The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: A randomized controlled trial

BMC Complementary and Alternative Medicine

Volumn 16, Issue 1, 2016, Pages

  Farhangi, Mahdieh Abbasalizad ^a   Dehghan, Parvin ^a   Tajmiri, Siroos ^b   Abbasi, Mehran Mesgari ^c  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Hashimoto's thyroiditis; Nesfatin 1; Nigella sativa; VEGF

Indexed keywords

HERBACEOUS AGENT; LIOTHYRONINE; NESFATIN 1; NEUROPEPTIDE; PLACEBO; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR 1; VASCULOTROPIN; CALCIUM BINDING PROTEIN; DNA BINDING PROTEIN; NERVE PROTEIN; NUCLEOBINDIN; PLANT EXTRACT; THYROID HORMONE; VASCULOTROPIN A;

ADULT; ANTHROPOMETRIC PARAMETERS; ANTIBODY BLOOD LEVEL; ARTICLE; BLACK CUMIN; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HASHIMOTO DISEASE; HUMAN; LIOTHYRONINE BLOOD LEVEL; MALE; PLANT SEED; POWDER; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; TREATMENT DURATION; WAIST HIP RATIO; WEIGHT REDUCTION; ANTHROPOMETRY; BLOOD; BODY WEIGHT; CHEMISTRY; MIDDLE AGED; PATHOPHYSIOLOGY; SECRETION (PROCESS); THYROID GLAND; YOUNG ADULT;

ADULT; ANTHROPOMETRY; BODY WEIGHT; CALCIUM-BINDING PROTEINS; DNA-BINDING PROTEINS; FEMALE; HASHIMOTO DISEASE; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NIGELLA SATIVA; PLANT EXTRACTS; THYROID GLAND; THYROID HORMONES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WAIST-HIP RATIO; YOUNG ADULT;

EID: 84997402737     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-016-1432-2     Document Type: Article

References (58)

