Chronic levothyroxin treatment is associated with ion channel abnormalities in cardiac and neuronal cells

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 10, 1999, Pages 819-821

  Dai, De Zai ^a   Hu, Hui Juan ^a   Yang, Dong Mei ^b   Hao, Xue Mei ^b   Zhang, Guang Qin ^a   Zhou, Pei Ai ^b   Wu, Cai Hong ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Anti arrhythmic agents; Heart; Hippocampal CA1 neuron; Patch clamp

Indexed keywords

ION CHANNEL; LEVOTHYROXINE;

ANIMAL CELL; CALCIUM CURRENT; CONFERENCE PAPER; DRUG MECHANISM; HEART ARRHYTHMIA; HEART MUSCLE CELL; ION CONDUCTANCE; ION CURRENT; NERVE CELL; NONHUMAN; POTASSIUM CURRENT; RAT; REPOLARIZATION;

EID: 0032878230     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03135.x     Document Type: Conference Paper

References (16)

1. 1. Tomaselli GF, Beuckelmann DJ, Calkins HG et al. Sudden cardiac death in heart failure. The role of abnormal repolarization. Circulation 1994; 90: 2534-9.
2. 2. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators, Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N. Engl. J. Med. 1989; 321: 406-12.
3. 3. Colatsky TJ. Antiarrhythmic drugs: Where are we going? Pharm. News 1995; 2: 17-23.
4. 4. Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995; 81: 299-307.
5. 5. Wilde AAM, Veldkamp MW. Ion channels, the QT interval, and arrhythmias. Pace 1997; 20: 2048-51.
6. 6. Priori SG, Napolitano C, Paganini V, Cantu F, Schwartz PJ. Molecular biology of the long QT syndrome: Impact on management. Pace 1997; 20: 2052-7.
7. 7. Qin D, Zhang ZH, Caref EB, Boutjdir M, Jain P, Ei-Sherif N. Cellular and ionic basis of arrhythmias in post-infarct remodeled ventricular myocardium. Circ. Res. 1996; 79: 461-73.
8. 8. Yu F, Dai DZ, An LF, Gou XF. Heart hypertrophy induced by levothyroxin aggravates ischemic lesions and reperfusion arrhythmias in rats. Acta Pharmacol. Sin. 1997; 118: 71-4.
9. 9. Zhu Y, Dai DZ, Zhu ZB. Cyclophosphamide regressing myocardial hypertrophy and increased ATPase activity induced by thyroxine. Clin. J. Pharmacol. Toxicol. 1995; 9: 75-6.
10. K in acutely isolated hippocampal CAI neurons. Brain Res. 1998; 809: 149-54.
11. 11. Kambouris NG, Nuss B, Johns DC, Tomaselli GF, Marban E, Balser JR. Phenotypic characterisation of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel. Circulation 1998; 97: 640-4.
12. 12. Bennett PB, Yamawa K, Makita N, George Jr AL. Molecular mechanism for an inherited cardiac arrhythmia. Nature 1995; 376: 683-5.
13. 13. Carmeliet E. Mechanisms and control of repolarization. Eur. Heart J. 1993; 14 (Suppl.): 3-13.
14. 14. Tomita F, Bassett AL, Myerburg RJ, Kimura S. Diminished transient outward currents in rat hypertrophied ventricular myocytes. Circ. Res. 1994; 75: 296-303.
15. 15. Warmke JW, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc. Natl Acad. Sci. USA 1994; 91: 3438-42.
16. 16. Dai DZ, Yu F, Li HT et al. Blockade on sodium, potassium, and calcium channels by a new antiarrhythmic agent CPU 86017. Drug Dev. Res. 1996; 39: 138-46.