-
1
-
-
0026503664
-
Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium
-
Chang K, Pastan I, Willingham MC: Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int J Cancer 50:373-381, 1992
-
(1992)
Int J Cancer
, vol.50
, pp. 373-381
-
-
Chang, K.1
Pastan, I.2
Willingham, M.C.3
-
2
-
-
0030069718
-
Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers
-
Chang K, Pastan I: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci USA 93:136-140, 1996
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 136-140
-
-
Chang, K.1
Pastan, I.2
-
3
-
-
0142169984
-
Application of mesothelin immunostaining in tumor diagnosis
-
Ordóñez NG: Application of mesothelin immunostaining in tumor diagnosis. Am J Surg Pathol 27:1418-1428, 2003
-
(2003)
Am J Surg Pathol
, vol.27
, pp. 1418-1428
-
-
Ordóñez, N.G.1
-
4
-
-
0026572069
-
Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma
-
Chang K, Pai LH, Pass H, et al: Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma. Am J Surg Pathol 16: 259-268, 1992
-
(1992)
Am J Surg Pathol
, vol.16
, pp. 259-268
-
-
Chang, K.1
Pai, L.H.2
Pass, H.3
-
6
-
-
0035674996
-
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression sage
-
Argani P, Iacobuzio-Donahue C, Ryu B, et al: Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res 7:3862-3868, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3862-3868
-
-
Argani, P.1
Iacobuzio-Donahue, C.2
Ryu, B.3
-
7
-
-
28444437055
-
Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis
-
Hassan R, Laszik ZG, Lerner M, et al: Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J Clin Pathol 124:838-845, 2005
-
(2005)
Am J Clin Pathol
, vol.124
, pp. 838-845
-
-
Hassan, R.1
Laszik, Z.G.2
Lerner, M.3
-
8
-
-
84929650189
-
High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis
-
Thomas A, Chen Y, Steinberg SM, et al: High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis. Oncotarget 6:11694-11703, 2015
-
(2015)
Oncotarget
, vol.6
, pp. 11694-11703
-
-
Thomas, A.1
Chen, Y.2
Steinberg, S.M.3
-
9
-
-
84896696863
-
Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrencefree and overall survival in early-stage lung adenocarcinoma
-
Erratum20: 3896, 2014
-
Kachala SS, Bograd AJ, Villena-Vargas J, et al: Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrencefree and overall survival in early-stage lung adenocarcinoma. Clin Cancer Res 20:1020-1028, 2014 [Erratum20: 3896, 2014]
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1020-1028
-
-
Kachala, S.S.1
Bograd, A.J.2
Villena-Vargas, J.3
-
10
-
-
84918568011
-
Mesothelin expression in triple negative breast carcinomas correlates significantly with basal-like phenotype, distant metastases and decreased survival
-
Tozbikian G, Brogi E, Kadota K, et al: Mesothelin expression in triple negative breast carcinomas correlates significantly with basal-like phenotype, distant metastases and decreased survival. PLoS One 9: e114900, 2014
-
(2014)
PLoS One
, vol.9
, pp. e114900
-
-
Tozbikian, G.1
Brogi, E.2
Kadota, K.3
-
11
-
-
34548588364
-
Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells
-
Steinbach D, Onda M, Voigt A, et al: Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells. Eur J Haematol 79:281-286, 2007
-
(2007)
Eur J Haematol
, vol.79
, pp. 281-286
-
-
Steinbach, D.1
Onda, M.2
Voigt, A.3
-
12
-
-
0033521739
-
111Indium-labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin
-
Hassan R, Wu C, Brechbiel MW, et al: 111Indium-labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin. Int J Cancer 80:559-563, 1999
-
(1999)
Int J Cancer
, vol.80
, pp. 559-563
-
-
Hassan, R.1
Wu, C.2
