-
1
-
-
84906273987
-
Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection
-
Bae, M., Patel, N., Xu, H., Lee, M., Tominaga-Yamanaka, K., Nath, A., Geiger, J., Gorospe, M., Mattson, M. P. and Haughey, N. J. (2014). Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection. J. Neurosci. 34, 11485-11503.
-
(2014)
J. Neurosci
, vol.34
, pp. 11485-11503
-
-
Bae, M.1
Patel, N.2
Xu, H.3
Lee, M.4
Tominaga-Yamanaka, K.5
Nath, A.6
Geiger, J.7
Gorospe, M.8
Mattson, M.P.9
Haughey, N.J.10
-
2
-
-
0033822172
-
Identification of the gene causing mucolipidosis type IV
-
Bargal, R., Avidan, N., Ben-Asher, E., Olender, Z., Zeigler, M., Frumkin, A., Raas-Rothschild, A., Glusman, G., Lancet, D. and Bach, G. (2000). Identification of the gene causing mucolipidosis type IV. Nat. Genet. 26, 118-123.
-
(2000)
Nat. Genet
, vol.26
, pp. 118-123
-
-
Bargal, R.1
Avidan, N.2
Ben-Asher, E.3
Olender, Z.4
Zeigler, M.5
Frumkin, A.6
Raas-Rothschild, A.7
Glusman, G.8
Lancet, D.9
Bach, G.10
-
3
-
-
0038125598
-
Calcium signalling: dynamics, homeostasis and remodelling
-
Berridge, M. J., Bootman, M. D. and Roderick, H. L. (2003). Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 4, 517-529.
-
(2003)
Nat. Rev. Mol. Cell Biol
, vol.4
, pp. 517-529
-
-
Berridge, M.J.1
Bootman, M.D.2
Roderick, H.L.3
-
4
-
-
67749143745
-
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
-
Brailoiu, E., Churamani, D., Cai, X., Schrlau, M. G., Brailoiu, G. C., Gao, X., Hooper, R., Boulware, M. J., Dun, N. J., Marchant, J. S. et al. (2009). Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J. Cell Biol. 186, 201-209.
-
(2009)
J. Cell Biol
, vol.186
, pp. 201-209
-
-
Brailoiu, E.1
Churamani, D.2
Cai, X.3
Schrlau, M.G.4
Brailoiu, G.C.5
Gao, X.6
Hooper, R.7
Boulware, M.J.8
Dun, N.J.9
Marchant, J.S.10
-
5
-
-
67349287016
-
NAADP mobilizes calcium from acidic organelles through two-pore channels
-
Calcraft, P. J., Ruas, M., Pan, Z., Cheng, X., Arredouani, A., Hao, X., Tang, J., Rietdorf, K., Teboul, L., Chuang, K.-T. et al. (2009). NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459, 596-600.
-
(2009)
Nature
, vol.459
, pp. 596-600
-
-
Calcraft, P.J.1
Ruas, M.2
Pan, Z.3
Cheng, X.4
Arredouani, A.5
Hao, X.6
Tang, J.7
Rietdorf, K.8
Teboul, L.9
Chuang, K.-T.10
-
8
-
-
84907320441
-
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
-
Chen, C. C., Keller, M., Hess, M., Schiffmann, R., Urban, N., Wolfgardt, A., Schaefer, M., Bracher, F., Biel, M., Wahl-Schott, C. et al. (2014). A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat. Commun. 5, 4681.
-
(2014)
Nat. Commun
, vol.5
, pp. 4681
-
-
Chen, C.C.1
Keller, M.2
Hess, M.3
Schiffmann, R.4
Urban, N.5
Wolfgardt, A.6
Schaefer, M.7
Bracher, F.8
Biel, M.9
Wahl-Schott, C.10
-
9
-
-
0036472494
-
pH-dependent regulation of lysosomal calcium in macrophages
-
Christensen, K. A., Myers, J. T. and Swanson, J. A. (2002). pH-dependent regulation of lysosomal calcium in macrophages. J. Cell Sci. 115, 599-607.
-
(2002)
J. Cell Sci
, vol.115
, pp. 599-607
-
-
Christensen, K.A.1
Myers, J.T.2
Swanson, J.A.3
-
10
-
-
37149029370
-
Calcium signaling
-
Clapham, D. E. (2007). Calcium signaling. Cell 131, 1047-1058.
-
(2007)
Cell
, vol.131
, pp. 1047-1058
-
-
Clapham, D.E.1
-
11
-
-
54049156405
-
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
-
Dong, X.-P., Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T. and Xu, H. (2008). The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature 455, 992-996.
-
(2008)
Nature
, vol.455
, pp. 992-996
-
-
Dong, X.-P.1
Cheng, X.2
Mills, E.3
Delling, M.4
Wang, F.5
Kurz, T.6
Xu, H.7
-
12
-
-
80051473235
-
2++ release channels in the endolysosome
-
2++ release channels in the endolysosome. Nat. Commun. 1, 38.
