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Volumn 9, Issue 12, 2016, Pages 1533-1546

A pharmacological overview of lamotrigine for the treatment of epilepsy

Author keywords

Epilepsy; lamotrigine; pharmacokinetics; sodium channel blocker; women

Indexed keywords

ANTICONVULSIVE AGENT; LAMOTRIGINE; TRIAZINE DERIVATIVE;

EID: 84996432109     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1080/17512433.2016.1254041     Document Type: Article
Times cited : (44)

References (123)
  • 1
    • 0015692017 scopus 로고
    • The epileptogenic action of sodium folate in the rat
    • Hommes OR, Obbens EA., The epileptogenic action of sodium folate in the rat. J Neurol Sci. 1972;20:269–272.
    • (1972) J Neurol Sci , vol.20 , pp. 269-272
    • Hommes, O.R.1    Obbens, E.A.2
  • 2
    • 84960564893 scopus 로고
    • Anticonvulsant therapy, megaloblastic hematopoiesis and folic acid metabolism
    • Reynolds EH, Milner G, Matthews PM, et al. Anticonvulsant therapy, megaloblastic hematopoiesis and folic acid metabolism. Q J Med. 1966;35:521–537.
    • (1966) Q J Med , vol.35 , pp. 521-537
    • Reynolds, E.H.1    Milner, G.2    Matthews, P.M.3
  • 3
    • 84937249974 scopus 로고    scopus 로고
    • Safety of lamotrigine in paediatrics: a systematic review
    • Oluwaseun E, Imti C, Helen MS. Safety of lamotrigine in paediatrics:a systematic review. BMJ Open. 2015;5:e007711.
    • (2015) BMJ Open , vol.5 , pp. e007711
    • Oluwaseun, E.1    Imti, C.2    Helen, M.S.3
  • 4
    • 84905236610 scopus 로고    scopus 로고
    • Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen?
    • Markus R, Sarah R, Manuela P, et al. Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs:time to screen? Neuropediatrics. 2014;45(4):226–233.
    • (2014) Neuropediatrics , vol.45 , Issue.4 , pp. 226-233
    • Markus, R.1    Sarah, R.2    Manuela, P.3
  • 5
    • 0003155836 scopus 로고
    • Add-on treatment with lamictal for intractable partial epilepsy: a placebo-controlled crossover trial
    • Schmidt D, Ried S, Rapp P. Add-on treatment with lamictal for intractable partial epilepsy:a placebo-controlled crossover trial. Epilepsia. 1993;34(Suppl. 2):66.
    • (1993) Epilepsia , vol.34 , pp. 66
    • Schmidt, D.1    Ried, S.2    Rapp, P.3
  • 7
    • 35848947010 scopus 로고    scopus 로고
    • Lamotrigine extended-release as adjunctive therapy for partial seizures
    • Naritoku DK, Warnock CR, Messenheimer JA, et al. Lamotrigine extended-release as adjunctive therapy for partial seizures. Neurology. 2007;69:1610–1618.
    • (2007) Neurology , vol.69 , pp. 1610-1618
    • Naritoku, D.K.1    Warnock, C.R.2    Messenheimer, J.A.3
  • 8
    • 78649904882 scopus 로고    scopus 로고
    • Adjunctive lamotrigine XR for primary generalized tonic-clonic seizures in a randomized, placebo-controlled study
    • Biton V, DiMemmo J, Shukla R, et al. Adjunctive lamotrigine XR for primary generalized tonic-clonic seizures in a randomized, placebo-controlled study. Epilepsy Behav. 2010;19:352–458.
    • (2010) Epilepsy Behav , vol.19 , pp. 352-458
    • Biton, V.1    DiMemmo, J.2    Shukla, R.3
  • 9
    • 67649159500 scopus 로고    scopus 로고
    • Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial
    • Guerdjikova AI, McElroy SL, Welge JA, et al. Lamotrigine in the treatment of binge-eating disorder with obesity:a randomized, placebo-controlled monotherapy trial. Int Clin Psychopharmacol. 2009;24:150–158.
    • (2009) Int Clin Psychopharmacol , vol.24 , pp. 150-158
    • Guerdjikova, A.I.1    McElroy, S.L.2    Welge, J.A.3
  • 10
    • 0033629142 scopus 로고    scopus 로고
    • Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy
    • Lee WT, Shen YZ, Chang C. Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid:evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy. Neuroscience. 2000;95(1):89–95.
    • (2000) Neuroscience , vol.95 , Issue.1 , pp. 89-95
    • Lee, W.T.1    Shen, Y.Z.2    Chang, C.3
  • 12
    • 84996443571 scopus 로고    scopus 로고
    • NC, USA: GlaxoSmithKline, Research Triangle Park
    • Lamictal™ Product Info. NC, USA:GlaxoSmithKline, Research Triangle Park; 2000.
    • (2000)
  • 13
    • 84996469808 scopus 로고    scopus 로고
    • NC, USA: GlaxoSmithKline, Research Triangle Park
    • Lamictal™ full prescribing information. NC, USA:GlaxoSmithKline, Research Triangle Park; 2011.
    • (2011)
  • 14
    • 0028006747 scopus 로고
    • Long-term observations on the clinical use of lamotrigine as add-on drug in patients with epilepsy
    • Cocito L, Maffini M, Loeb C. Long-term observations on the clinical use of lamotrigine as add-on drug in patients with epilepsy. Epilepsy Research. 1994;19:123–127.
    • (1994) Epilepsy Research , vol.19 , pp. 123-127
    • Cocito, L.1    Maffini, M.2    Loeb, C.3
  • 15
    • 0029651761 scopus 로고
    • Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy
    • Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet. 1995;345:476–479.
    • (1995) Lancet , vol.345 , pp. 476-479
    • Brodie, M.J.1    Richens, A.2    Yuen, A.W.C.3
  • 16
    • 0036711702 scopus 로고    scopus 로고
    • Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy
    • Brodie MJ, Chadwick DW, Anhut H, et al. Gabapentin versus lamotrigine monotherapy:a double-blind comparison in newly diagnosed epilepsy. Epilepsia. 2002;43(9):993–1000.
