Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: Time to screen?

Neuropediatrics

Volumn 45, Issue 4, 2014, Pages 226-233

  Rauchenzauner, Markus ^a   Roscia, Sarah ^b   Prieschl, Manuela ^b   Wildt, Ludwig ^b   Haberlandt, Edda ^b   Baumann, Matthias ^b   Rostasy, Kevin ^b   Agostinelli, Sergio ^c   Pizzolorusso, Antonella ^c   Luef, Gerhard ^b   Verrotti, Alberto ^c  

^a Saint Vincent Hospital Zams   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

AED; hyperandrogenism; pubertal females; reproductive endocrine dysfunctions

Indexed keywords

ANTICONVULSIVE AGENT; ETIRACETAM; LAMOTRIGINE; VALPROIC ACID; ENDOCRINE DISRUPTOR; PIRACETAM; TRIAZINE DERIVATIVE;

ACANTHOSIS; ADOLESCENT; AMENORRHEA; ARTICLE; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENDOCRINE DISEASE; EPILEPSY; FEMALE; HIRSUTISM; HUMAN; HYPERANDROGENISM; MENORRHAGIA; MENSTRUAL CYCLE; MENSTRUATION DISORDER; METRORRHAGIA; MONOTHERAPY; MULTICENTER STUDY (TOPIC); OBESITY; OLIGOMENORRHEA; PHYSICAL EXAMINATION; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUBERTY; QUESTIONNAIRE; REPRODUCTIVE HEALTH; SAMPLE SIZE; SCORING SYSTEM; SCREENING TEST; SEIZURE; TREATMENT DURATION; WEIGHT GAIN; ANALOGS AND DERIVATIVES; CLINICAL TRIAL; COHORT ANALYSIS; DRUG EFFECTS; DRUG SCREENING; MULTICENTER STUDY;

ADIPOSITY; ADOLESCENT; ANTICONVULSANTS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DRUG EVALUATION, PRECLINICAL; ENDOCRINE DISRUPTORS; EPILEPSY; FEMALE; HIRSUTISM; HUMANS; HYPERANDROGENISM; PIRACETAM; REPRODUCTIVE HEALTH; TRIAZINES; VALPROIC ACID;

EID: 84905236610     PISSN: 0174304X     EISSN: 14391899     Source Type: Journal    
DOI: 10.1055/s-0033-1364104     Document Type: Article

References (32)

