Antiepileptic drugs in pregnancy and lactation

Australian Prescriber

Volumn 31, Issue 3, 2008, Pages 70-72

  Lander, Cecilie M ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Birth defects; Folate; Valproate; Vitamin K

Indexed keywords

ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; CARBAMAZEPINE; CLONAZEPAM; ETHOSUXIMIDE; ETIRACETAM; FOLIC ACID; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PHYTOMENADIONE; PREGABALIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

AUTISM; BIRTH DEFECT; BREAST FEEDING EDUCATION; CLEFT LIP; CLEFT PALATE; COGNITIVE DEFECT; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG SAFETY; EPILEPSY; FETAL ANTICONVULSANT SYNDROME; FETUS DISEASE; FETUS MALFORMATION; HUMAN; LACTATION; LANGUAGE DISABILITY; MONOTHERAPY; PREGNANCY; RISK ASSESSMENT; SHORT SURVEY; SPINA BIFIDA; TERATOGENICITY; TREATMENT PLANNING;

EID: 45749126167     PISSN: 03128008     EISSN: None     Source Type: Journal    
DOI: 10.18773/austprescr.2008.041     Document Type: Short Survey

References (7)

1. Vinten J, Adab N, Kini U, Gorry J, Gregg J, Baker GA; Liverpool and Manchester Neurodevelopment Study Group. Neuropsychological effects of exposure to anticonvulsant medication in utero. Neurology 2005;64:949-54.
2. Choulika S, Grabowski E, Holmes LB. Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? Am J Obstet Gynecol 2004;190:882-3.
3. Vajda FJ, O'Brien TJ, Hitchcock A, Graham J, Cook M, Lander C, et al. Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 2004;11:854-8.
4. Holmes LB, Wyszynski DF, Baldwin EJ, Habecker E, Glassman LH, Smith CR. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy (abstract). Birth Defects Res A Clin Mol Teratol 2006;76:318.
5. Morrow J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8.
6. Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003;61:S35-S42.
7. Tomson T, Palm R, Kallen K, Ben-Menachem E, Soderfeldt B, Danielsson B, et al. Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia 2007;48:1111-16.