    • (2002) Epilepsia , vol.43 , Issue.9 , pp. 993-1000
    • Brodie, M.J.1    Chadwick, D.W.2    Anhut, H.3
  • 17
    • 33947241772 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
    • Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy:an unblinded randomised controlled trial. Lancet. 2007;369:1000–1015.
    • (2007) Lancet , vol.369 , pp. 1000-1015
    • Marson, A.G.1    Al-Kharusi, A.M.2    Alwaidh, M.3
  • 18
    • 45949112016 scopus 로고    scopus 로고
    • Lamotrigine in pregnancy: Clearance, therapeutic drug monitoring, and seizure frequency
    • Pennell PB, Peng L, Newport DJ, et al. Lamotrigine in pregnancy:Clearance, therapeutic drug monitoring, and seizure frequency. Neurology. 2008;70:2130–2136.
    • (2008) Neurology , vol.70 , pp. 2130-2136
    • Pennell, P.B.1    Peng, L.2    Newport, D.J.3
  • 19
    • 79958781995 scopus 로고    scopus 로고
    • Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry
    • Tomson T, Battino D, Bonizzoni E, et al. Dose-dependent risk of malformations with antiepileptic drugs:an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol. 2011;10:609–617.
    • (2011) Lancet Neurol , vol.10 , pp. 609-617
    • Tomson, T.1    Battino, D.2    Bonizzoni, E.3
  • 20
    • 85027926729 scopus 로고    scopus 로고
    • The LaLiMo Trial: lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsydan open-label, prospective, randomised controlled multicenter study
    • Rosenow F, Schade Brittinger C, Burchardi N, et al. The LaLiMo Trial:lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsydan open-label, prospective, randomised controlled multicenter study. J Neurol Neurosurg Psychiatry. 2012. doi:10.1136/jnnp-2011-301999
    • (2012) J Neurol Neurosurg Psychiatry
    • Rosenow, F.1    Schade Brittinger, C.2    Burchardi, N.3
  • 21
    • 84876328485 scopus 로고    scopus 로고
    • Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study
    • Meador KJ, Baker GA, Browning N, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study):a prospective observational study. Lancet Neurol. 2013;12:244–252.
    • (2013) Lancet Neurol , vol.12 , pp. 244-252
    • Meador, K.J.1    Baker, G.A.2    Browning, N.3
  • 22
    • 84959203619 scopus 로고    scopus 로고
    • Lamotrigine monotherapy for newly diagnosed typical absence seizures in children: a multi-center, uncontrolled, open-label study
    • Yasumoto S, Shimizu M, Sato K, et al. Lamotrigine monotherapy for newly diagnosed typical absence seizures in children:a multi-center, uncontrolled, open-label study. Brain & Development. 2015. doi:10.1016/j.braindev.2015.10.007
    • (2015) Brain & Development
    • Yasumoto, S.1    Shimizu, M.2    Sato, K.3
  • 23
    • 0027491284 scopus 로고
    • Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures
    • Matsuo F, Bergen D, Faught E, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology. 1993;43(11):2284.
    • (1993) Neurology , vol.43 , Issue.11 , pp. 2284
    • Matsuo, F.1    Bergen, D.2    Faught, E.3
  • 24
    • 0031453973 scopus 로고    scopus 로고
    • Lamotrigine for generalised seizures associated with the lennox-gastaut syndrome
    • Motte J, Trevathan E, Arvidsson JF. Lamotrigine for generalised seizures associated with the lennox-gastaut syndrome. N Engl J Med. 1997;337:12–1807.
    • (1997) N Engl J Med , vol.337 , pp. 12-1807
    • Motte, J.1    Trevathan, E.2    Arvidsson, J.F.3
  • 25
    • 0032443667 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, lamotrigine in treatment-resistant crossover study of generalised epilepsy
    • Beran RG, Berkovic SF, Dunagan FM, et al. Double-blind, placebo-controlled, lamotrigine in treatment-resistant crossover study of generalised epilepsy. Epilepsia. 1998;39(12):1329–1333.
    • (1998) Epilepsia , vol.39 , Issue.12 , pp. 1329-1333
    • Beran, R.G.1    Berkovic, S.F.2    Dunagan, F.M.3
  • 26
    • 0033544351 scopus 로고    scopus 로고
    • A placebo controlled trial of lamotrigine add-on therapy for partial seizures in children
    • Duchowny M, Pellock JM, Graf WD, et al. A placebo controlled trial of lamotrigine add-on therapy for partial seizures in children. Neurology. 1999;53(8):1724–1731.
    • (1999) Neurology , vol.53 , Issue.8 , pp. 1724-1731
    • Duchowny, M.1    Pellock, J.M.2    Graf, W.D.3
  • 27
    • 33645062986 scopus 로고    scopus 로고
    • Double blind, placebo controlled study of lamotrigine in primary generalized tonic-clonic seizures
    • Biton V, Sackellares JC, Vuong A, et al. Double blind, placebo controlled study of lamotrigine in primary generalized tonic-clonic seizures. Neurology. 2005;65(11):1737–1743.• A nice article giving an insight into lamotrigine and its action on sodium channels.
    • (2005) Neurology , vol.65 , Issue.11 , pp. 1737-1743
    • Biton, V.1    Sackellares, J.C.2    Vuong, A.3
  • 28
    • 84896491499 scopus 로고    scopus 로고
    • Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy
    • Veiby G, Daltveit AK, Engelsen BA, et al. Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol. 2014;261(3):579–588.
    • (2014) J Neurol , vol.261 , Issue.3 , pp. 579-588
    • Veiby, G.1    Daltveit, A.K.2    Engelsen, B.A.3
  • 29
    • 84865135028 scopus 로고    scopus 로고
    • Teratogenic effects of antiepileptic drugs
    • Tomson T, Battino D. Teratogenic effects of antiepileptic drugs. Lancet Neurol. 2012;11(9):803–813.
    • (2012) Lancet Neurol , vol.11 , Issue.9 , pp. 803-813
    • Tomson, T.1    Battino, D.2
  • 30
    • 84905439439 scopus 로고    scopus 로고
    • Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers
    • Campbell E, Kennedy F, Russell A, et al. Malformation risks of antiepileptic drug monotherapies in pregnancy:updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatr. 2014;85(9):1029–1034.