Brechbiel, M.W.3
-
13
-
-
84924242164
-
Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using single photon emission computed tomography-computed tomography (SPECT-CT) imaging
-
Lindenberg L, Thomas A, Adler S, et al: Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using single photon emission computed tomography-computed tomography (SPECT-CT) imaging. Oncotarget 6: 4496-4504, 2015
-
(2015)
Oncotarget
, vol.6
, pp. 4496-4504
-
-
Lindenberg, L.1
Thomas, A.2
Adler, S.3
-
14
-
-
84964318513
-
ImmunoPET with antimesothelin antibody in patients with pancreatic and ovarian cancer before anti-mesothelin antibody-drug conjugate treatment
-
Lamberts LE, Menke-van der Houven van Oordt CW, ter Weele EJ, et al: ImmunoPET with antimesothelin antibody in patients with pancreatic and ovarian cancer before anti-mesothelin antibody-drug conjugate treatment. Clin Cancer Res 22:1642-1652, 2016
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1642-1652
-
-
Lamberts, L.E.1
Menke-Van Der Houven Van Oordt, C.W.2
Ter Weele, E.J.3
-
15
-
-
84902124061
-
Discovery of mesothelin and exploiting it as a target for immunotherapy
-
Pastan I, Hassan R: Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res 74:2907-2912, 2014
-
(2014)
Cancer Res
, vol.74
, pp. 2907-2912
-
-
Pastan, I.1
Hassan, R.2
-
16
-
-
34548858453
-
Phase i study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. Infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
-
Hassan R, Bullock S, Premkumar A, et al: Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin Cancer Res 13:5144-5149, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5144-5149
-
-
Hassan, R.1
Bullock, S.2
Premkumar, A.3
-
17
-
-
0028039864
-
A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5
-
Yamaguchi N, Hattori K, Oh-eda M, et al: A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. J Biol Chem 269:805-808, 1994
-
(1994)
J Biol Chem
, vol.269
, pp. 805-808
-
-
Yamaguchi, N.1
Hattori, K.2
Oh-Eda, M.3
-
18
-
-
80052190561
-
Cytotoxic activity of immunotoxin SS1P is modulated by TACEdependent mesothelin shedding
-
Zhang Y, Chertov O, Zhang J, et al: Cytotoxic activity of immunotoxin SS1P is modulated by TACEdependent mesothelin shedding. Cancer Res 71: 5915-5922, 2011
-
(2011)
Cancer Res
, vol.71
, pp. 5915-5922
-
-
Zhang, Y.1
Chertov, O.2
Zhang, J.3
-
19
-
-
4244083959
-
Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22
-
Zwaenepoel I, Mustapha M, Leibovici M, et al: Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci USA 99:6240-6245, 2002
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6240-6245
-
-
Zwaenepoel, I.1
Mustapha, M.2
Leibovici, M.3
-
20
-
-
58649093264
-
Mesothelin, stereocilin, and otoancorin are predicted to have superhelical structures with ARMtype repeats
-
Sathyanarayana BK, Hahn Y, Patankar MS, et al: Mesothelin, stereocilin, and otoancorin are predicted to have superhelical structures with ARMtype repeats. BMC Struct Biol 9:1, 2009
-
(2009)
BMC Struct Biol
, vol.9
, pp. 1
-
-
Sathyanarayana, B.K.1
Hahn, Y.2
Patankar, M.S.3
-
21
-
-
84864872763
-
Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009
-
Ma J, Tang WK, Esser L, et al: Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009. Acta Crystallogr Sect F Struct Biol Cryst Commun 68: 950-953, 2012
-
(2012)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.68
, pp. 950-953
-
-
Ma, J.1
Tang, W.K.2
Esser, L.3
-
22
-
-
0034071034
-
Mesothelin is not required for normal mouse development or reproduction
-
Bera TK, Pastan I: Mesothelin is not required for normal mouse development or reproduction. Mol Cell Biol 20:2902-2906, 2000
