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Volumn 85, Issue 1, 2009, Pages 117-123

Human eosinophils constitutively express multiple th1, th2, and immunoregulatory cytokines that are secreted rapidly and differentially

Author keywords

Immunmomdulation; Innate cells; Intracellular granule

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

EID: 58149271090     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0108058     Document Type: Article
Times cited : (222)

References (39)
  • 1
    • 0037180805 scopus 로고    scopus 로고
    • Helper T cells regulate Eype-2 innate immunity in vivo
    • Shinkai, K., Mohrs. M., Locksley, R. M. (2002) Helper T cells regulate Eype-2 innate immunity in vivo. Nature 420, 825-829.
    • (2002) Nature , vol.420 , pp. 825-829
    • Shinkai, K.1    Mohrs, M.2    Locksley, R.M.3
  • 2
    • 1642362240 scopus 로고    scopus 로고
    • Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
    • Voehringer, D., Shinkai, K., Locksley, R. M. (2004) Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20, 267-277.
    • (2004) Immunity , vol.20 , pp. 267-277
    • Voehringer, D.1    Shinkai, K.2    Locksley, R.M.3
  • 4
    • 0037013925 scopus 로고    scopus 로고
    • Mattes, J., Yang, M., Mahalingam, S., Kuehr, J., Webb, D. C., Simson. L., Hogan, S. P., Koskinen, A., McKenzie, A. N., Den I, L. A., Rothenberg, M. E., Matthaei. K. I., Young, I. C., Foster, P. S. (2002) Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperre-activity in experimental asthma. J. Exp. Med. 195, 1433-1444.
    • Mattes, J., Yang, M., Mahalingam, S., Kuehr, J., Webb, D. C., Simson. L., Hogan, S. P., Koskinen, A., McKenzie, A. N., Den I, L. A., Rothenberg, M. E., Matthaei. K. I., Young, I. C., Foster, P. S. (2002) Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperre-activity in experimental asthma. J. Exp. Med. 195, 1433-1444.
  • 5
    • 0034086376 scopus 로고    scopus 로고
    • Lymph node trafficking and antigen presentation by endobronchial eosinophils
    • Shi, H. Z., Humbles, A., Gerard, C., Jin. Z., Weller, P. F. (2000) Lymph node trafficking and antigen presentation by endobronchial eosinophils. J. Clin. Invest. 105, 945-953.
    • (2000) J. Clin. Invest , vol.105 , pp. 945-953
    • Shi, H.Z.1    Humbles, A.2    Gerard, C.3    Jin, Z.4    Weller, P.F.5
  • 6
    • 0035884933 scopus 로고    scopus 로고
    • Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function
    • MacKenzie, J. R., Mattes, J., Dent. L. A., Foster, P. S. (2001) Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function. J. Immunol. 167, 3146-3155.
    • (2001) J. Immunol , vol.167 , pp. 3146-3155
    • MacKenzie, J.R.1    Mattes, J.2    Dent, L.A.3    Foster, P.S.4
  • 7
    • 33646914079 scopus 로고    scopus 로고
    • Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis
    • Padigel, U. M., Lee, J. J., Nolan, T. J., Schad, G. A., Abraham. D. (2006) Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect. Immun. 74, 3232-3238,
    • (2006) Infect. Immun , vol.74 , pp. 3232-3238
    • Padigel, U.M.1    Lee, J.J.2    Nolan, T.J.3    Schad, G.A.4    Abraham, D.5
  • 8
    • 38849110762 scopus 로고    scopus 로고
    • Airway eosinophils: Allergic inflammation recruited professional antigen-presenting cells
    • Wang, H. B., Ghiran, I., Matthaei, K., Weller, P. F. (2007) Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. J. Immunol. 179, 7585-7592.
    • (2007) J. Immunol , vol.179 , pp. 7585-7592
    • Wang, H.B.1    Ghiran, I.2    Matthaei, K.3    Weller, P.F.4
  • 9
    • 0034053586 scopus 로고    scopus 로고
    • Eosinophil cytokines
    • Lacy, P., Moqbel, R. (2000) Eosinophil cytokines. Chem. Immunol. 76, 134-155.