    • (2014) J Neurol Neurosurg Psychiatr , vol.85 , Issue.9 , pp. 1029-1034
    • Campbell, E.1    Kennedy, F.2    Russell, A.3
  • 31
    • 84873669013 scopus 로고    scopus 로고
    • Levetiracetam in pregnancy: results from the UK and Ireland Epilepsy and Pregnancy Registers
    • Mawhinney E, Craig J, Morrow J, et al. Levetiracetam in pregnancy:results from the UK and Ireland Epilepsy and Pregnancy Registers. Neurology. 2013;80(4):400–405.
    • (2013) Neurology , vol.80 , Issue.4 , pp. 400-405
    • Mawhinney, E.1    Craig, J.2    Morrow, J.3
  • 32
    • 50549083309 scopus 로고    scopus 로고
    • UK Epilepsy and Pregnancy Register, topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register
    • Hunt S, Russell A, Smithson WH, et al. UK Epilepsy and Pregnancy Register, topiramate in pregnancy:preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology. 2008;71(4):272–276.
    • (2008) Neurology , vol.71 , Issue.4 , pp. 272-276
    • Hunt, S.1    Russell, A.2    Smithson, W.H.3
  • 33
    • 84863633751 scopus 로고    scopus 로고
    • North American AED Pregnancy Registry. Comparative safety of antiepileptic drugs during pregnancy
    • Herna´ndez-Dı´az S, Smith CR, Shen A, et al. North American AED Pregnancy Registry. Comparative safety of antiepileptic drugs during pregnancy. Neurology. 2012;78(21):1692–1699.
    • (2012) Neurology , vol.78 , Issue.21 , pp. 1692-1699
    • Herna´ndez-Dı´az, S.1    Smith, C.R.2    Shen, A.3
  • 34
    • 77951572957 scopus 로고    scopus 로고
    • The teratogenic risk of antiepileptic drug polytherapy
    • Vajda FJ, Hitchcock AA, Graham J, et al. The teratogenic risk of antiepileptic drug polytherapy. Epilepsia. 2010;51(5):805–810.
    • (2010) Epilepsia , vol.51 , Issue.5 , pp. 805-810
    • Vajda, F.J.1    Hitchcock, A.A.2    Graham, J.3
  • 35
    • 79958171026 scopus 로고    scopus 로고
    • Final results from 18 years of the International Lamotrigine Pregnancy Registry
    • Cunnington MC, Weil JG, Messenheimer JA, et al. Final results from 18 years of the International Lamotrigine Pregnancy Registry. Neurology. 2011;76:1817–1823.
    • (2011) Neurology , vol.76 , pp. 1817-1823
    • Cunnington, M.C.1    Weil, J.G.2    Messenheimer, J.A.3
  • 36
    • 0022900644 scopus 로고
    • Pharmacological studies on lamotrigine, a novel antiepileptic drug: II. Neurochemical studies on the mechanism of action
    • Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel antiepileptic drug:II. Neurochemical studies on the mechanism of action. Epilepsia. 1986;27:490–497.
    • (1986) Epilepsia , vol.27 , pp. 490-497
    • Leach, M.J.1    Marden, C.M.2    Miller, A.A.3
  • 37
    • 0026443902 scopus 로고
    • An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
    • Cheung H, Kamp D, Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res. 1992;13:107–112.
    • (1992) Epilepsy Res , vol.13 , pp. 107-112
    • Cheung, H.1    Kamp, D.2    Harris, E.3
  • 38
    • 0027310109 scopus 로고
    • Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex
    • Lees G, Leach MJ. Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex. Brain Res. 1993;612:190–199.
    • (1993) Brain Res , vol.612 , pp. 190-199
    • Lees, G.1    Leach, M.J.2
  • 39
    • 0030594562 scopus 로고    scopus 로고
    • Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications
    • Stefani A, Spadoni F, Siniscalchi A, et al. Lamotrigine inhibits Ca2+ currents in cortical neurons:functional implications. Eur J Pharmacol. 1996;307:113–116.
    • (1996) Eur J Pharmacol , vol.307 , pp. 113-116
    • Stefani, A.1    Spadoni, F.2    Siniscalchi, A.3
  • 41
    • 0031000788 scopus 로고    scopus 로고
    • Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin and topiramate against human absence seizures
    • Hosford DA, Wang Y. Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin and topiramate against human absence seizures. Epilepsia. 1997;38(4):408–414.
    • (1997) Epilepsia , vol.38 , Issue.4 , pp. 408-414
    • Hosford, D.A.1    Wang, Y.2
  • 42
    • 0024535118 scopus 로고
    • Effects of lamotrigine on electrically-induced after discharge duration in anaesthetized rat, dog, and marmoset
    • Wheatley PL, Miller AA. Effects of lamotrigine on electrically-induced after discharge duration in anaesthetized rat, dog, and marmoset. Epilepsia. 1989;30:34–40.
    • (1989) Epilepsia , vol.30 , pp. 34-40
    • Wheatley, P.L.1    Miller, A.A.2
  • 43
    • 0026005583 scopus 로고
    • Pharmacokinetics and safety of lamotrigine in patients with epilepsy
    • Ramsey RE, Pellock JM, Garnett WR, et al. Pharmacokinetics and safety of lamotrigine in patients with epilepsy. Epilepsy Res. 1991;10:191–200.•• Study dedicated to establish pharmacokinetics and safety of lamotrigine.
    • (1991) Epilepsy Res , vol.10 , pp. 191-200
    • Ramsey, R.E.1    Pellock, J.M.2    Garnett, W.R.3
  • 44
    • 0002961461 scopus 로고
    • Lamotrigine: absorption, distribution, and excretion
    • Levy R.H., Mattson R.H., Meldrum B.S., (eds), 4th, NY, USA: Raven Press
    • Parsons DN, Dickins M, Morley TJ. Lamotrigine:absorption, distribution, and excretion. In:Levy RH, Mattson RH, Meldrum BS, Editors. Antiepileptic Drugs. 4th ed. NY, USA:Raven Press; 1995. p. 877–881.
    • (1995) Antiepileptic Drugs , pp. 877-881
    • Parsons, D.N.1    Dickins, M.2    Morley, T.J.3
  • 45
    • 0029852003 scopus 로고    scopus 로고
    • Lamotrigine–an Update
    • Martin JB. Lamotrigine–an Update. Can J Neurol Sci. 1996;23(Suppl 2):S6–S9.
