5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Wang, Qingyi ^a   Zhang, Huiyuan ^a   Xu, Hao ^a   Guo, Dongqing ^a   Shi, Hui ^a   Li, Yuan ^a   Zhang, Weiwei ^a   Gu, Yuchun ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CARRIER PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR;

ANIMAL; BAGG ALBINO MOUSE; CARDIAC MUSCLE CELL; CELL CULTURE; CELL HYPOXIA; CYTOLOGY; GENETICS; HEART MITOCHONDRION; METABOLISM; MITOCHONDRIAL MEMBRANE; NEWBORN; RNA INTERFERENCE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELL HYPOXIA; CELLS, CULTURED; MICE, INBRED BALB C; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MYOCYTES, CARDIAC; RECEPTORS, SEROTONIN, 5-HT3; RECEPTORS, SEROTONIN, 5-HT4; RNA INTERFERENCE;

EID: 84996911019     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep37336     Document Type: Article

References (38)

1. Kang, K., Park, S., Kim, Y. S., Lee, S., Back, K. Biosynthesis and biotechnological production of serotonin derivatives. Applied microbiology and biotechnology 83, 27-34, doi: 10.1007/s00253-009-1956-1 (2009).
2. Eddahibi, S. et al. Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonininduced smooth muscle hyperplasia. Circulation 113, 1857-1864, doi: 10.1161/CIRCULATIONAHA.105.591321 (2006).
3. Marwood, J. F., Stokes, G. S. Serotonin (5HT) and its antagonists: involvement in the cardiovascular system. Clinical and experimental pharmacology & physiology 11, 439-455 (1984).
4. Bianchi, P., Pimentel, D. R., Murphy, M. P., Colucci, W. S., Parini, A. A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 19, 641-643, doi: 10.1096/fj.04-2518fje (2005).
5. Fornai, F., Ruffoli, R., Soldani, P., Ruggieri, S., Paparelli, A. The "Parkinsonian heart": from novel vistas to advanced therapeutic approaches in Parkinson's disease. Current medicinal chemistry 14, 2421-2428 (2007).
6. Fu, L. W., Longhurst, J. C. Activated platelets contribute to stimulation of cardiac afferents during ischaemia in cats: role of 5-HT(3) receptors. The Journal of physiology 544, 897-912 (2002).
7. Beattie, D. T. et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. British journal of pharmacology 143, 549-560, doi: 10.1038/sj.bjp.0705929 (2004).
8. Chance, B., Williams, G. R. The respiratory chain and oxidative phosphorylation. Advances in enzymology and related subjects of biochemistry 17, 65-134 (1956).
9. Balaban, R. S. The role of Ca(2+ ) signaling in the coordination of mitochondrial ATP production with cardiac work. Biochimica et biophysica acta 1787, 1334-1341, doi: 10.1016/j.bbabio.2009.05.011 (2009).
10. Rottenberg, H., Scarpa, A. Calcium uptake and membrane potential in mitochondria. Biochemistry 13, 4811-4817 (1974).
11. Zhang, S. Z., Gao, Q., Cao, C. M., Bruce, I. C., Xia, Q. Involvement of the mitochondrial calcium uniporter in cardioprotection by ischemic preconditioning. Life sciences 78, 738-745, doi: 10.1016/j.lfs.2005.05.076 (2006).
12. Sari, Y., Zhou, F. C. Serotonin and its transporter on proliferation of fetal heart cells. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience 21, 417-424 (2003).
13. Monassier, L., Laplante, M. A., Ayadi, T., Doly, S., Maroteaux, L. Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin. Pharmacology & therapeutics 128, 559-567, doi: 10.1016/j.pharmthera.2010.08.004 (2010).
14. Doggrell, S. A. The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation. Expert opinion on investigational drugs 12, 805-823, doi: 10.1517/13543784.12.5.805 (2003).
15. White, C. et al. The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nature cell biology 7, 1021-1028, doi: 10.1038/ncb1302 (2005).
16. Blondel, O. et al. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS letters 412, 465-474 (1997).
17. Hannon, J., Hoyer, D. Molecular biology of 5-HT receptors. Behavioural brain research 195, 198-213, doi: 10.1016/j. bbr.2008.03.020 (2008).
