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Volumn 16, Issue 1, 2017, Pages 9-15

Poorly Differentiated Clusters: Clinical Impact in Colorectal Cancer

Author keywords

Epithelial mesenchymal transition; Grading; KRAS; Microsatellite instability; Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84997241503     PISSN: 15330028     EISSN: 19380674     Source Type: Journal    
DOI: 10.1016/j.clcc.2016.06.002     Document Type: Review
Times cited : (32)

References (53)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • 1 Ferlay, J., Soerjomataram, I., Dikshit, R., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136 (2015), E359–E386.
    • (2015) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3
  • 2
    • 79961088717 scopus 로고    scopus 로고
    • Carcinoma of the colon and rectum
    • T. Bosman F. Carneiro R.H. Hruban N.D. Theise IARC Press Lyon, France
    • 2 Hamilton, S.R., Bosman, F.T., Boffetta, P., et al. Carcinoma of the colon and rectum. Bosman, T., Carneiro, F., Hruban, R.H., Theise, N.D., (eds.) WHO Classification of Tumors of the Digestive System, 2010, IARC Press, Lyon, France, 134–146.
    • (2010) WHO Classification of Tumors of the Digestive System , pp. 134-146
    • Hamilton, S.R.1    Bosman, F.T.2    Boffetta, P.3
  • 3
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    • 3 O'Connell, J.B., Maggard, M.A., Ko, C.Y., Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 96 (2004), 1420–1425.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1420-1425
    • O'Connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 4
    • 84880572228 scopus 로고    scopus 로고
    • AJCC Cancer Staging Manual 7th edition criteria for colon cancer: do the complex modifications improve prognostic assessment?
    • 4 Hari, D.M., Leung, A.M., Lee, J.H., et al. AJCC Cancer Staging Manual 7th edition criteria for colon cancer: do the complex modifications improve prognostic assessment?. J Am Coll Surg 217 (2013), 181–190.
    • (2013) J Am Coll Surg , vol.217 , pp. 181-190
    • Hari, D.M.1    Leung, A.M.2    Lee, J.H.3
  • 5
    • 84857720543 scopus 로고    scopus 로고
    • New criteria for histologic grading of colorectal cancer
    • 5 Ueno, H., Kajiwara, Y., Shimazaki, H., et al. New criteria for histologic grading of colorectal cancer. Am J Surg Pathol 36 (2012), 193–201.
    • (2012) Am J Surg Pathol , vol.36 , pp. 193-201
    • Ueno, H.1    Kajiwara, Y.2    Shimazaki, H.3
  • 6
    • 84871501676 scopus 로고    scopus 로고
    • Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional grading
    • 6 Barresi, V., Reggiani Bonetti, L., Branca, G., Di Gregorio, C., Ponz de Leon, M., Tuccari, G., Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional grading. Virchows Arch 461 (2012), 621–628.
    • (2012) Virchows Arch , vol.461 , pp. 621-628
    • Barresi, V.1    Reggiani Bonetti, L.2    Branca, G.3    Di Gregorio, C.4    Ponz de Leon, M.5    Tuccari, G.6
  • 7
    • 84892790948 scopus 로고    scopus 로고
    • Histological grading based on the count of poorly differentiated clusters in pre-operative biopsy predicts nodal involvement and pTNM stage in colorectal cancer patients
    • 7 Barresi, V., Reggiani Bonetti, L., Ieni, A., Branca, G., Baron, L., Tuccari, G., Histological grading based on the count of poorly differentiated clusters in pre-operative biopsy predicts nodal involvement and pTNM stage in colorectal cancer patients. Hum Pathol 45 (2014), 268–275.
    • (2014) Hum Pathol , vol.45 , pp. 268-275
    • Barresi, V.1    Reggiani Bonetti, L.2    Ieni, A.3    Branca, G.4    Baron, L.5    Tuccari, G.6
  • 8
    • 84893006967 scopus 로고    scopus 로고
    • Site-specific tumor grading system in colorectal cancer: multicenter pathologic review of the value of quantifying poorly differentiated clusters
    • 8 Ueno, H., Hase, K., Hashiguchi, Y., et al. Site-specific tumor grading system in colorectal cancer: multicenter pathologic review of the value of quantifying poorly differentiated clusters. Am J Surg Pathol 38 (2014), 197–204.