    • (1996) Can J Neurol Sci , vol.23 , pp. S6-S9
    • Martin, J.B.1
  • 47
    • 84996436430 scopus 로고    scopus 로고
    • Available from, cited, Sep
    • Lamotrigine. Available from:http://www.drugbank.ca/drugs/DB00555 [cited 2016 Sep 07].
    • (2016)
  • 48
    • 0025879343 scopus 로고
    • Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, lamotrigine
    • Doig MV, Clare RA. Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, lamotrigine. J Chromatogr. 1991;554:181–189.
    • (1991) J Chromatogr , vol.554 , pp. 181-189
    • Doig, M.V.1    Clare, R.A.2
  • 49
    • 0026539337 scopus 로고
    • Sodium valproate acutely inhibits lamotrigine metabolism
    • Yuen AWC, Land G, Weatherley BC, et al. Sodium valproate acutely inhibits lamotrigine metabolism. Br J Clin Pharmacol. 1992;33:511–513.
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 511-513
    • Yuen, A.W.C.1    Land, G.2    Weatherley, B.C.3
  • 50
    • 0001967224 scopus 로고
    • Lamotrigine: interactions with other drugs
    • Levy R.H., Mattson R.H., Meldrum B.S., (eds), 4th, NY, USA: Raven Press
    • Yuen AWC. Lamotrigine:interactions with other drugs. In:Levy RH, Mattson RH, Meldrum BS, Editors. Antiepileptic Drugs. 4th ed. NY, USA:Raven Press; 1995. p. 883–887.
    • (1995) Antiepileptic Drugs , pp. 883-887
    • Yuen, A.W.C.1
  • 51
    • 0024453369 scopus 로고
    • Double-blind cross-over trial of Lamictal (lamotrigine) as add-on therapy in intractable epilepsy
    • Binnie CD, Debets RMC, Engelsman M, et al. Double-blind cross-over trial of Lamictal (lamotrigine) as add-on therapy in intractable epilepsy. Epilepsy Res. 1989;4:222–229.
    • (1989) Epilepsy Res , vol.4 , pp. 222-229
    • Binnie, C.D.1    Debets, R.M.C.2    Engelsman, M.3
  • 52
    • 0024335018 scopus 로고
    • Controlled trial of Lamictal (lamotrigine) for refractory partial seizures
    • Jawad S, Richens A, Goodwin G, et al. Controlled trial of Lamictal (lamotrigine) for refractory partial seizures. Epilepsia. 1989;30:356–363.
    • (1989) Epilepsia , vol.30 , pp. 356-363
    • Jawad, S.1    Richens, A.2    Goodwin, G.3
  • 53
    • 0025122852 scopus 로고
    • A randomised double-blind placebo controlled add-on trial of Lamictal in patients with severe epilepsy
    • Sander J, Patsalos PN, Oxley JR, et al. A randomised double-blind placebo controlled add-on trial of Lamictal in patients with severe epilepsy. Epilepsy Res. 1990;6:221–226.
    • (1990) Epilepsy Res , vol.6 , pp. 221-226
    • Sander, J.1    Patsalos, P.N.2    Oxley, J.R.3
  • 54
    • 0025087187 scopus 로고
    • A randomised double-blind placebocontrolled cross-over add-on trial of Lamictal in patients with treatmentresistant partial seizures
    • Loiseau P, Yuen AWC, Douche B, et al. A randomised double-blind placebocontrolled cross-over add-on trial of Lamictal in patients with treatmentresistant partial seizures. Epilepsy Res. 1990;7:136–145.
    • (1990) Epilepsy Res , vol.7 , pp. 136-145
    • Loiseau, P.1    Yuen, A.W.C.2    Douche, B.3
  • 55
    • 0027254062 scopus 로고
    • Double-blind placebo-controlled cross-over study of lamotrigine in treatment-resistant partial seizures
    • Schapel GJ, Beran RG, Vajda FJE, et al. Double-blind placebo-controlled cross-over study of lamotrigine in treatment-resistant partial seizures. J Neurol Neurosurg Psychiatry. 1993;56:448–453.
    • (1993) J Neurol Neurosurg Psychiatry , vol.56 , pp. 448-453
    • Schapel, G.J.1    Beran, R.G.2    Vajda, F.J.E.3
  • 56
    • 74949138710 scopus 로고    scopus 로고
    • Drug interactions involving the new second- and third-generation antiepileptic drugs
    • Johannessen LC, Patsalos PN. Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Rev Neurother. 2010;10:119–140.•• A good study focusing on second- and third-generation antiepileptic drug interactions.
    • (2010) Expert Rev Neurother , vol.10 , pp. 119-140
    • Johannessen, L.C.1    Patsalos, P.N.2
  • 57
    • 33748684235 scopus 로고    scopus 로고
    • Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    • Contin M, Albani F, Ambrosetto G, et al. Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy. Epilepsia. 2006;47:1573–1575.
    • (2006) Epilepsia , vol.47 , pp. 1573-1575
    • Contin, M.1    Albani, F.2    Ambrosetto, G.3
  • 58
    • 33847667999 scopus 로고    scopus 로고
    • Oral contraceptives induce lamotrigine metabolism: evidence from a double-blind, placebo-controlled trial
    • Christensen J, Petrenaite V, Atterman J, et al. Oral contraceptives induce lamotrigine metabolism:evidence from a double-blind, placebo-controlled trial. Epilepsia. 2007;48:484–489.
    • (2007) Epilepsia , vol.48 , pp. 484-489
    • Christensen, J.1    Petrenaite, V.2    Atterman, J.3
  • 59
    • 0033674051 scopus 로고    scopus 로고
    • Effects of steadystate bupropion on the pharmacokinetics of lamotrigine in healthy subjects
    • Odishaw J, Chen C. Effects of steadystate bupropion on the pharmacokinetics of lamotrigine in healthy subjects. Pharmacotherapy. 2000;20:1448–1453.