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2902-2906
-
-
Bera, T.K.1
Pastan, I.2
-
23
-
-
33645984873
-
The use of the monoclonal antibody mesothelin in the diagnosis of malignant mesothelioma in pleural biopsies
-
GallowayML, Murray D, Moffat DF: The use of the monoclonal antibody mesothelin in the diagnosis of malignant mesothelioma in pleural biopsies. Histopathology 48:767-769, 2006
-
(2006)
Histopathology
, vol.48
, pp. 767-769
-
-
Galloway, M.L.1
Murray, D.2
Moffat, D.F.3
-
24
-
-
33847112141
-
Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma
-
Kushitani K, Takeshima Y, Amatya VJ, et al: Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma. Pathol Int 57:190-199, 2007
-
(2007)
Pathol Int
, vol.57
, pp. 190-199
-
-
Kushitani, K.1
Takeshima, Y.2
Amatya, V.J.3
-
25
-
-
0037310823
-
Expression of calretinin, thrombomodulin, keratin 5, andmesothelin in lung carcinomas of different types: An immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura
-
Miettinen M, Sarlomo-Rikala M: Expression of calretinin, thrombomodulin, keratin 5, andmesothelin in lung carcinomas of different types: An immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura. Am J Surg Pathol 27:150-158, 2003
-
(2003)
Am J Surg Pathol
, vol.27
, pp. 150-158
-
-
Miettinen, M.1
Sarlomo-Rikala, M.2
-
26
-
-
0037341494
-
Value of mesothelin immunostaining in the diagnosis of mesothelioma
-
Ordó ñez NG: Value of mesothelin immunostaining in the diagnosis of mesothelioma. Mod Pathol 16:192-197, 2003
-
(2003)
Mod Pathol
, vol.16
, pp. 192-197
-
-
Ordóñez, N.G.1
-
27
-
-
77955919405
-
Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter
-
Tan K, Kajino K, Momose S, et al: Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. Hum Pathol 41:1330-1338, 2010
-
(2010)
Hum Pathol
, vol.41
, pp. 1330-1338
-
-
Tan, K.1
Kajino, K.2
Momose, S.3
-
28
-
-
84958793905
-
Mesothelin expression in advanced gastroesophageal cancer represents a novel target for immunotherapy
-
Illei PB, Alewine C, Zahurak M, et al: Mesothelin expression in advanced gastroesophageal cancer represents a novel target for immunotherapy. Appl Immunohistochem Mol Morphol 24:246-252, 2016
-
(2016)
Appl Immunohistochem Mol Morphol
, vol.24
, pp. 246-252
-
-
Illei, P.B.1
Alewine, C.2
Zahurak, M.3
-
29
-
-
84918771947
-
An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models
-
Scales SJ, Gupta N, Pacheco G, et al: An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models. Mol Cancer Ther 13: 2630-2640, 2014
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2630-2640
-
-
Scales, S.J.1
Gupta, N.2
Pacheco, G.3
-
30
-
-
0038207068
-
Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas
-
Frierson HF Jr, Moskaluk CA, Powell SM, et al: Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas. Hum Pathol 34:605-609, 2003
-
(2003)
Hum Pathol
, vol.34
, pp. 605-609
-
-
Moskaluk, C.A.1
Powell, S.M.2
-
31
-
-
12144288836
-
Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays
-
Swierczynski SL, Maitra A, Abraham SC, et al: Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. Hum Pathol 35:357-366, 2004
-
(2004)
Hum Pathol
, vol.35
, pp. 357-366
-
-
Swierczynski, S.L.1
Maitra, A.2
Abraham, S.C.3
-
32
-
-
84863692393
-
A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers
-
Erratum: PLoS One 7, 2012
-
Winter JM, Tang LH, Klimstra DS, et al: A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers. PLoS One 7:e40157, 2012 [Erratum: PLoS One 7, 2012]
-
(2012)
PLoS One
, vol.7
, pp. e40157
-
-
Winter, J.M.1
Tang, L.H.2
Klimstra, D.S.3
-
33
-
-
84858999573
-
Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma
-
Shimizu A, Hirono S, Tani M, et al: Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma. Cancer Sci 103:739-746, 2012
-
(2012)
Cancer Sci
, vol.103
, pp. 739-746
-
-
Shimizu, A.1
Hirono, S.2
Tani, M.3
-
34
-
-
32944468551
-
Diffuse mesothelin expression correlates with prolonged patient survival in ovarian serous carcinoma
-
Yen MJ, Hsu CY, Mao TL, et al: Diffuse mesothelin expression correlates with prolonged patient survival in ovarian serous carcinoma. Clin Cancer Res 12:827-831, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 827-831
-
-
Yen, M.J.1
Hsu, C.Y.2
Mao, T.L.3
-
35
-
-
63949085839
-
High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
-
Cheng WF, Huang CY, Chang MC, et al: High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. Br J Cancer 100:1144-1153, 2009
-
(2009)
Br J Cancer
, vol.100
, pp. 1144-1153
-
-
Cheng, W.F.1
Huang, C.Y.2
Chang, M.C.3
-
36
-
-
33947357849
-
Mesothelin expression in human lung cancer
-
Ho M, Bera TK, Willingham MC, et al: Mesothelin expression in human lung cancer. Clin Cancer Res 13:1571-1575, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1571-1575
-
-
Ho, M.1
Bera, T.K.2
Willingham, M.C.3
-
37
-
-
56149125001
-
Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: Translational implications for diagnosis and therapy
-
Alvarez H, Rojas PL, Yong KT, et al:Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: Translational implications for diagnosis and therapy. Nanomedicine (Lond) 4:295-301, 2008
-
(2008)
Nanomedicine (Lond
, vol.4
, pp. 295-301
-
-
Alvarez, H.1
Rojas, P.L.2
Yong, K.T.3
-
38
-
-
84855357265
-
Mesothelin expression correlates with prolonged patient survival in gastric cancer
-
Baba K, Ishigami S, Arigami T, et al: Mesothelin expression correlates with prolonged patient survival in gastric cancer. J Surg Oncol 105:195-199, 2012
-
(2012)
J Surg Oncol
, vol.105
, pp. 195-199
-
-
Baba, K.1
Ishigami, S.2
Arigami, T.3
-
39
-
-
84863006209
-
Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer
-
Einama T, Homma S, Kamachi H, et al: Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer. Br J Cancer 107:137-142, 2012
-
(2012)
Br J Cancer
, vol.107
, pp. 137-142
-
-
Einama, T.1
Homma, S.2
Kamachi, H.3
-
40
-
-
84891919468
-
ERC/mesothelin is expressed in human gastric cancer tissues and cell lines
-
Ito T, Kajino K, Abe M, et al: ERC/mesothelin is expressed in human gastric cancer tissues and cell lines. Oncol Rep 31:27-33, 2014
-
(2014)
Oncol Rep
, vol.31
, pp. 27-33
-
-
Ito, T.1
Kajino, K.2
Abe, M.3
-
41
-
-
84869773333
-
Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer
-
Kawamata F, Kamachi H, Einama T, et al: Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer. Int J Oncol 41:2109-2118, 2012
-
(2012)
Int J Oncol
, vol.41
, pp. 2109-2118
-
-
Kawamata, F.1
Kamachi, H.2
Einama, T.3
-
42
-
-
84897141947
-
Mesothelin expression is a prognostic factor in cholangiocellular carcinoma
-
Nomura R, Fujii H, Abe M, et al: Mesothelin expression is a prognostic factor in cholangiocellular carcinoma. Int Surg 98:164-169, 2013
-
(2013)
Int Surg
, vol.98
, pp. 164-169
-
-
Nomura, R.1
Fujii, H.2
Abe, M.3
-
43
-
-
34247860743
-
S100A4 protein and mesothelin expression in dysplasia and carcinoma of the extrahepatic bile duct
-
Zhao H, Davydova L, Mandich D, et al: S100A4 protein and mesothelin expression in dysplasia and carcinoma of the extrahepatic bile duct. Am J Clin Pathol 127:374-379, 2007
-
(2007)
Am J Clin Pathol
, vol.127
, pp. 374-379
-
-
Zhao, H.1
Davydova, L.2
Mandich, D.3
-
44
-
-
77349110458
-
Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors
-
Obulhasim G, Fujii H, Matsumoto T, et al: Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors. Eur J Gynaecol Oncol 31:63-71, 2010
-
(2010)
Eur J Gynaecol Oncol
, vol.31
, pp. 63-71
-
-
Obulhasim, G.1
Fujii, H.2
Matsumoto, T.3
-
45
-
-
84918533722
-
Mesothelin expression is associated with poor outcomes in breast cancer
-
Li YR, Xian RR, Ziober A, et al: Mesothelin expression is associated with poor outcomes in breast cancer. Breast Cancer Res Treat 147:675-684, 2014
-
(2014)
Breast Cancer Res Treat
, vol.147
, pp. 675-684
-
-
Li, Y.R.1
Xian, R.R.2
Ziober, A.3
-
46
-
-
84863727010
-
Mesothelin, a novel immunotherapy target for triple negative breast cancer
-
Tchou J, Wang LC, Selven B, et al: Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast Cancer Res Treat 133: 799-804, 2012
-
(2012)
Breast Cancer Res Treat
, vol.133
, pp. 799-804
-
-
Tchou, J.1
Wang, L.C.2
Selven, B.3
-
47
-
-
1542365125
-
Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion
-
Rump A, Morikawa Y, Tanaka M, et al: Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem 279: 9190-9198, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 9190-9198
-
-
Rump, A.1
Morikawa, Y.2
Tanaka, M.3
-
48
-
-
33750998782
-
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
-
Gubbels JA, Belisle J, Onda M, et al: Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer 5:50, 2006
-
(2006)
Mol Cancer
, vol.5
, pp. 50
-
-
Gubbels, J.A.1
Belisle, J.2
Onda, M.3
-
49
-
-
40349102093
-
Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells
-
Uehara N, Matsuoka Y, Tsubura A:Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells. Mol Cancer Res 6:186-193, 2008
-
(2008)
Mol Cancer Res
, vol.6
, pp. 186-193
-
-
Uehara, N.1
Matsuoka, Y.2
Tsubura, A.3
-
50
-
-
84860506230
-
Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients
-
Servais EL, Colovos C, Rodriguez L, et al: Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res 18:2478-2489, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2478-2489
-
-
Servais, E.L.1
Colovos, C.2
Rodriguez, L.3
-
51
-
-
84878623168
-
Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation
-
Chen SH, Hung WC, Wang P, et al: Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation. Sci Rep 3:1870, 2013
-
(1870)
Sci Rep 3
, vol.2013
-
-
Chen, S.H.1
Hung, W.C.2
Wang, P.3
-
52
-
-
84863116491
-
Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways
-
Chang MC, Chen CA, Chen PJ, et al: Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. Biochem J 442:293-302, 2012
-
(2012)
Biochem J
, vol.442
, pp. 293-302
-
-
Chang, M.C.1
Chen, C.A.2
Chen, P.J.3
-
53
-
-
79960068710
-
Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation
-
Bharadwaj U, Marin-Muller C, Li M, et al: Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis 32:1013-1024, 2011
-
(2011)
Carcinogenesis
, vol.32
, pp. 1013-1024
-
-
Bharadwaj, U.1
Marin-Muller, C.2
Li, M.3
-
54
-
-
80052143814
-
Mesothelin confers pancreatic cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-kB activation and IL-6/Mcl-1 overexpression
-
Bharadwaj U, Marin-Muller C, Li M, et al: Mesothelin confers pancreatic cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-kB activation and IL-6/Mcl-1 overexpression. Mol Cancer 10:106, 2011
-
(2011)
Mol Cancer
, vol.10
, pp. 106
-
-
Bharadwaj, U.1
Marin-Muller, C.2
Li, M.3
-
55
-
-
0042674172
-
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
-
Sato N, Maitra A, Fukushima N, et al: Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 63: 4158-4166, 2003
-
(2003)
Cancer Res
, vol.63
