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Volumn 7, Issue , 2016, Pages

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

(276)  Ried, Janina S a   Jeff, Janina M b   Chu, Audrey Y c   Bragg Gresham, Jennifer L d   Van Dongen, Jenny e   Huffman, Jennifer E f   Ahluwalia, Tarunveer S g,h,i   Cadby, Gemma j   Eklund, Niina k   Eriksson, Joel l   Esko, Toñu m,n,o,p   Feitosa, Mary F q   Goel, Anuj r,s   Gorski, Mathias t,u   Hayward, Caroline f   Heard Costa, Nancy L v,w   Jackson, Anne U x   Jokinen, Eero y   Kanoni, Stavroula z,aa   Kristiansson, Kati k,y   more..


Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CD47 ANTIGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

EID: 85000900079     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13357     Document Type: Article
Times cited : (65)

References (48)
  • 1
    • 84908890496 scopus 로고    scopus 로고
    • Defining the role of common variation in the genomic and biological architecture of adult human height
    • Wood, A. R. et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet. 46, 1173-1186 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 1173-1186
    • Wood, A.R.1
  • 2
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206 (2015).
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1
  • 3
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen, H. et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838 (2010).
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1
  • 4
    • 84923169934 scopus 로고    scopus 로고
    • New genetic loci link adipose and insulin biology to body fat distribution
    • Shungin, D. et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187-196 (2015).
    • (2015) Nature , vol.518 , pp. 187-196
    • Shungin, D.1
  • 5
    • 84884607859 scopus 로고    scopus 로고
    • Genome-wide association of body fat distribution in African ancestry populations suggests new loci
    • Liu, C. T. et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS. Genet. 9, e1003681 (2013).
    • (2013) PLoS. Genet. , vol.9 , pp. 1003681
    • Liu, C.T.1
  • 6
    • 79960895140 scopus 로고    scopus 로고
    • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    • Kilpelainen, T. O. et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat. Genet. 43, 753-760 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 753-760
    • Kilpelainen, T.O.1
  • 7
    • 84860350999 scopus 로고    scopus 로고
    • A genome-wide association meta-analysis identifies new childhood obesity loci
    • Bradfield, J. P. et al. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat. Genet. 44, 526-531 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 526-531
    • Bradfield, J.P.1
  • 8
    • 84878569025 scopus 로고    scopus 로고
    • Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
    • Wheeler, E. et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat. Genet. 45, 513-517 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 513-517
    • Wheeler, E.1
  • 9
    • 59149097625 scopus 로고    scopus 로고
    • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    • Meyre, D. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157-159 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 157-159
    • Meyre, D.1
  • 10
    • 84907195706 scopus 로고    scopus 로고
    • Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease
    • Myint, P. K., Kwok, C. S., Luben, R. N., Wareham, N. J., Khaw, K. T. Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease. Heart 100, 1613-1619 (2014).
    • (2014) Heart , vol.100 , pp. 1613-1619
    • Myint, P.K.1    Kwok, C.S.2    Luben, R.N.3    Wareham, N.J.4    Khaw, K.T.5
  • 11
    • 84864659280 scopus 로고    scopus 로고
    • Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: The EPIC-InterAct case-cohort study
    • InterAct, C. et al. Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med. 9, e1001230 (2012).
    • (2012) PLoS Med. , vol.9 , pp. 1001230
    • InterAct, C.1
  • 12
    • 84936073085 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
    • He, M. et al. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum. Mol. Genet. 24, 1791-1800 (2015).
    • (2015) Hum. Mol. Genet. , vol.24 , pp. 1791-1800
    • He, M.1
  • 13
    • 84873488838 scopus 로고    scopus 로고
    • Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
    • Pendergrass, S. A. et al. Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet. 9, e1003087 (2013).
    • (2013) PLoS Genet. , vol.9 , pp. 1003087
    • Pendergrass, S.A.1
  • 14
    • 77952822074 scopus 로고    scopus 로고
    • Phe WAS: Demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
    • Denny, J. C. et al. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics 26, 1205-1210 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 1205-1210
    • Denny, J.C.1
  • 15
    • 84862832570 scopus 로고    scopus 로고
    • Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
    • Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, S1-S3 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 51-53