    • (2000) Pharmacotherapy , vol.20 , pp. 1448-1453
    • Odishaw, J.1    Chen, C.2
  • 60
    • 0025009830 scopus 로고
    • Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine
    • Depot M, Powell JR, Messenheimer JA, et al. Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine. Clin Pharmacol Ther. 1990;48:346–355.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 346-355
    • Depot, M.1    Powell, J.R.2    Messenheimer, J.A.3
  • 62
    • 0026742049 scopus 로고
    • Lamotrigine: preliminary clinical observations on pharmacokinetics and interactions with traditional antiepileptic drugs
    • Wolf P. Lamotrigine:preliminary clinical observations on pharmacokinetics and interactions with traditional antiepileptic drugs. J Epilepsy. 1992;5:73–79.
    • (1992) J Epilepsy , vol.5 , pp. 73-79
    • Wolf, P.1
  • 63
    • 0025776405 scopus 로고
    • Could lamotrigine be useful in status epilepticus? A case report
    • Pisani F, Gallito G, Di Perri R. Could lamotrigine be useful in status epilepticus? A case report. J Neurol Neurosurg Psychiatry. 1991;54:845–846.• A study describing lamotrigine and its use in status epilepticus.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 845-846
    • Pisani, F.1    Gallito, G.2    Di Perri, R.3
  • 64
    • 0028101030 scopus 로고
    • Lamotrigine versus other antiepileptic drugs: a star rating system is born
    • Brodie MJ. Lamotrigine versus other antiepileptic drugs:a star rating system is born. Epilepsia. 1994;35(suppl 5):S41–S46.
    • (1994) Epilepsia , vol.35 , pp. S41-S46
    • Brodie, M.J.1
  • 65
    • 0001792563 scopus 로고
    • Effect of lamotrigine on the pharmacology of the combined oral contraceptive pill
    • Holdish T, Whiteman P, Orme M, et al. Effect of lamotrigine on the pharmacology of the combined oral contraceptive pill. Epilepsia. 1991;32(Suppl. 5):173(Abstract).
    • (1991) Epilepsia , vol.32
    • Holdish, T.1    Whiteman, P.2    Orme, M.3
  • 66
    • 77949408596 scopus 로고    scopus 로고
    • Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives
    • Doodipala SR. Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. Expert Rev Clin Pharmacol. 2010;3(2):183–192.
    • (2010) Expert Rev Clin Pharmacol , vol.3 , Issue.2 , pp. 183-192
    • Doodipala, S.R.1
  • 67
    • 0026645920 scopus 로고
    • Multiorgan failure and disseminated intravascular coagulation in severe convulsive seizures
    • Yuen AWC, Bihari DJ. Multiorgan failure and disseminated intravascular coagulation in severe convulsive seizures. Lancet. 1992;340:618.
    • (1992) Lancet , vol.340 , pp. 618
    • Yuen, A.W.C.1    Bihari, D.J.2
  • 68
    • 0028933226 scopus 로고
    • Rechallenge with lamotrigine after initial rash
    • Tavernor SJ, Wong ICK, Newton R, et al. Rechallenge with lamotrigine after initial rash. Seizure. 1995;4:67–71.
    • (1995) Seizure , vol.4 , pp. 67-71
    • Tavernor, S.J.1    Wong, I.C.K.2    Newton, R.3
  • 69
    • 84970852950 scopus 로고
    • Leucopenia associated with lamotrigine
    • Nicholson RJ, Kelly KP, Grant IS. Leucopenia associated with lamotrigine. Bmj. 1995;310(6978):504.
    • (1995) Bmj , vol.310 , Issue.6978 , pp. 504
    • Nicholson, R.J.1    Kelly, K.P.2    Grant, I.S.3
  • 70
    • 0023038693 scopus 로고
    • The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy
    • Jawad S, Oxley J, Yuen WC, et al. The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. Br J Clin Pharmacol. 1986;22:191–193.
    • (1986) Br J Clin Pharmacol , vol.22 , pp. 191-193
    • Jawad, S.1    Oxley, J.2    Yuen, W.C.3
  • 71
    • 0028268250 scopus 로고
    • Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial
    • Messenheimer J, Ramsay RE, Willmore LJ, et al. Lamotrigine therapy for partial seizures:a multicenter, placebo-controlled, double-blind, cross-over trial. Epilepsia. 1994;35:113–121.
    • (1994) Epilepsia , vol.35 , pp. 113-121
    • Messenheimer, J.1    Ramsay, R.E.2    Willmore, L.J.3
  • 72
    • 0027534819 scopus 로고
    • Outcomes of add-on treatment with lamotrigine in partial epilepsy
    • Smith D, Baker G, Davies G, et al. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia. 1993;34:312–322.
    • (1993) Epilepsia , vol.34 , pp. 312-322
    • Smith, D.1    Baker, G.2    Davies, G.3
  • 73
    • 0029616551 scopus 로고
    • Lamotrigine for the treatment of epilepsy in childhood
    • Besag FM, Wallace SJ, Dulac O, et al. Lamotrigine for the treatment of epilepsy in childhood. J Pediatr. 1995;127:991–997.
    • (1995) J Pediatr , vol.127 , pp. 991-997
    • Besag, F.M.1    Wallace, S.J.2    Dulac, O.3
  • 74
    • 0031414153 scopus 로고    scopus 로고
    • Lamotrigine in absence and primary generalized epilepsies
    • Mikati MA, Holmes GL. Lamotrigine in absence and primary generalized epilepsies. J Child Neurol. 1997;12:S29–37.
    • (1997) J Child Neurol , vol.12 , pp. S29-S37
    • Mikati, M.A.1    Holmes, G.L.2
  • 75
    • 0031453973 scopus 로고    scopus 로고
    • Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group
    • Motte J, Trevathan E, Arvidsson JF, et al. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group. N Engl J Med. 1997;337:1807–1812.
    • (1997) N Engl J Med , vol.337 , pp. 1807-1812
    • Motte, J.1    Trevathan, E.2    Arvidsson, J.F.3
  • 76
    • 0026572381 scopus 로고
    • Lamotrigine in primary generalised epilepsy
    • Timmings PL, Richens A. Lamotrigine in primary generalised epilepsy. Lancet. 1992;339:1300–1301.
    • (1992) Lancet , vol.339 , pp. 1300-1301
    • Timmings, P.L.1    Richens, A.2
  • 77
    • 0027094188 scopus 로고
    • Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome
    • Timmings PL, Richens A. Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol. 1992;32:305–307.