1. Luef G., Rauchenzauner M. Epilepsy and hormones: a critical review. Epilepsy Behav: 2009; 15 1 73 77
2. Verrotti A., D'Egidio C., Mohn A., Coppola G., Parisi P., Chiarelli F. Antiepileptic drugs, sex hormones, and PCOS. Epilepsia: 2011; 52 2 199 211
3. Herzog A. G., Coleman A. E., Jacobs A. R., et al. Interictal EEG discharges, reproductive hormones, and menstrual disorders in epilepsy. Ann Neurol: 2003; 54 5 625 637 (Pubitemid 37346069)
4. Herzog A. G., Friedman M. N. Menstrual cycle interval and ovulation in women with localization-related epilepsy. Neurology: 2001; 57 11 2133 2135 (Pubitemid 33126891)
5. Herzog A. G., Seibel M. M., Schomer D. L., Vaitukaitis J. L., Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol: 1986; 43 4 341 346 (Pubitemid 16106951)
6. Bauer J. Epilepsy and prolactin in adults: a clinical review. Epilepsy Res: 1996; 24 1 1 7 (Pubitemid 26191607)
7. Bauer J., Cooper-Mahkorn D. Reproductive dysfunction in women with epilepsy: menstrual cycle abnormalities, fertility, and polycystic ovary syndrome. Int Rev Neurobiol: 2008; 83 135 155
8. Betts T., Yarrow H., Dutton N., Greenhill L., Rolfe T. A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. Seizure: 2003; 12 6 323 329 (Pubitemid 37062760)
9. Isojärvi J. I., Laatikainen T. J., Knip M., Pakarinen A. J., Juntunen K. T., Myllylä V. V. Obesity and endocrine disorders in women taking valproate for epilepsy. Ann Neurol: 1996; 39 5 579 584 (Pubitemid 26143595)
10. Isojärvi J. I., Laatikainen T. J., Pakarinen A. J., Juntunen K. T., Myllylä V. V. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med: 1993; 329 19 1383 1388 (Pubitemid 23317348)
11. Isojärvi J. I., Rättyä J., Myllylä V. V., et al. Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Ann Neurol: 1998; 43 4 446 451 (Pubitemid 28231718)
12. Isojärvi J. I., Tauboll E., Herzog A. G. Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy. CNS Drugs: 2005; 19 3 207 223 (Pubitemid 40460661)
13. Levesque L. A., Herzog A. G., Seibel M. M. The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement. J Clin Endocrinol Metab: 1986; 63 1 243 245 (Pubitemid 16093038)
14. Verrotti A., D'Egidio C., Mohn A., Coppola G., Chiarelli F. Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. Obes Rev: 2011; 12 5 e32 e43
15. Victor A., Lundberg P. O., Johansson E. D. Induction of sex hormone binding globulin by phenytoin. BMJ: 1977; 2 6092 934 935 (Pubitemid 8191258)
16. Briggs D. E., French J. A. Levetiracetam safety profiles and tolerability in epilepsy patients. Expert Opin Drug Saf: 2004; 3 5 415 424 (Pubitemid 39242716)
17. Morrell M. J., Isojärvi J., Taylor A. E., et al. Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. Epilepsy Res: 2003; 54 2-3 189 199 (Pubitemid 36776737)
18. Rauchenzauner M., Bitsche G., Svalheim S., et al. Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children-results from a pilot study. Epilepsy Res: 2010; 88 2-3 264 268
19. Svalheim S., Tauboll E., Luef G., et al. Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults. Epilepsy Behav: 2009; 16 2 281 287
20. Berg A. T., Berkovic S. F., Brodie M. J., et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia: 2010; 51 4 676 685
21. Herzog A. G., Schachter S. C. Valproate and the polycystic ovarian syndrome: final thoughts. Epilepsia: 2001; 42 3 311 315 (Pubitemid 32275907)
22. Practice Committee of the American Society for Reproductive Medicine The clinical relevance of luteal phase deficiency: a committee opinion. Fertil Steril: 2012; 98 5 1112 1117
23. Ferriman D., Gallwey J. D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab: 1961; 21 1440 1447
24. Murialdo G., Galimberti C. A., Gianelli M. V., et al. Effects of valproate, phenobarbital, and carbamazepine on sex steroid setup in women with epilepsy. Clin Neuropharmacol: 1998; 21 1 52 58 (Pubitemid 28078336)
25. Vainionpää L. K., Rättyä J., Knip M., et al. Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy. Ann Neurol: 1999; 45 4 444 450 (Pubitemid 29165810)
26. Morrell M. J., Hayes F. J., Sluss P. M., et al. Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. Ann Neurol: 2008; 64 2 200 211
27. Kwan P., Yip F. P., Hui A. C., et al. Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study. Epilepsy Behav: 2009; 14 4 610 616
28. Stephen L. J., Sills G. J., Leach J. P., et al. Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. Epilepsy Res: 2007; 75 2-3 122 129 (Pubitemid 47048653)
29. Tauboll E., Gregoraszczuk E. L., Tworzydo A., Wójtowicz A. K., Ropstad E. Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells. Epilepsia: 2006; 47 9 1580 1583 (Pubitemid 44393874)
30. Svalheim S., Tauboll E., Surdova K., et al. Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats. Seizure: 2008; 17 2 203 209
31. Gidal B. E., Sheth R. D., Magnus L., Herbeuval A. F. Levetiracetam does not alter body weight: analysis of randomized, controlled clinical trials. Epilepsy Res: 2003; 56 2-3 121 126 (Pubitemid 37464925)
32. Biton V., Mirza W., Montouris G., Vuong A., Hammer A. E., Barrett P. S. Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Neurology: 2001; 56 2 172 177 (Pubitemid 32095356)