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Volumn 12, Issue 12, 2016, Pages 1407-1417

DPP-4 inhibitor plus SGLT-2 inhibitor as combination therapy for type 2 diabetes: from rationale to clinical aspects

Author keywords

Combined therapy; DPP 4 inhibitor; fixed dose combination; SGLT2 inhibitor; type 2 diabetes mellitus

Indexed keywords

ALOGLIPTIN; CANAGLIFLOZIN; DAPAGLIFLOZIN; DAPAGLIFLOZIN PLUS SAXAGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EMPAGLIFLOZIN; EMPAGLIFLOZIN PLUS LINAGLIPTIN; ERTUGLIFLOZIN; IPRAGLIFLOZIN; LINAGLIPTIN; METFORMIN; METFORMIN PLUS SAXAGLIPTIN; SAXAGLIPTIN; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; TENELIGLIPTIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 84996488587     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1080/17425255.2016.1215427     Document Type: Review
Times cited : (80)

References (65)
  • 1
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo RA., Banting Lecture. From the triumvirate to the ominous octet:a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773–795.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • DeFronzo, R.A.1
  • 2
    • 84925489733 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycaemia in type 2 diabetes, 2015:a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia. 2015;58:429–442.
    • (2015) Diabetologia , vol.58 , pp. 429-442
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 3
    • 84982074515 scopus 로고    scopus 로고
    • Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2016 executive summary
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2016 executive summary. Endocr Pract. 2016;22:84–113.
    • (2016) Endocr Pract , vol.22 , pp. 84-113
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3
  • 4
    • 84942296704 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in triple oral therapy regimens in patients with type 2 diabetes mellitus
    • Barnett AH, Charbonnel B, Moses RG, et al. Dipeptidyl peptidase-4 inhibitors in triple oral therapy regimens in patients with type 2 diabetes mellitus. Curr Med Res Opin. 2015;31:1919–1931.
    • (2015) Curr Med Res Opin , vol.31 , pp. 1919-1931
    • Barnett, A.H.1    Charbonnel, B.2    Moses, R.G.3
  • 5
    • 84964058550 scopus 로고    scopus 로고
    • Clinical use of dipeptidyl peptidase-4 and sodium-glucose cotransporter 2 inhibitors in combination therapy for type 2 diabetes mellitus
    • Guthrie RM. Clinical use of dipeptidyl peptidase-4 and sodium-glucose cotransporter 2 inhibitors in combination therapy for type 2 diabetes mellitus. Postgrad Med. 2015;127:463–479.
    • (2015) Postgrad Med , vol.127 , pp. 463-479
    • Guthrie, R.M.1
  • 6
    • 84917673108 scopus 로고    scopus 로고
    • A review of gliptins for 2014
    • Scheen AJ. A review of gliptins for 2014. Exp Opin Pharmacother. 2015;16:43–62.
    • (2015) Exp Opin Pharmacother , vol.16 , pp. 43-62
    • Scheen, A.J.1
  • 7
    • 84924961701 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes
    • Scheen AJ. Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opin Drug Saf. 2015;14:505–524.
    • (2015) Expert Opin Drug Saf , vol.14 , pp. 505-524
    • Scheen, A.J.1
  • 8
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • Scheen AJ. Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs. 2015;75:33–59.
    • (2015) Drugs , vol.75 , pp. 33-59
    • Scheen, A.J.1
  • 9
    • 84951905769 scopus 로고    scopus 로고
    • SGLT2 inhibition: efficacy and safety in type 2 diabetes treatment
    • Scheen AJ. SGLT2 inhibition:efficacy and safety in type 2 diabetes treatment. Exp Opin Drug Safety. 2015;14:1879–1904.
    • (2015) Exp Opin Drug Safety , vol.14 , pp. 1879-1904
    • Scheen, A.J.1
  • 10
    • 84969915634 scopus 로고    scopus 로고
    • Efficacy and safety of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis
    • Zaccardi F, Webb DR, Htike ZZ, et al. Efficacy and safety of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus:systematic review and network meta-analysis. Diabetes Obesity Metab. 2016;18:783–794.