    • (2014) Am J Surg Pathol , vol.38 , pp. 197-204
    • Ueno, H.1    Hase, K.2    Hashiguchi, Y.3
  • 9
    • 84945470597 scopus 로고    scopus 로고
    • Prognostic significance of grading based on the counting of poorly differentiated clusters in colorectal mucinous adenocarcinoma
    • 9 Barresi, V., Reggiani Bonetti, L., Ieni, A., Domati, F., Tuccari, G., Prognostic significance of grading based on the counting of poorly differentiated clusters in colorectal mucinous adenocarcinoma. Hum Pathol 46 (2015), 1722–1729.
    • (2015) Hum Pathol , vol.46 , pp. 1722-1729
    • Barresi, V.1    Reggiani Bonetti, L.2    Ieni, A.3    Domati, F.4    Tuccari, G.5
  • 10
    • 84907171211 scopus 로고    scopus 로고
    • Micropapillary pattern and poorly differentiated clusters represent the same biological phenomenon in colorectal cancer: a proposal for a change in terminology
    • 10 Barresi, V., Branca, G., Vitarelli, E., Tuccari, G., Micropapillary pattern and poorly differentiated clusters represent the same biological phenomenon in colorectal cancer: a proposal for a change in terminology. Am J Clin Pathol 142 (2014), 375–383.
    • (2014) Am J Clin Pathol , vol.142 , pp. 375-383
    • Barresi, V.1    Branca, G.2    Vitarelli, E.3    Tuccari, G.4
  • 11
    • 84938603443 scopus 로고    scopus 로고
    • Clinicopathologic impacts of poorly differentiated cluster-based grading system in colorectal carcinoma
    • 11 Kim, J.W., Shin, M.K., Kim, B.C., Clinicopathologic impacts of poorly differentiated cluster-based grading system in colorectal carcinoma. J Korean Med Sci 30 (2015), 16–23.
    • (2015) J Korean Med Sci , vol.30 , pp. 16-23
    • Kim, J.W.1    Shin, M.K.2    Kim, B.C.3
  • 12
    • 84978083253 scopus 로고    scopus 로고
    • Prognostic relevance of histopathological features in signet ring cell carcinoma of the colorectum
    • [Epub ahead of print]
    • 12 Barresi, V., Reggiani Bonetti, L., Domati, V.F., Baron, L., Prognostic relevance of histopathological features in signet ring cell carcinoma of the colorectum. Virchows Arch, 2016, 10.1007/s00428-016-1983-0 [Epub ahead of print].
    • (2016) Virchows Arch
    • Barresi, V.1    Reggiani Bonetti, L.2    Domati, V.F.3    Baron, L.4
  • 13
    • 84880141949 scopus 로고    scopus 로고
    • Colorectal carcinoma grading quantified by counting poorly differentiated clusters: is it feasible on endoscopic biopsies?
    • 13 Barresi, V., Tuccari, G., Colorectal carcinoma grading quantified by counting poorly differentiated clusters: is it feasible on endoscopic biopsies?. Am J Surg Pathol 37 (2013), 943–945.
    • (2013) Am J Surg Pathol , vol.37 , pp. 943-945
    • Barresi, V.1    Tuccari, G.2
  • 14
    • 0028785465 scopus 로고
    • Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines
    • 14 Kikuchi, R., Takano, M., Takagi, K., et al. Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines. Dis Colon Rectum 38 (1995), 1286–1295.
    • (1995) Dis Colon Rectum , vol.38 , pp. 1286-1295
    • Kikuchi, R.1    Takano, M.2    Takagi, K.3
  • 15
    • 84880985405 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of histopathological factors influencing the risk of lymph node metastasis in early colorectal cancer
    • 15 Beaton, C., Twine, C.P., Williams, G.L., Radcliffe, A.G., Systematic review and meta-analysis of histopathological factors influencing the risk of lymph node metastasis in early colorectal cancer. Colorectal Dis 15 (2013), 788–797.
    • (2013) Colorectal Dis , vol.15 , pp. 788-797
    • Beaton, C.1    Twine, C.P.2    Williams, G.L.3    Radcliffe, A.G.4
  • 16
    • 84902329015 scopus 로고    scopus 로고
    • Poorly differentiated clusters (PDCs) as a novel histological predictor of nodal metastases in pT1 colorectal cancer
    • 16 Barresi, V., Branca, G., Ieni, A., et al. Poorly differentiated clusters (PDCs) as a novel histological predictor of nodal metastases in pT1 colorectal cancer. Virchows Arch 464 (2014), 655–662.
