Citrus junos Tanaka peel ameliorates hepatic lipid accumulation in HepG2 cells and in mice fed a high-cholesterol diet

BMC Complementary and Alternative Medicine

Volumn 16, Issue 1, 2016, Pages

  Shin, Eun Ju ^a   Park, Jae Ho ^a   Sung, Mi Jeong ^a   Chung, Min Yu ^a   Hwang, Jin Taek ^a  

^a University of Science and Technology (UST)   (South Korea)

Author keywords

Citrus junos Tanaka; Hepatic lipid accumulation; HepG2 cell; High cholesterol diet

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE I; CITRUS JUNOS EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLANT EXTRACT; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL INTAKE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CITRUS; CITRUS JUNOS; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; FAT CONTENT; HEPG2 CELL LINE; HYPOCHOLESTEROLEMIC ACTIVITY; LIMIT OF QUANTITATION; LIPID STORAGE; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRADITIONAL MEDICINE; UPREGULATION; ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; CHOLESTEROL INTAKE; DIET THERAPY; DRUG EFFECTS; HEP-G2 CELL LINE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIVER; METABOLISM; SIGNAL TRANSDUCTION; SOUTH KOREA;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOMARKERS; CARNITINE O-PALMITOYLTRANSFERASE; CHOLESTEROL, DIETARY; CITRUS; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; PPAR GAMMA; REPUBLIC OF KOREA; SIGNAL TRANSDUCTION;

EID: 85000948030     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-016-1460-y     Document Type: Article

References (20)

1. Patel RS, Scopelliti EM, Savelloni J. Therapeutic management of familial hypercholesterolemia: current and emerging drug therapies. Pharmacotherapy. 2015;35:1189-203.
2. Natsume M, Baba S. Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipoprotein E-deficient mice. Subcell Biochem. 2014;77:189-98.
3. Bento AP, Cominetti C, Simões Filho A, Naves MM. Baru almond improves lipid profile in mildly hypercholesterolemic subjects: a randomized, controlled, crossover study. Nutr Metab Cardiovasc Dis. 2014;24:1330-6.
4. Liu S, Jing F, Yu C, Gao L, Qin Y, Zhao J. AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver. PLoS One. 2015;10, e0124951.
5. Brousseau ME. Statins, super-statins and cholesterol absorption inhibitors. IDrugs. 2003;6:458-63.
6. Kim SH, Hur HJ, Yang HJ, Kim HJ, Kim MJ, Park JH, Sung MJ, Kim MS, Kwon DY, Hwang JT. Citrus junos Tanaka peel extract exerts antidiabetic effects via AMPK and PPAR-γ both in vitro and in vivo in mice fed a high-Fat diet. Evid Based Complement Alternat Med. 2013;2013:921012.
7. Kim SH, Shin EJ, Hur HJ, Park JH, Sung MJ, Kwon DY, Hwang JT. Citrus junos Tanaka peel extract attenuates experimental colitis and inhibits tumour growth in a mouse xenograft model. J Funct Foods. 2014;8:301-8.
8. Foster DW. The role of the carnitine system in human metabolism. Ann N Y Acad Sci. 2004;1033:1-16.
9. Babu PV, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem. 2013;24:1777-89.
10. Lammi C, Zanoni C, Arnoldi A. A simple and high-throughput in-cell Western assay using HepG2 cell line for investigating the potential hypocholesterolemic effects of food components and nutraceutics. Food Chem. 2015;169:59-64.
11. Ramadan WH, Kabbara WK. Sitagliptin/Simvastatin: a first combination tablet to treat type 2 diabetes and hypercholesterolemia--a review of its characteristics. Vasc Health Risk Manag. 2015;11:125-32.
12. Quan HY, Kim DY, Chung SH. Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells. BMB Rep. 2013;46:207-12.
13. Wu N, Sarna LK, Siow YL, Karmin OK. Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol. 2011;300:R635-43.
14. Wang ZQ, Zhang XH, Yu Y, Tipton RC, Raskin I, Ribnicky D, Johnson W, Cefalu WT. Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. Metabolism. 2013;62:1239-49.
15. Seida A, El-Hefnawy H, Abou-Hussein D, Mokhtar FA, Abdel-Naim A. Evaluation of Medicago sativa L. sprouts as antihyperlipidemic and antihyperglycemic agent. Pak J Pharm Sci. 2015;28:2061-74.
16. Olmez E, Vural K, Gok S, Ozturk Z, Kayalar H, Ayhan S, Var A. Olive leaf extract improves the atherogenic lipid profile in rats Fed a high cholesterol diet. Phytother Res. 2015;29:1652-7.
17. Monsef-Esfahani HR, Amini M, Goodarzi N, Saiedmohammadi F, Hajiaghaee R, Faramarzi MA, Tofighi Z, Ghahremani MH. Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice. Daru. 2013;21:51.
18. Kurowska EM, Manthey JA, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids. 2004;39:143-51.
19. Kim MS, Hur HJ, Kwon DY, Hwang JT. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. Mol Cell Endocrinol. 2012;358:127-34.
20. Li Y, Dai F, Jin XL, Ma MM, Wang YH, Ren XR, Zhou B. An effective strategy to develop active cinnamic acid-directed antioxidants based on elongating the conjugated chains. Food Chem. 2014;158:41-7.