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Volumn 29, Issue 3, 2016, Pages 295-307

Management of CML-blast crisis

Author keywords

CML blast crisis; Diagnosis; Early prediction; Prevention; Therapy

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTHRACYCLINE; AXITINIB; AZACITIDINE; BOSUTINIB; CARBOPLATIN; CYTARABINE; DASATINIB; DAUNORUBICIN; DECITABINE; DEXAMETHASONE; ETOPOSIDE; FINGOLIMOD; FLUDARABINE; HOMOHARRINGTONINE; IDARUBICIN; IMATINIB; LONAFARNIB; MERCAPTOPURINE; METHOTREXATE; MITOXANTRONE; NILOTINIB; PONATINIB; PREDNISONE; TIOGUANINE; TRIPTOLIDE; UNINDEXED DRUG; VINCRISTINE; PROTEIN KINASE INHIBITOR;

EID: 84995446611     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2016.10.005     Document Type: Review
Times cited : (56)

References (100)
  • 1
    • 0036202470 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic evolution of chronic myeloid leukemia
    • [1] Johansson, B., Fioretos, T., Mitelman, F., Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. Acta Haematol 107 (2002), 76-94.
    • (2002) Acta Haematol , vol.107 , pp. 76-94
    • Johansson, B.1    Fioretos, T.2    Mitelman, F.3
  • 2
    • 80051573352 scopus 로고    scopus 로고
    • BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet
    • [2] Soverini, S., Hochhaus, A., Nicolini, F.E., et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 118 (2011), 1208-1215.
    • (2011) Blood , vol.118 , pp. 1208-1215
    • Soverini, S.1    Hochhaus, A.2    Nicolini, F.E.3
  • 3
    • 84864446464 scopus 로고    scopus 로고
    • How I treat CML blast crisis
    • [3] Hehlmann, R., How I treat CML blast crisis. Blood 120 (2012), 737-747.
    • (2012) Blood , vol.120 , pp. 737-747
    • Hehlmann, R.1
  • 4
    • 0017184649 scopus 로고
    • Non-random karyotypic evolution in chronic myeloid leukemia
    • [4] Mitelman, F., Levan, G., Nilsson, P.G., et al. Non-random karyotypic evolution in chronic myeloid leukemia. Int J Cancer 18 (1976), 24-30.
    • (1976) Int J Cancer , vol.18 , pp. 24-30
    • Mitelman, F.1    Levan, G.2    Nilsson, P.G.3
  • 6
    • 84255197306 scopus 로고    scopus 로고
    • Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV
    • [6] Fabarius, A., Leitner, A., Hochhaus, A., et al. Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood 118 (2011), 6760-6768.
    • (2011) Blood , vol.118 , pp. 6760-6768
    • Fabarius, A.1    Leitner, A.2    Hochhaus, A.3
  • 7
    • 84974574951 scopus 로고    scopus 로고
    • Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy
    • [7] Wang, W., Cortes, J.E., Tang, G., et al. Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood 127 (2016), 2742-2750.
    • (2016) Blood , vol.127 , pp. 2742-2750
    • Wang, W.1    Cortes, J.E.2    Tang, G.3
  • 8
    • 84958817965 scopus 로고    scopus 로고
    • Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy
    • [8] Chen, Z., Cortes, J.E., Jorgensen, J.L., et al. Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia, 2016.
    • (2016) Leukemia
    • Chen, Z.1    Cortes, J.E.2    Jorgensen, J.L.3
  • 9
    • 84939143043 scopus 로고    scopus 로고
    • Clonal evolution and blast crisis correlate with enhanced proteolytic activity of separase in BCR-ABL b3a2 fusion type CML under imatinib therapy
    • [9] Haaß, W., Kleiner, H., Weiß, C., et al. Clonal evolution and blast crisis correlate with enhanced proteolytic activity of separase in BCR-ABL b3a2 fusion type CML under imatinib therapy. PLoS One, 10, 2015, e0129648.
    • (2015) PLoS One , vol.10 , pp. e0129648
    • Haaß, W.1    Kleiner, H.2    Weiß, C.3
  • 10
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • [10] Soverini, S., Martinelli, G., Rosti, G., et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 23 (2005), 4100-4109.
    • (2005) J Clin Oncol , vol.23 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3
  • 11
    • 0027999617 scopus 로고
    • Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages
    • [11] Prokocimer, M., Rotter, V., Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages. Blood 84 (1994), 2391-2411.
    • (1994) Blood , vol.84 , pp. 2391-2411
    • Prokocimer, M.1    Rotter, V.2
  • 12
    • 0028900889 scopus 로고
    • Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia
    • [12] Sill, H., Goldman, J.M., Cross, N.C.P., Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 85 (1995), 2013-2016.
    • (1995) Blood , vol.85 , pp. 2013-2016
    • Sill, H.1    Goldman, J.M.2    Cross, N.C.P.3
  • 13
    • 79952451556 scopus 로고    scopus 로고
    • A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases
    • [13] Grossmann, V., Kohlmann, A., Zenger, M., et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia 25 (2011), 557-560.
