A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder

International Clinical Psychopharmacology

Volumn 24, Issue 5, 2009, Pages 270-275

  Reich, Donald Bradford ^a   Zanarini, Mary C ^b   Bieri, Katheryn A ^b  

^a MCLEAN HOSPITAL   (United States)

^b NONE

Author keywords

Affective instability; Borderline personality disorder; Lamotrigine; Pharmacotherapy

Indexed keywords

LAMOTRIGINE; PAROXETINE; PLACEBO;

ADULT; ARTICLE; BIPOLAR DISORDER; BORDERLINE STATE; CLINICAL ARTICLE; CLINICAL TRIAL; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; HEADACHE; HUMAN; IMPULSIVENESS; INTERVIEW; IRRITABILITY; MALE; MENTAL INSTABILITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; RATING SCALE; SCORING SYSTEM; SEDATION; SIDE EFFECT; TREATMENT DURATION;

ADULT; ANTIMANIC AGENTS; BORDERLINE PERSONALITY DISORDER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MOOD DISORDERS; TRIAZINES;

EID: 69549091810     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/YIC.0b013e32832d6c2f     Document Type: Article

References (24)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association.
2. Clarkin JF, Hull JW, Hurt ST (1993). Factor structure of borderline personality criteria. J Pers Disorders 7:137-143.
3. Cowdry RW, Gardner DL (1988). Pharmacotherapy of borderline personality disorder: alprazolam, carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry 45:111-119.
4. First MB, Spitzer RL, Gibbon M, Willams JBL (1996). Structured clinical interview for axis I disorders. New York, NY: Biometric Research, New York State Psychiatric Institute.
5. Frankenburg FR, Zanarini MC (2002). Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study. J Clin Psychiatry 63:442-446.
6. Grilo CM, Shea MT, Sanislow CA, Skodol AE, Gunderson JG, Stout RL, et al. (2004). Two-year stability and change in schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders. J Consult Clin Psychol 72:767-775.
7. Harvey PD, Greenberg BR, Serper MR (1989). The affective lability scale: development, reliability, and validity. J Clin Psychol 45:786-793. (Pubitemid 19271464)
8. Hollander E, Swann AC, Coccaro EF, Jiang P, Smith TB (2005). Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder. Am J Psychiatry 162:621-624. (Pubitemid 40343936)
9. Hollingshead AB (1965). Two factor index of social position. New Haven, CT: Yale University.
10. Koenigsberg HW, Harvey PD, Mitropoulou V, New AS, Goodman M, Silverman J, et al. (2001). Are the interpersonal and identity disturbances in the borderline personality disorder criteria linked to the traits of an affective instability and impulsivity? J Pers Disorders 15:358-370.
11. Loew TH, Nickel MK, Muehlbacker M, Kaplan P, Nickel C, Kettler C, et al. (2006). Topirimate treatment for women with borderline personality disorder: a double-blind, placebo-controlled study. J Clin Psychopharmacol 26:61-66. (Pubitemid 43167093)
12. Nickel MK, Nickel C, Mitterlehner FO, Tritt K, Lahmann C, Leiberich PK, et al. (2004). Topirimate treatment of aggression in female borderline personality disorder patients: a double-blind, placebo-controlled study. J Clin Psychiatry 65:1515-1519.
13. Nickel MK, Nickel C, Kaplan P, Lahmann C, Muhlbacker M, Triitt K, et al. (2005). Treatment of aggression with topirimate in male borderline patients: a double-blind, placebo-controlled study. Biol Psychiatry 57:495-499. (Pubitemid 40311984)
14. Pinto OC, Akiskal HS (1998). Lamotrigine as a promising approach to borderline personality disorder: an open case series without concurrent DSM-IV major mood disorder. J Affect Disord 51:333-343.
15. Preston GA, Marchant BK, Remherr FW, Strong RE, Hedges DW. (2004). Borderline personality disorder in patients with bipolar disorder and response to lamotrigine. J Affect Disord 7:297-303. (Pubitemid 38340560)
16. Rinne T, van den Brink W, Wouters L, van Dyck R (2002). SSRI treatment of borderline personality disorder: a placebo-controlled clinical trial for female patients with borderline personality disorder. Am J Psychiatry 159:2048-2054. (Pubitemid 35423864)
17. Sanislow CA, Grilo CM, McGlashan TH (2000). Factor analysis of the DSM-III-R borderline personality disorder criteria in psychiatric inpatients. Am J Psychiatry 157:1629-1633.
18. Thomson PDR (2007). Physicians' desk reference. Montvale NJ: Thomson Reuters.
19. Tritt K, Nickel C, Lahmann C, Leiberich PK, Rother WK, Loew TH, Nickel MK. (2005). Lamotrigine treatment of aggression in female borderline patients: a randomized, double-blind, placebo-controlled study. J Psychopharmacol 19:287-291. (Pubitemid 40694947)
20. Weinstein W, Jamison K (2007). Retrospective case review of lamotrigine use for affective instability of borderline personality disorder. CNS Spectr 12:207-210. (Pubitemid 46555889)
21. Zanarini MC, Gunderson JG, Frankenburg FR, Chauncey DL (1989). The revised diagnostic interview for borderlines: discriminating BPD from other axis II disorders. J Personal Disord 3:10-18.
22. Zanarini MC, Frankenburg FR, Sickel AE, Yong L (1996). The diagnostic interview for DSM-IV personality disorders. Belmont, MA: McLean Hospital.
23. Zanarini MC, Frankenburg FR, Hennen J, Silk KR (2003a). The longitudinal course of borderline psychopathology: 6-year prospective follow-up of the phenomenology phenomenology of borderline personality disorder. Am J Psychiatry 160:274-283. (Pubitemid 41110452)
24. Zanarini MC, Vujanivic AA, Parachini EA, Boulanger J, Frankenburg FR, Hennen J (2003b). Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline personality psychopathology. J Pers Disord 17:233-242.