 84867587446 scopus 로고    scopus 로고
    • Early intensive care sedation predicts long-term mortality in ventilated critically ill patients
    • Shehabi Y, et al. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med. 2012;186(8):724-31.
    • (2012) Am J Respir Crit Care Med , vol.186 , Issue.8 , pp. 724-731
    • Shehabi, Y.1
  • 30
    • 0023203410 scopus 로고
    • Association of elevated plasma anticholinergic activity with delirium in surgical patients
    • Golinger RC, Peet T, Tune LE. Association of elevated plasma anticholinergic activity with delirium in surgical patients. Am J Psychiatry. 1987;144(9):1218-20.
    • (1987) Am J Psychiatry , vol.144 , Issue.9 , pp. 1218-1220
    • Golinger, R.C.1    Peet, T.2    Tune, L.E.3
  • 31
    • 0034920302 scopus 로고    scopus 로고
    • Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients
    • Han L, et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch Intern Med. 2001;161(8):1099-105.
    • (2001) Arch Intern Med , vol.161 , Issue.8 , pp. 1099-1105
    • Han, L.1
  • 32
    • 33645500101 scopus 로고    scopus 로고
    • Postoperative delirium: the importance of pain and pain management
    • Vaurio LE, et al. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006;102(4):1267-73.
    • (2006) Anesth Analg , vol.102 , Issue.4 , pp. 1267-1273
    • Vaurio, L.E.1
  • 33
    • 84858419995 scopus 로고    scopus 로고
    • Potential use of melatonin in sleep and delirium in the critically ill
    • Bellapart J, Boots R. Potential use of melatonin in sleep and delirium in the critically ill. Br J Anaesth. 2012;108(4):572-80.
    • (2012) Br J Anaesth , vol.108 , Issue.4 , pp. 572-580
    • Bellapart, J.1    Boots, R.2
  • 34
    • 3042570072 scopus 로고    scopus 로고
    • Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients
    • Olofsson K, et al. Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand. 2004;48(6):679-84.
    • (2004) Acta Anaesthesiol Scand , vol.48 , Issue.6 , pp. 679-684
    • Olofsson, K.1
  • 35
    • 0035814368 scopus 로고    scopus 로고
    • Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    • Ely EW, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA. 2001;286(21):2703-10.
    • (2001) JAMA , vol.286 , Issue.21 , pp. 2703-2710
    • Ely, E.W.1
  • 36
    • 0035210918 scopus 로고    scopus 로고
    • The impact of delirium in the intensive care unit on hospital length of stay
    • Ely EW, et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med. 2001;27(12):1892-900.
    • (2001) Intensive Care Med , vol.27 , Issue.12 , pp. 1892-1900
    • Ely, E.W.1
  • 37
    • 33845929011 scopus 로고    scopus 로고
    • Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients
    • Ely EW, et al. Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med. 2007;35(1):112-7.
    • (2007) Crit Care Med , vol.35 , Issue.1 , pp. 112-117
    • Ely, E.W.1
  • 39
    • 77954088532 scopus 로고    scopus 로고
    • Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    • Girard TD, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010;38(7):1513-20.
    • (2010) Crit Care Med , vol.38 , Issue.7 , pp. 1513-1520
    • Girard, T.D.1
  • 40
    • 3543025110 scopus 로고    scopus 로고
    • The association between delirium and cognitive decline: a review of the empirical literature
    • Jackson JC, et al. The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol Rev. 2004;14(2):87-98.
    • (2004) Neuropsychol Rev , vol.14 , Issue.2 , pp. 87-98
    • Jackson, J.C.1
  • 41
    • 84055173340 scopus 로고    scopus 로고
    • Delirium in critically ill patients: impact on long-term health-related quality of life and cognitive functioning
    • van den Boogaard M, et al. Delirium in critically ill patients: impact on long-term health-related quality of life and cognitive functioning. Crit Care Med. 2012;40(1):112-8.
    • (2012) Crit Care Med , vol.40 , Issue.1 , pp. 112-118
    • Boogaard, M.1
  • 42
    • 8544281694 scopus 로고    scopus 로고
    • The impact of delirium on the survival of mechanically ventilated patients
    • Lin SM, et al. The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med. 2004;32(11):2254-9.
