ROS-responsive mitochondria-targeting blended nanoparticles: Chemo- and photodynamic synergistic therapy for lung cancer with on-demand drug release upon irradiation with a single light source

Theranostics

Volumn 6, Issue 13, 2016, Pages 2352-2366

  Yue, Caixia ^a,b   Yang, Yuming ^a,b   Zhang, Chunlei ^a,b   Alfranca, Gabriel ^a,b   Cheng, Shangli ^a,b   Ma, Lijun ^b   Liu, Yanlei ^a,b   Zhi, Xiao ^a,b   Ni, Jian ^a,b   Jiang, Weihua ^c   Song, Jie ^a,b   de la Fuente, Jesús M ^a,b   Cui, Daxiang ^a,b  

^a Shanghai Jiao Tong University   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Camptothecin; Mitochondria targeting nanoparticles; Photodynamic therapy; ROS responsive; Zinc phthalocyanine

Indexed keywords

CAMPTOTHECIN; CATION; COPOLYMER; MACROGOL; NANOPARTICLE; PHOSPHATIDYLETHANOLAMINE; PHOSPHONIUM DERIVATIVE; PHTHALOCYANINE ZINC; REACTIVE OXYGEN METABOLITE; TRIPHENYLPHOSPHINE; TRIPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CELL NUCLEUS; CHEMICAL MODIFICATION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DNA REPLICATION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; IRRADIATION; LASER; LUNG CANCER; MITOCHONDRION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; SURFACE PROPERTY; SYNTHESIS; TARGET CELL DESTRUCTION; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; DRUG EFFECTS; DRUG THERAPY; LIGHT; LUNG NEOPLASMS; METABOLISM; MULTIMODALITY CANCER THERAPY; PHOTOCHEMOTHERAPY; PROCEDURES; RADIATION RESPONSE; TREATMENT OUTCOME; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; COMBINED MODALITY THERAPY; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; DRUG THERAPY; HETEROGRAFTS; HUMANS; LIGHT; LUNG NEOPLASMS; MICE, INBRED BALB C; MITOCHONDRIA; NANOPARTICLES; PHOTOCHEMOTHERAPY; REACTIVE OXYGEN SPECIES; TREATMENT OUTCOME;

EID: 84999622359     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.15433     Document Type: Article

References (41)