1. Chistiakov DA. Immunogenetics of Hashimoto's thyroiditis. J Autoimmune Dis. 2005;2:1-21.
2. Wang C, Crapo LM. The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin North Am. 1997;26:189-218.
3. Tunbridge WM, Vanderpump MP. Population screening for autoimmune thyroid disease. Endocrinol Metab Clin North Am. 2000;29:239-53.
4. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995;43:55-69.
5. Zaletel K, Gaberscek S. Hashimoto's thyroiditis: from genes to the disease. Curr Genomics. 2011;12(8):576-80.
6. Farhangi MA, Eshraghian M, Keshavarz SA, Saboor-Yaraghi AA. Thyroid-stimulating hormone, triiodotyronine and thyroxine concentrations and their relationship with metabolic parameters, anthropometric variables and body composition in premenopausal euthyroid obese women. Turk Jem. 2015;19:1-6.
7. Ott RA, McCall AR, McHenry C, Jarosz H, Armin A, Lawrence AM, et al. The incidence of thyroid carcinoma in Hashimoto's thyroiditis. Am Surg. 1987;53(8):442-5.
8. Repplinger D, Bargren A, Zhang YW, Adler JT, Haymart M, Chen H. Is Hashimoto's thyroiditis a risk factor for papillary thyroid cancer? J Surg Res. 2008;150(1):49-52.
9. Westermark K, Karlsson FA, Westermark B. Epidermal growth factor modulates thyroid growth and function in culture. Endocrinology. 1983;112(5):1680-6.
10. Wang JF, Milosveski V, Schramek C, Fong GH, Becks GP, Hill DJ. Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function. J Endocrinol. 1998;157:5-12.
11. Soh EY, Sobhi SA, Wong M, Meng YG, Siperstein AE, Clark OH, et al. Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines. Surgery. 1996;120(6):944-7.
12. Ayada C, Toru U, Korkut Y. Nesfatin-1 and its effects on different systems. Hippokratia. 2015;19(1):4-10.
13. Sawicka B, Bossowski A. Analysis of serum levels of nesfatin-1 in children and adolescents with autoimmune thyroid diseases. Pediatr Endocrinol Diabetes Metab. 2012;19(1):5-10.
14. Tohma Y, Akturk M, Altinova A, Yassibas E, Cerit ET, Gulbahar O, et al. Circulating levels of Orexin-A, Nesfatin-1, Agouti-Related peptide, and neuropeptide Y in patients with hyperthyroidism. Thyroid. 2015;2015(25):776-83.
15. Liu F, Yang Q, Gao N, Liu F, Chen S. Decreased plasma Nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus. J Diab Res. 2014:1-5. doi: 10.1155/2014/128014. Article ID 128014.
16. Yang M, Zhang Z, Wang C, Li K, Li S, Boden G, et al. Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance. Diabetes. 2012;61(8):1959-68.
17. Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Yoshida N, et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology. 2008;149(3):1295-301.
18. Monzani F, Di Bello V, Caraccio N, Bertini A, Giorgi D, Giusti C, et al. Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study. J Endocrinol Metab. 2001;86(3):1110-5.
19. Dai DZ, Hu HJ, Yang DM, Hao XM, Zhang GQ, Zhou PA, et al. Chronic levothyroxin treatment is associated with ion channel abnormalities in cardiac and neuronal cells. Clin Exp Pharmacol Physiol. 1999;26(10):819-21.
20. Panebianco P, Rosso D, Destro G, Scarpinato RA, Tropea S, Rizzo A, et al. Use of disphosphonates in the treatment of osteoporosis in thyroidectomized patients on levothyroxin replacement therapy. Arch Gerontol Geriatr. 1997;25(2):219-25.
21. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5(13):1749-70.
22. Dollah MA, Parhizkar S, Latiff LA, Hassan MHB. Toxicity effect of Nigella sativa on the liver function of rats. Adv Pharm Bull. 2013;3(1):97-102.
23. Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. WJG. 2005;11(42):6684-8.
24. Abdel-Sater KA. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol. 2009;1(2):143-9.
25. Khalawi AA, Al-Robai AA, Khoja SM, Shaker AS. Can Nigella Sativa oil (NSO) reverse hypothyroid status induced by PTU in rat? biochemical and histological studies. Life Sci J. 2013;10(2):1-5.
26. Cevikbas HIA, Gurer US, Kiran B, Uresin Y, Rayaman P, et al. Potential adjuvant effects of Nigella Sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract. 2010;19(3):206-11.
27. Ibrahim RM, Hamdan NS, Mahmud R, Imam MU, Saini SM, Rashid SNA, et al. A randomized controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women. J Transl Med. 2014;12:82-9.
28. Al-Asoom LI, Al-Shaikh BA, Bamosa AO, El-Bahai MN. Effect of Nigella sativa supplementation to exercise training in a novel model of physiological cardiac hypertrophy. Cardiovasc Toxicol. 2014;14(3):243-50.
29. Omar A, Ghosheh S, Abdulghani A, Houdi A, Crookscor PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L). J Pharm Biomed Anal. 1999;19:757-62.
30. Khader M, Eckl PM. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014;17:950-7.
31. Bacak Gullu E, Avci G. Effects of thymoquinone on plasma leptin, insulin, thyroid hormones and lipid profile in rats fed a fatty diet. Kafkas Univ Vet Fak Derg. 2013;19(6):1011-6.
