Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H + secretion

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Garnett, James Peter ^a,b   Kalsi, Kameljit K ^c   Sobotta, Mirko ^b   Bearham, Jade ^c   Carr, Georgina ^a   Powell, Jason ^a   Brodlie, Malcolm ^a   Ward, Christopher ^a   Tarran, Robert ^d   Baines, Deborah L ^c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID DERIVATIVE; MONOCARBOXYLATE TRANSPORTER; SLC16A7 PROTEIN, HUMAN;

CELL CULTURE; CYSTIC FIBROSIS; EPITHELIUM CELL; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PH; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RESPIRATORY MUCOSA;

CELLS, CULTURED; CYSTIC FIBROSIS; EPITHELIAL CELLS; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERGLYCEMIA; LACTATES; MONOCARBOXYLIC ACID TRANSPORTERS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY MUCOSA;

EID: 84999740048     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep37955     Document Type: Article

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