    • (1992) Eur Neurol , vol.32 , pp. 305-307
    • Timmings, P.L.1    Richens, A.2
  • 79
    • 4244014950 scopus 로고
    • Controlled trial of lamotrigine (Lamictal) for the treatment-resistant partial epilepsy
    • Boas J, Cooke EA, Yuen WAC. Controlled trial of lamotrigine (Lamictal) for the treatment-resistant partial epilepsy. Epilepsia. 1995;35:S113.
    • (1995) Epilepsia , vol.35 , pp. S113
    • Boas, J.1    Cooke, E.A.2    Yuen, W.A.C.3
  • 80
    • 0036711702 scopus 로고    scopus 로고
    • Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy
    • Brodie MJ, Anhut H, Murray G, et al. Gabapentin versus lamotrigine monotherapy:a double-blind comparison in newly diagnosed epilepsy. Epilepsia. 2002;43(9):993–1000.
    • (2002) Epilepsia , vol.43 , Issue.9 , pp. 993-1000
    • Brodie, M.J.1    Anhut, H.2    Murray, G.3
  • 81
    • 33947228816 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
    • Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy:an unblinded randomised controlled trial. Lancet. 2007;369:1016–1026.
    • (2007) Lancet , vol.369 , pp. 1016-1026
    • Marson, A.G.1    Al-Kharusi, A.M.2    Alwaidh, M.3
  • 82
    • 33947241772 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
    • Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy:an unblinded randomised controlled trial. Lancet. 2007;369:1000–1015.
    • (2007) Lancet , vol.369 , pp. 1000-1015
    • Marson, A.G.1    Al-Kharusi, A.M.2    Alwaidh, M.3
  • 83
    • 84936845969 scopus 로고    scopus 로고
    • Valproate in the treatment of epilepsy in girls and women of childbearing potential
    • Tomson T, Marson A, Boon P, et al. Valproate in the treatment of epilepsy in girls and women of childbearing potential. Epilepsia. 2015;56:1006–1019.
    • (2015) Epilepsia , vol.56 , pp. 1006-1019
    • Tomson, T.1    Marson, A.2    Boon, P.3
  • 85
    • 84955237505 scopus 로고    scopus 로고
    • Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug. [Internet]
    • Tomson T, Dina B, Emilio P. Valproic acid after five decades of use in epilepsy:time to reconsider the indications of a time-honoured drug. [Internet]. Lancet Neurol. 2015.doi:10.1016/S1474-4422(15)00314-2
    • (2015) Lancet Neurol
    • Tomson, T.1    Dina, B.2    Emilio, P.3
  • 86
    • 84902250496 scopus 로고    scopus 로고
    • Lamotrigine extended-release as adjunctive therapy with optional conversion to monotherapy in older adults with epilepsy
    • Wechsler RT, Leroy R, Van CA. Lamotrigine extended-release as adjunctive therapy with optional conversion to monotherapy in older adults with epilepsy. Epilepsy Res. 2014;108(6):1128–1136.
    • (2014) Epilepsy Res , vol.108 , Issue.6 , pp. 1128-1136
    • Wechsler, R.T.1    Leroy, R.2    Van, C.A.3
  • 87
    • 84940892669 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: use of stable isotope methodology
    • Akshanth RP, Rory PR, Richard CB, et al. Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients:use of stable isotope methodology. J Clin Pharmacol. 2015;55(10):1101–1108.
    • (2015) J Clin Pharmacol , vol.55 , Issue.10 , pp. 1101-1108
    • Akshanth, R.P.1    Rory, P.R.2    Richard, C.B.3
  • 88
    • 84856611764 scopus 로고    scopus 로고
    • Lamotrigine XR conversion to monotherapy: first study using a historical control group
    • French JA, Temkin N, Shneker BF, et al. Lamotrigine XR conversion to monotherapy:first study using a historical control group. Neurotherapeutics. 2012;9:176–184.
    • (2012) Neurotherapeutics , vol.9 , pp. 176-184
    • French, J.A.1    Temkin, N.2    Shneker, B.F.3
  • 89
    • 84877016242 scopus 로고    scopus 로고
    • Long-term tolerability and safety of lamotrigine extended-release: pooled analysis of three clinical trials
    • Victor B, Bassel FS, Dean N, et al. Long-term tolerability and safety of lamotrigine extended-release:pooled analysis of three clinical trials. Clin Drug Investig. 2013;33:359–364.
    • (2013) Clin Drug Investig , vol.33 , pp. 359-364
    • Victor, B.1    Bassel, F.S.2    Dean, N.3
  • 90
    • 0028217246 scopus 로고
    • Lamotrigine in the treatment of 120 children with epilepsy
    • Schlumberger E, Chavez F, Palacios L, et al. Lamotrigine in the treatment of 120 children with epilepsy. Epilepsia. 1994;35(2):359–367.
    • (1994) Epilepsia , vol.35 , Issue.2 , pp. 359-367
    • Schlumberger, E.1    Chavez, F.2    Palacios, L.3
  • 92
    • 0028915290 scopus 로고
    • Lamotrigine as an add-on drug in typical absence seizures
    • Ferrie CD, Robinson RO, Knott C, et al. Lamotrigine as an add-on drug in typical absence seizures. Acta Neurol Scand. 1995;91(3):200–202.
    • (1995) Acta Neurol Scand , vol.91 , Issue.3 , pp. 200-202
    • Ferrie, C.D.1    Robinson, R.O.2    Knott, C.3
  • 93
    • 0033051765 scopus 로고    scopus 로고
    • Lamictal (lamotrigine) monotherapy for typical absence seizures in children
    • Frank LM, Enlow T, Holmes GL, et al. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia. 1999;40(7):973–979.
    • (1999) Epilepsia , vol.40 , Issue.7 , pp. 973-979
    • Frank, L.M.1    Enlow, T.2    Holmes, G.L.3
  • 95
    • 84978427231 scopus 로고    scopus 로고
    • Guideline conform initial monotherapy increases in patients with focal epilepsy: a population based study on German health insurance data
    • Ertl J, Hapfelmeier J, Peckmann T, et al. Guideline conform initial monotherapy increases in patients with focal epilepsy:a population based study on German health insurance data. Seizure. 2016;41:9–15.