    • (2014) Virchows Arch , vol.464 , pp. 655-662
    • Barresi, V.1    Branca, G.2    Ieni, A.3
  • 17
    • 84861466427 scopus 로고    scopus 로고
    • Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection
    • 17 Nakadoi, K., Tanaka, S., Kanao, H., et al. Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection. J Gastroenterol Hepatol 27 (2012), 1057–1062.
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 1057-1062
    • Nakadoi, K.1    Tanaka, S.2    Kanao, H.3
  • 18
    • 84856032575 scopus 로고    scopus 로고
    • Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review
    • 18 Repici, A., Hassan, C., De Paula Pessoa, D., et al. Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review. Endoscopy 44 (2012), 137–150.
    • (2012) Endoscopy , vol.44 , pp. 137-150
    • Repici, A.1    Hassan, C.2    De Paula Pessoa, D.3
  • 19
    • 0036168227 scopus 로고    scopus 로고
    • Risk of lymph node metastasis in T1 carcinoma of the colon and rectum
    • 19 Nascimbeni, R., Burgart, L.J., Nivatvongs, S., Larson, D.R., Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum 45 (2002), 200–206.
    • (2002) Dis Colon Rectum , vol.45 , pp. 200-206
    • Nascimbeni, R.1    Burgart, L.J.2    Nivatvongs, S.3    Larson, D.R.4
  • 20
    • 3042804834 scopus 로고    scopus 로고
    • Analysis of pathological risk factors for lymph node metastasis of submucosal invasive colon cancer
    • 20 Egashira, Y., Yoshida, T., Hirata, I., et al. Analysis of pathological risk factors for lymph node metastasis of submucosal invasive colon cancer. Mod Pathol 17 (2004), 503–511.
    • (2004) Mod Pathol , vol.17 , pp. 503-511
    • Egashira, Y.1    Yoshida, T.2    Hirata, I.3
  • 21
    • 77955172282 scopus 로고    scopus 로고
    • Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma
    • 21 Tateishi, Y., Nakanishi, Y., Taniguchi, H., Shimoda, T., Umemura, S., Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma. Mod Pathol 23 (2010), 1068–1072.
    • (2010) Mod Pathol , vol.23 , pp. 1068-1072
    • Tateishi, Y.1    Nakanishi, Y.2    Taniguchi, H.3    Shimoda, T.4    Umemura, S.5
  • 22
    • 84864522308 scopus 로고    scopus 로고
    • Tumor budding as a risk factor of lymph node metastasis in submucosal invasive T1 colorectal carcinoma: a retrospective study
    • 22 Kye, B.H., Jung, J.H., Kim, H.J., Kang, S.G., Cho, H.M., Kim, J.G., Tumor budding as a risk factor of lymph node metastasis in submucosal invasive T1 colorectal carcinoma: a retrospective study. BMC Surg, 12, 2012, 16.
    • (2012) BMC Surg , vol.12 , pp. 16
    • Kye, B.H.1    Jung, J.H.2    Kim, H.J.3    Kang, S.G.4    Cho, H.M.5    Kim, J.G.6
  • 23
    • 84862296538 scopus 로고    scopus 로고
    • Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
    • 23 Watanabe, T., Itabashi, M., Shimada, Y., et al., Japanese Society for Cancer of the Colon and Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol 17 (2012), 1–29.
    • (2012) Int J Clin Oncol , vol.17 , pp. 1-29
    • Watanabe, T.1    Itabashi, M.2    Shimada, Y.3
  • 24
    • 78651334389 scopus 로고    scopus 로고
    • Quality assurance in pathology in colorectal cancer screening and diagnosis—European recommendations
    • 24 Quirke, P., Risio, M., Lambert, R., von Karsa, L., Vieth, M., Quality assurance in pathology in colorectal cancer screening and diagnosis—European recommendations. Virchows Arch 458 (2011), 1–19.
    • (2011) Virchows Arch , vol.458 , pp. 1-19
    • Quirke, P.1    Risio, M.2    Lambert, R.3    von Karsa, L.4    Vieth, M.5
  • 25
    • 84908263241 scopus 로고    scopus 로고
    • Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review
    • 25 Ueno, H., Hase, K., Hashiguchi, Y., et al. Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review. J Gastroenterol 49 (2014), 1314–1323.
