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Volumn 473, Issue 14, 2016, Pages 2187-2203

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics

Author keywords

Adipose derived stem cells; Endo metabolome; Exo metabolome; Metabolomics; Obesity

Indexed keywords

AMINO ACID; CARBOHYDRATE; LIPID; PENTOSE PHOSPHATE; POLYOL; TRICARBOXYLIC ACID;

EID: 85002568378     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160241     Document Type: Article
Times cited : (31)

References (68)
  • 1
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ
    • CrossRef PubMed
    • Trayhurn, P. And Beattie, J. H. (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc. 60, 329-339 CrossRef PubMed
    • (2001) Proc. Nutr. Soc. , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 2
    • 0033789518 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • CrossRef PubMed
    • Ahima, R. S. And Flier, J. S. (2000) Adipose tissue as an endocrine organ. Trends Endocrinol. Metab. 11, 327-332 CrossRef PubMed
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 327-332
    • Ahima, R.S.1    Flier, J.S.2
  • 3
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • CrossRef PubMed
    • Kershaw, E. E. And Flier, J. S. (2004) Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89, 2548-2556 CrossRef PubMed
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 5
    • 33646103658 scopus 로고    scopus 로고
    • Fat tissue: An underappreciated source of stem cells for biotechnology
    • CrossRef PubMed
    • Fraser, J. K., Wulur, I., Alfonso, Z. And Hedrick, M. H. (2006) Fat tissue: An underappreciated source of stem cells for biotechnology. Trends Biotechnol 24, 150-154 CrossRef PubMed
    • (2006) Trends Biotechnol , vol.24 , pp. 150-154
    • Fraser, J.K.1    Wulur, I.2    Alfonso, Z.3    Hedrick, M.H.4
  • 7
    • 65349104062 scopus 로고    scopus 로고
    • Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix
    • CrossRef PubMed
    • Cheng, N. C., Estes, B. T., Awad, H. A. And Guilak, F. (2009) Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue Eng. Part A 15, 231-241 CrossRef PubMed
    • (2009) Tissue Eng. Part A , vol.15 , pp. 231-241
    • Cheng, N.C.1    Estes, B.T.2    Awad, H.A.3    Guilak, F.4
  • 8
    • 2342491483 scopus 로고    scopus 로고
    • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells
    • CrossRef PubMed
    • Safford, K. M., Safford, S. D., Gimble, J. M., Shetty, A. K. And Rice, H. E. (2004) Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. Exp. Neurol. 187, 319-328 CrossRef PubMed
    • (2004) Exp. Neurol. , vol.187 , pp. 319-328
    • Safford, K.M.1    Safford, S.D.2    Gimble, J.M.3    Shetty, A.K.4    Rice, H.E.5
  • 9
    • 33845527292 scopus 로고    scopus 로고
    • Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells
    • CrossRef PubMed
    • Ning, H., Lin, G., Lue, T. F. And Lin, C. S. (2006) Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells. Differentiation 74, 510-518 CrossRef PubMed
    • (2006) Differentiation , vol.74 , pp. 510-518
    • Ning, H.1    Lin, G.2    Lue, T.F.3    Lin, C.S.4
  • 11
    • 84906931889 scopus 로고    scopus 로고
    • The current landscape of adipose-derived stem cells in clinical applications
    • CrossRef PubMed
    • Lim, M. H., Ong, W. K. And Sugii, S. (2014) The current landscape of adipose-derived stem cells in clinical applications. Expert Rev. Mol. Med. 16, e8 CrossRef PubMed
    • (2014) Expert Rev. Mol. Med. , vol.16 , pp. e8
    • Lim, M.H.1    Ong, W.K.2    Sugii, S.3
  • 12
    • 66749124768 scopus 로고    scopus 로고
    • Adipose-derived stem cells for tissue repair and regeneration: Ten years of research and a literature review