    • (2016) Seizure , vol.41 , pp. 9-15
    • Ertl, J.1    Hapfelmeier, J.2    Peckmann, T.3
  • 96
    • 0345073529 scopus 로고    scopus 로고
    • Broad spectrum activity of lamotrigine monotherapy in patients with juvenile myoclonic epilepsy
    • Morris G, Schimschock J, Vuong A, et al. Broad spectrum activity of lamotrigine monotherapy in patients with juvenile myoclonic epilepsy. Epilepsia. 2000;41(Suppl. 7):90.
    • (2000) Epilepsia , vol.41 , pp. 90
    • Morris, G.1    Schimschock, J.2    Vuong, A.3
  • 97
    • 0344211306 scopus 로고    scopus 로고
    • Lamotrigine therapy in patients with juvenile myoclonic epilepsy and valproate-related progressive weight gain
    • Kivity S, Rechtman E. Lamotrigine therapy in patients with juvenile myoclonic epilepsy and valproate-related progressive weight gain. Epilepsia. 2001;42(Suppl. 4):41.
    • (2001) Epilepsia , vol.42 , pp. 41
    • Kivity, S.1    Rechtman, E.2
  • 98
    • 0344642832 scopus 로고    scopus 로고
    • Efficacy of lamotrigine in children with juvenile myoclonic epilepsy
    • Mandelbaum DE, Venkatasubramanian A, Kugler SL. Efficacy of lamotrigine in children with juvenile myoclonic epilepsy. Epilepsia. 1999;40(Suppl. 7):133–134.
    • (1999) Epilepsia , vol.40 , pp. 133-134
    • Mandelbaum, D.E.1    Venkatasubramanian, A.2    Kugler, S.L.3
  • 99
    • 0022409205 scopus 로고
    • Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam
    • Cohen AF, Ashby L, Crowley D, et al. Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam. Br J Clin Pharmacol. 1985;20:619–629.
    • (1985) Br J Clin Pharmacol , vol.20 , pp. 619-629
    • Cohen, A.F.1    Ashby, L.2    Crowley, D.3
  • 100
    • 69549091810 scopus 로고    scopus 로고
    • A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder
    • Reich DB, Zanarini MC, Bieri KA. A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder. Int Clin Psychopharmacol. 2009;24:270–275.
    • (2009) Int Clin Psychopharmacol , vol.24 , pp. 270-275
    • Reich, D.B.1    Zanarini, M.C.2    Bieri, K.A.3
  • 101
    • 18844404957 scopus 로고    scopus 로고
    • Lamotrigine treatment of aggression in female borderline-patients: a randomized, double-blind, placebo-controlled study
    • Tritt K, Nickel C, Lahmann C, et al. Lamotrigine treatment of aggression in female borderline-patients:a randomized, double-blind, placebo-controlled study. J Psychopharmacol. 2005;19:287–291.
    • (2005) J Psychopharmacol , vol.19 , pp. 287-291
    • Tritt, K.1    Nickel, C.2    Lahmann, C.3
  • 102
    • 67649274340 scopus 로고    scopus 로고
    • A double-blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive
    • Glick ID, Bosch J, Casey DE. A double-blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive. J Clin Psychopharmacol. 2009;29:267–271.
    • (2009) J Clin Psychopharmacol , vol.29 , pp. 267-271
    • Glick, I.D.1    Bosch, J.2    Casey, D.E.3
  • 103
    • 78651307268 scopus 로고    scopus 로고
    • Lamotrigine in the immediate treatment of outpatients with depersonalization disorder without psychiatric comorbidity: randomized, double-blind, placebo-controlled study
    • Aliyev NA, Aliyev ZN. Lamotrigine in the immediate treatment of outpatients with depersonalization disorder without psychiatric comorbidity:randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2011;31:61–65.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 61-65
    • Aliyev, N.A.1    Aliyev, Z.N.2
  • 104
    • 0033135984 scopus 로고    scopus 로고
    • A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder
    • Hertzberg MA, Butterfield MI, Feldman ME, et al. A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol Psychiatry. 1999;45:1226–1229.
    • (1999) Biol Psychiatry , vol.45 , pp. 1226-1229
    • Hertzberg, M.A.1    Butterfield, M.I.2    Feldman, M.E.3
  • 105
    • 0035321893 scopus 로고    scopus 로고
    • Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebo-controlled trial
    • Belsito KM, Law PA, Kirk KS, et al. Lamotrigine therapy for autistic disorder:a randomized, double-blind, placebo-controlled trial. J Autism Dev Disord. 2001;31:175–181.
    • (2001) J Autism Dev Disord , vol.31 , pp. 175-181
    • Belsito, K.M.1    Law, P.A.2    Kirk, K.S.3
  • 106
    • 20144370003 scopus 로고    scopus 로고
    • A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence
    • Berger SP, Winhusen TM, Somoza EC, et al. A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence. Addiction. 2005;100:58–67.
    • (2005) Addiction , vol.100 , pp. 58-67
    • Berger, S.P.1    Winhusen, T.M.2    Somoza, E.C.3
  • 107
    • 0002319698 scopus 로고    scopus 로고
    • Lack of neuropsychological effects of lamotrigine compared to carbamazepine as monotherapy
    • Brodie MJ, Read CL, Gillham R, et al. Lack of neuropsychological effects of lamotrigine compared to carbamazepine as monotherapy. Epilepsia. 1999;40(suppl 2):94.
    • (1999) Epilepsia , vol.40 , pp. 94
    • Brodie, M.J.1    Read, C.L.2    Gillham, R.3
  • 108
    • 0034890813 scopus 로고    scopus 로고
    • Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat
    • Halonen T, Nissinen J, Pitkanen A. Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat. Epilepsy Res. 2001;46:205–223.• Studies dedicated to lamotrigine and its effect on status epilepticus-induced neuronal damage and memory impairment in rat.
    • (2001) Epilepsy Res , vol.46 , pp. 205-223
    • Halonen, T.1    Nissinen, J.2    Pitkanen, A.3
  • 109
    • 0342618284 scopus 로고    scopus 로고
    • Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest
    • Crumrine CR, Bergstrand K, Cooper AT. Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest. Stroke. 1997;28:2230–2237.
