Synthesis and biological evaluation of novel 3-O-tethered triazoles of diosgenin as potent antiproliferative agents

Steroids

Volumn 118, Issue , 2017, Pages 1-8

  Masood ur Rahman, ^a,b   Mohammad, Younis ^c   Fazili, Khalid Majid ^c   Bhat, Khursheed Ahmad ^b   Ara, Tabassum ^a  

^a NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c UNIVERSITY OF KASHMIR   (India)

Author keywords

Cancer; Click chemistry; Dioscorea deltoidea; Diosgenin; Triazoles

Indexed keywords

1 NAPTHALEN 1 YL (1H 1,2,3 TRIAZOL 4YL)METHOXY DIOSGENIN; 1 PHENYL (1H 1,2,3 TRIAZOL 4YL)METHOXY DIOSGENIN; 1 [2 BROMOPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [2 CYANOPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [2 METHOXYPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [2 NITROPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [2,5 DIMETHYLPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [3 CYANOPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [3 METHOXYPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [3 NITROPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [3,4,5 TRIMETHOXYPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [4 BROMOPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [4 CYANOPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [4 FLUOROPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [4 HYDROXYMETHYLPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [4 METHOXYPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 1 [4 NITROPHENYL (1H 1,2,3 TRIAZOL 4YL)]METHOXY DIOSGENIN; 3 (PROP 2 YNYLOXY)DIOSGENIN; ANTINEOPLASTIC AGENT; CYANOPHENYL; DACTOLISIB; DIOSCOREA DELTOIDEA EXTRACT; DIOSGENIN; DIOSGENIN DERIVATIVE; FUNCTIONAL GROUP; NITROPHENYL; PHENYL GROUP; PLANT EXTRACT; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIOSCOREA DELTOIDEA; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; HCT116 CELL LINE; HUMAN; HUMAN CELL; IC50; MOLECULAR MODEL; MTT ASSAY; RHIZOME; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; YAM; A-549 CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CLICK CHEMISTRY; DRUG EFFECTS; SYNTHESIS;

A549 CELLS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CLICK CHEMISTRY; DIOSGENIN; HUMANS; MOLECULAR STRUCTURE; PLANT EXTRACTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84997523851     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2016.11.003     Document Type: Article

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