    • (2011) Leukemia , vol.25 , pp. 557-560
    • Grossmann, V.1    Kohlmann, A.2    Zenger, M.3
  • 14
    • 43549086237 scopus 로고    scopus 로고
    • RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL(+) leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance
    • [14] Roche-Lestienne, C., Deluche, L., Corm, S., et al. RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL(+) leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance. Blood 111 (2008), 3735-3741.
    • (2008) Blood , vol.111 , pp. 3735-3741
    • Roche-Lestienne, C.1    Deluche, L.2    Corm, S.3
  • 15
    • 43049139905 scopus 로고    scopus 로고
    • BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    • [15] Mullighan, C.G., Miller, C.B., Radtke, I., et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453 (2008), 110-115.
    • (2008) Nature , vol.453 , pp. 110-115
    • Mullighan, C.G.1    Miller, C.B.2    Radtke, I.3
  • 16
    • 33744466526 scopus 로고    scopus 로고
    • Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis
    • [16] Zheng, C., Li, L., Haak, M., et al. Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis. Leukemia 20 (2006), 1028-1034.
    • (2006) Leukemia , vol.20 , pp. 1028-1034
    • Zheng, C.1    Li, L.2    Haak, M.3
  • 17
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • [17] Radich, J.P., Dai, H., Mao, M., et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A 103 (2006), 2794-2799.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2794-2799
    • Radich, J.P.1    Dai, H.2    Mao, M.3
  • 18
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • [18] Jamieson, C.H., Ailles, L.E., Dylla, S.J., et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351 (2004), 657-667.
    • (2004) N Engl J Med , vol.351 , pp. 657-667
    • Jamieson, C.H.1    Ailles, L.E.2    Dylla, S.J.3
  • 19
    • 70350451078 scopus 로고    scopus 로고
    • The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data
    • [19] Oehler, V.G., Yeung, K.Y., Choi, Y.E., et al. The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data. Blood 114 (2009), 3292-3298.
    • (2009) Blood , vol.114 , pp. 3292-3298
    • Oehler, V.G.1    Yeung, K.Y.2    Choi, Y.E.3
  • 20
    • 77954977940 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: mechanisms of blastic transformation
    • [20] Perrotti, D., Jamieson, C., Goldman, J., et al. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest 120 (2010), 2254-2264.
    • (2010) J Clin Invest , vol.120 , pp. 2254-2264
    • Perrotti, D.1    Jamieson, C.2    Goldman, J.3
  • 21
    • 84964222417 scopus 로고    scopus 로고
    • Natural course and biology of CML
    • [21] Chereda, B., Melo, J.V., Natural course and biology of CML. Ann Hematol 94:Suppl. 2 (2015), 107-121.
    • (2015) Ann Hematol , vol.94 , pp. 107-121
    • Chereda, B.1    Melo, J.V.2
  • 22
    • 0036560577 scopus 로고    scopus 로고
    • Oncogenic tyrosine kinases and the DNA-damage response
    • [22] Skorski, T., Oncogenic tyrosine kinases and the DNA-damage response. Nat Rev Cancer 2 (2002), 351-360.
    • (2002) Nat Rev Cancer , vol.2 , pp. 351-360
    • Skorski, T.1
  • 23
    • 33745608455 scopus 로고    scopus 로고
    • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
    • [23] Koptyra, M., Falinski, R., Nowicki, M.O., et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 108 (2006), 319-327.
    • (2006) Blood , vol.108 , pp. 319-327
    • Koptyra, M.1    Falinski, R.2    Nowicki, M.O.3
  • 24
    • 9444264703 scopus 로고    scopus 로고
    • BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks
    • [24] Nowicki, M.O., Falinski, R., Koptyra, M., et al. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood 104 (2004), 3746-3753.
    • (2004) Blood , vol.104 , pp. 3746-3753
    • Nowicki, M.O.1    Falinski, R.2    Koptyra, M.3
  • 25
    • 70349254450 scopus 로고    scopus 로고
    • Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors
    • [25] Soverini, S., Gnani, A., Colarossi, S., et al. Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors. Blood 114 (2009), 2168-2171.
    • (2009) Blood , vol.114 , pp. 2168-2171
    • Soverini, S.1    Gnani, A.2    Colarossi, S.3
  • 26
    • 0034637599 scopus 로고    scopus 로고
    • The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
    • [26] Sattler, M., Verma, S., Shrikhande, G., et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem 275 (2000), 24273-24278.
    • (2000) J Biol Chem , vol.275 , pp. 24273-24278
    • Sattler, M.1    Verma, S.2    Shrikhande, G.3
  • 27
    • 0015856431 scopus 로고
    • The treatment of terminal metamorphosis of chronic granulocytic leukaemia with corticosteroids and vincristine
    • [27] Marmont, A.M., Damasio, E.E., The treatment of terminal metamorphosis of chronic granulocytic leukaemia with corticosteroids and vincristine. Acta Haematol 50 (1973), 1-8.
    • (1973) Acta Haematol , vol.50 , pp. 1-8
    • Marmont, A.M.1    Damasio, E.E.2
  • 28
    • 0018143980 scopus 로고
    • Terminal transferase as a predictor of initial responsiveness to vincristine and prednisone in blastic chronic myelogenous leukemia
    • [28] Marks, S.M., Baltimore, D., McCaffrey, R., Terminal transferase as a predictor of initial responsiveness to vincristine and prednisone in blastic chronic myelogenous leukemia. N Engl J Med 298 (1978), 812-814.
