Accumulation of mitochondrial genome variations in Persian LQTS patients: a possible risk factor?

Cardiovascular Pathology

Volumn 19, Issue 2, 2010, Pages

  Khatami, Mehri ^a   Houshmand, Massoud ^b,d   Sadeghizadeh, Majid ^a   Eftekharzadeh, Mahmood ^c   Heidari, Mohammad Mehdi ^a   Saber, Siamak ^d   Banihashemi, Kambiz ^d   Scheiber Mojdehkar, Barbara ^e  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b NATIONAL INSTITUTE OF GENETIC ENGINEERING AND BIOTECHNOLOGY   (Iran)

^c Heart Arrhythmia Center   (Iran)

^d Special Medical Center Iran   (Iran)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cardiac arrhythmia; Long QT syndrome; mtDNA; Polymorphism; TTGE

Indexed keywords

ADENOSINE TRIPHOSPHATE; ION CHANNEL; MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GEL ELECTROPHORESIS; GENETIC RISK; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART DEATH; HEART MUSCLE CELL; HUMAN; IRAN; LONG QT SYNDROME; MALE; MITOCHONDRIAL GENOME; POINT MUTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SYNCOPE;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; ELECTROPHORESIS, AGAR GEL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME, MITOCHONDRIAL; HUMANS; IRAN; LONG QT SYNDROME; MALE; MIDDLE AGED; MITOCHONDRIAL DISEASES; MUTATION; MYOCYTES, CARDIAC; POLYMORPHISM, GENETIC; RISK FACTORS; TEMPERATURE; YOUNG ADULT;

EID: 75149136664     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carpath.2008.12.009     Document Type: Article

References (25)

1. Antzelevitch C. Heterogeneity and cardiac arrhythmias; an overview. Heart Rhythm 4 (2007) 964-972
2. Vincent G.M. The long QT syndrome. Indian Pacing Electrophysiol J 2 (2002) 127-147
3. Towbin J.A. Molecular genetic basis of sudden cardiac death. Cardiovasc Pathol 10 (2001) 283-295
4. Wilde A.M., and Bezzina C. Genetics of cardiac arrhythmias. Heart 91 (2005) 1352-1358
5. Mohler P.J., Splawsk I., Napolitano C., Bottelli G., Sharpe L., Timothy K., Priori S.G., Keating M.T., and Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci U S A 101 (2004) 9137-9142
6. ATP activators during ischemia and reperfusion in an intact anesthetized rabbit model. J Pharmacol 55 (2003) 771-786
7. Priori S.G. Inherited arrhythmogenic diseases, the complexity beyond monogenic disorders. Circ Res 94 (2004) 140-145
8. Mohamed S.A., Hanke T., Erasmi A.W., Bechtel M.J.F., Scharfschwerdt M., Meissner C., Sievers H.H., and Alexander Gosslau A. Mitochondrial DNA deletions and the aging heart. Exp Gerontol 41 (2006) 508-517
9. Arbostini E., Diegoli M., Fasani R., Grasso M., Morbini P., Banchieri N., et al. Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy. Am J Pathol 153 (1998) 1501-1510
10. Bindoff L. Mitochondria and the heart. Eur Heart J 24 (2003) 221-224
11. Matsuoka R., Furutani M., Hayashi J., Isobe K., Akimoto K., and Shibata T. A mitochondrial DNA mutation cosegregates with the pathophysiological U wave. Biochem Biophys Res Commun 257 (1999) 228-233
12. Arnestad M., Opdal S.H., Vege A., and Rgnum T.O. A mitochondrial DNA polymorphism associated with cardiac arrhythmia investigated in sudden infant death syndrome. Acta Paediatr 52 (2007) 1-5
13. Opdal S.H., Vege A., Egeland T., Musse M.A., and Rognum T.O. Possible role of mtDNA mutations in sudden infant death. Pediatr Neurol 27 (2002) 23-29
14. Houshmand M., Mahmoudi T., Shafa Shariat Panahi M., Seyedena Y., Saber S., and Ataei M. Identification of a new human mtDNA polymorphism (A14290) in the NADH dehydrogenase subunit 6 gene. Braz J Med Biol Res 39 (2006) 725-730
15. Kurtz A., Lueth M., Kluwe L., Zhang T., Foster R., Mautner V.F., et al. Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors. Mol Cancer Res 2 (2004) 433-441
16. Penta J.S., Johnson F.M., and Wachsman T. Mitochondrial DNA in human malignancy. Mutat Res 488 (2001) 119-133
17. Wong L.J.C., Liang M.H., Kwon H., Park J., Bai R.K., and Tan D.J. Comprehensive scanning of the entire mitochondrial genome for mutations. Clin Chem 48 (2002) 1901-1912
18. Ito M., Tran Le S., Chaudhari D., Higashimoto T., Maslim A., and Boles R.G. Screening of mitochondrial DNA heteroplasmy in children at risk for mitochondrial disease. Mitochondrion 1 (2001) 269-278
19. Anderson S., Bankier A.T., Barrel B.G., de Bruijin M.H.L., Coulson A.R., Drouin J., et al. Sequence and organization of the human mitochondrial genome. Nature 290 (1981) 457-465
20. MITOMAP: a human mitochondrial genome database. Available from: (2008). http://www.mitomap.org/
21. Priori S.G., and Cerrone M. Molecular genetics: Is it making an impact in the management of inherited arrhythmogenic syndromes?. Hell J Cardiol 46 (2005) 83-87
22. Casademont J., and Miro O. Electron transport chain defects in heart failure. Heart Fail Reviews 7 (2002) 131-139
23. Optal S.H., and Rognum T.O. The sudden infant death syndrome gene: does it exist?. Pediatrics 114 (2004) 506-512
24. DiMauro S. Mitochondrial medicine. Biomed Biophis Acta 1659 (2004) 107-114
25. Tan D.J., Bai R.K., and Wong L.J.C. Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer. Cancer Res 62 (2002) 972-976