Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase

Human Molecular Genetics

Volumn 25, Issue 11, 2016, Pages 2234-2244

  McCorvie, Thomas J ^a   Kopec, Jolanta ^a   Pey, Angel L ^b   Fitzpatrick, Fiona ^a,c   Patel, Dipali ^a   Chalk, Rod ^a   Shrestha, Leela ^a   Yue, Wyatt W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; ENZYME VARIANT; GALACTOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; GLUCOSE 1 PHOSPHATE; HOMODIMER; RECOMBINANT ENZYME; ZINC; GALACTOSE; TERNARY COMPLEX FACTOR;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME MODIFICATION; ENZYME STABILITY; ENZYME STRUCTURE; GALACTOSEMIA; GENE MUTATION; HUMAN; METAL BINDING; MODEL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN MISFOLDING; PROTEIN SECONDARY STRUCTURE; URIDYLYLATION; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PATHOLOGY; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GALACTOSE; GALACTOSEMIAS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TERNARY COMPLEX FACTORS; UTP-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE;

EID: 84998879845     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw091     Document Type: Article

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