    • (1978) N Engl J Med , vol.298 , pp. 812-814
    • Marks, S.M.1    Baltimore, D.2    McCaffrey, R.3
  • 29
    • 0022458162 scopus 로고
    • High-dose cytosine arabinoside: treatment and cellular pharmacology of chronic myelogenous leukemia blast crisis
    • [29] Iacoboni, S.J., Plunkett, W., Kantarjian, H.M., et al. High-dose cytosine arabinoside: treatment and cellular pharmacology of chronic myelogenous leukemia blast crisis. J Clin Oncol 4 (1986), 1079-1088.
    • (1986) J Clin Oncol , vol.4 , pp. 1079-1088
    • Iacoboni, S.J.1    Plunkett, W.2    Kantarjian, H.M.3
  • 30
    • 77949767505 scopus 로고    scopus 로고
    • International randomized study of interferon vs STI571 (IRIS) 8-Year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib
    • [30] Deininger, M., O'Brien, S.G., Guilhot, F., et al. International randomized study of interferon vs STI571 (IRIS) 8-Year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. ASH Annu Meet Abstr, 114, 2009, 1126.
    • (2009) ASH Annu Meet Abstr , vol.114 , pp. 1126
    • Deininger, M.1    O'Brien, S.G.2    Guilhot, F.3
  • 31
    • 79955018499 scopus 로고    scopus 로고
    • Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-alpha in newly diagnosed chronic myeloid leukemia
    • [31] Hehlmann, R., Lauseker, M., Jung-Munkwitz, S., et al. Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-alpha in newly diagnosed chronic myeloid leukemia. J Clin Oncol 29 (2011), 1634-1642.
    • (2011) J Clin Oncol , vol.29 , pp. 1634-1642
    • Hehlmann, R.1    Lauseker, M.2    Jung-Munkwitz, S.3
  • 32
    • 84926011629 scopus 로고    scopus 로고
    • Management of chronic myeloid leukemia in blast crisis
    • [32] Saussele, S., Silver, R.T., Management of chronic myeloid leukemia in blast crisis. Ann Hematol 94:Suppl. 2 (2015), 159-165.
    • (2015) Ann Hematol , vol.94 , pp. 159-165
    • Saussele, S.1    Silver, R.T.2
  • 33
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • [33] Druker, B.J., Sawyers, C.L., Kantarjian, H., et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344 (2001), 1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 34
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study
    • [34] Sawyers, C.L., Hochhaus, A., Feldman, E., et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 99 (2002), 3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 35
    • 0037092980 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
    • [35] Kantarjian, H.M., Cortes, J., O'Brien, S., et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood 99 (2002), 3547-3553.
    • (2002) Blood , vol.99 , pp. 3547-3553
    • Kantarjian, H.M.1    Cortes, J.2    O'Brien, S.3
  • 36
    • 0344823969 scopus 로고    scopus 로고
    • Imatinib mesylate as treatment for blastic transformation of Philadelphia chromosome positive chronic myelogenous leukemia
    • [36] Sureda, A., Carrasco, M., de Miguel, M., et al. Imatinib mesylate as treatment for blastic transformation of Philadelphia chromosome positive chronic myelogenous leukemia. Haematologica 88 (2003), 1213-1220.
    • (2003) Haematologica , vol.88 , pp. 1213-1220
    • Sureda, A.1    Carrasco, M.2    de Miguel, M.3
  • 37
    • 57349124075 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: outcome of the patients alive after a 6-year follow-up
    • [37] Palandri, F., Castagnetti, F., Testoni, N., et al. Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: outcome of the patients alive after a 6-year follow-up. Haematologica 93 (2008), 1792-1796.
    • (2008) Haematologica , vol.93 , pp. 1792-1796
    • Palandri, F.1    Castagnetti, F.2    Testoni, N.3
  • 38
    • 84973137731 scopus 로고    scopus 로고
    • European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia
    • [38] Steegmann, J.L., Baccarani, M., Breccia, M., et al. European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia. Leukemia 30 (2016), 1648-1671.
    • (2016) Leukemia , vol.30 , pp. 1648-1671
    • Steegmann, J.L.1    Baccarani, M.2    Breccia, M.3
  • 39
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • [39] Talpaz, M., Shah, N.P., Kantarjian, H., et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354 (2006), 2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 40
    • 57849159300 scopus 로고    scopus 로고
    • Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase
    • [40] Cortes, J., Kim, D.W., Raffoux, E., et al. Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase. Leukemia 22 (2008), 2176-2183.
    • (2008) Leukemia , vol.22 , pp. 2176-2183
    • Cortes, J.1    Kim, D.W.2    Raffoux, E.3
  • 41
    • 77956823937 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily
    • [41] Saglio, G., Hochhaus, A., Goh, Y.T., et al. Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily. Cancer 116 (2010), 3852-3861.
    • (2010) Cancer , vol.116 , pp. 3852-3861
    • Saglio, G.1    Hochhaus, A.2    Goh, Y.T.3
  • 42
    • 51649111035 scopus 로고    scopus 로고
    • Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia
    • [42] Porkka, K., Koskenvesa, P., Lundan, T., et al. Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. Blood 112 (2008), 1005-1012.