    • CrossRef PubMed
    • Mizuno, H. (2009) Adipose-derived stem cells for tissue repair and regeneration: Ten years of research and a literature review. J. Nippon Med. Sch. 76, 56-66 CrossRef PubMed
    • (2009) J. Nippon Med. Sch. , vol.76 , pp. 56-66
    • Mizuno, H.1
  • 13
    • 84944550414 scopus 로고    scopus 로고
    • Current progress in use of adipose derived stem cells in peripheral nerve regeneration
    • CrossRef PubMed
    • Zack-Williams, S. D., Butler, P. E. And Kalaskar, D. M. (2015) Current progress in use of adipose derived stem cells in peripheral nerve regeneration. World J. Stem Cells 7, 51-64 CrossRef PubMed
    • (2015) World J. Stem Cells , vol.7 , pp. 51-64
    • Zack-Williams, S.D.1    Butler, P.E.2    Kalaskar, D.M.3
  • 14
    • 84958179636 scopus 로고    scopus 로고
    • Adipose tissue-adequate, accessible regenerative material
    • CrossRef PubMed
    • Kolaparthy, L. K., Sanivarapu, S., Moogla, S. And Kutcham, R. S. (2015) Adipose tissue-adequate, accessible regenerative material. Int. J. Stem Cells 8, 121-127 CrossRef PubMed
    • (2015) Int. J. Stem Cells , vol.8 , pp. 121-127
    • Kolaparthy, L.K.1    Sanivarapu, S.2    Moogla, S.3    Kutcham, R.S.4
  • 15
    • 84860523401 scopus 로고    scopus 로고
    • Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine
    • CrossRef PubMed
    • Mizuno, H., Tobita, M. And Uysal, A. C. (2012) Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine. Stem Cells 30, 804-810 CrossRef PubMed
    • (2012) Stem Cells , vol.30 , pp. 804-810
    • Mizuno, H.1    Tobita, M.2    Uysal, A.C.3
  • 16
    • 44849144740 scopus 로고    scopus 로고
    • Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells
    • CrossRef PubMed
    • Aksu, A. E., Rubin, J. P., Dudas, J. R. And Marra, K. G. (2008) Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells. Ann. Plast. Surg. 60, 306-322 CrossRef PubMed
    • (2008) Ann. Plast. Surg. , vol.60 , pp. 306-322
    • Aksu, A.E.1    Rubin, J.P.2    Dudas, J.R.3    Marra, K.G.4
  • 17
    • 42549164595 scopus 로고    scopus 로고
    • Regional anatomic and age effects on cell function of human adipose-derived stem cells
    • CrossRef PubMed
    • Schipper, B. M., Marra, K. G., Zhang, W., Donnenberg, A. D. And Rubin, J. P. (2008) Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann. Plast. Surg. 60, 538-544 CrossRef PubMed
    • (2008) Ann. Plast. Surg. , vol.60 , pp. 538-544
    • Schipper, B.M.1    Marra, K.G.2    Zhang, W.3    Donnenberg, A.D.4    Rubin, J.P.5
  • 18
    • 78649696999 scopus 로고    scopus 로고
    • Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells
    • CrossRef PubMed
    • Cramer, C., Freisinger, E., Jones, R. K., Slakey, D. P., Dupin, C. L., Newsome, E. R., Alt, E. U. And Izadpanah, R. (2010) Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells. Stem Cells Dev 19, 1875-1884 CrossRef PubMed
    • (2010) Stem Cells Dev , vol.19 , pp. 1875-1884
    • Cramer, C.1    Freisinger, E.2    Jones, R.K.3    Slakey, D.P.4    Dupin, C.L.5    Newsome, E.R.6    Alt, E.U.7    Izadpanah, R.8
  • 19
    • 84887863573 scopus 로고    scopus 로고
    • Obese-derived ASCs show impaired migration and angiogenesis properties
    • CrossRef PubMed
    • Perez, L. M., Bernal, A., San Martin, N. And Galvez, B. G. (2013) Obese-derived ASCs show impaired migration and angiogenesis properties. Arch. Physiol. Biochem. 119, 195-201 CrossRef PubMed
    • (2013) Arch. Physiol. Biochem. , vol.119 , pp. 195-201
    • Perez, L.M.1    Bernal, A.2    San Martin, N.3    Galvez, B.G.4
  • 21
    • 85047687329 scopus 로고    scopus 로고
