Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells

Stem Cells

Volumn 32, Issue 11, 2014, Pages 3023-3030

  Matatall, Katie A ^a   Shen, Ching Chieh ^b   Challen, Grant A ^b   King, Katherine Y ^a  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hematopoietic stem cell; Innate immunity; Interferon gamma; Myeloid differentiation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; GAMMA INTERFERON;

ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CYTOLOGY; GENETICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; METABOLISM; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; INTERFERON-GAMMA; MICE, INBRED C57BL; MYELOID CELLS; SIGNAL TRANSDUCTION;

EID: 84907900072     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1799     Document Type: Article

References (37)

1. Binder D, Fehr J, Hengartner H, et al. Virus-induced transient bone marrow aplasia: Major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus. J Exp Med 1997; 185: 517-530.
2. Young NS, Scheinberg P, Calado RT,. Aplastic anemia. Curr Opin Hematol 2008; 15: 162-168.
3. Preudhomme C, Guilhot J, Nicolini FE, et al. Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med 2010; 363: 2511-2521.
4. Lu M, Wang J, Li Y, et al. Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells. Blood 2010; 116: 4284-4287.
5. Simonsson B, Gedde-Dahl T, Markevärn B, et al. Combination of pegylated interferon-alpha-2b with imatinib increases molecular response rates in patients with low or intermediate risk chronic myeloid leukemia. Blood 2011; 118 (12): 3228-3235.
6. Baldridge MT, King KY, Boles NC, et al. Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection. Nature 2010; 465: 793-797.
7. Essers MAG, Offner S, Blanco-Bose WE, et al. IFNα activates dormant haematopoietic stem cells in vivo. Nature 2009; 458: 904-908.
8. King KY, Baldridge MT, Weksberg DC, et al. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 2011; 118: 1525-1533.
9. Benz C, Copley MR, Kent DG, et al. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 2012; 10: 273-283.
10. Dykstra B, Kent D, Bowie M, et al. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 2007; 1: 218-229.
11. Challen GA, Boles NC, Chambers SM, et al. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta. Cell Stem Cell 2010; 6: 265-278.
12. Mallaney C, Kothari A, Martens A, et al. Clonal-level responses of functionally distinct hematopoietic stem cells to trophic factors. Exp Hematol 2013; 42 (4): 317-327.
13. Pang WW, Price EA, Sahoo D, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA 2011; 108 (50): 20012-20017.
14. Huang S, Hendriks W, Althage A, et al. Immune response in mice that lack the interferon-gamma receptor. Science 1993; 259: 1742-1745.
15. Müller U, Steinhoff U, Reis LF, et al. Functional role of type I and type II interferons in antiviral defense. Science 1994; 264: 1918-1921.
16. Durbin JE, Hackenmiller R, Simon MC, et al. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996; 84: 443-450.
17. Hildeman D, Yañez D, Pederson K, et al. Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease. J Virol 1997; 71: 9672-9678.
18. Feng CG, Weksberg DC, Taylor GA, et al. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2008; 2: 83-89.
19. Kiel MJ, Yilmaz OH, Iwashita T, et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121: 1109-1121.
20. Weissman IL, Anderson DJ, Gage F,. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001; 17: 387-403.
21. Mccausland M, Crotty S,. Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J Virol Meth 2008; 147: 167-176.
22. Park H, Jang H, Kim C, et al. Detection and identification of mycobacteria by amplification of the internal transcribed spacer regions with genus- and species-specific PCR primers. J Clin Microbiol 2000; 38: 4080-4085.
23. Kondo M,. Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. Immunol Rev 2010; 238: 37-46.
24. Hofer M, Li W, Manders P, et al. Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. J Virol 2012; 86: 6932-6946.
25. Baldridge MT, King KY, Goodell MA,. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol 2011; 32: 57-65.
26. Takizawa H, Boettcher S, Manz MG,. Demand-adapted regulation of early hematopoiesis in infection and inflammation. Blood 2012; 119 (13): 2991-3002.
27. Zoller EE, Lykens JE, Terrell CE, et al. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 2011; 208: 1203-1214.
28. Wilson A, Murphy MJ, Oskarsson T, et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 2004; 18: 2747-2763.
29. Passegué E, Wagers AJ, Giuriato S, et al. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005; 202: 1599-1611.
30. Hirai H, Zhang P, Dayaram T, et al. C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol 2006; 7: 732-739.
31. Zhang H, Nguyen-Jackson H, Panopoulos AD, et al. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood 2010; 116 (14): 2462-2471.
32. Flõrido M, Pearl JE, Solache A, et al. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 2005; 73: 3577-3586.
33. González-Pérez M, Mariño-Ramírez L, Parra-Lõpez CA, et al. Virulence and immune response induced by Mycobacterium avium complex strains in a model of progressive pulmonary tuberculosis and subcutaneous infection in BALB/c mice. Infect Immun 2013; 81: 4001-4012.
34. Pietras EM, Lakshminarasimhan R, Techner JM, et al. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med 2014; 211 (2): 245-262.
35. de Bruin AM, Libregts SF, Valkhof M, et al. IFNγ induces monopoiesis and inhibits neutrophil development during inflammation. Blood 2012; 119: 1543-1554.
36. Belyaev NN, Brown DE, Diaz AG, et al. Induction of an IL7-R+c-Kithi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria. Nat Immunol 2010; 11: 477-485.
37. Zaidi MR, Merlino G,. The two faces of interferon-γ in cancer. Clin Cancer Res 2011; 17: 6118-6124.