    • (2008) Blood , vol.112 , pp. 1005-1012
    • Porkka, K.1    Koskenvesa, P.2    Lundan, T.3
  • 43
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • [43] Kantarjian, H., Giles, F., Wunderle, L., et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 354 (2006), 2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 44
    • 84860785167 scopus 로고    scopus 로고
    • Nilotinib is effective in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blastic phase
    • [44] Giles, F.J., Kantarjian, H.M., le Coutre, P.D., et al. Nilotinib is effective in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blastic phase. Leukemia 26 (2012), 959-962.
    • (2012) Leukemia , vol.26 , pp. 959-962
    • Giles, F.J.1    Kantarjian, H.M.2    le Coutre, P.D.3
  • 45
    • 34247131285 scopus 로고    scopus 로고
    • Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis
    • [45] Fruehauf, S., Topaly, J., Buss, E.C., et al. Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis. Cancer 109 (2007), 1543-1549.
    • (2007) Cancer , vol.109 , pp. 1543-1549
    • Fruehauf, S.1    Topaly, J.2    Buss, E.C.3
  • 46
    • 33847395041 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia
    • [46] Oki, Y., Kantarjian, H.M., Gharibyan, V., et al. Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia. Cancer 109 (2007), 899-906.
    • (2007) Cancer , vol.109 , pp. 899-906
    • Oki, Y.1    Kantarjian, H.M.2    Gharibyan, V.3
  • 47
    • 34247853362 scopus 로고    scopus 로고
    • A pilot study of imatinib, low-dose cytarabine and idarubicin for patients with chronic myeloid leukemia in myeloid blast phase
    • [47] Quintas-Cardama, A., Kantarjian, H., Garcia-Manero, G., et al. A pilot study of imatinib, low-dose cytarabine and idarubicin for patients with chronic myeloid leukemia in myeloid blast phase. LeukLymphoma 48 (2007), 283-289.
    • (2007) LeukLymphoma , vol.48 , pp. 283-289
    • Quintas-Cardama, A.1    Kantarjian, H.2    Garcia-Manero, G.3
  • 48
    • 34548799800 scopus 로고    scopus 로고
    • Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib
    • [48] Cortes, J., Jabbour, E., Daley, G.Q., et al. Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib. Cancer 110 (2007), 1295-1302.
    • (2007) Cancer , vol.110 , pp. 1295-1302
    • Cortes, J.1    Jabbour, E.2    Daley, G.Q.3
  • 49
    • 77956955079 scopus 로고    scopus 로고
    • Standard-dose imatinib plus low-dose homoharringtonine and granulocyte colony-stimulating factor is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis who have failed prior single-agent therapy with imatinib
    • [49] Fang, B., Li, N., Song, Y., et al. Standard-dose imatinib plus low-dose homoharringtonine and granulocyte colony-stimulating factor is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis who have failed prior single-agent therapy with imatinib. Ann Hematol 89 (2010), 1099-1105.
    • (2010) Ann Hematol , vol.89 , pp. 1099-1105
    • Fang, B.1    Li, N.2    Song, Y.3
  • 50
    • 33644550315 scopus 로고    scopus 로고
    • High-dose imatinib mesylate combined with vincristine and dexamethasone (DIV regimen) as induction therapy in patients with resistant Philadelphia-positive acute lymphoblastic leukemia and lymphoid blast crisis of chronic myeloid leukemia
    • [50] Rea, D., Legros, L., Raffoux, E., et al. High-dose imatinib mesylate combined with vincristine and dexamethasone (DIV regimen) as induction therapy in patients with resistant Philadelphia-positive acute lymphoblastic leukemia and lymphoid blast crisis of chronic myeloid leukemia. Leukemia 20 (2006), 400-403.
    • (2006) Leukemia , vol.20 , pp. 400-403
    • Rea, D.1    Legros, L.2    Raffoux, E.3
  • 51
    • 79955583107 scopus 로고    scopus 로고
    • The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study)
    • [51] Deau, B., Nicolini, F.E., Guilhot, J., et al. The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study). Leuk Res 35 (2011), 777-782.
    • (2011) Leuk Res , vol.35 , pp. 777-782
    • Deau, B.1    Nicolini, F.E.2    Guilhot, J.3
  • 52
    • 84857752508 scopus 로고    scopus 로고
    • Efficacy of combining dasatinib and FLAG-IDA for patients with chronic myeloid leukemia in blastic transformation
    • [52] Milojkovic, D., Ibrahim, A., Reid, A., et al. Efficacy of combining dasatinib and FLAG-IDA for patients with chronic myeloid leukemia in blastic transformation. Haematol Hematol J 97 (2012), 473-474.
    • (2012) Haematol Hematol J , vol.97 , pp. 473-474
    • Milojkovic, D.1    Ibrahim, A.2    Reid, A.3
  • 53
    • 84892944529 scopus 로고    scopus 로고
    • HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia
    • [53] Strati, P., Kantarjian, H., Thomas, D., et al. HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia. Cancer 120 (2014), 373-380.