-
(2010)
Nat. Commun
, vol.1
, pp. 38
-
-
Dong, X.P.1
Shen, D.2
Wang, X.3
Dawson, T.4
Li, X.5
Zhang, Q.6
Cheng, X.7
Zhang, Y.8
Weisman, L.S.9
Delling, M.10
-
13
-
-
29244449301
-
Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3
-
Falcón-Pérez, J. M., Nazarian, R., Sabatti, C. and Dell'Angelica, E. C. (2005). Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3. J. Cell Sci. 118, 5243-5255.
-
(2005)
J. Cell Sci
, vol.118
, pp. 5243-5255
-
-
Falcón-Pérez, J.M.1
Nazarian, R.2
Sabatti, C.3
Dell'Angelica, E.C.4
-
14
-
-
84930531803
-
2++ signalling: from sea urchin eggs to mammalian cells
-
2++ signalling: from sea urchin eggs to mammalian cells. Cell Calcium 58, 27-47.
-
(2015)
Cell Calcium
, vol.58
, pp. 27-47
-
-
Galione, A.1
-
16
-
-
37649014647
-
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse
-
Grimm, C., Cuajungco, M. P., van Aken, A. F., Schnee, M., Jors, S., Kros, C. J., Ricci, A. J. and Heller, S. (2007). A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proc. Natl. Acad. Sci. USA 104, 19583-19588.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19583-19588
-
-
Grimm, C.1
Cuajungco, M.P.2
van Aken, A.F.3
Schnee, M.4
Jors, S.5
Kros, C.J.6
Ricci, A.J.7
Heller, S.8
-
17
-
-
77049105199
-
Small molecule activators of TRPML3
-
Grimm, C., Jörs, S., Saldanha, S. A., Obukhov, A. G., Pan, B., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P. and Heller, S. (2010). Small molecule activators of TRPML3. Chem. Biol. 17, 135-148.
-
(2010)
Chem. Biol
, vol.17
, pp. 135-148
-
-
Grimm, C.1
Jörs, S.2
Saldanha, S.A.3
Obukhov, A.G.4
Pan, B.5
Oshima, K.6
Cuajungco, M.P.7
Chase, P.8
Hodder, P.9
Heller, S.10
-
18
-
-
84863317314
-
Role of TRPML and two-pore channels in endo-lysosomal cation homeostasis
-
Grimm, C., Hassan, S., Wahl-Schott, C. and Biel, M. (2012). Role of TRPML and two-pore channels in endo-lysosomal cation homeostasis. J. Pharmacol. Exp. Ther. 342, 236-244.
-
(2012)
J. Pharmacol. Exp. Ther
, vol.342
, pp. 236-244
-
-
Grimm, C.1
Hassan, S.2
Wahl-Schott, C.3
Biel, M.4
-
19
-
-
15744374825
-
A functional link between store-operated and TRPC channels revealed by the 3, 5-bis(trifluoromethyl)pyrazole derivative, BTP2
-
He, L.-P., Hewavitharana, T., Soboloff, J., Spassova, M. A. and Gill, D. L. (2005). A functional link between store-operated and TRPC channels revealed by the 3, 5-bis(trifluoromethyl)pyrazole derivative, BTP2. J. Biol. Chem. 280, 10997-11006.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 10997-11006
-
-
He, L.-P.1
Hewavitharana, T.2
Soboloff, J.3
Spassova, M.A.4
Gill, D.L.5
-
20
-
-
84921415558
-
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
-
Hockey, L. N., Kilpatrick, B. S., Eden, E. R., Lin-Moshier, Y., Brailoiu, G. C., Brailoiu, E., Futter, C., Schapira, A. H., Marchant, J. S. and Patel, S. (2015). Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. J. Cell Sci. 128, 232-238.
-
(2015)
J. Cell Sci
, vol.128
, pp. 232-238
-
-
Hockey, L.N.1
Kilpatrick, B.S.2
Eden, E.R.3
Lin-Moshier, Y.4
Brailoiu, G.C.5
Brailoiu, E.6
Futter, C.7
Schapira, A.H.8
Marchant, J.S.9
Patel, S.10
-
21
-
-
0021426953
-
Intralysosomal hydrolysis of glycyl-L-phenylalanine 2-naphthylamide
-
Jadot, M., Colmant, C., Wattiaux-De Coninck, S. and Wattiaux, R. (1984). Intralysosomal hydrolysis of glycyl-L-phenylalanine 2-naphthylamide. Biochem. J. 219, 965-970.
-
(1984)
Biochem. J
, vol.219
, pp. 965-970
-
-
Jadot, M.1
Colmant, C.2
Wattiaux-De Coninck, S.3
Wattiaux, R.4
-
23
-
-
37549009562
-
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype
-
Kim, H. J., Li, Q., Tjon-Kon-Sang, S., So, I., Kiselyov, K. and Muallem, S. (2007). Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J. Biol. Chem. 282, 36138-36142.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 36138-36142
-
-
Kim, H.J.1
Li, Q.2
Tjon-Kon-Sang, S.3
So, I.4
Kiselyov, K.5
Muallem, S.6
-
25
-
-
84940796652
-
2++ homeostasis via TRPML1 by regulating vATPasemediated lysosome acidification
-
2++ homeostasis via TRPML1 by regulating vATPasemediated lysosome acidification. Cell Rep. 12, 1430-1444.