    • (2000) Chem. Immunol , vol.76 , pp. 134-155
    • Lacy, P.1    Moqbel, R.2
  • 10
    • 0031317530 scopus 로고    scopus 로고
    • Eokines: Synthesis, storage and release from human eosinophils
    • Lacy, P., Moqbel, R. (1997) Eokines: synthesis, storage and release from human eosinophils. Mem. Frist. Oswaldo Cruz 92 (Suppl. 2). 125-133.
    • (1997) Mem. Frist. Oswaldo Cruz , vol.92 , Issue.SUPPL. 2 , pp. 125-133
    • Lacy, P.1    Moqbel, R.2
  • 11
    • 33745107556 scopus 로고    scopus 로고
    • Differential secretion of cytokines
    • Moqbel, R., Coughlin. J. J. (2006) Differential secretion of cytokines. Sci. STKE 2006, Pe26.
    • (2006) Sci. STKE , vol.2006
    • Moqbel, R.1    Coughlin, J.J.2
  • 13
    • 0033575793 scopus 로고    scopus 로고
    • Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon γ): Inhibition by immunoglobulin A complexes
    • Woerly. G., Roger, N., Loiseau. S., Dombrowiez, D., Capron. A., Capron. M. (1999) Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon γ): inhibition by immunoglobulin A complexes. J. Exp. Med. 190, 487-495.
    • (1999) J. Exp. Med , vol.190 , pp. 487-495
    • Woerly, G.1    Roger, N.2    Loiseau, S.3    Dombrowiez, D.4    Capron, A.5    Capron, M.6
  • 14
    • 0034693362 scopus 로고    scopus 로고
    • EliCell: A gel-phase dual antibody capture and detection assay to measure cytokine release from eosinophils
    • Bandeira-Melo, C., Gillard. G., Ghiran, I., Weller, P. F. (2000) EliCell: a gel-phase dual antibody capture and detection assay to measure cytokine release from eosinophils. J. Immunol. Methods 244, 105-115.
    • (2000) J. Immunol. Methods , vol.244 , pp. 105-115
    • Bandeira-Melo, C.1    Gillard, G.2    Ghiran, I.3    Weller, P.F.4
  • 15
    • 33644765838 scopus 로고    scopus 로고
    • Cytokine receptor-mediated trafficking of preformed IL.-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
    • Spencer. L. A., Melo. R. C., Perez, S. A., Hafford, S. P., Dvorak, A. M., Weller, P. F, (2006) Cytokine receptor-mediated trafficking of preformed IL.-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Nat I. Acad. Sci. USA 103, 3333-3338.
    • (2006) Proc Nat I. Acad. Sci. USA , vol.103 , pp. 3333-3338
    • Spencer, L.A.1    Melo, R.C.2    Perez, S.A.3    Hafford, S.P.4    Dvorak, A.M.5    Weller, P.F.6
  • 16
    • 0030786414 scopus 로고    scopus 로고
    • Incorporation of cells into an ELTSA system enhances antigen-driven lymphokine detection
    • Beech. J. T., Bainbridge. T., Thompson. S. J. (1997) Incorporation of cells into an ELTSA system enhances antigen-driven lymphokine detection. J. Immunol. Methods 205, 163-168.
    • (1997) J. Immunol. Methods , vol.205 , pp. 163-168
    • Beech, J.T.1    Bainbridge, T.2    Thompson, S.J.3
  • 17
    • 0026011845 scopus 로고
    • Mature eosinophils stimulated to develop in human cord blood mononuclear cell cultures supplemented with recombinant human inter-leukin-5. Part F. Piecemeal degranulation of specific; granules and distribution of Charcot-Leyden crystal protein
    • Dvorak, A. M., Furitsu, T., Letourneau, L., Ishizaka, T., Ackerman, S. J. (1991) Mature eosinophils stimulated to develop in human cord blood mononuclear cell cultures supplemented with recombinant human inter-leukin-5. Part F. Piecemeal degranulation of specific; granules and distribution of Charcot-Leyden crystal protein. Am. J. Pathoi. 138, 69-82.
    • (1991) Am. J. Pathoi , vol.138 , pp. 69-82
    • Dvorak, A.M.1    Furitsu, T.2    Letourneau, L.3    Ishizaka, T.4    Ackerman, S.J.5
  • 18
    • 26944471127 scopus 로고    scopus 로고
    • Human eosinophils secrete preformed, granule-stored inteileukin-4 through distinct vesicular compartments