    • (2014) Cancer , vol.120 , pp. 373-380
    • Strati, P.1    Kantarjian, H.2    Thomas, D.3
  • 54
    • 84886796489 scopus 로고
    • Clinical efficacy of second generation tyrosine kinase inhibitor and 5-azacytidine combination in chronic myelogenous leukaemia in myeloid blast crisis
    • Oxford, England
    • [54] Ghez, D., Micol, J.B., Pasquier, F., et al. Clinical efficacy of second generation tyrosine kinase inhibitor and 5-azacytidine combination in chronic myelogenous leukaemia in myeloid blast crisis. Eur J cancer 2013:49 (1990), 3666-3670 Oxford, England.
    • (1990) Eur J cancer , vol.2013 , Issue.49 , pp. 3666-3670
    • Ghez, D.1    Micol, J.B.2    Pasquier, F.3
  • 55
    • 84952715285 scopus 로고    scopus 로고
    • Bosutinib for the treatment of chronic myeloid leukemia
    • [55] Doan, V., Wang, A., Prescott, H., Bosutinib for the treatment of chronic myeloid leukemia. Am J Health Syst Pharm 72 (2015), 439-447.
    • (2015) Am J Health Syst Pharm , vol.72 , pp. 439-447
    • Doan, V.1    Wang, A.2    Prescott, H.3
  • 56
    • 84887127701 scopus 로고    scopus 로고
    • A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias
    • [56] Cortes, J.E., Kim, D.W., Pinilla-Ibarz, J., et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 369 (2013), 1783-1796.
    • (2013) N Engl J Med , vol.369 , pp. 1783-1796
    • Cortes, J.E.1    Kim, D.W.2    Pinilla-Ibarz, J.3
  • 57
    • 84922342262 scopus 로고    scopus 로고
    • Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors
    • [57] Valent, P., Hadzijusufovic, E., Schernthaner, G.H., et al. Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors. Blood 125 (2015), 901-906.
    • (2015) Blood , vol.125 , pp. 901-906
    • Valent, P.1    Hadzijusufovic, E.2    Schernthaner, G.H.3
  • 58
    • 84925947209 scopus 로고    scopus 로고
    • Management of adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukemia
    • [58] Rea, D., Management of adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukemia. Ann Hematol 94:Suppl. 2 (2015), 149-158.
    • (2015) Ann Hematol , vol.94 , pp. 149-158
    • Rea, D.1
  • 59
    • 33646017748 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
    • [59] Gratwohl, A., Brand, R., Apperley, J., et al. Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 91 (2006), 513-521.
    • (2006) Haematologica , vol.91 , pp. 513-521
    • Gratwohl, A.1    Brand, R.2    Apperley, J.3
  • 60
    • 77950391550 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV
    • [60] Saussele, S., Lauseker, M., Gratwohl, A., et al. Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV. Blood 115 (2010), 1880-1885.
    • (2010) Blood , vol.115 , pp. 1880-1885
    • Saussele, S.1    Lauseker, M.2    Gratwohl, A.3
  • 61
    • 84995414189 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation (HSCT) in the imatinib-era: update on the survival outcome following allogeneic HSCT after imatinib failure; results of the German CML study IV
    • Abstract No. 2567
    • [61] Saussele, S., Lauseker, M., Muller, M.C., et al. Allogeneic hematopoietic stem cell transplantation (HSCT) in the imatinib-era: update on the survival outcome following allogeneic HSCT after imatinib failure; results of the German CML study IV. Blood, 124, 2014 Abstract No. 2567.
    • (2014) Blood , vol.124
    • Saussele, S.1    Lauseker, M.2    Muller, M.C.3
  • 62
    • 85027936063 scopus 로고    scopus 로고
    • Allogeneic hematopoietic SCT in combination with tyrosine kinase inhibitor treatment compared with TKI treatment alone in CML blast crisis
    • [62] Jiang, H., Xu, L.P., Liu, D.H., et al. Allogeneic hematopoietic SCT in combination with tyrosine kinase inhibitor treatment compared with TKI treatment alone in CML blast crisis. Bone Marrow Transpl 49 (2014), 1146-1154.
    • (2014) Bone Marrow Transpl , vol.49 , pp. 1146-1154
    • Jiang, H.1    Xu, L.P.2    Liu, D.H.3
  • 63
    • 84959355599 scopus 로고    scopus 로고
    • Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment
    • [63] Gratwohl, A., Pfirrmann, M., Zander, A., et al. Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment. Leukemia 30 (2016), 562-569.
    • (2016) Leukemia , vol.30 , pp. 562-569
    • Gratwohl, A.1    Pfirrmann, M.2    Zander, A.3
  • 64
    • 84877028031 scopus 로고    scopus 로고
    • Outcome of allogeneic SCT in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy
    • [64] Oyekunle, A., Zander, A.R., Binder, M., et al. Outcome of allogeneic SCT in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Ann Hematol 92 (2013), 487-496.
    • (2013) Ann Hematol , vol.92 , pp. 487-496
    • Oyekunle, A.1    Zander, A.R.2    Binder, M.3
  • 65
    • 72149119119 scopus 로고    scopus 로고
    • Current role of stem cell transplantation in chronic myeloid leukaemia
    • [65] Gratwohl, A., Heim, D., Current role of stem cell transplantation in chronic myeloid leukaemia. Best Pract Res Clin Haematol 22 (2009), 431-443.