    • (2016) Diabetes Obesity Metab , vol.18 , pp. 783-794
    • Zaccardi, F.1    Webb, D.R.2    Htike, Z.Z.3
  • 11
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 12
    • 84964465677 scopus 로고    scopus 로고
    • Reduction in cardiovascular and all-cause mortality in the EMPA-REG OUTCOME trial: a critical analysis
    • Scheen AJ. Reduction in cardiovascular and all-cause mortality in the EMPA-REG OUTCOME trial:a critical analysis. Diabetes Metab. 2016;42:71–76.
    • (2016) Diabetes Metab , vol.42 , pp. 71-76
    • Scheen, A.J.1
  • 13
    • 84931955457 scopus 로고    scopus 로고
    • Potential for combination of dipeptidyl peptidase-4 inhibitors and sodium-glucose co-transporter-2 inhibitors for the treatment of type 2 diabetes
    • Sharma MD. Potential for combination of dipeptidyl peptidase-4 inhibitors and sodium-glucose co-transporter-2 inhibitors for the treatment of type 2 diabetes. Diabetes Obesity Metab. 2015;17:616–621.
    • (2015) Diabetes Obesity Metab , vol.17 , pp. 616-621
    • Sharma, M.D.1
  • 14
    • 84940101393 scopus 로고    scopus 로고
    • Where does combination therapy with an SGLT2 inhibitor plus a DPP-4 inhibitor fit in the management of type 2 diabetes?
    • Abdul-Ghani M. Where does combination therapy with an SGLT2 inhibitor plus a DPP-4 inhibitor fit in the management of type 2 diabetes? Diabetes Care. 2015;38:373–375.
    • (2015) Diabetes Care , vol.38 , pp. 373-375
    • Abdul-Ghani, M.1
  • 15
    • 84928171802 scopus 로고    scopus 로고
    • Single-pill combination therapy for type 2 diabetes mellitus: linagliptin plus empagliflozin
    • Aronson R. Single-pill combination therapy for type 2 diabetes mellitus:linagliptin plus empagliflozin. Curr Med Res Opin. 2015;31:901–911.
    • (2015) Curr Med Res Opin , vol.31 , pp. 901-911
    • Aronson, R.1
  • 16
    • 84949623130 scopus 로고    scopus 로고
    • Empagliflozin/linagliptin single-tablet combination: first-in-class treatment option
    • Woo V. Empagliflozin/linagliptin single-tablet combination:first-in-class treatment option. Int J Clin Pract. 2015;69:1427–1437.
    • (2015) Int J Clin Pract , vol.69 , pp. 1427-1437
    • Woo, V.1
  • 17
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • Merovci A, Solis-Herrera C, Daniele G, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014;124:509–514.
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 18
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E, Muscelli E, Frascerra S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014;124:499–508.
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 19
    • 84918546698 scopus 로고    scopus 로고
    • Metabolic effects of SGLT-2 inhibitors beyond increased glucosuria: a review of the clinical evidence
    • Scheen AJ, Paquot N. Metabolic effects of SGLT-2 inhibitors beyond increased glucosuria:a review of the clinical evidence. Diabetes Metab. 2014;40:S4–S11.
    • (2014) Diabetes Metab , vol.40 , pp. S4-S11
    • Scheen, A.J.1    Paquot, N.2
  • 20
    • 84975698839 scopus 로고    scopus 로고
    • Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
    • Fitchett D, Zinman B, Wanner C, et al. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk:results of the EMPA-REG OUTCOME® trial. Eur Heart J. 2016;37:1526–1534.
    • (2016) Eur Heart J , vol.37 , pp. 1526-1534
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3
  • 21
    • 84939457713 scopus 로고    scopus 로고
    • Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial
    • Scirica BM, Braunwald E, Raz I, et al. Heart failure, saxagliptin, and diabetes mellitus:observations from the SAVOR-TIMI 53 randomized trial. Circulation. 2015;132:e121–e122.
