Patient-derived xenografts: A relevant preclinical model for drug development

Journal of Experimental and Clinical Cancer Research

Volumn 35, Issue 1, 2016, Pages

  Pompili, Luca ^a,b   Porru, Manuela ^a   Caruso, Carla ^b   Biroccio, Annamaria ^a   Leonetti, Carlo ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF TUSCIA   (Italy)

Author keywords

Immunosuppressed mice; Orthotopic; Patient derived xenografts; Predictive value; Subcutaneous; Tumor heterogeneity

Indexed keywords

CETUXIMAB; CISPLATIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEFITINIB; LAPATINIB; PANITUMUMAB; PIMASERTIB; TRASTUZUMAB;

BIOLOGICAL MODEL; BREAST CANCER; COLON CANCER; COLORECTAL CANCER; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG RESPONSE; DRUG SENSITIVITY; GENE EXPRESSION PROFILING; GENERAL ASPECTS OF DISEASE; GENETIC ASSOCIATION; HUMAN; MORPHOLOGY; NOD SCID GAMMA MOUSE; NOD SCID MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; NUDE MOUSE; ONCOLOGICAL PARAMETERS; OUTCOME ASSESSMENT; OVARY CANCER; PANCREAS CANCER; PATIENT DERIVED ORTHOTOPIC XENOGRAFT; PATIENT DERIVED XENOGRAFT; PATIENT SELECTION; PERSONALIZED MEDICINE; PRECLINICAL MODEL; PREDICTIVE VALUE; PRIORITY JOURNAL; RELIABILITY; REVIEW; SCID MOUSE; SMALL CELL LUNG CANCER; TUMOR ENGRAFTMENT; TUMOR FRAGMENT; TUMOR HETEROGENEITY; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; DRUG SCREENING; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; XENOGRAFT;

ANIMALS; HUMANS; MICE; NEOPLASMS; PRECISION MEDICINE; TRANSPLANTATION, HETEROLOGOUS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85002410428     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-016-0462-4     Document Type: Review

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