    • (2009) Best Pract Res Clin Haematol , vol.22 , pp. 431-443
    • Gratwohl, A.1    Heim, D.2
  • 66
    • 30444452088 scopus 로고    scopus 로고
    • Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate
    • [66] Jabbour, E., Kantarjian, H., O'Brien, S., et al. Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate. Blood 107 (2006), 480-482.
    • (2006) Blood , vol.107 , pp. 480-482
    • Jabbour, E.1    Kantarjian, H.2    O'Brien, S.3
  • 67
    • 84925937033 scopus 로고    scopus 로고
    • The role of hematopoietic stem cell transplantation in chronic myeloid leukemia
    • [67] Gratwohl, A., Baldomero, H., Passweg, J., The role of hematopoietic stem cell transplantation in chronic myeloid leukemia. Ann Hematol 94:Suppl. 2 (2015), 177-186.
    • (2015) Ann Hematol , vol.94 , pp. 177-186
    • Gratwohl, A.1    Baldomero, H.2    Passweg, J.3
  • 68
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • [68] Neviani, P., Santhanam, R., Trotta, R., et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 8 (2005), 355-368.
    • (2005) Cancer Cell , vol.8 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3
  • 69
    • 79959252521 scopus 로고    scopus 로고
    • Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
    • [69] Lucas, C.M., Harris, R.J., Giannoudis, A., et al. Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood 117 (2011), 6660-6668.
    • (2011) Blood , vol.117 , pp. 6660-6668
    • Lucas, C.M.1    Harris, R.J.2    Giannoudis, A.3
  • 70
    • 84961221160 scopus 로고    scopus 로고
    • High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia
    • [70] Lucas, C.M., Milani, M., Butterworth, M., et al. High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. Leukemia 30 (2016), 1273-1281.
    • (2016) Leukemia , vol.30 , pp. 1273-1281
    • Lucas, C.M.1    Milani, M.2    Butterworth, M.3
  • 71
    • 80055108071 scopus 로고    scopus 로고
    • BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
    • [71] Hurtz, C., Hatzi, K., Cerchietti, L., et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 208 (2011), 2163-2174.
    • (2011) J Exp Med , vol.208 , pp. 2163-2174
    • Hurtz, C.1    Hatzi, K.2    Cerchietti, L.3
  • 72
    • 84863338358 scopus 로고    scopus 로고
    • HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
    • [72] Zhang, H., Li, H., Xi, H.S., et al. HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood 119 (2012), 2595-2607.
    • (2012) Blood , vol.119 , pp. 2595-2607
    • Zhang, H.1    Li, H.2    Xi, H.S.3
  • 73
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • 776-U117
    • [73] Zhao, C., Chen, A., Jamieson, C.H., et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature, 458, 2009 776-U117.
    • (2009) Nature , vol.458
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 74
    • 84859650054 scopus 로고    scopus 로고
    • Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors
    • [74] Mak, D.H., Wang, R.Y., Schober, W.D., et al. Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors. Leukemia 26 (2012), 788-794.
    • (2012) Leukemia , vol.26 , pp. 788-794
    • Mak, D.H.1    Wang, R.Y.2    Schober, W.D.3
  • 75
    • 79960279190 scopus 로고    scopus 로고
    • The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells
    • [75] Pellicano, F., Simara, P., Sinclair, A., et al. The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. Leukemia 25 (2011), 1159-1167.
    • (2011) Leukemia , vol.25 , pp. 1159-1167
    • Pellicano, F.1    Simara, P.2    Sinclair, A.3
  • 76
    • 84880538079 scopus 로고    scopus 로고
    • Combination of rapamycin and imatinib in treating refractory chronic myeloid leukemia myeloid blast crisis:a case report(025B3;)
    • [76] Xie, J., Zhang, X., Fang, B.Z., et al. Combination of rapamycin and imatinib in treating refractory chronic myeloid leukemia myeloid blast crisis:a case report(025B3;). Chin Med Sci J 28 (2013), 127-128.
    • (2013) Chin Med Sci J , vol.28 , pp. 127-128
    • Xie, J.1    Zhang, X.2    Fang, B.Z.3
  • 77
    • 84924308784 scopus 로고    scopus 로고
    • Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
    • [77] Pemovska, T., Johnson, E., Kontro, M., et al. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation. Nature 519 (2015), 102-105.
    • (2015) Nature , vol.519 , pp. 102-105
    • Pemovska, T.1    Johnson, E.2    Kontro, M.3
  • 78
    • 85018214882 scopus 로고    scopus 로고
    • Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing
    • [78] Pietarinen, P.O., Pemovska, T., Kontro, M., et al. Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing. Blood Cancer J, 5, 2015, e309.
    • (2015) Blood Cancer J , vol.5 , pp. e309
    • Pietarinen, P.O.1    Pemovska, T.2    Kontro, M.3
  • 79
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • [79] Postow, M.A., Chesney, J., Pavlick, A.C., et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 372 (2015), 2006-2017.