, pp. 4158-4166
-
-
Sato, N.1
Maitra, A.2
Fukushima, N.3
-
56
-
-
35148837128
-
High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif
-
Hucl T, Brody JR, Gallmeier E, et al: High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif. Cancer Res 67:9055-9065, 2007
-
(2007)
Cancer Res
, vol.67
, pp. 9055-9065
-
-
Hucl, T.1
Brody, J.R.2
Gallmeier, E.3
-
57
-
-
79953303845
-
Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers
-
Ren YR, Patel K, Paun BC, et al: Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers. J Biol Chem 286:11960-11969, 2011
-
(2011)
J Biol Chem
, vol.286
, pp. 11960-11969
-
-
Ren, Y.R.1
Patel, K.2
Paun, B.C.3
-
58
-
-
84887027457
-
A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer
-
Marin-Muller C, Li D, Bharadwaj U, et al: A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res 19:5901-5913, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5901-5913
-
-
Marin-Muller, C.1
Li, D.2
Bharadwaj, U.3
-
59
-
-
0031931487
-
Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity
-
Chowdhury PS, Viner JL, Beers R, et al: Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proc Natl Acad Sci USA 95:669-674, 1998
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 669-674
-
-
Chowdhury, P.S.1
Viner, J.L.2
Beers, R.3
-
60
-
-
0033056238
-
Improving antibody affinity by mimicking somatic hypermutation in vitro
-
Chowdhury PS, Pastan I: Improving antibody affinity by mimicking somatic hypermutation in vitro. Nat Biotechnol 17:568-572, 1999
-
(1999)
Nat Biotechnol
, vol.17
, pp. 568-572
-
-
Chowdhury, P.S.1
Pastan, I.2
-
62
-
-
69349100450
-
Phase i trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P
-
Kreitman RJ, Hassan R, Fitzgerald DJ, et al: Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clin Cancer Res 15: 5274-5279, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5274-5279
-
-
Kreitman, R.J.1
Hassan, R.2
Fitzgerald, D.J.3
-
63
-
-
84925032574
-
Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for frontline therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125
-
Hassan R, Sharon E, Thomas A, et al: Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for frontline therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125. Cancer 120:3311-3319, 2014
-
(2014)
Cancer
, vol.120
, pp. 3311-3319
-
-
Hassan, R.1
Sharon, E.2
Thomas, A.3
-
64
-
-
84886382139
-
Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression
-
Hassan R, Miller AC, Sharon E, et al: Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Sci Transl Med 5:208ra147, 2013
-
(2013)
Sci Transl Med
, vol.5
, pp. 208ra147
-
-
Hassan, R.1
Miller, A.C.2
Sharon, E.3
-
66
-
-
84905643817
-
Vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer
-
Hollevoet K, Mason-Osann E, Liu XF, et al: In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer. Mol Cancer Ther 13:2040-2049, 2014
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2040-2049
-
-
Hollevoet, K.1
Mason-Osann, E.2
Liu, X.F.3
-
67
-
-
84918775119
-
Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers
-
Alewine C, Xiang L, Yamori T, et al: Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. Mol Cancer Ther 13:2653-2661, 2014
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2653-2661
-
-
Alewine, C.1
Xiang, L.2
Yamori, T.3
-
68
-
-
84863957822
-
Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes
-
Liu W, Onda M, Lee B, et al: Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proc Natl Acad Sci USA 109: 11782-11787, 2012
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 11782-11787
-
-
Liu, W.1
Onda, M.2
Lee, B.3
-
69
-
-
0035152718