    • (2014) J Gastroenterol , vol.49 , pp. 1314-1323
    • Ueno, H.1    Hase, K.2    Hashiguchi, Y.3
  • 26
    • 84863912807 scopus 로고    scopus 로고
    • TNM Classification of Malignant Tumors
    • Wiley Blackwell Chichester, UK
    • 26 Leslie Sobin, M.G., Wittekind, C., TNM Classification of Malignant Tumors. 2009, Wiley Blackwell, Chichester, UK.
    • (2009)
    • Leslie Sobin, M.G.1    Wittekind, C.2
  • 28
    • 4344587783 scopus 로고    scopus 로고
    • American Society of Clinical Oncology recommendations on adjuvant chemotherapy for Stage II colon cancer
    • 28 Benson, A.B. 3rd, Schrag, D., Somerfield, M.R., et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for Stage II colon cancer. J Clin Oncol 22 (2004), 3408–3419.
    • (2004) J Clin Oncol , vol.22 , pp. 3408-3419
    • Benson, A.B.1    Schrag, D.2    Somerfield, M.R.3
  • 29
    • 0030271679 scopus 로고    scopus 로고
    • Clinical features, frequency and prognosis of Dukes' A colorectal carcinoma: a population-based investigation
    • 29 Di Gregorio, C., Fante, R., Roncucci, L., et al. Clinical features, frequency and prognosis of Dukes' A colorectal carcinoma: a population-based investigation. Eur J Cancer 32A (1996), 1957–1962.
    • (1996) Eur J Cancer , vol.32A , pp. 1957-1962
    • Di Gregorio, C.1    Fante, R.2    Roncucci, L.3
  • 30
    • 79960273638 scopus 로고    scopus 로고
    • Lymph node micrometastasis and survival of patients with Stage I (Dukes' A) colorectal carcinoma
    • 30 Reggiani Bonetti, L., Di Gregorio, C., De Gaetani, C., et al. Lymph node micrometastasis and survival of patients with Stage I (Dukes' A) colorectal carcinoma. Scand J Gastroenterol 46 (2011), 881–886.
    • (2011) Scand J Gastroenterol , vol.46 , pp. 881-886
    • Reggiani Bonetti, L.1    Di Gregorio, C.2    De Gaetani, C.3
  • 31
    • 84875666104 scopus 로고    scopus 로고
    • Clinicopathological risk factors of Stage II colon cancer: results of a prospective study
    • 31 Santos, C., López-Doriga, A., Navarro, M., et al. Clinicopathological risk factors of Stage II colon cancer: results of a prospective study. Colorectal Dis 15 (2013), 414–422.
    • (2013) Colorectal Dis , vol.15 , pp. 414-422
    • Santos, C.1    López-Doriga, A.2    Navarro, M.3
  • 32
    • 84946882007 scopus 로고    scopus 로고
    • Histologic prognostic markers in stage IIA colorectal cancer: a comparative study
    • 32 Barresi, V., Reggiani Bonetti, L., Ieni, A., Branca, G., Tuccari, G., Histologic prognostic markers in stage IIA colorectal cancer: a comparative study. Scand J Gastroenterol 51 (2016), 314–320.
    • (2016) Scand J Gastroenterol , vol.51 , pp. 314-320
    • Barresi, V.1    Reggiani Bonetti, L.2    Ieni, A.3    Branca, G.4    Tuccari, G.5
  • 33
    • 84927178194 scopus 로고    scopus 로고
    • Prognostic impact of histological categorisation of epithelial-mesenchymal transition in colorectal cancer
    • 33 Ueno, H., Shinto, E., Kajiwara, Y., et al. Prognostic impact of histological categorisation of epithelial-mesenchymal transition in colorectal cancer. Br J Cancer 111 (2014), 2082–2090.
    • (2014) Br J Cancer , vol.111 , pp. 2082-2090
    • Ueno, H.1    Shinto, E.2    Kajiwara, Y.3
  • 34
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • 34 Hay, E.D., An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 154 (1995), 8–20.
    • (1995) Acta Anat (Basel) , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 35
    • 79958170449 scopus 로고    scopus 로고
    • Heterogeneity of metalloproteinase expression in colorectal cancer—relation of molecular findings to basic morphology
    • 35 Kajiwara, Y., Ueno, H., Hashiguchi, Y., et al. Heterogeneity of metalloproteinase expression in colorectal cancer—relation of molecular findings to basic morphology. Anticancer Res 1 (2011), 567–575.