    • (2004) Crit Care Med , vol.32 , Issue.11 , pp. 2254-2259
    • Lin, S.M.1
  • 43
    • 72749113044 scopus 로고    scopus 로고
    • Days of delirium are associated with 1-year mortality in an older intensive care unit population
    • Pisani MA, et al. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009;180(11):1092-7.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.11 , pp. 1092-1097
    • Pisani, M.A.1
  • 44
    • 74349119273 scopus 로고    scopus 로고
    • Can the costs of critical care be controlled?
    • Halpern NA. Can the costs of critical care be controlled? Curr Opin Crit Care. 2009;15(6):591-6.
    • (2009) Curr Opin Crit Care , vol.15 , Issue.6 , pp. 591-596
    • Halpern, N.A.1
  • 45
    • 77649193771 scopus 로고    scopus 로고
    • Impact of the post-World War II generation on intensive care needs in Norway
    • Laake JH, et al. Impact of the post-World War II generation on intensive care needs in Norway. Acta Anaesthesiol Scand. 2010;54(4):479-84.
    • (2010) Acta Anaesthesiol Scand , vol.54 , Issue.4 , pp. 479-484
    • Laake, J.H.1
  • 46
    • 74949114615 scopus 로고    scopus 로고
    • Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study
    • Devlin JW, et al. Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study. Crit Care Med. 2010;38(2):419-27.
    • (2010) Crit Care Med , vol.38 , Issue.2 , pp. 419-427
    • Devlin, J.W.1
  • 47
    • 67649450488 scopus 로고    scopus 로고
    • Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial
    • Reade MC, et al. Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Crit Care. 2009;13(3):R75.
    • (2009) Crit Care , vol.13 , Issue.3 , pp. R75
    • Reade, M.C.1
  • 48
    • 74949100313 scopus 로고    scopus 로고
    • Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    • Girard TD, et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med. 2010;38(2):428-37.
    • (2010) Crit Care Med , vol.38 , Issue.2 , pp. 428-437
    • Girard, T.D.1
  • 49
    • 84883447031 scopus 로고    scopus 로고
    • Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial
    • Page VJ, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2013;1(7):515-23.
    • (2013) Lancet Respir Med , vol.1 , Issue.7 , pp. 515-523
    • Page, V.J.1
  • 50
    • 78649474311 scopus 로고    scopus 로고
    • Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial
    • van Eijk MM, et al. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet. 2010;376(9755):1829-37.
    • (2010) Lancet , vol.376 , Issue.9755 , pp. 1829-1837
    • Eijk, M.M.1
  • 51
    • 84860744394 scopus 로고    scopus 로고
    • Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial
    • Hakim SM, Othman AI, Naoum DO. Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial. Anesthesiology. 2012;116(5):987-97.
    • (2012) Anesthesiology , vol.116 , Issue.5 , pp. 987-997
    • Hakim, S.M.1    Othman, A.I.2    Naoum, D.O.3
  • 52
    • 84857554831 scopus 로고    scopus 로고
    • Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial*
    • Wang W, et al. Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial*. Crit Care Med. 2012;40(3):731-9.
    • (2012) Crit Care Med , vol.40 , Issue.3 , pp. 731-739
    • Wang, W.1
  • 53
    • 85002954072 scopus 로고    scopus 로고
    • Available from:Accessed Dec 2016.
    • U.S. Food and Drug Administration, Haldol. 2008. Available from: www.accessdata.fda.gov/drugsatfda_docs/label/2008/015923s082,018701s057lbl.pdf. Accessed Dec 2016.
    • (2008)
  • 54
    • 84866073732 scopus 로고    scopus 로고
    • Sedation for critically ill or injured adults in the intensive care unit: a shifting paradigm
    • Roberts DJ, Haroon B, Hall RI. Sedation for critically ill or injured adults in the intensive care unit: a shifting paradigm. Drugs. 2012;72(14):1881-916.
    • (2012) Drugs , vol.72 , Issue.14 , pp. 1881-1916
    • Roberts, D.J.1    Haroon, B.2    Hall, R.I.3
  • 55
    • 54449093594 scopus 로고    scopus 로고
    • The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis
    • Ho KM, Ng JY. The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis. Intensive Care Med. 2008;34(11):1969-79.
