Combined Effect of Metastasis-Related MicroRNA, miR-34 and miR-124 Family, Methylation on Prognosis of Non–Small-Cell Lung Cancer

Clinical Lung Cancer

Volumn 18, Issue 1, 2017, Pages e13-e20

  Kim, Young Hun ^a   Lee, Won Kee ^a   Lee, Eung Bae ^a   Son, Ji Woong ^b   Kim, Dong Sun ^a   Park, Jae Yong ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Konyang University College of Medicine   (South Korea)

Author keywords

MicroRNA 124; MicroRNA 34; MSP; NSCLC; Prognosis

Indexed keywords

GENOMIC DNA; MICRORNA; MICRORNA 124; MICRORNA 124 1; MICRORNA 124 2; MICRORNA 124 3; MICRORNA 34; MICRORNA 34A; MICRORNA 34B; MICRORNA 34C; UNCLASSIFIED DRUG; MIRN124 MICRORNA, HUMAN; MIRN34 MICRORNA, HUMAN; TUMOR MARKER;

ADULT; AGE; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENDER; GENETIC ASSOCIATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; RNA METHYLATION; SMOKING; ADENOCARCINOMA; CANCER STAGING; CASE CONTROL STUDY; COMPARATIVE STUDY; DNA METHYLATION; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; LUNG NEOPLASMS; LYMPH NODE METASTASIS; PATHOLOGY; PROGNOSIS; SECONDARY; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TUMOR RECURRENCE;

ADENOCARCINOMA; BIOMARKERS, TUMOR; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; SURVIVAL RATE;

EID: 84997109187     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2016.06.005     Document Type: Article

References (23)

1. 1 Siegel, R., Naishadham, D., Jemal, A., Cancer statistics, 2012. CA Cancer J Clin 62 (2012), 10–29.
2. 2 Coello, M.C., Luketich, J.D., Litle, V.R., Godfrey, T.E., Prognostic significance of micrometastasis in non-small-cell lung cancer. Clin Lung Cancer 5 (2004), 214–225.
3. 3 Valastyan, S., Weinberg, R.A., Tumor metastasis: molecular insights and evolving paradigms. Cell 147 (2011), 275–292.
4. 4 Langevin, S.M., Kratzke, R.A., Kelsey, K.T., Epigenetics of lung cancer. Transl Res 165 (2015), 74–90.
5. 5 Kim, D.S., Cha, S.I., Lee, J.H., et al. Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features. Cancer 110 (2007), 2785–2792.
6. 6 He, L., Hannon, G.J., MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5 (2004), 522–531.
7. 7 Garzon, R., Calin, G.A., Croce, C.M., MicroRNAs in cancer. Annu Rev Med 60 (2009), 167–179.
8. 8 Ma, L., Weinberg, R.A., Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet 24 (2008), 448–456.
9. 9 Hermeking, H., The miR-34 family in cancer and apoptosis. Cell Death Differ 17 (2010), 193–199.
10. 10 Lv, X.B., Jiao, Y., Qing, Y., et al. miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. Chin J Cancer 30 (2011), 821–830.
11. 11 Zheng, F., Liao, Y.J., Cai, M.Y., et al. The putative tumor suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 61 (2012), 278–289.
12. 12 Lodygin, D., Tarasov, V., Epanchintsev, A., et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7 (2008), 2591–2600.
13. 13 Toyota, M., Suzuki, H., Sasaki, Y., et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68 (2008), 4123–4132.
14. 14 Vogt, M., Munding, J., Gruner, M., et al. Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Arch 458 (2011), 313–322.
15. 15 Furuta, M., Kozaki, K.I., Tanaka, S., Arii, S., Imoto, I., Inazawa, J., miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis 31 (2010), 766–776.
16. 16 Wang, P., Chen, L., Zhang, J., et al. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. Oncogene 33 (2014), 514–524.
17. 17 Ando, T., Yoshida, T., Enomoto, S., et al. DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer 124 (2009), 2367–2374.
18. 18 Izzotti, A., Calin, G.A., Arrigo, P., Steele, V.E., Croce, C.M., Flora, S.D., Downregulation of microRNA expression in the lung of rats exposed to cigarette smoke. FASEB J 23 (2009), 806–812.
19. 19 Wang, Z., Chen, Z., Gao, Y., et al. DNA hypermethylation of microRNA-34b/c has prognostic value for stage I non-small cell lung cancer. Cancer Biol Ther 11 (2011), 490–496.
20. 20 Nadal, E., Chen, G., Gallegos, M., et al. Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma. Clin Cancer Res 19 (2013), 6842–6852.
21. 21 Kitano, K., Watanabe, K., Emoto, N., et al. CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer. Cancer Sci 102 (2011), 2126–2131.
22. 22 Tanaka, N., Toyooka, S., Soh, J., et al. Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. Lung Cancer 76 (2012), 32–38.
23. 23 Patnaik, S.K., Kannisto, E., Knudsen, S., Yendamuri, S., Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection. Cancer Res 70 (2010), 36–45.