    • (2011) Anticancer Res , vol.1 , pp. 567-575
    • Kajiwara, Y.1    Ueno, H.2    Hashiguchi, Y.3
  • 36
    • 79960137356 scopus 로고    scopus 로고
    • Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer
    • 36 Kajiwara, Y., Ueno, H., Hashiguchi, Y., et al. Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer. Am J Clin Pathol 136 (2011), 138–144.
    • (2011) Am J Clin Pathol , vol.136 , pp. 138-144
    • Kajiwara, Y.1    Ueno, H.2    Hashiguchi, Y.3
  • 37
    • 84886724834 scopus 로고    scopus 로고
    • Prognostic significance of lymphovascular or perineural invasion in patients with locally advanced colorectal cancer
    • 37 Huh, J.W., Lee, J.H., Kim, H.R., Kim, Y.J., Prognostic significance of lymphovascular or perineural invasion in patients with locally advanced colorectal cancer. Am J Surg 206 (2013), 758–763.
    • (2013) Am J Surg , vol.206 , pp. 758-763
    • Huh, J.W.1    Lee, J.H.2    Kim, H.R.3    Kim, Y.J.4
  • 38
    • 84944534122 scopus 로고    scopus 로고
    • Clinical significance of perineural invasion in stages II and III colorectal cancer
    • 38 Zhou, Y., Wang, H., Gong, H., Cao, M., Zhang, G., Wang, Y., Clinical significance of perineural invasion in stages II and III colorectal cancer. Pathol Res Pract 211 (2015), 839–844.
    • (2015) Pathol Res Pract , vol.211 , pp. 839-844
    • Zhou, Y.1    Wang, H.2    Gong, H.3    Cao, M.4    Zhang, G.5    Wang, Y.6
  • 39
    • 77952867243 scopus 로고    scopus 로고
    • Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study
    • 39 Chou, J.F., Row, D., Gonen, M., Liu, Y.H., Schrag, D., Weiser, M.R., Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study. Cancer 116 (2010), 2560–2570.
    • (2010) Cancer , vol.116 , pp. 2560-2570
    • Chou, J.F.1    Row, D.2    Gonen, M.3    Liu, Y.H.4    Schrag, D.5    Weiser, M.R.6
  • 40
    • 80051577232 scopus 로고    scopus 로고
    • Lymph node ratio is a powerful prognostic index in patients with stage III distal rectal cancer: a Japanese multicenter study
    • 40 Kobayashi, H., Mochizuki, H., Kato, T., et al., Study Group for Rectal Cancer Surgery of the Japanese Society for Cancer of the Colon and Rectum. Lymph node ratio is a powerful prognostic index in patients with stage III distal rectal cancer: a Japanese multicenter study. Int J Colorectal Dis 26 (2011), 891–896.
    • (2011) Int J Colorectal Dis , vol.26 , pp. 891-896
    • Kobayashi, H.1    Mochizuki, H.2    Kato, T.3
  • 41
    • 84957438479 scopus 로고    scopus 로고
    • The number of metastatic lymph nodes exhibiting poorly differentiated clusters predicts survival in patients with pStage III colorectal cancer
    • 41 Kinoshita, O., Kishimoto, M., Murayama, Y., et al. The number of metastatic lymph nodes exhibiting poorly differentiated clusters predicts survival in patients with pStage III colorectal cancer. Int J Colorectal Dis 31 (2016), 283–290.
    • (2016) Int J Colorectal Dis , vol.31 , pp. 283-290
    • Kinoshita, O.1    Kishimoto, M.2    Murayama, Y.3
  • 42
    • 84888386258 scopus 로고    scopus 로고
    • Classifying the stage IV colorectal cancer: prognostic impact of radical resection for colorectal liver metastases and proposal for a new staging system
    • 42 Chen, Y.-G., Liu, X., Wang, X.-S., Classifying the stage IV colorectal cancer: prognostic impact of radical resection for colorectal liver metastases and proposal for a new staging system. Cell Biochem Biophys 67 (2013), 1445–1449.
