111Indium-labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin

International Journal of Cancer

Volumn 80, Issue 4, 1999, Pages 559-563

  Hassan, Raffit ^a   Wu, Chuanchu ^b   Brechbiel, Martin W ^b   Margulies, Inger ^b   Kreitman, Robert J ^b   Pastan, Ira ^b  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 ISOTHIOCYANATOBENZYL)CYCLOHEXYLDIETHYLENETRIAMINEPENTAACETIC ACID; DIFFERENTIATION ANTIGEN; MESOTHELIN; MONOCLONAL ANTIBODY IN 111; MONOCLONAL ANTIBODY K1 IN 111; PENTETIC ACID DERIVATIVE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G; INDIUM; MEGAKARYOCYTE POTENTIATING FACTOR; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; HUMAN; HUMAN CELL; MESOTHELIOMA; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CARCINOMA; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT; ANIMAL; CELL CULTURE; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; OVARY TUMOR; TISSUE DISTRIBUTION; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOGLOBULIN G; INDIUM RADIOISOTOPES; MEMBRANE GLYCOPROTEINS; MICE; MICE, NUDE; OVARIAN NEOPLASMS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0033521739     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990209)80:4<559::AID-IJC13>3.0.CO;2-Y     Document Type: Article

References (23)

1. BOUTIN, C. and REY, F., Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. Part I: Diagnosis. Cancer, 72, 389-393 (1993).
2. CHANG, K., PAI, L.H., PASS, H., POGREBNIAK, H.W., TSAO, M.S., PASTAN, I. and WILLINGHAM, M.C., Monoclonal antibody K1 reacts with epithelial mesotheliomas hut not with lung adenocarcinoma. Amer. J. surg. Pathol., 16, 259-268 (1992a).
3. CHANG, K. and PASTAN, I., Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc. nat. Acad. Sci. (Wash.), 93, 136-140 (1996).
4. CHANG, K., PASTAN, I. and WILLINGHAM, M.C., Isolation and characterization of a monoclonal antibody K1 reactive with ovarian cancers and normal mesothelium. Int. J. Cancer. 50, 373-381 (1992b).
5. 111Ind-labeled OC 125 monoclonal antibody intraperitoneally injected into patients operated on for ovarian carcinomas. Cancer Res., 49, 3087-3094 (1989).
6. CRIPPA, F. BURAGGI, G.L., DI RE, E., GASPARINI, M., SEREGNI, E., CANEVARI, S., GADINA, M., PRESTI, M., MARINI, A. and SECCAMANI, E., Radioimmunoscintigraphy of ovarian cancer with the MOv18 monoclonal antibody. Europ. J. Cancer, 27, 724-729 (1991).
7. DONNA, A., BETTA, P.G., CHIODERA, P., BELLINGERI, D., LIBENER, R., ZORZI, F. and TASSI, G.F., Newly marketed tissue markers for malignant mesotheliomas. Hum. Pathol., 28, 929-937 (1997).
8. GASPARINI, M., BOMBARDIERI, E., TONDINI, C., MAFFIOLI, L., HUGHES, L., BURRAGGI, G.L. and GOLDENBERG, D.M., Clinical utility of radioimmunoscintigraphy of non-Hodgkin's lymphoma with radiolabeled LL2 monoclonal antibody, Lymphoscan TM: preliminary results. Tumori. 81, 173-178 (1995).
9. GOLDENBERG, D.M. and LARSON, S.M., Radioimmunodetection in cancer identification. J. nucl. Med., 33, 803-814 (1992).
10. KOHLER, G. and MILSTEIN, C., Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (Lond.), 256, 495-497 (1975).
11. LAKSON, S.M., Lymphoma, melanoma, colon cancer: diagnosis and treatment with radiolabeled monoclonal antibodies. Radiology, 165, 297-304 (1987).
12. 2 fragments of monoclonal antihody OC 125. Cancer Res., 50, 937s-940s (1990).
13. LINDMO, T., BOVEN, E., CUTTITTA, F.J.F. and BUNN, P.A., JR., Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J. immunol. Methods, 72, 77-89 (1984).
14. 111In-KC-4G3 murine monoclonal antibody in athymic nude mice with or without human tumor xenografts. Cancer Res., 50, 5954-5961 (1990).
15. METHOD, M.W., SERAFINI, A.N., AVERETTE, H.E., RODRIGUEZ, M., PENALVER, M.A. and SEVIN, B.U., The role of radioimmunoscintigraphy and computed tomography scan prior to reassessment laparotomy of patients with ovarian carcinoma. Cancer, 77, 2286-2293 (1996).
16. MIRZADEH, S., BRECHBIEL, M.W., ATCHER, R.W. and GANSOW, A.O., Radiometal labeling of immunoproteins: covalent linkage of 2-(4-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid ligands to immunoglobulin. Bioconjugate Chem., 1, 59-65 (1990).
17. PAI, L.H. and PASTAN, I., Immunotoxin therapy. In: V.T. DeVita, S. Hellman, and S.A. Rosenberg (eds.), Cancer principles and practice of oncology (5th ed.), pp. 3045-3058, Lippincott-Raven. Philadelphia (1997).
18. PARKER, S.L., TONG, T., BOLDEN, S. and WINGO, P.A., Cancer statistics. CA Cancer J. Clin., 47, 5-27 (1997).
19. PATT, Y.Z., PODOLOFFM, D.A., CURLEY, S., KASI, L., SMITH, R., BHADKAMKAR, V. and CHARNSANGAVEJ, C., Technetium 99m-labeled IMMU-4, a monoclonal antibody against carcinoembryonic antigen, for imaging of occult recurrent colorectal cancer in patients with rising serum carcinoembryonic antigen levels. J. clin. Oncol., 12, 489-495 (1994).
20. 111In-CYT-103 immunoscintigraphy in ovarian cancer. Gynecol. Oncol., 48, 285-292 (1993).
21. TRUCCO, M. and DEPETVIS, S., Determination of equilibrium binding parameters of monoclonal antibodies specific for cell surface antigens. In: I. Lefkovits and B. Pernis (eds.), Immunological methods, pp. 1-26. Academic Press, New York (1981).
22. 2 antibody injected into the same patients. J. nucl. Med., 32, 221-227 (1991).
23. WU, C., KOBAYASHI, H., SUN, B., YOO, T.M., PAIK, C.H., GANSOW, A.O., CARRASQUILLO, J.A., PASTAN, I. and BRECHBIEL, M.W., Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA. Bioorg. med. Chem., 5, 1920-1934 (1997).