Lamotrigine in the treatment of binge-eating disorder with obesity: A randomized, placebo-controlled monotherapy trial

International Clinical Psychopharmacology

Volumn 24, Issue 3, 2009, Pages 150-158

  Guerdjikova, Anna I ^a   McElroy, Susan L ^a   Welge, Jeffrey A ^a   Nelson, Erik ^a   Keck, Paul E ^a,b   Hudson, James I ^c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MCLEAN HOSPITAL   (United States)

Author keywords

Binge eating disorder; Lamotrigine; Obesity; Randomized clinical trial

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; LAMOTRIGINE; LEPTIN; PLACEBO; TRIACYLGLYCEROL; TRANQUILIZER; TRIAZINE DERIVATIVE;

ADULT; AGED; ARTICLE; BINGE EATING DISORDER; BODY MASS; BODY WEIGHT; CLINICAL EVALUATION; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIARRHEA; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; FATIGUE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IMPULSIVENESS; INSOMNIA; INSULIN BLOOD LEVEL; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORNING DOSAGE; OBESITY; OBSESSIVE COMPULSIVE DISORDER; OUTCOME ASSESSMENT; OUTPATIENT; PATHOLOGY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; REDUCTION; SEXUAL FUNCTION; SIDE EFFECT; SINUSITIS; SOMNOLENCE; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT REFUSAL; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; XEROSTOMIA; ADOLESCENT; BLOOD; BULIMIA; DRUG EFFECT; MIDDLE AGED; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE;

ADOLESCENT; ADULT; AGED; ANTIMANIC AGENTS; BODY MASS INDEX; BULIMIA NERVOSA; DOUBLE-BLIND METHOD; FEMALE; GHRELIN; HUMANS; IMPULSIVE BEHAVIOR; LEPTIN; MALE; MIDDLE AGED; OBESITY; OBSESSIVE-COMPULSIVE DISORDER; PSYCHIATRIC STATUS RATING SCALES; TREATMENT OUTCOME; TRIAZINES; WEIGHT LOSS; YOUNG ADULT;

EID: 67649159500     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/YIC.0b013e328329c7b5     Document Type: Article

References (66)