    • (2013) Cell Biochem Biophys , vol.67 , pp. 1445-1449
    • Chen, Y.-G.1    Liu, X.2    Wang, X.-S.3
  • 43
    • 84882617256 scopus 로고    scopus 로고
    • Prognostic scoring system for stage IV colorectal cancer: is the AJCC sub-classification of stage IV colorectal cancer appropriate?
    • 43 Kobayashi, H., Kotake, K., Sugihara, K., Prognostic scoring system for stage IV colorectal cancer: is the AJCC sub-classification of stage IV colorectal cancer appropriate?. Int J Clin Oncol 18 (2013), 696–703.
    • (2013) Int J Clin Oncol , vol.18 , pp. 696-703
    • Kobayashi, H.1    Kotake, K.2    Sugihara, K.3
  • 44
    • 84878842926 scopus 로고    scopus 로고
    • Clinical impact of tumor infiltrating lymphocytes for survival in curatively resected stage IV colon cancer with isolated liver or lung metastasis
    • 44 Lee, W.-S., Kang, M., Bae, J.-H., Lee, J.-I., Ha, S.Y., Clinical impact of tumor infiltrating lymphocytes for survival in curatively resected stage IV colon cancer with isolated liver or lung metastasis. Ann Surg Oncol 20 (2013), 697–702.
    • (2013) Ann Surg Oncol , vol.20 , pp. 697-702
    • Lee, W.-S.1    Kang, M.2    Bae, J.-H.3    Lee, J.-I.4    Ha, S.Y.5
  • 45
    • 84929045018 scopus 로고    scopus 로고
    • Prognostic value of poorly differentiated clusters in the primary tumor in patients undergoing hepatectomy for colorectal liver metastasis
    • 45 Ueno, H., Konishi, T., Ishikawa, Y., et al. Prognostic value of poorly differentiated clusters in the primary tumor in patients undergoing hepatectomy for colorectal liver metastasis. Surgery 157 (2015), 899–908.
    • (2015) Surgery , vol.157 , pp. 899-908
    • Ueno, H.1    Konishi, T.2    Ishikawa, Y.3
  • 47
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • 47 Cunningham, D., Humblet, Y., Siena, S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351 (2004), 337–345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 48
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • 48 De Roock, W., Claes, B., Bernasconi, D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 11 (2010), 753–762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 49
    • 84938644063 scopus 로고    scopus 로고
    • KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases
    • 49 Barresi, V., Bonetti, L.R., Bettelli, S., KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases. Pathology 47 (2015), 551–556.
    • (2015) Pathology , vol.47 , pp. 551-556
    • Barresi, V.1    Bonetti, L.R.2    Bettelli, S.3
  • 50
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic KRas and N-Ras on proliferation, differentiation and tumor progression in the colon
    • 50 Haigis, K.M., Kendall, K.R., Wang, Y., et al. Differential effects of oncogenic KRas and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 40 (2008), 600–608.
    • (2008) Nat Genet , vol.40 , pp. 600-608
    • Haigis, K.M.1    Kendall, K.R.2    Wang, Y.3
  • 51
    • 84904024982 scopus 로고    scopus 로고
    • KRAS and YAP1 converge to regulate EMT and tumor survival
    • 51 Shao, D.D., Xue, W., Krall, E.B., et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell 3 (2014), 171–184.
    • (2014) Cell , vol.3 , pp. 171-184
    • Shao, D.D.1    Xue, W.2    Krall, E.B.3
  • 52
    • 84908207866 scopus 로고    scopus 로고
    • Should the grading of colorectal adenocarcinoma include microsatellite instability status?
    • 52 Rosty, C., Williamson, E.J., Clendenning, M., et al. Should the grading of colorectal adenocarcinoma include microsatellite instability status?. Hum Pathol 45 (2014), 2077–2084.
    • (2014) Hum Pathol , vol.45 , pp. 2077-2084
    • Rosty, C.1    Williamson, E.J.2    Clendenning, M.3
  • 53
    • 84931011311 scopus 로고    scopus 로고
    • Correlation between microsatellite instability status and grading assessed by the counting of poorly differentiated clusters in colorectal cancer
    • 53 Barresi, V., Bonetti, L.R., Correlation between microsatellite instability status and grading assessed by the counting of poorly differentiated clusters in colorectal cancer. Hum Pathol, 46, 2015, 1063.
    • (2015) Hum Pathol , vol.46 , pp. 1063
    • Barresi, V.1    Bonetti, L.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.