Expression of L1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer

American Journal of Clinical Pathology

Volumn 136, Issue 1, 2011, Pages 138-144

  Kajiwara, Yoshiki ^a   Ueno, Hideki ^a   Hashiguchi, Yojiro ^a   Shinto, Eiji ^a   Shimazaki, Hideyuki ^a   Mochizuki, Hidetaka ^a   Hase, Kazuo ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Colorectal cancer; Invasive front; Poorly differentiated component; Solid cancer nest; Tumor budding

Indexed keywords

MESSENGER RNA; NERVE CELL ADHESION MOLECULE L1;

ARTICLE; CANCER GRADING; CANCER INVASION; CLINICAL FEATURE; COLORECTAL CANCER; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEURAL CELL ADHESION MOLECULE L1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 79960137356     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCP63NRBNGCTXVF     Document Type: Article

References (21)

1. Gabbert H. Mechanism of tumor invasion: evidence from in vivo observations. Cancer Metastasis Rev. 1985;4:293-309.
2. Hase K, Shatney C, Johnson D, et al. Prognostic value of tumor "budding" in patients with colorectal cancer. Dis Colon Rectum. 1993;36:627-635.
3. Ueno H, Murphy J, Jass JR, et al. Tumor "budding" as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology. 2002;40:127-132. (Pubitemid 34122114)
4. Okuyama T, Nakamura T, Yamaguchi M. Budding is useful to select high-risk patients in stage II well-differentiated or moderately differentiated colon adenocarcinoma. Dis Colon Rectum. 2003;46:1400-1406. (Pubitemid 37267636)
5. Prall F, Nizze H, Barten M. Tumour budding as prognostic factor in stage I/II colorectal carcinoma. Histopathology. 2005;47:17-24. (Pubitemid 40978809)
6. Nakamura T, Mitomi H, Kanazawa H, et al. Tumor budding as an index to identify high-risk patients with stage II colon cancer. Dis Colon Rectum. 2008;51:568-572.
7. Wang LM, Kevans D, Mulcahy H, et al. Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. Am J Surg Pathol. 2009;33:134-141.
8. Ueno H, Mochizuki H, Hashiguchi Y, et al. Histological grading of colorectal cancer: a simple and objective method. Ann Surg. 2008;247:811-818. (Pubitemid 351591516)
9. Lindner J, Rathjen FG, Schachner M. L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum. Nature. 1983;305:427-430. (Pubitemid 14225148)
10. Fritz G. Rathjen MS. Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. EMBO J. 1984;3:1-10.
11. Primiano T, Baig M, Maliyekkel A, et al. Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. Cancer Cell. 2003;4:41-53. (Pubitemid 36904160)
12. Arlt MJ, Novak-Hofer I, Gast D, et al. Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. Cancer Res. 2006;66:936-943. (Pubitemid 43165961)
13. Gavert N, Conacci-Sorrell M, Gast D, et al. L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol. 2005;168:633-642. (Pubitemid 40271028)
14. Gavert N, Sheffer M, Raveh S, et al. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 2007;67:7703-7712. (Pubitemid 47281363)
15. Raveh S, Gavert N, Ben-Ze'ev A. L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 2009;282:137-145.
16. Boo Y-J, Park J-M, Kim J, et al. L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer. Ann Surg Oncol. 2007;14:1703-1711. (Pubitemid 46790990)
17. Kaifi JT, Reichelt U, Quaas A, et al. L1 is associated with micrometastasis spread and poor outcome in colorectal cancer. Mod Pathol. 2007;20:1183-1190. (Pubitemid 47609067)
18. Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal Carcinoma: Clinicopathological Findings. Tokyo, Japan: Kanehara; 1997:4-19.
19. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:research0034.1-research0034.11.
20. Silletti S, Yebra M, Perez B, et al. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004;279:28880-28888. (Pubitemid 38915755)
21. Shtutman M, Levina E, Ohouo P, et al. Cell adhesion molecule L1 disrupts e-cadherin-containing adherence junctions and increases scattering and motility of MCF7 breast carcinoma cells. Cancer Res. 2006;66:11370-11380. (Pubitemid 46009968)