    • (2015) Circulation , vol.132 , pp. e121-e122
    • Scirica, B.M.1    Braunwald, E.2    Raz, I.3
  • 22
    • 84963764907 scopus 로고    scopus 로고
    • DPP-4 inhibitors, heart failure and type 2 diabetes: all eyes on safety
    • Paneni F. DPP-4 inhibitors, heart failure and type 2 diabetes:all eyes on safety. Cardiovasc Diagn Ther. 2015;5:471–478.
    • (2015) Cardiovasc Diagn Ther , vol.5 , pp. 471-478
    • Paneni, F.1
  • 23
    • 84942162793 scopus 로고    scopus 로고
    • Combination therapy with saxagliptin and dapagliflozin for the treatment of type 2 diabetes
    • Williams DM, Stephens JW. Combination therapy with saxagliptin and dapagliflozin for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2015;16:2373–2379.
    • (2015) Expert Opin Pharmacother , vol.16 , pp. 2373-2379
    • Williams, D.M.1    Stephens, J.W.2
  • 24
    • 84873429530 scopus 로고    scopus 로고
    • Simultaneous oral therapeutic and intravenous (1)(4)C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin
    • Boulton DW, Kasichayanula S, Keung CFA, et al. Simultaneous oral therapeutic and intravenous (1)(4)C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin. Br J Clin Pharmacol. 2013;75:763–768.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 763-768
    • Boulton, D.W.1    Kasichayanula, S.2    Keung, C.F.A.3
  • 25
    • 84988826967 scopus 로고    scopus 로고
    • Bioequivalence of saxagliptin/dapagliflozin fixed-dose combination tablets compared with coadministration of the individual tablets to healthy subjects
    • Vakkalagadda B, Vetter ML, Rana J, et al. Bioequivalence of saxagliptin/dapagliflozin fixed-dose combination tablets compared with coadministration of the individual tablets to healthy subjects. Pharmacol Res Perspect. 2015;3:e00201.• Pharmacokinetic study demonstrating that saxagliptin/dapagliflozin FDC tablets are bioequivalent to coadministration of the individual components in healthy subjects under fasted conditions, without clinically meaningful effect of food intake.
    • (2015) Pharmacol Res Perspect , vol.3 , pp. e00201
    • Vakkalagadda, B.1    Vetter, M.L.2    Rana, J.3
  • 26
    • 84872418644 scopus 로고    scopus 로고
    • A randomized, open-label, crossover study to evaluate the pharmacokinetics of empagliflozin and linagliptin after coadministration in healthy male volunteers
    • Friedrich C, Metzmann K, Rose P, et al. A randomized, open-label, crossover study to evaluate the pharmacokinetics of empagliflozin and linagliptin after coadministration in healthy male volunteers. Clin Ther. 2013;35:A33–42.• Pharmacokinetic study showing the absence of drug–drug interaction between empagliflozin and linagliptin and supporting the coadministration of the two medications without dose adjustments in T2D patients.
    • (2013) Clin Ther , vol.35 , pp. A33-A42
    • Friedrich, C.1    Metzmann, K.2    Rose, P.3
  • 27
    • 84918559571 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers
    • Kinoshita S, Kondo K. Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers. Expert Opin Drug Metab Toxicol. 2015;11:7–14.
    • (2015) Expert Opin Drug Metab Toxicol , vol.11 , pp. 7-14
    • Kinoshita, S.1    Kondo, K.2
  • 28
    • 84917742055 scopus 로고    scopus 로고
    • Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy
    • Hansen L, Iqbal N, Ekholm E, et al. Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy. Endocr Pract. 2014;20:1187–1197.
    • (2014) Endocr Pract , vol.20 , pp. 1187-1197
    • Hansen, L.1    Iqbal, N.2    Ekholm, E.3
  • 29
    • 84928201032 scopus 로고    scopus 로고
    • Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin
    • Rosenstock J, Hansen L, Zee P, et al. Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy:a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin. Diabetes Care. 2015;38:376–383.•• Clinical trial showing greater improvements in glycemic control with triple therapy by the dual addition of saxagliptin and dapagliflozin than dual therapy with the addition of saxagliptin or dapagliflozin alone in T2D patients poorly controlled with metformin.
