Potential adjuvant effects of nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients

Medical Principles and Practice

Volumn 19, Issue 3, 2010, Pages 206-211

  Işik, Hülya ^a   Çevikbaş, Adile ^a   Gürer, Ümran Soyoǧul ^a   Kiran, Bayram ^c   Üresin, Yaǧiz ^c   Rayaman, Pervin ^a   Rayaman, Erkan ^a   Gürbüz, Burçak ^a   Büyüköztürk, Suna ^b  

^a MARMARA UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Active immunotherapy; Allergic rhinitis; Intracellular killing activity; Nigella sativa; Phagocytosis

Indexed keywords

ALUTARD; HERBACEOUS AGENT; PLACEBO;

ADULT; ALLERGIC RHINITIS; ARTICLE; BLACK CUMIN; CD19 T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEMATOLOGICAL PARAMETERS; HOUSE DUST ALLERGY; HUMAN; HUMAN TISSUE; IMMUNOTHERAPY; INTRACELLULAR KILLING; MALE; NEUTROPHIL; PHAGOCYTOSIS; PLANT SEED; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANIMALS; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HUMANS; LYMPHOCYTE COUNT; MALE; NEUTROPHILS; NIGELLA SATIVA; PHYTOTHERAPY; PYROGLYPHIDAE; RHINITIS, ALLERGIC, PERENNIAL; SEEDS;

EID: 77950547785     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000285289     Document Type: Article

References (20)

1. El-Dakhakhny M, Barakat M, El-Halim MA, Aly SM: Effect of N. sativa oil on gastric secretion and ethanol induced ulcer in rats. J Ethnopharmacol 2000; 72: 299-302.
2. Salem ML: Immunomodulatory and immunotherapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005; 5: 1749-1770. (Pubitemid 41594584)
3. Chakravarty N: Inhibition of histamin release from mast cells by nigellone. Ann Allergy 1993; 70: 237-242. (Pubitemid 23085939)
4. Swamy SMK, Tan BKH: Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol 2000; 70: 1-7.
5. Burits M, Bucar F: Antioxidant activity of Nigella sativa essential oil. Phytother Res 2000; 14: 323-328. (Pubitemid 30655515)
6. Haq A, Abdullatif M, Lobo IP, Khabar SAK, Sheth UK, Al-Sedairy TS: Nigella sativa : effect on human lymphocytes and polymorphonuclear leucocyte phagocytic activity. Immunopharmacology 1995; 30: 147-155.
7. Büyüköztürk S, Gelincik A, Ozşeker F, Genç S, Savran FO, Kiran B, Yillar G, Erden S, Aydin F, Colakoǧlu B, Dal M, Ozer H, Bilir A: Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice. J Ethnopharmacol 2005; 100: 295-298. (Pubitemid 41206624)
8. Abbas AT, Abdel-Aziz MM, Zalata KR, Abd Al-Galel Tel-D: Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol 2005; 12: 95-102.
9. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC: Antiinflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol 2006; 6: 1135-1142. (Pubitemid 43728167)
10. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H: Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett 2006;106: 72-81. (Pubitemid 44093055)
11. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H: Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res 2003; 17: 1209-1214. (Pubitemid 38057181)
12. Bousquet J, Lockey RF, Malling HJ (eds): WHO position paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy 1998; 53(suppl 44):1-42. (Pubitemid 28346358)
13. Boyum A: Isolation of molecular cells and granulocyte from human blood: isolation of mononuclear cells by one centrifugation and granulocyte by combining centrifugation and sedimentation at 1 g . Scand J Clin Lab Invest 1968; 97: 77-89.
14. Alexander JW, Windhorst DB, Good RA: Improved tests for the evolution of neutrophil function in human disease. J Lab Clin Med 1968; 72: 136-148.
15. Barbior BM, Cohen HJ: Measurement of neutrophil function: phagocytosis, degranulation, the respiratory burst and bacterial killing; in Cline MJ (ed): Methods in Hematology, Leukocyte Function, ed 1. New York, Churchill Livingstone, 1981, pp 1-38.
16. Gocer P, Gurer SU, Erten N, Palanduz S, Rayaman E, Akarsu B, Karan A, Cevikbas A: Comparison of polymorphonuclear leukocyte functions in elderly patients and healthy young volunteers. Med Princ Pract 2005; 14: 382-385. (Pubitemid 41442840)
17. Richardson MD, Scott G., Shankland GS: Effect of cilofungin on phagocytosis and intracellular killing of Candida albicans by human neutrophils. Eur J Clin Microbiol Infect Dis 1992; 11: 22-26.
18. Gurer SU, Gocer P, Ercag E, Erten N, Rayaman E, Gurbuz B, Uzer A, Karan A, Cevikbas A: The effects of some antibiotics on polymorphonuclear leukocyte functions of elderly patients in vitro before and after zinc supplementation. Int Immunopharmacol 2006; 5: 808-816.
19. Matricardi PM, Bonini S: Mimicking microbial 'education' of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma? Respir Res 2000; 1: 129-132.
20. Haq A, Lobo IP, Al-Tufail M, Rama RN, Al Sedairy TS: Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol 1999; 21: 283-295. (Pubitemid 29241780)