    • (2015) N Engl J Med , vol.372 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 80
    • 33646590620 scopus 로고    scopus 로고
    • Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy
    • [80] Kaeda, J., O'Shea, D., Szydlo, R.M., et al. Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy. Blood 107 (2006), 4171-4176.
    • (2006) Blood , vol.107 , pp. 4171-4176
    • Kaeda, J.1    O'Shea, D.2    Szydlo, R.M.3
  • 81
    • 84897574239 scopus 로고    scopus 로고
    • Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV
    • [81] Hehlmann, R., Müller, M.C., Lauseker, M., et al. Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV. J Clin Oncol 32 (2014), 415-423.
    • (2014) J Clin Oncol , vol.32 , pp. 415-423
    • Hehlmann, R.1    Müller, M.C.2    Lauseker, M.3
  • 82
    • 84925945641 scopus 로고    scopus 로고
    • Discontinuation of tyrosine kinase therapy in CML
    • [82] Mahon, F.X., Discontinuation of tyrosine kinase therapy in CML. Ann Hematol 94:Suppl. 2 (2015), S187-S193.
    • (2015) Ann Hematol , vol.94 , pp. S187-S193
    • Mahon, F.X.1
  • 83
    • 79960685618 scopus 로고    scopus 로고
    • Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score
    • [83] Hasford, J., Baccarani, M., Hoffmann, V., et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood 118 (2011), 686-692.
    • (2011) Blood , vol.118 , pp. 686-692
    • Hasford, J.1    Baccarani, M.2    Hoffmann, V.3
  • 84
    • 84953356030 scopus 로고    scopus 로고
    • Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia
    • [84] Pfirrmann, M., Baccarani, M., Saussele, S., et al. Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia. Leukemia 30 (2016), 48-56.
    • (2016) Leukemia , vol.30 , pp. 48-56
    • Pfirrmann, M.1    Baccarani, M.2    Saussele, S.3
  • 85
    • 70349575806 scopus 로고    scopus 로고
    • Chronic myeloid leukemia (CML) with P190BCR-ABL: analysis of characteristics, outcomes, and prognostic significance
    • [85] Verma, D., Kantarjian, H.M., Jones, D., et al. Chronic myeloid leukemia (CML) with P190BCR-ABL: analysis of characteristics, outcomes, and prognostic significance. Blood 114 (2009), 2232-2235.
    • (2009) Blood , vol.114 , pp. 2232-2235
    • Verma, D.1    Kantarjian, H.M.2    Jones, D.3
  • 86
    • 0037330989 scopus 로고    scopus 로고
    • Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate
    • [86] Schoch, C., Haferlach, T., Kern, W., et al. Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate. Leukemia 17 (2003), 461-463.
    • (2003) Leukemia , vol.17 , pp. 461-463
    • Schoch, C.1    Haferlach, T.2    Kern, W.3
  • 87
    • 0012906888 scopus 로고    scopus 로고
    • Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy
    • [87] Cortes, J.E., Talpaz, M., Giles, F., et al. Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Blood 101 (2003), 3794-3800.
    • (2003) Blood , vol.101 , pp. 3794-3800
    • Cortes, J.E.1    Talpaz, M.2    Giles, F.3
  • 88
    • 84995438946 scopus 로고    scopus 로고
    • Major route additional chromosomal aberrations (ACA) precede increase of blasts in chronic myeloid leukemia (CML) independent of therapy. An analysis of CML studies III, IIIA and IV
    • Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie Abstract P201
    • [88] Voskanyan, A., Dietz, C.T., Fabarius, A.C., et al. Major route additional chromosomal aberrations (ACA) precede increase of blasts in chronic myeloid leukemia (CML) independent of therapy. An analysis of CML studies III, IIIA and IV. Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 2016 Abstract P201.
    • (2016)
    • Voskanyan, A.1    Dietz, C.T.2    Fabarius, A.C.3
  • 89
    • 77949423503 scopus 로고    scopus 로고
    • Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment
    • [89] Haferlach, C., Bacher, U., Schnittger, S., et al. Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment. Leukemia 24 (2010), 638-640.
    • (2010) Leukemia , vol.24 , pp. 638-640
    • Haferlach, C.1    Bacher, U.2    Schnittger, S.3
  • 90
    • 77952845388 scopus 로고    scopus 로고
    • Survival outcomes for clonal evolution in chronic myeloid leukemia patients on second generation tyrosine kinase inhibitor therapy
    • [90] Verma, D., Kantarjian, H., Shan, J., et al. Survival outcomes for clonal evolution in chronic myeloid leukemia patients on second generation tyrosine kinase inhibitor therapy. Cancer 116 (2010), 2673-2681.
    • (2010) Cancer , vol.116 , pp. 2673-2681
    • Verma, D.1    Kantarjian, H.2    Shan, J.3
  • 91
    • 84881298446 scopus 로고    scopus 로고
    • European LeukemiaNet recommendations for the management of chronic myeloid leukemia
    • [91] Baccarani, M., Deininger, M.W., Rosti, G., et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia. Blood 2013:122 (2013), 872-884.
    • (2013) Blood , vol.2013 , Issue.122 , pp. 872-884
    • Baccarani, M.1    Deininger, M.W.2    Rosti, G.3
  • 92
    • 84925986690 scopus 로고    scopus 로고
    • Response-related predictors of survival in CML
    • [92] Hanfstein, B., Muller, M.C., Hochhaus, A., Response-related predictors of survival in CML. Ann Hematol 94:Suppl. 2 (2015), 227-239.