    • Melo. R. C., Spencer, L. A., Perez, S. A., Ghiran. J., Dvorak, A. M., Weller, P. F. (2005) Human eosinophils secrete preformed, granule-stored inteileukin-4 through distinct vesicular compartments. Traffic 6, 1047- 1057.
    • (2005) Traffic , vol.6 , pp. 1047-1057
    • Melo, R.C.1    Spencer, L.A.2    Perez, S.A.3    Ghiran, J.4    Dvorak, A.M.5    Weller, P.F.6
  • 19
    • 24944528428 scopus 로고    scopus 로고
    • Intragranular vesieulotubular compartments are involved in piecemeal degranulation by activated human eosinophils
    • Melo, R. C., Perez, S. A., Spencer. L. A., Dvorak, A. M., Weller, P. F. (2005) Intragranular vesieulotubular compartments are involved in piecemeal degranulation by activated human eosinophils. Traffic 6, 866-879.
    • (2005) Traffic , vol.6 , pp. 866-879
    • Melo, R.C.1    Perez, S.A.2    Spencer, L.A.3    Dvorak, A.M.4    Weller, P.F.5
  • 21
    • 0032055525 scopus 로고    scopus 로고
    • Intracellular localization of mterleukin-6 in eosinophils from atopic asthmatics and effects of interferon γ
    • Lacy. P., Levi-Schaffer, F., Mahmudi- Azer, S., Bablitz, B., Hagen, S. C., Velazquez, J., Kay. A. B., Moqbel, R. (1998) Intracellular localization of mterleukin-6 in eosinophils from atopic asthmatics and effects of interferon γ. Blood 91, 2508-2516.
    • (1998) Blood , vol.91 , pp. 2508-2516
    • Lacy, P.1    Levi-Schaffer, F.2    Mahmudi- Azer, S.3    Bablitz, B.4    Hagen, S.C.5    Velazquez, J.6    Kay, A.B.7    Moqbel, R.8
  • 23
    • 0027525264 scopus 로고
    • Ultrastructural immunogold localization of tumor necrosis factor-α to the matrix compartment of eosinophil secondary granules in patients with idiopathic hypereosinophilic syndrome
    • Beil, W. J., Weller, P. F., Tzizik, D. M., Galli, S. J., Dvorak. A. M. (1993) Ultrastructural immunogold localization of tumor necrosis factor-α to the matrix compartment of eosinophil secondary granules in patients with idiopathic hypereosinophilic syndrome. J. Histochem. Cytochem. 41, 1611-1615. '
    • (1993) J. Histochem. Cytochem , vol.41 , pp. 1611-1615
    • Beil, W.J.1    Weller, P.F.2    Tzizik, D.M.3    Galli, S.J.4    Dvorak, A.M.5
  • 24
    • 0026550459 scopus 로고    scopus 로고
    • Dvorak, A, M., Ackerman, S. J., Furitsu, T., Estrella, P., Letourneau. L., Ishizaka. T. (1992) Mature eosinophils stimulated to develop in human-cord blood mononuclear cell cultures supplemented with recombinant human interleukm-5. II. Vesicular transport of specific; granule matrix peroxidase, a mechanism for effecting piecemeal degranulation. Am. J. Pathol. 140, 795-807.
    • Dvorak, A, M., Ackerman, S. J., Furitsu, T., Estrella, P., Letourneau. L., Ishizaka. T. (1992) Mature eosinophils stimulated to develop in human-cord blood mononuclear cell cultures supplemented with recombinant human interleukm-5. II. Vesicular transport of specific; granule matrix peroxidase, a mechanism for effecting piecemeal degranulation. Am. J. Pathol. 140, 795-807.
  • 25
    • 0029870226 scopus 로고    scopus 로고
    • Subcellular localization of transforming growth factor-α in human eosinophil granulocytes
    • Egesten, A., Calafat, J., Knol, E. F., Janssen, H., Walz, T. M. (1996) Subcellular localization of transforming growth factor-α in human eosinophil granulocytes. Blood 87, 3910-3918.
    • (1996) Blood , vol.87 , pp. 3910-3918
    • Egesten, A.1    Calafat, J.2    Knol, E.F.3    Janssen, H.4    Walz, T.M.5
  • 26
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Thl commitment
    • Takeda, A., Hamano. S., Yamanaka, A., Hanada, T., Ishibashi. T., Mak, T. W., Yoshimura, A., Yoshida. H. (2003) Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Thl commitment. J. Immunol. 170, 4886-4890.