    • (2008) Intensive Care Med , vol.34 , Issue.11 , pp. 1969-1979
    • Ho, K.M.1    Ng, J.Y.2
  • 56
    • 84858657050 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    • Jakob SM, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012;307(11):1151-60.
    • (2012) JAMA , vol.307 , Issue.11 , pp. 1151-1160
    • Jakob, S.M.1
  • 57
    • 37149040245 scopus 로고    scopus 로고
    • Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    • Pandharipande PP, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298(22):2644-53.
    • (2007) JAMA , vol.298 , Issue.22 , pp. 2644-2653
    • Pandharipande, P.P.1
  • 58
    • 59649127447 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    • Riker RR, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009;301(5):489-99.
    • (2009) JAMA , vol.301 , Issue.5 , pp. 489-499
    • Riker, R.R.1
  • 59
    • 84884535114 scopus 로고    scopus 로고
    • Morphine is a reasonable alternative to haloperidol in the treatment of postoperative hyperactive-type delirium after cardiac surgery
    • Atalan N, et al. Morphine is a reasonable alternative to haloperidol in the treatment of postoperative hyperactive-type delirium after cardiac surgery. J Cardiothorac Vasc Anesth. 2013;27(5):933-8.
    • (2013) J Cardiothorac Vasc Anesth , vol.27 , Issue.5 , pp. 933-938
    • Atalan, N.1
  • 60
    • 67651203271 scopus 로고    scopus 로고
    • Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass
    • Hudetz JA, et al. Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2009;23(5):651-7.
    • (2009) J Cardiothorac Vasc Anesth , vol.23 , Issue.5 , pp. 651-657
    • Hudetz, J.A.1
  • 61
    • 63849105841 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011].
    • The Cochrane Collaboration. Accessed Dec 2016
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. 2011. Available from: www.handbook.cochrane.org. Accessed Dec 2016.
    • (2011)
    • Higgins, J.P.T.1    Green, S.2
  • 62
    • 84957434707 scopus 로고    scopus 로고
    • Twelve recommendations for integrating existing systematic reviews into new reviews: EPC guidance
    • Robinson KA, et al. Twelve recommendations for integrating existing systematic reviews into new reviews: EPC guidance. J Clin Epidemiol. 2016;70:38-44.
    • (2016) J Clin Epidemiol , vol.70 , pp. 38-44
    • Robinson, K.A.1
  • 63
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
    • Liberati A, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
    • (2009) BMJ , vol.339 , pp. b2700
    • Liberati, A.1
  • 64
    • 85002746068 scopus 로고    scopus 로고
    • Accessed Dec 2016.
    • European Medicines Agency, Guideline for Good Clinical Practice (minor update July 2002). 2002. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002874.pdf. Accessed Dec 2016.
    • (2002)
  • 65
    • 85002893267 scopus 로고    scopus 로고
    • Accessed Dec 2016.
    • Covidence. Available from: https://www.covidence.org/. Accessed Dec 2016.
  • 66
    • 84952360296 scopus 로고    scopus 로고
    • ROBIS: A new tool to assess risk of bias in systematic reviews was developed
    • Whiting P, et al. ROBIS: A new tool to assess risk of bias in systematic reviews was developed. J Clin Epidemiol. 2016;69:225-34.
    • (2016) J Clin Epidemiol , vol.69 , pp. 225-234
    • Whiting, P.1
  • 67
    • 84952341156 scopus 로고    scopus 로고
    • ROBIS: Tool to assess risk of bias in systematic reviews - Guidance on how to use ROBIS
    • Accessed Dec 2016.
    • Whiting P, Savovic J, Higgins J, Caldwell D, Reeves B, Shea B, et al. ROBIS: Tool to assess risk of bias in systematic reviews - Guidance on how to use ROBIS. Available from: http://www.bristol.ac.uk/media-library/sites/social-community-medicine/robis/robisguidancedocument.pdf. Accessed Dec 2016.
    • Whiting, P.1    Savovic, J.2    Higgins, J.3    Caldwell, D.4    Reeves, B.5    Shea, B.6
  • 68
    • 37049035730 scopus 로고    scopus 로고
    • Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    • Wetterslev J, et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol. 2008;61(1):64-75.