    • Metabolic rescue of obese adipose-derived stem cells by Lin28/Let7 pathway
    • CrossRef PubMed
    • Perez, L. M., Bernal, A., San Martin, N., Lorenzo, M., Fernandez-Veledo, S. And Galvez, B. G. (2013) Metabolic rescue of obese adipose-derived stem cells by Lin28/Let7 pathway. Diabetes 62, 2368-2379 CrossRef PubMed
    • (2013) Diabetes , vol.62 , pp. 2368-2379
    • Perez, L.M.1    Bernal, A.2    San Martin, N.3    Lorenzo, M.4    Fernandez-Veledo, S.5    Galvez, B.G.6
  • 25
    • 84939934067 scopus 로고    scopus 로고
    • A novel cell-free strategy for promoting mouse liver regeneration: Utilization of a conditioned medium from adipose-derived stem cells
    • CrossRef PubMed
    • Lee, S. K., Lee, S. C. And Kim, S. J. (2015) A novel cell-free strategy for promoting mouse liver regeneration: utilization of a conditioned medium from adipose-derived stem cells. Hepatol. Int. 9, 310-320 CrossRef PubMed
    • (2015) Hepatol. Int. , vol.9 , pp. 310-320
    • Lee, S.K.1    Lee, S.C.2    Kim, S.J.3
  • 26
    • 84887828340 scopus 로고    scopus 로고
    • Review of the adipose derived stem cell secretome
    • CrossRef PubMed
    • Kapur, S. K. And Katz, A. J. (2013) Review of the adipose derived stem cell secretome. Biochimie 95, 2222-2228 CrossRef PubMed
    • (2013) Biochimie , vol.95 , pp. 2222-2228
    • Kapur, S.K.1    Katz, A.J.2
  • 27
    • 84929992390 scopus 로고    scopus 로고
    • Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human
    • CrossRef PubMed
    • Perez, L. M., Bernal, A., de Lucas, B., San Martin, N., Mastrangelo, A., Garcia, A., Barbas, C. And Gálvez, B. G. (2015) Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human. PLoS One 10 4, e0123397 CrossRef PubMed
    • (2015) PLoS One , vol.10 , Issue.4 , pp. e0123397
    • Perez, L.M.1    Bernal, A.2    De Lucas, B.3    San Martin, N.4    Mastrangelo, A.5    Garcia, A.6    Barbas, C.7    Gálvez, B.G.8
  • 28
    • 84871786233 scopus 로고    scopus 로고
    • Method for obtaining committed adult mesenchymal precursors from skin and lung tissue
    • CrossRef PubMed
    • Bernal, A., Fernandez, M., Perez, L. M., San Martin, N. And Galvez, B. G. (2012) Method for obtaining committed adult mesenchymal precursors from skin and lung tissue. PLoS One 7 12, e53215 CrossRef PubMed
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e53215
    • Bernal, A.1    Fernandez, M.2    Perez, L.M.3    San Martin, N.4    Galvez, B.G.5
  • 29
    • 53549134683 scopus 로고    scopus 로고
    • Identification of white adipocyte progenitor cells in vivo
    • CrossRef PubMed
    • Rodeheffer, M. S., Birsoy, K. And Friedman, J. M. (2008) Identification of white adipocyte progenitor cells in vivo. Cell 135, 240-249 CrossRef PubMed
    • (2008) Cell , vol.135 , pp. 240-249
    • Rodeheffer, M.S.1    Birsoy, K.2    Friedman, J.M.3
  • 32
    • 84901421544 scopus 로고    scopus 로고
    • Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania
    • CrossRef PubMed
    • Canuto, G. A., Castilho-Martins, E. A., Tavares, M. F., Rivas, L., Barbas, C. And Lopez-Gonzalvez, A. (2014) Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania. Anal. Bioanal. Chem. 406, 3459-3476 CrossRef PubMed
    • (2014) Anal. Bioanal. Chem. , vol.406 , pp. 3459-3476
    • Canuto, G.A.1    Castilho-Martins, E.A.2    Tavares, M.F.3    Rivas, L.4    Barbas, C.5    Lopez-Gonzalvez, A.6
  • 33
    • 72449186517 scopus 로고    scopus 로고
    • FiehnLib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
    • CrossRef PubMed
    • Kind, T., Wohlgemuth, G., Lee, do Y., Lu, Y., Palazoglu, M., Shahbaz, S. And Fiehn, O. (2009) FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal. Chem. 81, 10038-10048 CrossRef PubMed