-
Novel allogeneic granulocyte-macrophage colonystimulating factor-secreting tumor vaccine for pancreatic cancer: A phase i trial of safety and immune activation
-
Jaffee EM, Hruban RH, Biedrzycki B, et al: Novel allogeneic granulocyte-macrophage colonystimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation. J Clin Oncol 19:145-156, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 145-156
-
-
Jaffee, E.M.1
Hruban, R.H.2
Biedrzycki, B.3
-
70
-
-
3543060047
-
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
-
Thomas AM, Santarsiero LM, Lutz ER, et al: Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J ExpMed 200:297-306, 2004
-
(2004)
J ExpMed
, vol.200
, pp. 297-306
-
-
Thomas, A.M.1
Santarsiero, L.M.2
Lutz, E.R.3
-
71
-
-
4644297195
-
Listeria-based cancer vaccines that segregate immunogenicity from toxicity
-
Brockstedt DG, Giedlin MA, Leong ML, et al: Listeria-based cancer vaccines that segregate immunogenicity from toxicity. Proc Natl Acad Sci USA 101:13832-13837, 2004
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13832-13837
-
-
Brockstedt, D.G.1
Gieldin, M.A.2
Leong, M.L.3
-
72
-
-
84856519280
-
A liveattenuated Listeria vaccine (ANZ-100) and a liveattenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase i studies of safety and immune induction
-
Le DT, Brockstedt DG, Nir-Paz R, et al: A liveattenuated Listeria vaccine (ANZ-100) and a liveattenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction. Clin Cancer Res 18: 858-868, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 858-868
-
-
Le Brockstedt, D.T.D.G.1
Nir-Paz, R.2
-
73
-
-
37449006756
-
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin
-
Hassan R, Ebel W, Routhier EL, et al: Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer Immun 7:20, 2007
-
(2007)
Cancer Immun
, vol.7
, pp. 20
-
-
Hassan, R.1
Ebel, W.2
Routhier, E.L.3
-
74
-
-
78650339895
-
Phase i clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelinexpressing cancers
-
Hassan R, Cohen SJ, Phillips M, et al: Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelinexpressing cancers. Clin Cancer Res 16:6132-6138, 2010
-
(2010)
Clin Cancer Res
, vol.16
, pp. 6132-6138
-
-
Hassan, R.1
Cohen, S.J.2
Phillips, M.3
-
75
-
-
84902687265
-
Anetumab ravtansine: A novel mesothelin-targeting antibodydrug conjugate cures tumors with heterogeneous target expression favored by bystander effect
-
Golfier S, Kopitz C, Kahnert A, et al: Anetumab ravtansine: A novel mesothelin-targeting antibodydrug conjugate cures tumors with heterogeneous target expression favored by bystander effect. Mol Cancer Ther 13:1537-1548, 2014
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 1537-1548
-
-
Golfier, S.1
Kopitz, C.2
Kahnert, A.3
-
76
-
-
84997507847
-
Phase i study of anti-mesothelin antibody drug conjugate anetumab ravtansine
-
Presented at the Denver, CO, September 6-9
-
Hassan R, Blumenschein G Jr, Kindler HL, et al: Phase I study of anti-mesothelin antibody drug conjugate anetumab ravtansine. Presented at the 16th World Conference on Lung Cancer, Denver, CO, September 6-9, 2015
-
(2015)
16th World Conference on Lung Cancer
-
-
Hassan, R.1
Kindler, H.L.2
-
77
-
-
84964389814
-
Phase i study of DMOT4039A, an antibody-drug conjugate targeting mesothelin, in patients with unresectable pancreatic or platinum-resistant ovarian cancer
-
Weekes CD, Lamberts LE, Borad MJ, et al: Phase I study of DMOT4039A, an antibody-drug conjugate targeting mesothelin, in patients with unresectable pancreatic or platinum-resistant ovarian cancer. Mol Cancer Ther 15:439-447, 2016
-
(2016)
Mol Cancer Ther