    • (2003) J. Immunol , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5    Mak, T.W.6    Yoshimura, A.7    Yoshida, H.8
  • 28
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-produeing T cells
    • Batten. M., Li. J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage. F. J., Ghilardi, N. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-produeing T cells. Nat. Immunol. 7, 929-936.
    • (2006) Nat. Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6    Lee, J.7    de Sauvage, F.J.8    Ghilardi, N.9
  • 30
    • 0029671118 scopus 로고    scopus 로고
    • Roles of IFN-γ and TFN-α in IL-12-indueed T helper ceIL-1 development
    • Wenner, C. A., Guler, M. L., Macatonia, S. E., O'Garra, A., Murphy. K. M. (1996) Roles of IFN-γ and TFN-α in IL-12-indueed T helper ceIL-1 development. J. Immunol. 156, 1442-1447.
    • (1996) J. Immunol , vol.156 , pp. 1442-1447
    • Wenner, C.A.1    Guler, M.L.2    Macatonia, S.E.3    O'Garra, A.4    Murphy, K.M.5
  • 32
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • De Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., de Vries. J. E. (1991) Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174, 1209-1220.
    • (1991) J. Exp. Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    de Vries, J.E.5
  • 33
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea. A., Aste-Amezaga. M., Valiante, N. M., Ma, X., Kubin, M., Trinchieri. G. (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178, 1041-1048.
    • (1993) J. Exp. Med , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 34
    • 0037120054 scopus 로고    scopus 로고
    • Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion
    • Bandeira-Melo, C., Woods. L. J., Phoofolo, M., Weller, P. F. (2002) Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. J. Exp. Med. 196, 841-850.
    • (2002) J. Exp. Med , vol.196 , pp. 841-850
    • Bandeira-Melo, C.1    Woods, L.J.2    Phoofolo, M.3    Weller, P.F.4
  • 35
    • 0031058726 scopus 로고    scopus 로고
    • Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
    • Rincon, M., Anguita, J., Nakamura, T., Fikrig. E., Flavell. R. A. (1997) Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185, 461-469.
    • (1997) J. Exp. Med , vol.185 , pp. 461-469
    • Rincon, M.1    Anguita, J.2    Nakamura, T.3    Fikrig, E.4    Flavell, R.A.5
  • 37
    • 41149083753 scopus 로고    scopus 로고
    • Generation of Thl and Th2 chemokines by human eosinophils: Evidence for a critical role of TNF-α
    • Liu, L. Y., Bates, M. E., Jarjour, N. N., Busse. W. W., Berries, P. J., Kelly, E. A. (2007) Generation of Thl and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-α. J. Immunol. 179, 4840- 4848.
    • (2007) J. Immunol , vol.179 , pp. 4840-4848
    • Liu, L.Y.1    Bates, M.E.2    Jarjour, N.N.3    Busse, W.W.4    Berries, P.J.5    Kelly, E.A.6
  • 38
    • 34147130293 scopus 로고    scopus 로고
    • Yin and yang interplay of IFN-γ in inflammation and autoimmune disease
    • Zhang, J. (2007) Yin and yang interplay of IFN-γ in inflammation and autoimmune disease. J. Clin. Invest. 117, 871-873.
    • (2007) J. Clin. Invest , vol.117 , pp. 871-873
    • Zhang, J.1
  • 39
    • 0028833639 scopus 로고
    • IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells
    • Beissert, S., Hosoi, J., Grabbe, S., Asahina, A., Granstein. R. D. (1995) IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells. J. Immunol. 154, 1280-1286.
    • (1995) J. Immunol , vol.154 , pp. 1280-1286
    • Beissert, S.1    Hosoi, J.2    Grabbe, S.3    Asahina, A.4    Granstein, R.D.5


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