32. Panahi M, Namjoyan F, Shakerin Z. Evaluation of antioxidant effects of Nigella sativa on the ultrastructure of neural tube defects in diabetic rats offspring. Jundishapur J Nat Pharm Prod. 2011;6(1):16-23.
33. Goga A, Hasic S, Becirovic S, Cavar S. Phenolic compounds and antioxidant Activity of extracts of Nigella sativa L. Bull Chemists Technol Bosnia Herzegovina. 2012;39:15-9.
34. Houcher Z, Boudiaf K, Benboubetra M, Houcher B. Effects of methanolic extract and commercial oil of Nigella sativa L. on blood glucose and antioxidant capacity in alloxan-induced diabetic rats. Pteridines. 2007;18(1):8-18.
35. Ismail M, Zabid Y, Hanefi O, Ramazan U. Effect of Nigella sativa L. on serum concentration of thyroid hormone, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits. Ir Vet J. 2003;59(9):462-4.
36. Hmza AJA, Osman MT, Adnan A, Omar A. Immunomodulatory effect of Nigella Sativa oil in the disease process of type 1 diabetic rats. Res J Pharm, Bio Chem Sci. 2013;4(1):980-8.
37. Noor NA, Fahmy HM, Mohammed FF, Elsayed AA, Radwan NM. Nigella sativa ameliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats. Int J Clin Exp Pathol. 2015;8(6):6269-86.
38. Tajmiri S, Farhangi MA, Dehghan P. Nigella Sativa treatment and serum concentrations of thyroid hormones, transforming growth factor β (TGF- β) and interleukin 23 (IL-23) in patients with Hashimoto's Thyroiditis. Eur J Integ Med. doi: 10.1016/j.eujim.2016.03.003
39. Viglietto G, Maglione D, Rambaldi M. Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines. Oncogene. 1995;11:1569-79.
40. Lennard CM, Patel A, Wilson J, Reinhardt B, Tuman C, Fenton C, et al. Intensity of vascular endothelial growth factor expression is associated with increased risk of recurrence and decreased disease-free survival in papillary thyroid cancer. Surgery. 2001;129(5):552-8.
41. Klein M, Picard E, Vignaud JM, Marie B, Bresler L, Toussaint B, et al. Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma. J Endocrinol. 1999;161(1):41-9.
42. Medenica R, Janssens J, Tarasenko A, Lazovic G, Corbitt W, Powell D, et al. Anti-angiogenic activity of Nigella sativa plant extract in cancer therapy. Proc Annual Meeting Am Assoc Cancer Res. 1997;38:A1377.
43. Iddamaldeniya SS, Thabrew MI, Wickramasinghe SMDN, Ratnatunge N, Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. J Carcinog. 2006;5(1):11-7.
44. Lieb W, Safa R, Benjamin EJ, Xanthakis V, Yin X, Sullivan LM, et al. Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function. Eur Heart J. 2009;30:1121-7.
45. Visvikis-Siest S. Association of vascular endothelial growth factor genetic variant with metabolic syndrome. 2014, Google Patents.
46. Mick GJ, Wang X, McCormick K. White adipocyte vascular endothelial growth factor: regulation by insulin. Endocrinology. 2002;143(3):948-53.
47. Randeva HS, Lewandowski KC, Komorowski J, Murray RD, O'Callaghan CJ, et al. Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals. Circulation. 2004;109:2405-10.
48. Villela NR, Aguiar LGK, Bahia L, Bottino D, Bouskela E. Does endothelial dysfunction correlates better with wasit-to-hip ratio than with body mass index or waist circumference among obese patients? Clinics. 2006;61(1):53-8.
49. Ciccone MM, Pergola GD, Porcelli MT, Scicchitano P, Caldarola P, Iacoviello M, et al. Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage? BMC Cardiovasc Disord. 2010;10:22-30.
50. Atta MN, Elessawy R, Deghedy A, Hafez A, Elsherbiny TM. Hashimoto thyroiditis is an independent cardiovascular risk factor in clinically hypothyroid patients. Alexandria J Med. 2011;47(4):267-76.
51. Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol. 2002;79(1):23-6.
52. Datau E, Surachmanto E, Pandelaki K, Langi J. Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Medica Indonesiana. 2010;42(3):130-4.
53. Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety and tolerability of powdered Nigella sativa [kalonji] seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med. 2009;15:639-44.
54. Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A systematic review of anti-obesity medicinal plants-an update. J Diabetes Metab Disord. 2013;12(1):28-38.
55. Ajjan RA, Weetman AP. The pathogenesis of Hashimoto's thyroiditis: further developments in our understanding. Horm Metab Res. 2015;47(10):702-10.
56. Lee TP, Chiang BL. Sex differences in spontaneous versus induced animal models of autoimmunity. Autoimmun Rev. 2012;11:A422-9.
57. Brix TH, Hansen PS, Kyvik KO, Hegedus L. Aggregation of thyroid autoantibodies in twins from opposite-sex pairs suggests that microchimerism may play a role in the early stages of thyroid autoimmunity. J Clin Endocrinol Metab. 2009;94(11):4439-43.
58. Sahin SB, Ayaz T, Cure MC, Sumer F, Ilkkilic K. Association of nesfatin-1 levels with fasting and postload glucose levels in patients with hypothyroidism. J Exp Clin Med. 2014;31(4):217-20.