, vol.15
, pp. 439-447
-
-
Weekes, C.D.1
Lamberts, L.E.2
Borad, M.J.3
-
78
-
-
84957059458
-
Mesothelin-targeted CARs: Driving T cells to solid tumors
-
Morello A, Sadelain M, Adusumilli PS: Mesothelin-targeted CARs: Driving T cells to solid tumors. Cancer Discov 6:133-146, 2016
-
(2016)
Cancer Discov
, vol.6
, pp. 133-146
-
-
Morello, A.1
Sadelain, M.2
Adusumilli, P.S.3
-
79
-
-
84962564789
-
Mesothelin as a target for chimeric antigen receptormodified T cells as anticancer therapy
-
O'Hara M, Stashwick C, Haas AR, et al: Mesothelin as a target for chimeric antigen receptormodified T cells as anticancer therapy. Immunotherapy 8:449-460, 2016
-
(2016)
Immunotherapy
, vol.8
, pp. 449-460
-
-
O'Hara, M.1
Stashwick, C.2
Haas, A.R.3
-
80
-
-
84996572349
-
Mesothelin-specific chimeric antigen receptor mRNAengineered T cells induce anti-tumor activity in solid malignancies
-
Beatty GL, Haas AR, Maus MV, et al: Mesothelin-specific chimeric antigen receptor mRNAengineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunol Res 2:112-120, 2014
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 112-120
-
-
Beatty, G.L.1
Haas, A.R.2
Maus, M.V.3
-
81
-
-
84908891854
-
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
-
Adusumilli PS, Cherkassky L, Villena-Vargas J, et al: Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med 6:261ra151, 2014
-
(2014)
Sci Transl Med
, vol.6
, pp. 261ra151
-
-
Adusumilli, P.S.1
Cherkassky, L.2
Villena-Vargas, J.3
-
82
-
-
1642494793
-
Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1
-
Hassan R, Williams-Gould J, Watson T, et al: Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1. Clin Cancer Res 10:16-18, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 16-18
-
-
Hassan, R.1
Williams-Gould, J.2
Watson, T.3
-
83
-
-
79957890340
-
Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts
-
Mossoba ME, Onda M, Taylor J, et al: Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts. Clin Cancer Res 17:3697-3705, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3697-3705
-
-
Mossoba, M.E.1
Onda, M.2
Taylor, J.3
-
84
-
-
84918827048
-
Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma
-
Hassan R, Kindler HL, Jahan T, et al: Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res 20:5927-5936, 2014
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5927-5936
-
-
Hassan, R.1
Kindler, H.L.2
Jahan, T.3
-
85
-
-
84959147343
-
Population pharmacokinetics and exposure-response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection
-
Gupta A, Hussein Z, Hassan R, et al: Population pharmacokinetics and exposure-response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection. Cancer Chemother Pharmacol 77:733-743, 2016
-
(2016)
Cancer Chemother Pharmacol
, vol.77
, pp. 733-743
-
-
Gupta, A.1
Hussein, Z.2
Hassan, R.3
-
86
-
-
85041117766
-
Antimesothelin vaccine CRS-207 plus chemotherapy as front-line treatment for malignant pleural mesothelioma (MPM
-
Presented at the Vienna, Austria, September 25-29
-
Hassan R, Antonia S, Alley E, et al: Antimesothelin vaccine CRS-207 plus chemotherapy as front-line treatment for malignant pleural mesothelioma (MPM). Presented at the European Cancer Congress, Vienna, Austria, September 25-29, 2015
-
(2015)
European Cancer Congress
-
-
Hassan, R.1
Antonia, S.2
Alley, E.3
-
87
-
-
84929431322
-
Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
-
Le DT, Wang-Gillam A, Picozzi V, et al: Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol 33:1325-1333, 2015
-
(2015)
J Clin Oncol
, vol.33
, pp. 1325-1333
-
-
Le, D.T.1
Wang-Gillam, A.2
Picozzi, V.3
|