    • Yang, J.1
  • 16
    • 84899972622 scopus 로고    scopus 로고
    • Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies
    • Aschard, H. et al. Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies. Am. J. Hum. Genet. 94, 662-676 (2014).
    • (2014) Am. J. Hum. Genet. , vol.94 , pp. 662-676
    • Aschard, H.1
  • 17
    • 84933279742 scopus 로고    scopus 로고
    • Meta-analysis of the heritability of human traits based on fifty years of twin studies
    • Polderman, T. J. et al. Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nat. Genet. 47, 702-709 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 702-709
    • Polderman, T.J.1
  • 18
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes, E. K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 937-948
    • Speliotes, E.K.1
  • 19
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • Heid, I. M. et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet. 42, 949-960 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 949-960
    • Heid, I.M.1
  • 20
    • 79957993750 scopus 로고    scopus 로고
    • Identification, replication, functional fine-mapping of expression quantitative trait loci in primary human liver tissue
    • Innocenti, F. et al. Identification, replication, functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet. 7, e1002078 (2011).
    • (2011) PLoS Genet. , vol.7 , pp. 1002078
    • Innocenti, F.1
  • 21
    • 84927747554 scopus 로고    scopus 로고
    • SNiPA: An interactive, genetic variant-centered annotation browser
    • Arnold, M., Raffler, J., Pfeufer, A., Suhre, K., Kastenmuller, G. SNiPA: an interactive, genetic variant-centered annotation browser. Bioinformatics 31, 1334-1336 (2015).
    • (2015) Bioinformatics , vol.31 , pp. 1334-1336
    • Arnold, M.1    Raffler, J.2    Pfeufer, A.3    Suhre, K.4    Kastenmuller, G.5
  • 22
    • 84871267657 scopus 로고    scopus 로고
    • Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population
    • Comuzzie, A. G. et al. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PLoS ONE 7, e51954 (2012).
    • (2012) PLoS ONE , vol.7 , pp. 51954
    • Comuzzie, A.G.1
  • 23
    • 84891790401 scopus 로고    scopus 로고
    • The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
    • Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42, D1001-D1006 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D1001-D1006
    • Welter, D.1
  • 24
    • 84902316955 scopus 로고    scopus 로고
    • GWAS Central: A comprehensive resource for the comparison and interrogation of genome-wide association studies
    • Beck, T., Hastings, R. K., Gollapudi, S., Free, R. C., Brookes, A. J. GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies. Eur. J. Hum. Genet. 22, 949-952 (2014).
    • (2014) Eur. J. Hum. Genet. , vol.22 , pp. 949-952
    • Beck, T.1    Hastings, R.K.2    Gollapudi, S.3    Free, R.C.4    Brookes, A.J.5
  • 25
    • 84861023442 scopus 로고    scopus 로고
    • GWASdb: A database for human genetic variants identified by genome-wide association studies
    • Li, M. J. et al. GWASdb: a database for human genetic variants identified by genome-wide association studies. Nucleic Acids Res. 40, D1047-D1054 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. D1047-D1054
    • Li, M.J.1
  • 26
    • 84937717236 scopus 로고    scopus 로고
    • CD47 signaling pathways controlling cellular differentiation and responses to stress
    • Soto-Pantoja, D. R., Kaur, S., Roberts, D. D. CD47 signaling pathways controlling cellular differentiation and responses to stress. Crit. Rev. Biochem. Mol. Biol. 1-19 (2015).
    • (2015) Crit. Rev. Biochem. Mol. Biol. , pp. 1-19
    • Soto-Pantoja, D.R.1    Kaur, S.2    Roberts, D.D.3
  • 27
    • 84924390135 scopus 로고    scopus 로고
    • CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity
    • Maimaitiyiming, H., Norman, H., Zhou, Q., Wang, S. CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity. Sci. Rep. 5, 8846 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 8846
    • Maimaitiyiming, H.1    Norman, H.2    Zhou, Q.3    Wang, S.4
  • 28
    • 80052840370 scopus 로고    scopus 로고
    • Genome-wide population-based association study of extremely overweight young adults-the GOYA study
    • Paternoster, L. et al. Genome-wide population-based association study of extremely overweight young adults-the GOYA study. PLoS ONE 6, e24303 (2011).
    • (2011) PLoS ONE , vol.6 , pp. 24303
    • Paternoster, L.1
  • 29
    • 77956637896 scopus 로고    scopus 로고
    • Genetics and beyond-the transcriptome of human monocytes and disease susceptibility
    • Zeller, T. et al. Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS ONE 5, e10693 (2010).
    • (2010) PLoS ONE , vol.5 , pp. 10693
    • Zeller, T.1
  • 30
    • 84899530967 scopus 로고    scopus 로고
    • DNA methylation study of fetus genome through a genome-wide analysis
    • Wang, H. D. et al. DNA methylation study of fetus genome through a genome-wide analysis. BMC Med. Genomics 7, 18 (2014).