    • (2015) Diabetes Care , vol.38 , pp. 376-383
    • Rosenstock, J.1    Hansen, L.2    Zee, P.3
  • 30
    • 84958650333 scopus 로고    scopus 로고
    • Randomized, double-blind, phase 3 trial of triple therapy with dapagliflozin add-on to saxagliptin plus metformin in type 2 diabetes
    • Mathieu C, Ranetti AE, Li D, et al. Randomized, double-blind, phase 3 trial of triple therapy with dapagliflozin add-on to saxagliptin plus metformin in type 2 diabetes. Diabetes Care. 2015;38:2009–2017.• Clinical trial demonstrating that triple therapy with dapagliflozin add-on to saxagliptin plus metformin improves glycemic control and is well tolerated in T2D not well controlled with saxagliptin plus metformin therapy.
    • (2015) Diabetes Care , vol.38 , pp. 2009-2017
    • Mathieu, C.1    Ranetti, A.E.2    Li, D.3
  • 31
    • 84962349319 scopus 로고    scopus 로고
    • Randomized, double-blind trial of triple therapy with saxagliptin add-on to dapagliflozin plus metformin in patients with type 2 diabetes
    • Matthaei S, Catrinoiu D, Celinski A, et al. Randomized, double-blind trial of triple therapy with saxagliptin add-on to dapagliflozin plus metformin in patients with type 2 diabetes. Diabetes Care. 2015;38:2018–2024.• Clinical trial showing that triple therapy with the addition of saxagliptin to dapagliflozin plus metformin is well tolerated and produces significant improvements in HbA1c in patients with T2D inadequately controlled with dapagliflozin plus metformin.
    • (2015) Diabetes Care , vol.38 , pp. 2018-2024
    • Matthaei, S.1    Catrinoiu, D.2    Celinski, A.3
  • 32
    • 84941188677 scopus 로고    scopus 로고
    • Empagliflozin/linagliptin: a review in type 2 diabetes
    • Kim ES, Deeks ED. Empagliflozin/linagliptin:a review in type 2 diabetes. Drugs. 2015;75:1547–1557.
    • (2015) Drugs , vol.75 , pp. 1547-1557
    • Kim, E.S.1    Deeks, E.D.2
  • 33
    • 84952717693 scopus 로고    scopus 로고
    • Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus
    • Triplitt C, Solis-Herrera C, Cersosimo E, et al. Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus. Expert Opin Pharmacother. 2015;16:2819–2833.
    • (2015) Expert Opin Pharmacother , vol.16 , pp. 2819-2833
    • Triplitt, C.1    Solis-Herrera, C.2    Cersosimo, E.3
  • 34
    • 84962497651 scopus 로고    scopus 로고
    • Empagliflozin/linagliptin: combination therapy in patients with type 2 diabetes
    • published online
    • Tan X, Hu J, Empagliflozin/linagliptin:combination therapy in patients with type 2 diabetes. Ann Endocrinol (Paris). 2016. published online. doi:10.1016/j.ando.2015.11.003.
    • (2016) Ann Endocrinol (Paris)
    • Tan, X.1    Hu, J.2
  • 35
    • 84871179173 scopus 로고    scopus 로고
    • Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus
    • Rauch T, Graefe-Mody U, Deacon CF, et al. Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus. Diabetes Ther. 2012;3:10.
    • (2012) Diabetes Ther , vol.3 , pp. 10
    • Rauch, T.1    Graefe-Mody, U.2    Deacon, C.F.3
  • 36
    • 84928199102 scopus 로고    scopus 로고
    • Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes
    • Lewin A, DeFronzo RA, Patel S, et al. Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes. Diabetes Care. 2015;38:394–402.•• Clinical trial in drug-naïve T2D patients showing significantly greater reductions in HbA1c with empagliflozin/linagliptin versus linagliptin 5 mg and empagliflozin 10 mg but not versus empagliflozin 25 mg.