1. APA (2000). Diagnostic and Statistical Manual of Mental Disorders DSM-IV.
2. Appolinario JC, Bacaltchuk J, Sichieri R, Claudino AM, Godoy-Matos A, Morgan C, et al. (2003). A randomized, double-blind, placebo-controlled study of sibutramine in the treatment of binge-eating disorder. Arch Gen Psychiatry 60:1109-1116.
3. Arnold LM, McElroy SL, Hudson JI, Welge JA, Bennett AJ, Keck PE (2002). A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder. J Clin Psychiatry 63:1028-1033.
4. Assmann G, Guerra R, Fox G, Cullen P, Schulte H, Willett D, et al. (2007). Harmonizing the definition of the metabolic syndrome: comparison of the criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations. Am J Cardiol 99:541-548.
5. Avena NM (2007). Examining the addictive-like properties of binge eating using an animal model of sugar dependence. Exp Clin Psychopharmacol 15:481-491.
6. Barbee JG, Jamhour NJ (2002). Lamotrigine as an augmentation agent in treatment-resistant depression. J Clin Psychiatry 63:737-741.
7. Barrat ES, Stanford MS (1995). Impulsiveness. In: Costello GC, editor. Impulsiveness in Personality characteristics of the personality disordered client. New York: Wiley; pp. 91-118.
8. Beghi E (2004). Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines. Lancet Neurol 3:618-621.
9. Bowden CL, Calabrese JR, Sachs G, Yatham LN, Asghar SA, Hompland M, et al. (2003). A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 60:392-400.
10. Bowden CL, Calabrese JR, Ketter TA, Sachs GS, White RL, Thompson TR (2006). Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. Am J Psychiatry 163:1199-1201.
11. Brennan BP, Roberts JL, Fogarty KV, Reynolds KA, Jonas JM, Hudson JI (2008). Memantine in the treatment of binge eating disorder: an open-label, prospective trial. Int J Eat Disord 41:520-526.
12. Calabrese JR, Bowden CL, Sachs G, Yatham LN, Behnke K, Mehtonen OP, et al. (2003). A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 64:1013-1024.
13. Calabrese JR, Huffman RF, White RL, Edwards S, Thompson TR, Ascher JA, et al. (2008). Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials. Bipolar Disord 10:323-333.
14. Carter WP, Hudson JI, Lalonde JK, Pindyck L, McElroy SL, Pope HG Jr (2003). Pharmacologic treatment of binge eating disorder. Int J Eat Disord 34 (Suppl):S74-S88.
15. Cavanna AE, Strigaro G, Monaco F (2007). Brain mechanisms underlying the placebo effect in neurological disorders. Funct Neurol 22:89-94.
16. Diederich NJ, Goetz CG (2008). The placebo treatments in neurosciences: new insights from clinical and neuroimaging studies. Neurology 71:677-684.
17. Edwards KR, Sackellares JC, Vuong A, Hammer AE, Barrett PS (2001). Lamotrigine monotherapy improves depressive symptoms in epilepsy: a double-blind comparison with valproate. Epilepsy Behav 2:28-36.
18. Ettinger AB, Kustra RP, Hammer AE (2007). Effect of lamotrigine on depressive symptoms in adult patients with epilepsy. Epilepsy Behav 10:148-154.
19. Fairburn CG, Beglin SJ (1994). Assessment of eating disorders: interview or self-report questionnaire? Int J Eat Disord 16:363-370.
20. First M, Spitzer R, Gibbon M, Williams JBW (2002). Structured Clinical Interview for DSM-IV-TR Axis I disorders, Research Version, Patient Edition (SCID-I/P). New York: Biometrics Research Department, New York State Psychiatric Institute.
21. Fitzmaurice GM, Laird NM, Ware JH (2004). Applied longitudinal analysis. Hoboken, New Jersey: John Wiley & Sons.
22. Fountoulakis KN, Vieta E (2008). Treatment of bipolar disorder: a systematic review of available data and clinical perspectives. Int J Neuropsychopharmacol 11:999-1029.
23. Friederich HC, Schild S, Schellberg D, Quenter A, Bode C, Herzog W, et al. (2006). Cardiac parasympathetic regulation in obese women with binge eating disorder. Int J Obes (Lond) 30:534-542.
24. Frye MA, Ketter TA, Kimbrell TA, Dunn RT, Speer AM, Osuch EA, et al. (2000). A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol 20:607-614.
25. Gass JT, Olive MF (2008). Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75:218-265.
26. Gibbons RD, Hedeker D, Elkin I, Waternaux C, Kraemer HC, Greenhouse JB, et al. (1993). Some conceptual and statistical issues in analysis of longitudinal psychiatric data. Application to the NIMH treatment of Depression Collaborative Research Program dataset. Arch Gen Psychiatry 50:739-750.
27. Golay A, Laurent-Jaccard A, Habicht F, Gachoud JP, Chabloz M, Kammer A, et al. (2005). Effect of orlistat in obese patients with binge eating disorder. Obes Res 13:1701-1708.
28. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, et al. (1989). The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 46:1012-1016.
29. Goodwin GM, Bowden CL, Calabrese JR, Grunze H, Kasper S, White R, et al. (2004). A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 65:432-441.
30. Grilo CM, Masheb RM, Salant SL (2005). Cognitive behavioral therapy guided self-help and orlistat for the treatment of binge eating disorder: a randomized, double-blind, placebo-controlled trial. Biol Psychiatry 57:1193-1201.
31. Grundy SM (2008). Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28:629-636.
32. Guy W (1976). ECDEU Assessment Manual for Psychopharmacology, US Department of Health, Education and Welfare publication (ADM). Rockville, Maryland: National Institute of Mental Health.