    • (1997) Stroke , vol.28 , pp. 2230-2237
    • Crumrine, C.R.1    Bergstrand, K.2    Cooper, A.T.3
  • 110
    • 0032192326 scopus 로고    scopus 로고
    • Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method
    • Yang Y, Shuaib A, Li Q. Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method. J Neurosci Methods. 1998;84(1–2):9–16.
    • (1998) J Neurosci Methods , vol.84 , Issue.1-2 , pp. 9-16
    • Yang, Y.1    Shuaib, A.2    Li, Q.3
  • 111
    • 45749126167 scopus 로고    scopus 로고
    • Antiepileptic drugs in pregnancy and lactation
    • Lander CM. Antiepileptic drugs in pregnancy and lactation. Aust Prescriber. 2008;31:70–72.
    • (2008) Aust Prescriber , vol.31 , pp. 70-72
    • Lander, C.M.1
  • 112
    • 84855193549 scopus 로고    scopus 로고
    • Teratogenicity of the newer antiepileptic drugs–the Australian experience
    • Vajda FJ, Graham J, Roten A, et al. Teratogenicity of the newer antiepileptic drugs–the Australian experience. J Clin Neurosci. 2012;19:57–59.
    • (2012) J Clin Neurosci , vol.19 , pp. 57-59
    • Vajda, F.J.1    Graham, J.2    Roten, A.3
  • 113
    • 0000291655 scopus 로고
    • Anticonvulsant side-effects: a self report questionnaire for use in community surveys
    • Brown SW, Tomlinson LL. Anticonvulsant side-effects:a self report questionnaire for use in community surveys. Br J Clin Pract. 1982;18:147–149.
    • (1982) Br J Clin Pract , vol.18 , pp. 147-149
    • Brown, S.W.1    Tomlinson, L.L.2
  • 114
    • 0029896518 scopus 로고    scopus 로고
    • Standardisation of a self-report questionnaire for use in evaluating cognitive, affective and behavioural side-effects of anti-epileptic drug treatments
    • Gillham R, Baker G, Thompson P, et al. Standardisation of a self-report questionnaire for use in evaluating cognitive, affective and behavioural side-effects of anti-epileptic drug treatments. Epilepsy Res. 1996;24:47–55.
    • (1996) Epilepsy Res , vol.24 , pp. 47-55
    • Gillham, R.1    Baker, G.2    Thompson, P.3
  • 115
    • 0007395007 scopus 로고
    • Quality of life improvement in patients treated with lamotrigine compared with valproate
    • Bryant-Comstock L, Kane K, Moorat A. Quality of life improvement in patients treated with lamotrigine compared with valproate. Epilepsia. 1990;40(suppl 9):98.
    • (1990) Epilepsia , vol.40 , pp. 98
    • Bryant-Comstock, L.1    Kane, K.2    Moorat, A.3
  • 116
    • 0032950428 scopus 로고    scopus 로고
    • Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin
    • Steiner TJ, Dellaportas CI, Findley LJ, et al. Lamotrigine monotherapy in newly diagnosed untreated epilepsy:a double-blind comparison with phenytoin. Epilepsia. 1999;40(5):601–607.
    • (1999) Epilepsia , vol.40 , Issue.5 , pp. 601-607
    • Steiner, T.J.1    Dellaportas, C.I.2    Findley, L.J.3
  • 117
    • 0842304131 scopus 로고    scopus 로고
    • Effect of epilepsy and antiepileptic drugs on male reproductive health
    • Isojarvi JI, Lofgren E, Juntunen KS, et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology. 2004;62:247–253.
    • (2004) Neurology , vol.62 , pp. 247-253
    • Isojarvi, J.I.1    Lofgren, E.2    Juntunen, K.S.3
  • 118
    • 0034864141 scopus 로고    scopus 로고
    • Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy
    • Stephen LJ, Kwan P, Shapiro D, et al. Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy. Epilepsia. 2001;42(8):1002–1006.
    • (2001) Epilepsia , vol.42 , Issue.8 , pp. 1002-1006
    • Stephen, L.J.1    Kwan, P.2    Shapiro, D.3
  • 119
    • 0026297623 scopus 로고
    • Human safety of lamotrigine
    • Betts T, Goodwin G, Withers RM, et al. Human safety of lamotrigine. Epilepsia. 1991;32(Suppl. 2):S17–S21.
    • (1991) Epilepsia , vol.32 , pp. S17-S21
    • Betts, T.1    Goodwin, G.2    Withers, R.M.3
  • 120
    • 34447312716 scopus 로고    scopus 로고
    • Idiosyncratic adverse reactions to antiepileptic drugs
    • Gaetano Z, Diego F, Emilio P. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia. 2007;48(7):1223–1244.
    • (2007) Epilepsia , vol.48 , Issue.7 , pp. 1223-1244
    • Gaetano, Z.1    Diego, F.2    Emilio, P.3
  • 121
    • 84871447367 scopus 로고    scopus 로고
    • Utility of plasma lamotrigine concentrations. Concept of the plasma therapeutic range for individual patients. Annual scientific meeting of European Neurological Society, Milan
    • Jun
    • Vajda FJ, Angelis-Stoforidis P, Eadie MJ. Utility of plasma lamotrigine concentrations. Concept of the plasma therapeutic range for individual patients. Annual scientific meeting of European Neurological Society, Milan. J Neurol. 1999 [1999 Jun5–10];246(Suppl. 1):196.
    • (1999) J Neurol , vol.246 , pp. 196
    • Vajda, F.J.1    Angelis-Stoforidis, P.2    Eadie, M.J.3
  • 122
    • 23944520609 scopus 로고    scopus 로고
    • Individual changes in lamotrigine plasma concentrations during pregnancy
    • Petrenaite V, Sabers A, Hansen-Schwartz J. Individual changes in lamotrigine plasma concentrations during pregnancy. Epilepsy Res. 2005;65:185–188.
    • (2005) Epilepsy Res , vol.65 , pp. 185-188
    • Petrenaite, V.1    Sabers, A.2    Hansen-Schwartz, J.3
  • 123
    • 0031753931 scopus 로고    scopus 로고
    • Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service
    • Morris RG, Black AB, Harris A, et al. Lamotrigine and therapeutic drug monitoring:retrospective survey following the introduction of a routine service. Br J Clin Pharmacol. 1998;46:547–551.
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 547-551
    • Morris, R.G.1    Black, A.B.2    Harris, A.3


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