    • (2014) BMC Med. Genomics , vol.7 , pp. 18
    • Wang, H.D.1
  • 31
    • 46249092087 scopus 로고    scopus 로고
    • EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase
    • Tegha-Dunghu, J. et al. EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. J. Cell. Sci. 121, 1718-1726 (2008).
    • (2008) J. Cell. Sci. , vol.121 , pp. 1718-1726
    • Tegha-Dunghu, J.1
  • 32
    • 84949117068 scopus 로고    scopus 로고
    • Towards a mechanistic understanding of lipodystrophy and seipin functions
    • Wee, K., Yang, W., Sugii, S., Han, W. Towards a mechanistic understanding of lipodystrophy and seipin functions. Biosci. Rep. 34 (2014).
    • (2014) Biosci. Rep. , vol.34
    • Wee, K.1    Yang, W.2    Sugii, S.3    Han, W.4
  • 33
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • Westra, H. J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238-1243 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1238-1243
    • Westra, H.J.1
  • 34
    • 84925746952 scopus 로고    scopus 로고
    • AHNAK KO Mice are protected from diet-induced obesity but are glucose intolerant
    • Ramdas, M., Harel, C., Armoni, M., Karnieli, E. AHNAK KO Mice are protected from diet-induced obesity but are glucose intolerant. Horm. Metab. Res. 47, 265-272 (2015).
    • (2015) Horm. Metab. Res. , vol.47 , pp. 265-272
    • Ramdas, M.1    Harel, C.2    Armoni, M.3    Karnieli, E.4
  • 35
    • 84866871814 scopus 로고    scopus 로고
    • Mapping cis-and trans-regulatory effects across multiple tissues in twins
    • Grundberg, E. et al. Mapping cis-and trans-regulatory effects across multiple tissues in twins. Nat. Genet. 44, 1084-1089 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 1084-1089
    • Grundberg, E.1
  • 36
    • 77951768942 scopus 로고    scopus 로고
    • Genetic loci influencing kidney function and chronic kidney disease
    • Chambers, J. C. et al. Genetic loci influencing kidney function and chronic kidney disease. Nat. Genet. 42, 373-375 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 373-375
    • Chambers, J.C.1
  • 37
    • 84859238629 scopus 로고    scopus 로고
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
    • Dastani, Z. et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 8, e1002607 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. 1002607
    • Dastani, Z.1
  • 38
    • 84895868553 scopus 로고    scopus 로고
    • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
    • Replication, D. I. G. et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet. 46, 234-244 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 234-244
    • Replication, D.I.G.1
  • 39
    • 84865693929 scopus 로고    scopus 로고
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • Scott, R. A. et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat. Genet. 44, 991-1005 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 991-1005
    • Scott, R.A.1
  • 40
    • 74249100913 scopus 로고    scopus 로고
    • A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
    • Richards, J. B. et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 5, e1000768 (2009).
    • (2009) PLoS Genet. , vol.5 , pp. 1000768
    • Richards, J.B.1
  • 41
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
    • (2010) Nature , vol.466 , pp. 707-713
    • Teslovich, T.M.1
  • 42
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • Global Lipids Genetics, C et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274-1283 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1274-1283
    • Global Lipids, G.C.1
  • 43
    • 78249239776 scopus 로고    scopus 로고
    • A genome-wide study reveals copy number variants exclusive to childhood obesity cases
    • Glessner, J. T. et al. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. Am. J. Hum. Genet. 87, 661-666 (2010).
    • (2010) Am. J. Hum. Genet. , vol.87 , pp. 661-666
    • Glessner, J.T.1
  • 44
    • 79953221100 scopus 로고    scopus 로고
    • A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
    • Coronary Artery Disease Genetics Consortium
    • Coronary Artery Disease Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43, 339-344 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 339-344
  • 45
    • 34447324105 scopus 로고    scopus 로고
    • Gen ABEL: An R library for genome-wide association analysis
    • Aulchenko, Y. S., Ripke, S., Isaacs, A., van Duijn, C. M. GenABEL: an R library for genome-wide association analysis. Bioinformatics 23, 1294-1296 (2007).
    • (2007) Bioinformatics , vol.23 , pp. 1294-1296
    • Aulchenko, Y.S.1    Ripke, S.2    Isaacs, A.3    Van Duijn, C.M.4
  • 46
    • 77955894071 scopus 로고    scopus 로고
    • METAL: Fast and efficient meta-analysis of genomewide association scans
    • Willer, C. J., Li, Y., Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190-2191 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2190-2191
    • Willer, C.J.1    Li, Y.2    Abecasis, G.R.3
  • 47
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1


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