    • (2009) Anal. Chem. , vol.81 , pp. 10038-10048
    • Kind, T.1    Wohlgemuth, G.2    Lee Do, Y.3    Lu, Y.4    Palazoglu, M.5    Shahbaz, S.6    Fiehn, O.7
  • 34
    • 84960445225 scopus 로고    scopus 로고
    • From sample treatment to biomarker discovery: A tutorial for untargeted metabolomics based on GC-(EI)-Q-MS
    • CrossRef
    • Mastrangelo, A., Ferrarini, A., Rey-Stolle, F., Garca, A. And Barbas, C. (2015) From sample treatment to biomarker discovery: A tutorial for untargeted metabolomics based on GC-(EI)-Q-MS. Analyt. Chim. Acta 900, 21-35 CrossRef
    • (2015) Analyt. Chim. Acta , vol.900 , pp. 21-35
    • Mastrangelo, A.1    Ferrarini, A.2    Rey-Stolle, F.3    Garca, A.4    Barbas, C.5
  • 35
    • 84867341623 scopus 로고    scopus 로고
    • The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans
    • CrossRef PubMed
    • Dunn, W. B., Wilson, I. D., Nicholls, A. W. And Broadhurst, D. (2012) The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans. Bioanalysis 4, 2249-2264 CrossRef PubMed
    • (2012) Bioanalysis , vol.4 , pp. 2249-2264
    • Dunn, W.B.1    Wilson, I.D.2    Nicholls, A.W.3    Broadhurst, D.4
  • 36
    • 84939883000 scopus 로고    scopus 로고
    • Controlling the quality of metabolomics data: New strategies to get the best out of the QC sample
    • CrossRef
    • Godzien, J., Alonso-Herranz, V., Barbas, C. And Armitage, E. (2015) Controlling the quality of metabolomics data: new strategies to get the best out of the QC sample. Metabolomics 11, 518-528 CrossRef
    • (2015) Metabolomics , vol.11 , pp. 518-528
    • Godzien, J.1    Alonso-Herranz, V.2    Barbas, C.3    Armitage, E.4
  • 37
    • 33749074122 scopus 로고    scopus 로고
    • A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis
    • CrossRef PubMed
    • Sangster, T., Major, H., Plumb, R., Wilson, A. J. And Wilson, I. D. (2006) A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis. Analyst 131, 1075-1078 CrossRef PubMed
    • (2006) Analyst , vol.131 , pp. 1075-1078
    • Sangster, T.1    Major, H.2    Plumb, R.3    Wilson, A.J.4    Wilson, I.D.5
  • 39
    • 0024286746 scopus 로고
    • Regulation of intracellular pH in eukaryotic cells
    • CrossRef PubMed
    • Madshus, I. H. (1988) Regulation of intracellular pH in eukaryotic cells. Biochem. J. 250, 1-8 CrossRef PubMed
    • (1988) Biochem. J. , vol.250 , pp. 1-8
    • Madshus, I.H.1
  • 40
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • CrossRef PubMed
    • Kahn, B. B. And Flier, J. S. (2000) Obesity and insulin resistance. J. Clin. Invest. 106, 473-481 CrossRef PubMed
    • (2000) J. Clin. Invest. , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 41
    • 37549022688 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • CrossRef PubMed
    • de Luca, C. And Olefsky, J. M. (2008) Inflammation and insulin resistance. FEBS Lett 582, 97-105 CrossRef PubMed
    • (2008) FEBS Lett , vol.582 , pp. 97-105
    • De Luca, C.1    Olefsky, J.M.2
  • 42
    • 0348222671 scopus 로고    scopus 로고
    • Inflammation: The link between insulin resistance, obesity and diabetes
    • CrossRef PubMed
    • Dandona, P., Aljada, A. And Bandyopadhyay, A. (2004) Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol 25, 4-7 CrossRef PubMed
    • (2004) Trends Immunol , vol.25 , pp. 4-7
    • Dandona, P.1    Aljada, A.2    Bandyopadhyay, A.3
  • 43
    • 33644633736 scopus 로고    scopus 로고
    • Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans
    • CrossRef PubMed
    • Vincent, H. K. And Taylor, A. G. (2006) Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int. J. Obes. (Lond.) 30, 400-418 CrossRef PubMed
