Analysis of galactosemia-linked mutations of GALT enzyme using a computational biology approach

Protein Engineering, Design and Selection

Volumn 23, Issue 2, 2010, Pages 103-113

  Facchiano, A ^a   Marabotti, A ^a  

^a CNR   (Italy)

Author keywords

Database; Galactose metabolism; Galactose 1 phosphate uridyltransferase; Single point mutants; Structure prediction

Indexed keywords

ACTIVE SITE; BIOINFORMATICS PROGRAMS; COMPUTATIONAL APPROACH; COMPUTATIONAL BIOLOGY; DATABASE; EXPERIMENTAL DATA; GALACTOSE METABOLISM; GENETIC DISEASE; H-BONDS; HOMOLOGY MODELING; MAIN EFFECT; MOLECULAR LEVELS; MUTANT PROTEINS; PROTEIN STABILITY; SALT BRIDGES; SECONDARY STRUCTURES; SINGLE POINT; STRUCTURAL MODELS; STRUCTURE PREDICTION; SURFACE FEATURE;

DATABASE SYSTEMS; ENZYMES; METABOLISM; MODEL STRUCTURES; MONOMERS; SURFACE STRUCTURE;

BIOINFORMATICS;

DIMER; GALACTOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; MONOMER; MUTANT PROTEIN;

ARTICLE; BIOINFORMATICS; ENZYME ANALYSIS; GALACTOSEMIA; HYDROGEN BOND; MOLECULAR MODEL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SIMULATION;

CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; GALACTOSEMIAS; HUMANS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; UTP-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE;

EID: 75649089285     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp076     Document Type: Article

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