Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans

Genome Biology

Volumn 17, Issue 1, 2016, Pages

  Sams, Aaron J ^a   Dumaine, Anne ^b   Nédélec, Yohann ^b,c   Yotova, Vania ^b   Alfieri, Carolina ^b,c   Tanner, Jerome E ^b   Messer, Philipp W ^a   Barreiro, Luis B ^b,c  

^a Department of Biological Statistics and Computational Biology ^*  (United States)

^b UNIVERSITY OF MONTREAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Innate immunity; Introgression; Natural selection

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; 2',5'-OLIGOADENYLATE SYNTHETASE 2, HUMAN; ISOPROTEIN; OAS1 PROTEIN, HUMAN; OAS3 PROTEIN, HUMAN;

ADULT; CONTROLLED STUDY; GENE; GENE LOCUS; HAPLOTYPE; HOMO NEANDERTHALENSIS; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTROGRESSION; MALE; NATURAL SELECTION; OAS1 GENE; OAS2 GENE; OAS3 GENE; REVIEW; TRANSCRIPTION REGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETIC SELECTION; GENETICS; HUMAN GENOME; IMMUNOLOGY; INFECTION; MOLECULAR EVOLUTION; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

2',5'-OLIGOADENYLATE SYNTHETASE; ANIMALS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOME, HUMAN; HAPLOTYPES; HUMANS; IMMUNITY, INNATE; INFECTION; NEANDERTHALS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ISOFORMS; SELECTION, GENETIC;

EID: 84999837754     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-1098-6     Document Type: Review

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