Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

Cell Reports

Volumn 17, Issue 10, 2016, Pages 2584-2595

  Matatall, Katie A ^a,b   Jeong, Mira ^a,b   Chen, Siyi ^d   Sun, Deqiang ^c   Chen, Fengju ^a   Mo, Qianxing ^a   Kimmel, Marek ^d,e   King, Katherine Y ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^d Rice University   (United States)

^e SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

bone marrow failure; chronic infection; hematopoietic stem cell; interferon gamma; pancytopenia; terminal differentiation

Indexed keywords

GAMMA INTERFERON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BATF2; TRANSCRIPTOME; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; BATF2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATYPICAL MYCOBACTERIOSIS; CELL DIFFERENTIATION; CELL SELF-RENEWAL; CELL STRESS; CONTROLLED STUDY; DEPLETION; GAIN OF FUNCTION MUTATION; HEMATOPOIETIC STEM CELL; LOSS OF FUNCTION MUTATION; MATHEMATICAL MODEL; MOUSE; MYELOFIBROSIS; NONHUMAN; PANCYTOPENIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL MOBILIZATION; ANIMAL; BONE MARROW CELL; CELL PROLIFERATION; GENETICS; HUMAN; INFECTION; METABOLISM; MICROBIOLOGY; MYCOBACTERIUM AVIUM; PATHOGENICITY; PATHOLOGY;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SELF RENEWAL; HEMATOPOIETIC STEM CELLS; HUMANS; INFECTION; INTERFERON-GAMMA; MICE; MYCOBACTERIUM AVIUM; SIGNAL TRANSDUCTION;

EID: 85002611150     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.11.031     Document Type: Article

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