    • (2006) Int. J. Obes. (Lond.) , vol.30 , pp. 400-418
    • Vincent, H.K.1    Taylor, A.G.2
  • 44
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • CrossRef PubMed
    • Giacco, F. And Brownlee, M. (2010) Oxidative stress and diabetic complications. Circ. Res. 107, 1058-1070 CrossRef PubMed
    • (2010) Circ. Res. , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 45
    • 0042867413 scopus 로고    scopus 로고
    • Contribution of polyol pathway to diabetes-induced oxidative stress
    • CrossRef PubMed
    • Chung, S. S., Ho, E. C., Lam, K. S. And Chung, S. K. (2003) Contribution of polyol pathway to diabetes-induced oxidative stress. J. Am. Soc. Nephrol. 14 8 Suppl 3, S233-S236 CrossRef PubMed
    • (2003) J. Am. Soc. Nephrol. , vol.14 , Issue.8 , pp. S233-S236
    • Chung, S.S.1    Ho, E.C.2    Lam, K.S.3    Chung, S.K.4
  • 48
    • 0030988742 scopus 로고    scopus 로고
    • Biochemistry and pathology of radical-mediated protein oxidation
    • CrossRef PubMed
    • Dean, R. T., Fu, S., Stocker, R. And Davies, M. J. (1997) Biochemistry and pathology of radical-mediated protein oxidation. Biochem. J. 324 Pt 1, 1-18 CrossRef PubMed
    • (1997) Biochem. J. , vol.324 , pp. 1-18
    • Dean, R.T.1    Fu, S.2    Stocker, R.3    Davies, M.J.4
  • 51
    • 84923321725 scopus 로고    scopus 로고
    • MTOR coordinates protein synthesis, mitochondrial activity and proliferation
    • CrossRef PubMed
    • Morita, M., Gravel, S. P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J. And Topisirovic, I. (2015) mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle 14, 473-480 CrossRef PubMed
    • (2015) Cell Cycle , vol.14 , pp. 473-480
    • Morita, M.1    Gravel, S.P.2    Hulea, L.3    Larsson, O.4    Pollak, M.5    St-Pierre, J.6    Topisirovic, I.7
  • 52
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • CrossRef PubMed
    • Kim, S. G., Buel, G. R. And Blenis, J. (2013) Nutrient regulation of the mTOR complex 1 signaling pathway. Mol. Cells 35, 463-473 CrossRef PubMed
    • (2013) Mol. Cells , vol.35 , pp. 463-473
    • Kim, S.G.1    Buel, G.R.2    Blenis, J.3
  • 53
    • 84910145403 scopus 로고    scopus 로고
    • Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids
    • CrossRef PubMed
    • Zheng, X., Liang, Y., He, Q., Yao, R., Bao, W., Bao, L., Wang, Y. And Wang, Z. (2014) Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids. Int. J. Mol. Sci. 15, 20753-20769 CrossRef PubMed
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 20753-20769
    • Zheng, X.1    Liang, Y.2    He, Q.3    Yao, R.4    Bao, W.5    Bao, L.6    Wang, Y.7    Wang, Z.8
  • 55
    • 84904251653 scopus 로고    scopus 로고
    • Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle
    • CrossRef PubMed
    • Saqcena, M., Menon, D., Patel, D., Mukhopadhyay, S., Chow, V. And Foster, D. A. (2013) Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. PLoS One 8 8, e74157 CrossRef PubMed
    • (2013) PLoS One , vol.8 , Issue.8 , pp. e74157
    • Saqcena, M.1    Menon, D.2    Patel, D.3    Mukhopadhyay, S.4    Chow, V.5    Foster, D.A.6
  • 56
    • 67650076833 scopus 로고    scopus 로고
    • Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb
    • CrossRef PubMed
    • Lee, M. N., Ha, S. H., Kim, J., Koh, A., Lee, C. S., Kim, J. H., Jeon, H., Kim, D. H., Suh, P. G. And Ryu, S. H. (2009) Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol. Cell Biol. 29, 3991-4001 CrossRef PubMed
    • (2009) Mol. Cell Biol. , vol.29 , pp. 3991-4001
    • Lee, M.N.1    Ha, S.H.2    Kim, J.3    Koh, A.4    Lee, C.S.5    Kim, J.H.6    Jeon, H.7    Kim, D.H.8    Suh, P.G.9    Ryu, S.H.10
  • 57