    • (2008) J Clin Epidemiol , vol.61 , Issue.1 , pp. 64-75
    • Wetterslev, J.1
  • 69
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1
  • 70
    • 84988602803 scopus 로고    scopus 로고
    • Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods
    • Jakobsen JC, et al. Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods. BMC Med Res Methodol. 2014;14:120.
    • (2014) BMC Med Res Methodol , vol.14 , pp. 120
    • Jakobsen, J.C.1
  • 71
    • 33748090675 scopus 로고    scopus 로고
    • A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints
    • Harbord RM, Egger M, Sterne JA. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med. 2006;25(20):3443-57.
    • (2006) Stat Med , vol.25 , Issue.20 , pp. 3443-3457
    • Harbord, R.M.1    Egger, M.2    Sterne, J.A.3
  • 72
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629-34.
    • (1997) BMJ , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1
  • 73
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088-101.
    • (1994) Biometrics , vol.50 , Issue.4 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 74
    • 85002599316 scopus 로고    scopus 로고
    • (RevMan) [Computer program]. Version 5.5. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • Review Manager (RevMan) [Computer program]. Version 5.5. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration. 2014.
    • (2014)
  • 75
    • 85002747941 scopus 로고    scopus 로고
    • Computer program. Copenhagen Trial Unit
    • Trial Sequential Analysis (TSA) [Computer program on www.ctu.dk/tsa/ ]. Copenhagen Trial Unit 2011.
    • (2011)
  • 76
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22(4):719-48.
    • (1959) J Natl Cancer Inst , vol.22 , Issue.4 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 77
    • 0023280282 scopus 로고
    • Methods for combining randomized clinical trials: strengths and limitations
    • Demets DL. Methods for combining randomized clinical trials: strengths and limitations. Stat Med. 1987;6(3):341-50.
    • (1987) Stat Med , vol.6 , Issue.3 , pp. 341-350
    • Demets, D.L.1
  • 78
    • 0036205370 scopus 로고    scopus 로고
    • Being sceptical about meta-analyses: a Bayesian perspective on magnesium trials in myocardial infarction
    • Higgins JP, Spiegelhalter DJ. Being sceptical about meta-analyses: a Bayesian perspective on magnesium trials in myocardial infarction. Int J Epidemiol. 2002;31(1):96-104.
    • (2002) Int J Epidemiol , vol.31 , Issue.1 , pp. 96-104
    • Higgins, J.P.1    Spiegelhalter, D.J.2
  • 79
    • 0037136930 scopus 로고    scopus 로고
    • Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial
    • Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet 2002;360(9341):1189-96.
    • (2002) Lancet , vol.360 , Issue.9341 , pp. 1189-1196
  • 80
    • 0036231757 scopus 로고    scopus 로고
    • The importance of effect mechanism in the design and interpretation of clinical trials: the role of magnesium in acute myocardial infarction
    • Woods KL, Abrams K. The importance of effect mechanism in the design and interpretation of clinical trials: the role of magnesium in acute myocardial infarction. Prog Cardiovasc Dis. 2002;44(4):267-74.
    • (2002) Prog Cardiovasc Dis , vol.44 , Issue.4 , pp. 267-274
    • Woods, K.L.1    Abrams, K.2
  • 81
    • 84977455805 scopus 로고    scopus 로고
    • Viewpoint: taking into account risks of random errors when analysing multiple outcomes in systematic reviews
    • Ed000111
    • Jakobsen JC, et al. Viewpoint: taking into account risks of random errors when analysing multiple outcomes in systematic reviews. Cochrane Database Syst Rev. 2016;3:Ed000111.
    • (2016) Cochrane Database Syst Rev , vol.3
    • Jakobsen, J.C.1
  • 82
    • 45949100256 scopus 로고    scopus 로고
    • Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    • Brok J, et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol. 2008;61(8):763-9.
    • (2008) J Clin Epidemiol , vol.61 , Issue.8 , pp. 763-769
    • Brok, J.1
  • 83
    • 60149098740 scopus 로고    scopus 로고
    • Apparently conclusive meta-analyses may be inconclusive-trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
    • Brok J, et al. Apparently conclusive meta-analyses may be inconclusive-trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol. 2009;38(1):287-98.