1. Murphy MP, Smith RAJ. Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliver Rev. 2000;41:235-50.
2. Aronis A, Melendez JA, Golan O, Shilo S, Dicter N, Tirosh O. Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species. Cell Death Differ. 2003;10:335-44.
3. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-12.
4. Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov. 2009;8:579-91.
5. Gogvadze V. Targeting mitochondria in fighting cancer. Curr Pharm Des. 2011;17:4034-46.
6. Liu P, Yue CX, Sheng ZH, Gao GH, Li MX, Yi HQ, et al. Photosensitizer-conjugated redox-responsive dextran theranostic nanoparticles for near-infrared cancer imaging and photodynamic therapy. Polym Chem-Uk. 2014;5:874-81.
7. Chen Q, Wang X, Wang C, Feng L, Li Y, Liu Z. Drug-induced self-assembly of modified albumins as nano-theranostics for tumor-targeted combination therapy. Acs Nano. 2015; 9:5223-33.
8. Chen Q, Wang C, Cheng L, He W, Cheng Z, Liu Z. Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy. Biomaterials. 2014;35:2915-23.
9. Yuan YY, Liu J, Liu B. Conjugated-polyelectrolyte-based polyprodrug: targeted and image-guided photodynamic and chemotherapy with on-demand drug release upon irradiation with a single light source. Angew Chem Int Edit. 2014;53:7163-8.
10. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483-95.
11. Hoye AT, Davoren JE, Wipf P, Fink MP, Kagan VE. Targeting mitochondria. Accounts of chemical research. 2008;41:87-97.
12. Yu Z, Sun Q, Pan W, Li N, Tang B. A near-infrared triggered nanophotosensitizer inducing domino effect on mitochondrial reactive oxygen species burst for cancer therapy. Acs Nano. 2015; 9:11064-74.
13. Summerhayes IC, Lampidis TJ, Bernal SD, Nadakavukaren JJ, Nadakavukaren KK, Shepherd EL, et al. Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. Proc Natl Acad Sci U S A. 1982;79:5292-6.
14. Modica-Napolitano JS, Aprille JR. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv Drug Deliver Rev. 2001;49:63-70.
15. Hu Q, Gao M, Feng G, Liu B. Mitochondria-targeted cancer therapy using a light-up probe with aggregation-induced-emission characteristics. Angewandte Chemie International Edition. 2014;53:14225-9.
16. Murphy MP. Selective targeting of bioactive compounds to mitochondria. Trends Biotechnol. 1997;15:326-30.
17. Smith RA, Porteous CM, Gane AM, Murphy MP. Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A. 2003;100:5407-12.
18. Burns RJ, Murphy MP. Labeling of mitochondrial proteins in living cells by the thiol probe thiobutyltriphenylphosphonium bromide. Arch Biochem Biophys. 1997;339:33-9.
19. Luo GF, Chen WH, Liu Y, Lei Q, Zhuo RX, Zhang XZ. Multifunctional enveloped mesoporous silica nanoparticles for subcellular co-delivery of drug and therapeutic peptide. Sci Rep. 2014;4:6064.
20. Marrache S, Dhar S. Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc Natl Acad Sci U S A. 2012;109:16288-93.
21. Marrache S, Pathak RK, Dhar S. Detouring of cisplatin to access mitochondrial genome for overcoming resistance. P Natl Acad Sci USA. 2014;111:10444-9.
22. Solomon MA, Shah AA, D'Souza GGM. In vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel. Mitochondrion. 2013;13:464-72.
23. Cho DY, Cho H, Kwon K, Yu M, Lee E, Huh KM, et al. Triphenylphosphonium-conjugated poly (e-caprolactone)-based self-assembled nanostructures as nanosized drugs and drug delivery carriers for mitochondria-targeting synergistic anticancer drug delivery. Advanced Functional Materials. 2015;25:5479-91.
24. Dong Y, Yang J, Liu H, Wang T, Tang S, Zhang J, et al. Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors. Theranostics. 2015;5:890-904.
25. Roy D, Brooks WLA, Sumerlin BS. New directions in thermoresponsive polymers. Chem Soc Rev. 2013;42:7214-43.
26. Li N, Li N, Yi QY, Luo K, Guo CH, Pan DY, et al. Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-responsive anti-cancer agent. Biomaterials. 2014;35:9529-45.
27. Chen LF, Wang WQ, Su B, Wen YQ, Li CB, Zhou YB, et al. A light-responsive release platform by controlling the wetting behavior of hydrophobic surface. Acs Nano. 2014;8:744-51.
28. Fomina N, Sankaranarayanan J, Almutairi A. Photochemical mechanisms of light-triggered release from nanocarriers. Adv Drug Deliver Rev. 2012;64:1005-20.
29. Shim MS, Xia YN. A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells. Angew Chem Int Edit. 2013;52:6926-9.
30. Wagner A, Denzer UW, Neureiter D, Kiesslich T, Puespoeck A, Rauws EA, et al. Temoporfin improves efficacy of photodynamic therapy in advanced biliary tract carcinoma: A multicenter prospective phase II study. Hepatology. 2015;62:1456-65.
31. Choudhary S, Nouri K, Elsaie ML. Photodynamic therapy in dermatology: a review. Laser Med Sci. 2009;24:971-80.
32. Gao J, Liu M, Zou Y, Mao M, Shen T, Zhang C, et al. Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway. Oncol Rep. 2015;34:3212-21.
33. Wang C, Sun X, Cheng L, Yin S, Yang G, Li Y, et al. Multifunctional theranostic red blood cells for magnetic-field-enhanced in vivo combination therapy of cancer. Advanced Materials. 2014;26:4794-802.
34. Josefsen LB, Boyle RW. Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics. Theranostics. 2012;2:916-66.
35. Li R, Zheng K, Hu P, Chen Z, Zhou S, Chen J, et al. A novel tumor targeting drug carrier for optical imaging and therapy. Theranostics. 2014;4:642-59.
36. Ganguly NC, Mondal P. Mild, Efficient, and greener dethioacetalization protocol using 30% hydrogen peroxide in catalytic combination with ammonium iodide. Synthetic Commun. 2011;41:2374-84.
37. Lee CS, Park W, Park SJ, Na K. Endolysosomal environment-responsive photodynamic nanocarrier to enhance cytosolic drug delivery via photosensitizer-mediated membrane disruption. Biomaterials. 2013;34:9227-36.
38. Li Y, Liu R, Yang J, Ma G, Zhang Z, Zhang X. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials. 2014;35:9731-45.
39. Zhen Z, Tang W, Guo C, Chen H, Lin X, Liu G, et al. Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. Acs Nano. 2013;7:6988-96.
40. Zhang CL, Zhou ZJ, Zhi X, Ma Y, Wang K, Wang YX, et al. Insights into the distinguishing stress-induced cytotoxicity of chiral gold nanoclusters and the relationship with GSTP1. Theranostics. 2015;5:134-49.
41. Ho CJH, Balasundaram G, Driessen W, McLaren R, Wong CL, Dinish U, et al. Multifunctional photosensitizer-based contrast agents for photoacoustic imaging. Scientific reports. 2014;4:5342.