33. Hudson JI, McElroy SL, Raymond NC, Crow S, Keck PE Jr, Carter WP, et al. (1998). Fluvoxamine in the treatment of binge-eating disorder: a multicenter placebo-controlled, double-blind trial. Am J Psychiatry 155:1756-1762.
34. Hudson JI, Lalonde JK, Berry JM, Pindyck LJ, Bulik CM, Crow SJ, et al. (2006). Binge-eating disorder as a distinct familial phenotype in obese individuals. Arch Gen Psychiatry 63:313-319.
35. Hudson JI, Hiripi E, Pope HG Jr, Kessler RC (2007). The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry 61:348-358.
36. Jacobs-Pilipski MJ, Wilfley DE, Crow SJ, Walsh BT, Lilenfeld LR, West DS, et al. (2007). Placebo response in binge eating disorder. Int J Eat Disord 40:204-211.
37. Leiberich PK, Nickel MK, Tritt K, Gil FP (2008). Lamotrigine treatment of aggression in female borderline patients, Part II: an 18-month follow-up. J Psychopharmacol 22:805-808.
38. Masheb RM, Grilo CM (2006). Emotional overeating and its associations with eating disorder psychopathology among overweight patients with binge eating disorder. Int J Eat Disord 39:141-146.
39. McElroy SL, Arnold LM, Shapira NA, Keck PE Jr, Rosenthal NR, Karim MR, et al. (2003a). Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial. Am J Psychiatry 160:255-261.
40. McElroy SL, Hudson JI, Malhotra S, Welge JA, Nelson EB, Keck PE Jr (2003b). Citalopram in the treatment of binge-eating disorder: a placebo-controlled trial. J Clin Psychiatry 64:807-813.
41. McElroy SL, Kotwal R, Guerdjikova AI, Welge JA, Nelson EB, Lake KA, et al. (2006). Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial. J Clin Psychiatry 67:1897-1906.
42. McElroy SL, Guerdjikova A, Kotwal R, Welge JA, Nelson EB, Lake KA, et al. (2007a). Atomoxetine in the treatment of binge-eating disorder: a randomized placebo-controlled trial. J Clin Psychiatry 68:390-398.
43. McElroy SL, Hudson JI, Capece JA, Beyers K, Fisher AC, Rosenthal NR (2007b). Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study. Biol Psychiatry 61:1039-1048.
44. Meister B (2007). Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav 92:263-271.
45. Merideth CH (2006). A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. J Clin Psychiatry 67:258-262.
46. Modell W, Houde RW (1958). Factors influencing clinical evaluation of drugs with special reference to the double-blind method. J Am Med Assoc 167:2190-2199.
47. Montgomery SA, Asberg M (1979). A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382-389.
48. Normann C, Hummel B, Scharer LO, Horn M, Grunze H, Walden J (2002). Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study. J Clin Psychiatry 63:337-344.
49. Padwal RS, Majumdar SR (2007). Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 369:71-77.
50. Peterson CB, Miller KB, Crow SJ, Thuras P, Mitchell JE (2005). Subtypes of binge eating disorder based on psychiatric history. Int J Eat Disord 38:273-276.
51. Peterson K, McDonagh MS, Fu R (2008). Comparative benefits and harms of competing medications for adults with attention-deficit hyperactivity disorder: a systematic review and indirect comparison meta-analysis. Psychopharmacology (Berl) 197:1-11.
52. Rieger E, Wilfley DE, Stein RI, Marino V, Crow SJ (2005). A comparison of quality of life in obese individuals with and without binge eating disorder. Int J Eat Disord 37:234-240.
53. Rubio G, Lopez-Munoz F, Alamo C (2006). Effects of lamotrigine in patients with bipolar disorder and alcohol dependence. Bipolar Disord 8:289-293.
54. Schatzberg AF, Kraemer HC (2000). Use of placebo control groups in evaluating efficacy of treatment of unipolar major depression. Biol Psychiatry 47:736-744.
55. Schienle A, Schäfer A, Hermann A, Vaitl D (2008). Binge-eating disorder: reward sensitivity and brain activation to images of food. Biol Psychiatry [Epub ahead of print]
56. Sheehan DV, Harnett-Sheehan K, Raj BA (1996). The measurement of disability. Int Clin Psychopharmacol 11 (Suppl 3):89-95.
57. Stanley BG, Willett VL III, Donias HW, Dee MG II, Duva MA (1996). Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. Am J Physiol 270:R443-R449.
58. Stunkard A, Messick S (1988). Eating Inventory Manual. San Antonio: The Psychological Corporation, Harcourt Brace & Company.
59. Sysko R, Walsh BT (2007). A systematic review of placebo response in studies of bipolar mania. J Clin Psychiatry 68:1213-1217.
60. Thongkhao-on K, Wirtshafter D, Shippy SA (2008). Feeding specific glutamate surge in the rat lateral hypothalamus revealed by low-flow push-pull perfusion. Pharmacol Biochem Behav 89:591-597.
61. Tritt K, Nickel C, Lahmann C, Leiberich PK, Rother WK, Loew TH, et al. (2005). Lamotrigine treatment of aggression in female borderline-patients: a randomized, double-blind, placebo-controlled study. J Psychopharmacol 19:287-291.
62. Walsh BT, Seidman SN, Sysko R, Gould M (2002). Placebo response in studies of major depression: variable, substantial, and growing. JAMA 287: 1840-1847.
63. Wilfley DE, Crow SJ, Hudson JI, Mitchell JE, Berkowitz RI, Blakesley V, et al. (2007). Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind study. Am J Psychiatry 165:51-58.
64. Yager J (2008). Binge eating disorder: the search for better treatments. Am J Psychiatry 165:4-6.
65. Yanovski SZ, Nelson JE, Dubbert BK, Spitzer RL (1993). Association of binge eating disorder and psychiatric comorbidity in obese subjects. Am J Psychiatry 150:1472-1479.
66. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978). A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429-435.