    • (2015) Diabetes Care , vol.38 , pp. 394-402
    • Lewin, A.1    DeFronzo, R.A.2    Patel, S.3
  • 37
    • 84928176749 scopus 로고    scopus 로고
    • Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin
    • DeFronzo RA, Lewin A, Patel S, et al. Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin. Diabetes Care. 2015;38:384–393.•• Clinical trial in metformin treated T2D patients demonstrating that combinations of empagliflozin/linagliptin (10/5 mg and 25/5 mg) as second-line therapy significantly reduce HbA1c compared with the individual components and are well tolerated.
    • (2015) Diabetes Care , vol.38 , pp. 384-393
    • DeFronzo, R.A.1    Lewin, A.2    Patel, S.3
  • 38
    • 84901830673 scopus 로고    scopus 로고
    • Canagliflozin: a review of its use in patients with type 2 diabetes mellitus
    • Plosker GL. Canagliflozin:a review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74:807–824.
    • (2014) Drugs , vol.74 , pp. 807-824
    • Plosker, G.L.1
  • 39
    • 84955184453 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin when used in conjunction with incretin-mimetic therapy in patients with type 2 diabetes
    • Fulcher G, Matthews DR, Perkovic V, et al. Efficacy and safety of canagliflozin when used in conjunction with incretin-mimetic therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2016;18:82–91.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 82-91
    • Fulcher, G.1    Matthews, D.R.2    Perkovic, V.3
  • 40
    • 85027921391 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin alone or as add-on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes: a 52-week open-label study
    • Inagaki N, Kondo K, Yoshinari T, et al. Efficacy and safety of canagliflozin alone or as add-on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes:a 52-week open-label study. J Diabetes Investig. 2015;6:210–218.
    • (2015) J Diabetes Investig , vol.6 , pp. 210-218
    • Inagaki, N.1    Kondo, K.2    Yoshinari, T.3
  • 41
    • 84928536746 scopus 로고    scopus 로고
    • Safety and efficacy of teneligliptin in Japanese patients with type 2 diabetes mellitus: a pooled analysis of two Phase III clinical studies
    • Kadowaki T, Marubayashi F, Yokota S, et al. Safety and efficacy of teneligliptin in Japanese patients with type 2 diabetes mellitus:a pooled analysis of two Phase III clinical studies. Expert Opin Pharmacother. 2015;16:971–981.
    • (2015) Expert Opin Pharmacother , vol.16 , pp. 971-981
    • Kadowaki, T.1    Marubayashi, F.2    Yokota, S.3
  • 42
    • 84945492290 scopus 로고    scopus 로고
    • Teneligliptin: a review in type 2 diabetes
    • Scott LJ. Teneligliptin:a review in type 2 diabetes. Clin Drug Investig. 2015;35:765–772.
    • (2015) Clin Drug Investig , vol.35 , pp. 765-772
    • Scott, L.J.1
  • 43
    • 84895736410 scopus 로고    scopus 로고
    • Sitagliptin: a review of its use in patients with type 2 diabetes mellitus
    • Plosker GL. Sitagliptin:a review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74:223–242.
    • (2014) Drugs , vol.74 , pp. 223-242
    • Plosker, G.L.1
  • 44
    • 78649715079 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects
    • Kasichayanula S, Liu X, Shyu WC, et al. Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects. Diabetes Obes Metab. 2011;13:47–54.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 47-54
    • Kasichayanula, S.1    Liu, X.2    Shyu, W.C.3
  • 45
    • 84865990718 scopus 로고    scopus 로고
    • No pharmacokinetic interaction between ipragliflozin and sitagliptin, pioglitazone, or glimepiride in healthy subjects
    • Smulders RA, Zhang W, Veltkamp SA, et al. No pharmacokinetic interaction between ipragliflozin and sitagliptin, pioglitazone, or glimepiride in healthy subjects. Diabetes Obes Metab. 2012;14:937–943.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 937-943
    • Smulders, R.A.1    Zhang, W.2    Veltkamp, S.A.3
  • 46
    • 84957973593 scopus 로고    scopus 로고
    • A pharmacokinetic/pharmacodynamic drug-drug interaction study of tofogliflozin (a new SGLT2 inhibitor) and selected anti-type 2 diabetes mellitus drugs
    • Kasahara N, Fukase H, Ohba Y, et al. A pharmacokinetic/pharmacodynamic drug-drug interaction study of tofogliflozin (a new SGLT2 inhibitor) and selected anti-type 2 diabetes mellitus drugs. Drug Res. 2016;66:74–81.