    • (2009) Int J Epidemiol , vol.38 , Issue.1 , pp. 287-298
    • Brok, J.1
  • 84
    • 79953740257 scopus 로고    scopus 로고
    • Sequential methods for random-effects meta-analysis
    • Higgins JP, Whitehead A, Simmonds M. Sequential methods for random-effects meta-analysis. Stat Med. 2011;30(9):903-21.
    • (2011) Stat Med , vol.30 , Issue.9 , pp. 903-921
    • Higgins, J.P.1    Whitehead, A.2    Simmonds, M.3
  • 85
    • 84948692253 scopus 로고    scopus 로고
    • Systematic reviews of anesthesiologic interventions reported as statistically significant: problems with power, precision, and type 1 error protection
    • Imberger G, et al. Systematic reviews of anesthesiologic interventions reported as statistically significant: problems with power, precision, and type 1 error protection. Anesth Analg. 2015;121(6):1611-22.
    • (2015) Anesth Analg , vol.121 , Issue.6 , pp. 1611-1622
    • Imberger, G.1
  • 86
    • 84948653129 scopus 로고    scopus 로고
    • Alpha, beta, meta: guidelines for assessing power and type I error in meta-analyses
    • Mascha EJ. Alpha, beta, meta: guidelines for assessing power and type I error in meta-analyses. Anesth Analg. 2015;121(6):1430-3.
    • (2015) Anesth Analg , vol.121 , Issue.6 , pp. 1430-1433
    • Mascha, E.J.1
  • 87
    • 0030703712 scopus 로고    scopus 로고
    • Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis
    • Pogue JM, Yusuf S. Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis. Control Clin Trials. 1997;18(6):580-93. discussion 661-6.
    • (1997) Control Clin Trials , vol.18 , Issue.6 , pp. 580-593
    • Pogue, J.M.1    Yusuf, S.2
  • 88
    • 84979828286 scopus 로고    scopus 로고
    • Does ondansetron modify sympathectomy due to subarachnoid anesthesia?: meta-analysis, meta-regression, and trial sequential analysis
    • Terkawi AS, et al. Does ondansetron modify sympathectomy due to subarachnoid anesthesia?: meta-analysis, meta-regression, and trial sequential analysis. Anesthesiology. 2016;124(4):846-69.
    • (2016) Anesthesiology , vol.124 , Issue.4 , pp. 846-869
    • Terkawi, A.S.1
  • 89
    • 60149107494 scopus 로고    scopus 로고
    • Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?
    • Thorlund K, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol. 2009;38(1):276-86.
    • (2009) Int J Epidemiol , vol.38 , Issue.1 , pp. 276-286
    • Thorlund, K.1
  • 90
    • 84859984959 scopus 로고    scopus 로고
    • User manual for trial sequential analysis (TSA) 2011
    • Accessed Dec 2016.
    • Gluud C, et al. User manual for trial sequential analysis (TSA) 2011. Available from: http://www.ctu.dk/tsa/files/tsa_manual.pdf. Accessed Dec 2016.
    • Gluud, C.1
  • 91
    • 84959368181 scopus 로고    scopus 로고
    • Trial sequential methods for meta-analysis
    • Kulinskaya E, Wood J. Trial sequential methods for meta-analysis. Res Synth Methods. 2014;5(3):212-20.
    • (2014) Res Synth Methods , vol.5 , Issue.3 , pp. 212-220
    • Kulinskaya, E.1    Wood, J.2
  • 92
    • 75649084582 scopus 로고    scopus 로고
    • Estimating required information size by quantifying diversity in random-effects model meta-analyses
    • Wetterslev J, et al. Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Med Res Methodol. 2009;9:86.
    • (2009) BMC Med Res Methodol , vol.9 , pp. 86
    • Wetterslev, J.1
  • 93
    • 84875424429 scopus 로고    scopus 로고
    • The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews
    • Turner RM, Bird SM, Higgins JP. The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews. PLoS One. 2013;8(3):e59202.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e59202
    • Turner, R.M.1    Bird, S.M.2    Higgins, J.P.3
  • 94
    • 43049113533 scopus 로고    scopus 로고
    • GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
    • Guyatt GH, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924-6.