18. Jackson M. B. Y. J. The 5-HT3 receptor channel. Annual Review of Physiology 57 (1995).
19. O'Rourke, B., Blatter, L. A. Mitochondrial Ca2+ uptake: tortoise or hare? Journal of molecular and cellular cardiology 46, 767-774, doi: 10.1016/j.yjmcc.2008.12.011 (2009).
20. Griffiths, E. J., Balaska, D., Cheng, W. H. The ups and downs of mitochondrial calcium signalling in the heart. Biochimica et biophysica acta 1797, 856-864, doi: 10.1016/j.bbabio.2010.02.022 (2010).
21. Verdejo, H. E. et al. Mitochondria, myocardial remodeling, and cardiovascular disease. Current hypertension reports 14, 532-539, doi: 10.1007/s11906-012-0305-4 (2012).
22. Ying, W. L., Emerson, J., Clarke, M. J., Sanadi, D. R. Inhibition of mitochondrial calcium ion transport by an oxo-bridged dinuclear ruthenium ammine complex. Biochemistry 30, 4949-4952 (1991).
23. Williams, G. S., Boyman, L., Chikando, A. C., Khairallah, R. J., Lederer, W. J. Mitochondrial calcium uptake. Proceedings of the National Academy of Sciences of the United States of America 110, 10479-10486, doi: 10.1073/pnas.1300410110 (2013).
24. Kirichok, Y., Krapivinsky, G., Clapham, D. E. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427, 360-364, doi: 10.1038/nature02246 (2004).
25. Chen, K., Thomas, S. R., Keaney, J. F. Jr. Beyond LDL oxidation: ROS in vascular signal transduction. Free radical biology & medicine 35, 117-132 (2003).
26. Jackson, W. F. Ion channels and vascular tone. Hypertension 35, 173-178 (2000).
27. Archer, S. L. et al. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. American journal of physiology. Heart and circulatory physiology 294, H570-H578, doi: 10.1152/ajpheart.01324.2007 (2008).
28. Evans, A. M. AMP-activated protein kinase underpins hypoxic pulmonary vasoconstriction and carotid body excitation by hypoxia in mammals. Experimental physiology 91, 821-827, doi: 10.1113/expphysiol.2006.033514 (2006).
29. Miyamae, M., Camacho, S. A., Weiner, M. W., Figueredo, V. M. Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+[m overload in rat hearts. The American journal of physiology 271, H2145-H2153 (1996).
30. Griffiths, E. J. et al. Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes. Cardiovascular research 39, 423-433 (1998).
31. Finsterer, J. Histiocytoid cardiomyopathy: a mitochondrial disorder. Clinical cardiology 31, 225-227, doi: 10.1002/clc.20224 (2008).
32. Khatami, M. et al. Accumulation of mitochondrial genome variations in Persian LQTS patients: a possible risk factor? Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology 19, e21-27, doi: 10.1016/j.carpath.2008.12.009 (2010).
33. Koopman, W. J., Willems, P. H., Smeitink, J. A. Monogenic mitochondrial disorders. The New England journal of medicine 366, 1132-1141, doi: 10.1056/NEJMra1012478 (2012).
34. Kawahara, K., Takase, M., Yamauchi, Y. Ruthenium red-induced transition from ventricular fibrillation to tachycardia in isolated rat hearts: possible involvement of changes in mitochondrial calcium uptake. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology 12, 311-321 (2003).
35. Florea, S. M., Blatter, L. A. The role of mitochondria for the regulation of cardiac alternans. Frontiers in physiology 1, 141, doi: 10.3389/fphys.2010.00141 (2010).
36. Gottlieb, R. A., Adachi, S. Nitrogen cavitation for cell disruption to obtain mitochondria from cultured cells. Methods in enzymology 322, 213-221 (2000).
37. Pallotti, F., Lenaz, G. Isolation and subfractionation of mitochondria from animal cells and tissue culture lines. Methods in cell biology 65, 1-35 (2001).
38. Iwaki, K., Sukhatme, V. P., Shubeita, H. E., Chien, K. R. Alpha-and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. The Journal of biological chemistry 265, 13809-13817 (1990).