Gestational diabetes is associated with changes in placental microbiota and microbiome

Pediatric Research

Volumn 80, Issue 6, 2016, Pages 777-784

  Bassols, Judit ^a   Serino, Matteo ^b,c   Carreras Badosa, Gemma ^a   Burcelin, Rémy ^b,c   Blasco Baque, Vincent ^b,c,d   Lopez Bermejo, Abel ^a   Fernandez Real, José Manuel ^e  

^a GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^b INSERM   (France)

^c Université de Toulouse   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE; INSULIN; INTERLEUKIN 10; ITGAX PROTEIN; LIPID; MRC1MR PROTEIN; TIMP3 PROTEIN; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL RNA; RNA 16S;

ACINETOBACTER; ACTINOBACTERIA; ADULT; ARTICLE; BACTEROIDETES; BLOOD CELL COUNT; CALCIUM SIGNALING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EOSINOPHIL COUNT; FEMALE; FIRMICUTES; HUMAN; IMMUNOLOGICAL TOLERANCE; METABOLISM; MICROBIOME; MICROFLORA; NONHUMAN; PHENOTYPE; PLACENTA; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOBACTERIA; PSEUDOMONADALES; THIRD TRIMESTER PREGNANCY; CASE CONTROL STUDY; GAMMAPROTEOBACTERIA; GENE EXPRESSION; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGY; PREGNANCY;

ACINETOBACTER; ADULT; CALCIUM SIGNALING; CASE-CONTROL STUDIES; CYTOKINES; DIABETES, GESTATIONAL; DNA, BACTERIAL; FEMALE; GAMMAPROTEOBACTERIA; GENE EXPRESSION; HUMANS; MICROBIOTA; PLACENTA; PREGNANCY; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S;

EID: 84995555923     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2016.155     Document Type: Article

References (39)

1. Schaefer-Graf UM, Heuer R, Kilavuz O, Pandura A, Henrich W, Vetter K. Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. J Perinat Med 2002;30:313-21.
2. Thornburg KL, O'Tierney PF, Louey S. Review: The placenta is a programming agent for cardiovascular disease. Placenta 2010;31 Suppl: S54-9.
3. Hillier TA, Pedula KL, Vesco KK, et al. Excess gestational weight gain: modifying fetal macrosomia risk associated with maternal glucose. Obstet Gynecol 2008;112:1007-14.
4. Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med 2014;6:237ra65.
5. Kumar R. Prenatal factors and the development of asthma. Curr Opin Pediatr 2008;20:682-7.
6. Peters JL, Suglia SF, Platts-Mills TA, Hosen J, Gold DR, Wright RJ. Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS. J Allergy Clin Immunol 2009;123:1041-6.
7. Ege MJ, Herzum I, Büchele G, et al.; Protection Against Allergy Study in Rural Environments (PASTURE) Study group. Prenatal exposure to a farm environment modifies atopic sensitization at birth. J Allergy Clin Immunol 2008;122:407-12, 412.e1-4.
8. Mortimer K, Neugebauer R, Lurmann F, Alcorn S, Balmes J, Tager I. Air pollution and pulmonary function in asthmatic children: effects of prenatal and lifetime exposures. Epidemiology 2008;19:550-7; discussion 561-2.
9. Rebordosa C, Kogevinas M, Sørensen HT, Olsen J. Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study. Int J Epidemiol 2008;37:583-90.
10. Wang C, Salam MT, Islam T, Wenten M, Gauderman WJ, Gilliland FD. Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing. Pediatrics 2008;122:e107-14.
11. Kumar R, Ouyang F, Story RE, et al. Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood. J Allergy Clin Immunol 2009;124:1031-8.e1.
12. Amar J, Serino M, Lange C, et al.; D.E.S.I.R. Study Group. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia 2011;54:3055-61.
13. Garidou L, Pomié C, Klopp P, et al. The gut microbiota regulates intestinal CD4 T cells expressing ROR?t and controls metabolic disease. Cell Metab 2015;22:100-12.
14. Amar J, Chabo C, Waget A, et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med 2011;3: 559-72.
15. Antony KM, Ma J, Mitchell KB, Racusin DA, Versalovic J, Aagaard K. The preterm placental microbiome varies in association with excess maternal gestational weight gain. Am J Obstet Gynecol 2015;212:653.e1-16.
16. Spencer LA, Szela CT, Perez SA, et al. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J Leukoc Biol 2009;85:117-23.
17. Saraiva M, O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol 2010;10:170-81.
18. Rusconi F, Galassi C, Forastiere F, et al. Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children. Am J Respir Crit Care Med 2007;175:16-21.
19. Husemoen LL, Glümer C, Lau C, Pisinger C, Mørch LS, Linneberg A. Association of obesity and insulin resistance with asthma and aeroallergen sensitization. Allergy 2008;63:575-82.
20. Fyhrquist N, Ruokolainen L, Suomalainen A, et al. Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation. J Allergy Clin Immunol 2014;134:1301-1309.e11.
21. Hanski I, von Hertzen L, Fyhrquist N, et al. Environmental biodiversity, human microbiota, and allergy are interrelated. Proc Natl Acad Sci USA 2012;109:8334-9.
22. Penders J, Thijs C, van den Brandt PA, et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut 2007;56:661-7.
23. Gore C, Munro K, Lay C, et al. Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. J Allergy Clin Immunol 2008;121:135-40.
24. Doreswamy V, Peden DB. Modulation of asthma by endotoxin. Clin Exp Allergy 2011;41:9-19.
25. Lloyd CM, Hawrylowicz CM. Regulatory T cells in asthma. Immunity 2009;31:438-49.
26. Hessle C, Andersson B, Wold AE. Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production. Infect Immun 2000;68:3581-6.
27. Zhang M, Liu M, Luther J, Kao JY. Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes 2010;1:325-9.
28. Brand S, Teich R, Dicke T, et al. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol 2011;128:618-25.e1-7.
29. Conrad ML, Ferstl R, Teich R, et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med 2009;206:2869-77.
30. Debarry J, Garn H, Hanuszkiewicz A, et al. Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergyprotective properties. J Allergy Clin Immunol 2007;119:1514-21.
31. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009;9:313-23.
32. Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 2010;330:1768-73.
33. Boyle KE, Hwang H, Janssen RC, et al. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One 2014;9:e106872.
34. Liang K, Du W, Lu J, et al. Alterations of the Ca signaling pathway in pancreatic beta-cells isolated from db/db mice. Protein Cell 2014;5:783-94.
35. Bergsten P. Pathophysiology of impaired pulsatile insulin release. Diabetes Metab Res Rev 2000;16:179-91.
36. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4:517-29.
37. Segata N, Izard J, Waldron L, et al. Metagenomic biomarker discovery and explanation. Genome Biol 2011;12:R60.
38. Langille MG, Zaneveld J, Caporaso JG, et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol 2013;31:814-21.
39. Parks DH, Tyson GW, Hugenholtz P, Beiko RG. STAMP: statistical analysis of taxonomic and functional profiles. Bioinformatics 2014;30:3123-4.