    • 84875953755 scopus 로고    scopus 로고
    • Stem cell metabolism in tissue development and aging
    • CrossRef PubMed
    • Shyh-Chang, N., Daley, G. Q. And Cantley, L. C. (2013) Stem cell metabolism in tissue development and aging. Development 140, 2535-2547 CrossRef PubMed
    • (2013) Development , vol.140 , pp. 2535-2547
    • Shyh-Chang, N.1    Daley, G.Q.2    Cantley, L.C.3
  • 59
    • 84865440201 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in white adipose tissue
    • CrossRef PubMed
    • Kusminski, C. M. And Scherer, P. E. (2012) Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol. Metab. 23, 435-443 CrossRef PubMed
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 435-443
    • Kusminski, C.M.1    Scherer, P.E.2
  • 60
    • 0014669160 scopus 로고
    • Plasma amino acid levels and insulin secretion in obesity
    • CrossRef PubMed
    • Felig, P., Marliss, E. And Cahill, Jr, G. F. (1969) Plasma amino acid levels and insulin secretion in obesity. N. Engl. J. Med. 281, 811-816 CrossRef PubMed
    • (1969) N. Engl. J. Med. , vol.281 , pp. 811-816
    • Felig, P.1    Marliss, E.2    Cahill, G.F.3
  • 61
    • 84862282554 scopus 로고    scopus 로고
    • Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
    • CrossRef PubMed
    • Adams, S. H. (2011) Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv. Nutr. 2, 445-556 CrossRef PubMed
    • (2011) Adv. Nutr. , vol.2 , pp. 445-556
    • Adams, S.H.1
  • 64
    • 70350754356 scopus 로고    scopus 로고
    • Regulation of stem cell pluripotency and neural differentiation by lysophospholipids
    • CrossRef PubMed
    • Pitson, S. M. And Pebay, A. (2009) Regulation of stem cell pluripotency and neural differentiation by lysophospholipids. Neurosignals 17, 242-254 CrossRef PubMed
    • (2009) Neurosignals , vol.17 , pp. 242-254
    • Pitson, S.M.1    Pebay, A.2
  • 65
    • 0141923912 scopus 로고    scopus 로고
    • Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1
    • CrossRef PubMed
    • Whetton, A. D., Lu, Y., Pierce, A., Carney, L. And Spooncer, E. (2003) Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood 102, 2798-2802 CrossRef PubMed
    • (2003) Blood , vol.102 , pp. 2798-2802
    • Whetton, A.D.1    Lu, Y.2    Pierce, A.3    Carney, L.4    Spooncer, E.5
  • 66
    • 76849111331 scopus 로고    scopus 로고
    • Purification and characterization of lysophospholipase C from pig brain
    • CrossRef PubMed
    • Hung, N. D., Kim, M. R. And Sok, D. E. (2010) Purification and characterization of lysophospholipase C from pig brain. Neurochem. Res. 35, 50-59 CrossRef PubMed
    • (2010) Neurochem. Res. , vol.35 , pp. 50-59
    • Hung, N.D.1    Kim, M.R.2    Sok, D.E.3
  • 67
    • 0034623231 scopus 로고    scopus 로고
    • Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis
    • PubMed
    • Rodrigues-Lima, F., Fensome, A. C., Josephs, M., Evans, J., Veldman, R. J. And Katan, M. (2000) Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis. J. Biol. Chem. 275, 28316-2825 PubMed
    • (2000) J. Biol. Chem. , vol.275 , pp. 28316-32825
    • Rodrigues-Lima, F.1    Fensome, A.C.2    Josephs, M.3    Evans, J.4    Veldman, R.J.5    Katan, M.6
  • 68
    • 33750590489 scopus 로고    scopus 로고
    • Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk
    • CrossRef PubMed
    • Samad, F., Hester, K. D., Yang, G., Hannun, Y. A. And Bielawski, J. (2006) Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk. Diabetes 55, 2579-2587 CrossRef PubMed
    • (2006) Diabetes , vol.55 , pp. 2579-2587
    • Samad, F.1    Hester, K.D.2    Yang, G.3    Hannun, Y.A.4    Bielawski, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.