Lymph node micrometastasis and survival of patients with Stage i (Dukes' A) colorectal carcinoma

Scandinavian Journal of Gastroenterology

Volumn 46, Issue 7-8, 2011, Pages 881-886

  Reggiani Bonetti, Luca ^a   Di Gregorio, Carmela ^a   De Gaetani, Carmela ^a   Pezzi, Annalisa ^a   Barresi, Gaetano ^b   Barresi, Valeria ^b   Roncucci, Luca ^a   Ponz De Leon, Maurizio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Cancer; Colon; Dukes' A Stage I; Micrometastasis; Rectum

Indexed keywords

CYTOKERATIN ANTIBODY;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER MORTALITY; CANCER REGISTRY; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENDOSCOPIC POLYPECTOMY; FEMALE; HEMICOLECTOMY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE MICROMETASTASIS; LYMPHADENECTOMY; MALE; MICROMETASTASIS; PRIORITY JOURNAL; PROGNOSIS; TUMOR CELL;

AGED; BLOOD VESSELS; CARCINOMA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; HUMANS; KERATINS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REGRESSION ANALYSIS;

EID: 79960273638     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2011.571708     Document Type: Article

References (30)

1. Ponz de Leon M, Sant M, Micheli A, Micheli A, Sacchetti C, Di Gregorio C, et al. Clinical and pathologic prognostic indicators in colorectal cancer. A population-based study. Cancer 1992;69:626-35.
2. Wolpin BM, Mayer RJ. Systemic treatment of colorectal cancer. Gastroenterol 2008;134:1296-310.
3. Zetter BR. The cellular basis of site-specific tumor metastasis. N Engl J Med 1990;322:605-12. (Pubitemid 20190796)
4. Ghossein RA, Bhattacharya S, Rosai J. Molecular detection of micrometastases and circulating tumor cells in solid tumors. Clin Cancer Res 1999;5:1950-60. (Pubitemid 29399243)
5. Ponz de Leon M, Rossi G, di Gregorio C, De Gaetani C, Rossi F, Ponti G, et al. Epidemiology of colorectal cancer: the 21-year experience of a specialised registry. Intern Emerg Med 2007;2:269-79.
6. Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med 2005;352:476-87.
7. Chau I, Cunningham D. Adjuvant therapy in colon cancer- what, when and how? Ann Oncol 2006:17:1347-59. (Pubitemid 44400373)
8. Benatti P, Sassatelli R, Roncucci L, Pedroni M, Fante R, Di Gregorio C, et al. Tumour spectrum in hereditary nonpolyposis colorectal cancer (HNPCC) and in families with "suspected HNPCC". A population-based study in northern Italy. Colorectal Cancer Study Group. Int J Cancer 1993;54: 371-77. (Pubitemid 23169672)
9. World Health Organization. International statistical classification of diseases and related health problems, tenth revision (ICD-10). World Health Organization, Geneva.
10. SNOMED. Systematized nomenclature of medicine. 2nd ed. College of American Pathologists, Skokie, IL; 1982.
11. Hutter RV, Sobin LH. A universal staging system for cancer of the colon and rectum. Let there be light. Arch Pathol Lab Med 1986;110:367-68. (Pubitemid 16104264)
12. Sasaki M, Watanabe H, Jass JR. Occult lymph node metastases detected by cytokeratin immunohistochemisty predict recurrence in 'node-negative' colorectal cancer. J Gastroenterol 1997;32:758-64. (Pubitemid 27524981)
13. Lee MR, Hong CW, Yoon SN, Lim SB, Park KJ, Lee MJ, et al. Isolated tumor cells in lymph nodes are not a prognostic marker for patients with stage I and stage II colorectal cancer. J Surg Oncol 2006;93:13-18. (Pubitemid 43038419)
14. Losi L, Ponti G, Gregorio CD, Marino R, Rossi G, Pedroni M, et al. Prognostic significance of histological features and biological parameters in stage I (pT1 and pT2) colorectal adenocarcinoma. Pathol Res Pract 2006; 202:663-70.
15. Ogawa T, Yoshida T, Tsuruta T, Tokuyama W, Adachi S, Kikuchi M, et al. Tumor budding is predictive of lymphatic involvement and lymph node metastases in submucosal invasive colorectal adenocarcinomas and in non-polypoid compared with polypoid growths. Scand J Gastroenterol 2009;44:605-14.
16. Scardovi I, Monari P. Metodologia Statistica in Biologia e Medicina. Torino: Utet; 1993.
17. Ponz de Leon M, Di Gregorio C. Pathology of colorectal cancer. Dig Liver Dis 2001; 33:372-88. (Pubitemid 32537027)
18. Cutait R, Alves VA, Lopes LC, Cutait DE, Borges JL, Singer J, et al. Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratin. Dis Colon Rectum 1999;34:917-20.
19. Jeffers MD, O'Dowd GM, Mulcahy H, Stagg M, O'Donogue DP, Toner M. The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma. J Pathol 1994;172:183-87. (Pubitemid 24098670)
20. Davies M, Arumugam PJ, Shah VI, Watkins A, Roger Morgan A, Carr ND, et al. The clinical significance of lymph node micrometastasis in stage I and stage II colorectal cancer. Clin Transl Oncol 2008;10:175-79.
21. van Schaik PM, Hermans E, van der Linden JC, Pruijt JR, Ernst MF, Bosscha K. Micro-metastases in stages I and II colon cancer are a predictor of the development of distant metastases and worse disease-free survival. Eur J Surg Oncol 2009;35:492-96.
22. Greenson JK, Isenhart CE, Rice R, Mojzik C, Houchens D, Martin EW Jr. Identification of occult micrometastases in pericolic lymph nodes of Duke's B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival. Cancer 1994; 73:563-69. (Pubitemid 24046594)
23. Isaka N, Nozue M, Doy M, Fukao K. Prognostic significance of perirectal lymph node micrometastases in Dukes' B rectal carcinoma: an immunohistochemical study by CAM5.2. Clin Cancer Res 1999;5:2065-68. (Pubitemid 29399259)
24. Keene SA, Demeure MJ. The clinical significance of micrometastases and molecular metastases. Surgery 2001;129:1-5. (Pubitemid 32099250)
25. Yamamoto N, Kato Y, Yanagisawa A, Ohta H, Takahashi T, Kitagawa T. Predictive value of genetic diagnosis for cancer micrometastasis: histologic and experimental appraisal. Cancer 1997;80:1393-98. (Pubitemid 27441012)
26. Oberg A, Stenling R, Tavelin B, Lindmark G. Are lymph node micrometastases of any clinical significance in Dukes' Stages A and B colorectal cancer? Dis Colon Rectum 1998; 41:1244-49. (Pubitemid 28477972)
27. Law CH, Wright FC, Rapanos T, Alzahrani M, Hanna SS, Khalifa M, et al. Impact of lymph node retrieval and pathological ultra-staging on the prognosis of stage II colon cancer. J Surg Oncol 2003;84:120-26. (Pubitemid 37363153)
28. Natsugoe S, Mueller J, Stein HJ, Feith M, Höfler H, Siewert JR. Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma: frequency, associated tumor characteristics, and impact on prognosis. Cancer 1998;83:858-66. (Pubitemid 28401917)
29. Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med 2005;352:476-87.
30. Quasar Collaborative Group, Gray R, Barnwell J, McConkey C, Hills RK, Williams NS, Kerr DJ. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 2007;370:2020-29.