    • (2008) BMJ , vol.336 , Issue.7650 , pp. 924-926
    • Guyatt, G.H.1
  • 95
    • 85002793100 scopus 로고    scopus 로고
    • Computer program on McMaster University.
    • GRADEpro [Computer program on gradepro.org]: McMaster University. 2014.
    • (2014)
  • 96
    • 33751001646 scopus 로고    scopus 로고
    • Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients
    • Lacasse H, Perreault MM, Williamson DR. Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients. Ann Pharmacother. 2006;40(11):1966-73.
    • (2006) Ann Pharmacother , vol.40 , Issue.11 , pp. 1966-1973
    • Lacasse, H.1    Perreault, M.M.2    Williamson, D.R.3
  • 97
    • 34047208991 scopus 로고    scopus 로고
    • Atypical antipsychotics versus haloperidol for treatment of delirium in acutely ill patients
    • Rea RS, et al. Atypical antipsychotics versus haloperidol for treatment of delirium in acutely ill patients. Pharmacotherapy. 2007;27(4):588-94.
    • (2007) Pharmacotherapy , vol.27 , Issue.4 , pp. 588-594
    • Rea, R.S.1
  • 98
    • 33846865310 scopus 로고    scopus 로고
    • Antipsychotics in the treatment of delirium: a systematic review
    • Seitz DP, Gill SS, van Zyl LT. Antipsychotics in the treatment of delirium: a systematic review. J Clin Psychiatry. 2007;68(1):11-21.
    • (2007) J Clin Psychiatry , vol.68 , Issue.1 , pp. 11-21
    • Seitz, D.P.1    Gill, S.S.2    Zyl, L.T.3
  • 99
    • 84867155878 scopus 로고    scopus 로고
    • Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalised patients: a review of data from prospective, randomised studies
    • Devlin JW, Al-Qadhee NS, Skrobik Y. Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalised patients: a review of data from prospective, randomised studies. Best Pract Res Clin Anaesthesiol. 2012;26(3):289-309.
    • (2012) Best Pract Res Clin Anaesthesiol , vol.26 , Issue.3 , pp. 289-309
    • Devlin, J.W.1    Al-Qadhee, N.S.2    Skrobik, Y.3
  • 101
    • 84884472617 scopus 로고    scopus 로고
    • The pharmacologic treatment of intensive care unit delirium: a systematic review
    • Bathula M, Gonzales JP. The pharmacologic treatment of intensive care unit delirium: a systematic review. Ann Pharmacother. 2013;47(9):1168-74.
    • (2013) Ann Pharmacother , vol.47 , Issue.9 , pp. 1168-1174
    • Bathula, M.1    Gonzales, J.P.2
  • 102
    • 84880720141 scopus 로고    scopus 로고
    • Pharmacological treatment of delirium in palliative care patients. A systematic literature review
    • Perrar KM, Golla H, Voltz R. Pharmacological treatment of delirium in palliative care patients. A systematic literature review. Schmerz. 2013;27(2):190-8.
    • (2013) Schmerz , vol.27 , Issue.2 , pp. 190-198
    • Perrar, K.M.1    Golla, H.2    Voltz, R.3
  • 103
    • 84919487930 scopus 로고    scopus 로고
    • Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically Ill patients: a meta-analysis of randomized controlled trials
    • Pasin L, et al. Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically Ill patients: a meta-analysis of randomized controlled trials. J Cardiothorac Vasc Anesth. 2014;28(6):1459-66.
    • (2014) J Cardiothorac Vasc Anesth , vol.28 , Issue.6 , pp. 1459-1466
    • Pasin, L.1
  • 104
    • 84901483156 scopus 로고    scopus 로고
    • Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis
    • Al-Qadheeb NS, et al. Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. Crit Care Med. 2014;42(6):1442-54.
    • (2014) Crit Care Med , vol.42 , Issue.6 , pp. 1442-1454
    • Al-Qadheeb, N.S.1
  • 105
    • 84930934677 scopus 로고    scopus 로고
    • Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
    • Serafim RB, et al. Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review. J Crit Care. 2015;30(4):799-807.
    • (2015) J Crit Care , vol.30 , Issue.4 , pp. 799-807
    • Serafim, R.B.1


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