    • (2016) Drug Res , vol.66 , pp. 74-81
    • Kasahara, N.1    Fukase, H.2    Ohba, Y.3
  • 47
    • 84996506901 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic interaction between ertugliflozin and sitagliptin or metformin in healthy subjects
    • (Abstract)
    • Kumar V, Sahasrabudhe V, Matschke K, et al. Lack of a pharmacokinetic interaction between ertugliflozin and sitagliptin or metformin in healthy subjects. Clin Pharmacol Ther. 2016;99:S47. (Abstract).
    • (2016) Clin Pharmacol Ther , vol.99 , pp. S47
    • Kumar, V.1    Sahasrabudhe, V.2    Matschke, K.3
  • 48
    • 84896701131 scopus 로고    scopus 로고
    • Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study
    • Jabbour SA, Hardy E, Sugg J, et al. Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin:a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes Care. 2014;37:740–750.
    • (2014) Diabetes Care , vol.37 , pp. 740-750
    • Jabbour, S.A.1    Hardy, E.2    Sugg, J.3
  • 50
    • 84874977086 scopus 로고    scopus 로고
    • Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes
    • Zambrowicz B, Ding ZM, Ogbaa I, et al. Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes. Clin Ther. 2013;35:273–85 e7.
    • (2013) Clin Ther , vol.35 , pp. 273-285
    • Zambrowicz, B.1    Ding, Z.M.2    Ogbaa, I.3
  • 51
    • 84939142605 scopus 로고    scopus 로고
    • Perspective: SGLT2 inhibitors may predispose to ketoacidosis
    • Taylor SI, Blau JE, Rother KI. Perspective:SGLT2 inhibitors may predispose to ketoacidosis. J Clin Endocrinol Metab. 2015;100:2849–2852.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 2849-2852
    • Taylor, S.I.1    Blau, J.E.2    Rother, K.I.3
  • 52
    • 84960100350 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studies
    • Li L, Li S, Deng K, et al. Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes:systematic review and meta-analysis of randomised and observational studies. BMJ. 2016;352:i610.
    • (2016) BMJ , vol.352 , pp. i610
    • Li, L.1    Li, S.2    Deng, K.3
  • 53
    • 77952315531 scopus 로고    scopus 로고
    • Addition of incretin therapy to metformin in type 2 diabetes
    • Scheen AJ, Radermecker RP. Addition of incretin therapy to metformin in type 2 diabetes. Lancet. 2010;375:1410–1412.
    • (2010) Lancet , vol.375 , pp. 1410-1412
    • Scheen, A.J.1    Radermecker, R.P.2
  • 54
    • 84864761131 scopus 로고    scopus 로고
    • Gliptin versus a sulphonylurea as add-on to metformin
    • Scheen AJ, Paquot N. Gliptin versus a sulphonylurea as add-on to metformin. Lancet. 2012;380:450–452.
    • (2012) Lancet , vol.380 , pp. 450-452
    • Scheen, A.J.1    Paquot, N.2
  • 55
    • 84885960694 scopus 로고    scopus 로고
    • SGLT2 versus DPP4 inhibitors for type 2 diabetes
    • Scheen AJ. SGLT2 versus DPP4 inhibitors for type 2 diabetes. Lancet Diabetes Endocrinol. 2013;1:168–170.
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 168-170
    • Scheen, A.J.1
  • 56
    • 84961199624 scopus 로고    scopus 로고
    • Real-world evaluation of glycemic control among patients with type 2 diabetes mellitus treated with canagliflozin versus dipeptidyl peptidase-4 inhibitors
    • Thayer S, Chow W, Korrer S, et al. Real-world evaluation of glycemic control among patients with type 2 diabetes mellitus treated with canagliflozin versus dipeptidyl peptidase-4 inhibitors. Curr Med Res Opin. 2016;32:1087–1096.