    • (2015) Ann Hematol , vol.94 , pp. 227-239
    • Hanfstein, B.1    Muller, M.C.2    Hochhaus, A.3
  • 93
    • 84921801141 scopus 로고    scopus 로고
    • Velocity of early BCR-ABL transcript elimination as an optimized predictor of outcome in chronic myeloid leukemia (CML) patients in chronic phase on treatment with imatinib
    • [93] Hanfstein, B., Shlyakhto, V., Lauseker, M., et al. Velocity of early BCR-ABL transcript elimination as an optimized predictor of outcome in chronic myeloid leukemia (CML) patients in chronic phase on treatment with imatinib. Leukemia 28 (2014), 1988-1992.
    • (2014) Leukemia , vol.28 , pp. 1988-1992
    • Hanfstein, B.1    Shlyakhto, V.2    Lauseker, M.3
  • 94
    • 84904887484 scopus 로고    scopus 로고
    • Prognosis for patients with CML and >10% BCR-ABL1 after 3 months of imatinib depends on the rate of BCR-ABL1 decline
    • [94] Branford, S., Yeung, D.T., Parker, W.T., et al. Prognosis for patients with CML and >10% BCR-ABL1 after 3 months of imatinib depends on the rate of BCR-ABL1 decline. Blood 124 (2014), 511-518.
    • (2014) Blood , vol.124 , pp. 511-518
    • Branford, S.1    Yeung, D.T.2    Parker, W.T.3
  • 95
    • 34648832173 scopus 로고    scopus 로고
    • FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
    • [95] Neviani, P., Santhanam, R., Oaks, J.J., et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest 117 (2007), 2408-2421.
    • (2007) J Clin Invest , vol.117 , pp. 2408-2421
    • Neviani, P.1    Santhanam, R.2    Oaks, J.J.3
  • 96
    • 84894513082 scopus 로고    scopus 로고
    • A novel SET antagonist (OP449) is cytotoxic to CML cells, including the highly-resistant BCR-ABLT315I mutant, and demonstrates enhanced efficacy in combination with ABL tyrosine kinase inhibitors
    • Abstract 3757
    • [96] Agarwal, A., MacKenzie, R., Oddo, J., et al. A novel SET antagonist (OP449) is cytotoxic to CML cells, including the highly-resistant BCR-ABLT315I mutant, and demonstrates enhanced efficacy in combination with ABL tyrosine kinase inhibitors. Blood, 118, 2011, 1603 Abstract 3757.
    • (2011) Blood , vol.118 , pp. 1603
    • Agarwal, A.1    MacKenzie, R.2    Oddo, J.3
  • 97
    • 84995535949 scopus 로고    scopus 로고
    • Dasatinib plus smoothened (SMO) inhibitor BMS-833923 in chronic myeloid leukemia (CML) with resistance or suboptimal response to a prior tyrosine kinase inhibitor (TKI): phase I study CA180323
    • [97] Shah, N.P., Cortes, J.E., Martinelli, G., et al. Dasatinib plus smoothened (SMO) inhibitor BMS-833923 in chronic myeloid leukemia (CML) with resistance or suboptimal response to a prior tyrosine kinase inhibitor (TKI): phase I study CA180323. Blood ASH Annu Meet Abstr, 124, 2014, 4539.
    • (2014) Blood ASH Annu Meet Abstr , vol.124 , pp. 4539
    • Shah, N.P.1    Cortes, J.E.2    Martinelli, G.3
  • 98
    • 84995435340 scopus 로고    scopus 로고
    • Combination targeted therapy to impair self-renewal capacity of human blast crisis leukemia stem cells
    • Abstract 1693
    • [98] Court Recart, A.C., Sadarangani, A., Goff, D., et al. Combination targeted therapy to impair self-renewal capacity of human blast crisis leukemia stem cells. Blood, 118, 2011, 737 Abstract 1693.
    • (2011) Blood , vol.118 , pp. 737
    • Court Recart, A.C.1    Sadarangani, A.2    Goff, D.3
  • 99
    • 84907368130 scopus 로고    scopus 로고
    • JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo
    • [99] Gallipoli, P., Cook, A., Rhodes, S., et al. JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo. Blood 124 (2014), 1492-1501.
    • (2014) Blood , vol.124 , pp. 1492-1501
    • Gallipoli, P.1    Cook, A.2    Rhodes, S.3
  • 100
    • 84924040330 scopus 로고    scopus 로고
    • The effect of nilotinib plus arsenic trioxide on the proliferation and differentiation of primary leukemic cells from patients with chronic myoloid leukemia in blast crisis
    • [100] Wang, W., Lv, F.F., Du, Y., et al. The effect of nilotinib plus arsenic trioxide on the proliferation and differentiation of primary leukemic cells from patients with chronic myoloid leukemia in blast crisis. Cancer Cell Int, 15, 2015, 10.
    • (2015) Cancer Cell Int , vol.15 , pp. 10
    • Wang, W.1    Lv, F.F.2    Du, Y.3


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