    • (2016) Curr Med Res Opin , vol.32 , pp. 1087-1096
    • Thayer, S.1    Chow, W.2    Korrer, S.3
  • 57
    • 84914159859 scopus 로고    scopus 로고
    • Oral antihyperglycemic treatment options for type 2 diabetes mellitus
    • Brietzke SA. Oral antihyperglycemic treatment options for type 2 diabetes mellitus. Med Clin North Am. 2015;99:87–106.
    • (2015) Med Clin North Am , vol.99 , pp. 87-106
    • Brietzke, S.A.1
  • 58
    • 84924964853 scopus 로고    scopus 로고
    • Pharmacokinetics and clinical use of incretin-based therapies in patients with chronic kidney disease and type 2 diabetes
    • Scheen AJ. Pharmacokinetics and clinical use of incretin-based therapies in patients with chronic kidney disease and type 2 diabetes. Clin Pharmacokinet. 2015;54:1–21.
    • (2015) Clin Pharmacokinet , vol.54 , pp. 1-21
    • Scheen, A.J.1
  • 59
    • 84933676007 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes mellitus and chronic kidney disease
    • Scheen AJ. Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes mellitus and chronic kidney disease. Clin Pharmacokinet. 2015;54:691–708.
    • (2015) Clin Pharmacokinet , vol.54 , pp. 691-708
    • Scheen, A.J.1
  • 60
    • 84979895487 scopus 로고    scopus 로고
    • Empagliflozin and progression of kidney disease in type 2 diabetes
    • [Epub ahead of print]
    • Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med. 2016. [Epub ahead of print].
    • (2016) N Engl J Med
    • Wanner, C.1    Inzucchi, S.E.2    Lachin, J.M.3
  • 61
    • 84902551303 scopus 로고    scopus 로고
    • Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes: a critical reappraisal
    • Scheen AJ, Charbonnel B. Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes:a critical reappraisal. Diabetes Metab. 2014;40:176–185.
    • (2014) Diabetes Metab , vol.40 , pp. 176-185
    • Scheen, A.J.1    Charbonnel, B.2
  • 62
    • 84981201738 scopus 로고    scopus 로고
    • Precision medicine: the future in diabetes care?
    • Scheen AJ. Precision medicine:the future in diabetes care? Diabetes Res Clin Pract. 2016;117:12–21.
    • (2016) Diabetes Res Clin Pract , vol.117 , pp. 12-21
    • Scheen, A.J.1
  • 63
    • 84946195706 scopus 로고    scopus 로고
    • Cost-effectiveness of dapagliflozin versus DPP-4 inhibitors as an add-on to metformin in the treatment of type 2 diabetes mellitus from a UK healthcare system perspective
    • Charokopou M, McEwan P, Lister S, et al. Cost-effectiveness of dapagliflozin versus DPP-4 inhibitors as an add-on to metformin in the treatment of type 2 diabetes mellitus from a UK healthcare system perspective. BMC Health Serv Res. 2015;15:496.
    • (2015) BMC Health Serv Res , vol.15 , pp. 496
    • Charokopou, M.1    McEwan, P.2    Lister, S.3
  • 64
    • 84929964372 scopus 로고    scopus 로고
    • Cost effectiveness of dipeptidyl peptidase-4 inhibitors for type 2 diabetes
    • Geng J, Yu H, Mao Y, et al. Cost effectiveness of dipeptidyl peptidase-4 inhibitors for type 2 diabetes. Pharmacoeconomics. 2015;33:581–597.
    • (2015) Pharmacoeconomics , vol.33 , pp. 581-597
    • Geng, J.1    Yu, H.2    Mao, Y.3
  • 65
    • 84944318704 scopus 로고    scopus 로고
    • Evaluating drug cost per response with SGLT2 inhibitors in patients with type 2 diabetes mellitus
    • Lopez JMS, Macomson B, Ektare V, et al. Evaluating drug cost per response with SGLT2 inhibitors in patients with type 2 diabetes mellitus. Am Health Drug Benefits. 2015;8:309–318.
    • (2015) Am Health Drug Benefits , vol.8 , pp. 309-318
    • Lopez, J.M.S.1    Macomson, B.2    Ektare, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.