-
(2015)
Cell Rep
, vol.12
, pp. 1430-1444
-
-
Lee, J.-H.1
McBrayer, M.K.2
Wolfe, D.M.3
Haslett, L.J.4
Kumar, A.5
Sato, Y.6
Lie, P.P.Y.7
Mohan, P.8
Coffey, E.E.9
Kompella, U.10
-
26
-
-
55549134611
-
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
-
Lloyd-Evans, E., Morgan, A. J., He, X., Smith, D. A., Elliot-Smith, E., Sillence, D. J., Churchill, G. C., Schuchman, E. H., Galione, A. and Platt, F. M. (2008). Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat. Med. 14, 1247-1255.
-
(2008)
Nat. Med
, vol.14
, pp. 1247-1255
-
-
Lloyd-Evans, E.1
Morgan, A.J.2
He, X.3
Smith, D.A.4
Elliot-Smith, E.5
Sillence, D.J.6
Churchill, G.C.7
Schuchman, E.H.8
Galione, A.9
Platt, F.M.10
-
28
-
-
84923820926
-
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
-
Medina, D. L., Di Paola, S., Peluso, I., Armani, A., De Stefani, D., Venditti, R., Montefusco, S., Scotto-Rosato, A., Prezioso, C., Forrester, A. et al. (2015). Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat. Cell Biol. 17, 288-299.
-
(2015)
Nat. Cell Biol
, vol.17
, pp. 288-299
-
-
Medina, D.L.1
Di Paola, S.2
Peluso, I.3
Armani, A.4
De Stefani, D.5
Venditti, R.6
Montefusco, S.7
Scotto-Rosato, A.8
Prezioso, C.9
Forrester, A.10
-
30
-
-
84957434829
-
Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV
-
Park, S., Ahuja, M., Kim, M. S., Brailoiu, G. C., Jha, A., Zeng, M., Baydyuk, M., Wu, L.-G., Wassif, C. A., Porter, F. D. et al. (2016). Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV. EMBO Rep. 17, 266-278.
-
(2016)
EMBO Rep
, vol.17
, pp. 266-278
-
-
Park, S.1
Ahuja, M.2
Kim, M.S.3
Brailoiu, G.C.4
Jha, A.5
Zeng, M.6
Baydyuk, M.7
Wu, L.-G.8
Wassif, C.A.9
Porter, F.D.10
-
31
-
-
84936860974
-
Function and dysfunction of two-pore channels
-
Patel, S. (2015). Function and dysfunction of two-pore channels. Sci. Signal. 8, re7.
-
(2015)
Sci. Signal
, vol.8
-
-
Patel, S.1
-
32
-
-
84856254303
-
2++ signals by NAADP-gated twopore channels: a role for membrane contact sites?
-
2++ signals by NAADP-gated twopore channels: a role for membrane contact sites? Biochem. Soc. Trans. 40, 153-157.
-
(2012)
Biochem. Soc. Trans
, vol.40
, pp. 153-157
-
-
Patel, S.1
Brailoiu, E.2
-
35
-
-
77953916412
-
Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals
-
Patel, S., Marchant, J. S. and Brailoiu, E. (2010). Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals. Cell Calcium 47, 480-490.
-
(2010)
Cell Calcium
, vol.47
, pp. 480-490
-
-
Patel, S.1
Marchant, J.S.2
Brailoiu, E.3
-
37
-
-
84940119926
-
Store-operated calcium channels
-
Prakriya, M. and Lewis, R. S. (2015). Store-operated calcium channels. Physiol. Rev. 95, 1383-1436.
-
(2015)
Physiol. Rev
, vol.95
, pp. 1383-1436
-
-
Prakriya, M.1
Lewis, R.S.2
-
38
-
-
0034729167
-
2++ in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles
-
2++ in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J. Cell Biol. 149, 1053-1062.
-
(2000)
J. Cell Biol
, vol.149
, pp. 1053-1062
-
-
Pryor, P.R.1
Mullock, B.M.2
Bright, N.A.3
Gray, S.R.4
Luzio, J.P.5
-
39
-
-
84884154195
-
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis
-
Samie, M., Wang, X., Zhang, X., Goschka, A., Li, X., Cheng, X., Gregg, E., Azar, M., Zhuo, Y., Garrity, A. G. et al. (2013). A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev. Cell 26, 511-524.
-
(2013)
Dev. Cell
, vol.26
, pp. 511-524
-
-
Samie, M.1
Wang, X.2
Zhang, X.3
Goschka, A.4
Li, X.5
Cheng, X.6
Gregg, E.7
Azar, M.8
Zhuo, Y.9
Garrity, A.G.10
-
40
-
-
84859175854
-
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
-
Shen, D., Wang, X., Li, X., Zhang, X., Yao, Z., Dibble, S., Dong, X.-P., Yu, T., Lieberman, A. P., Showalter, H. D. et al. (2012). Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat. Commun. 3, 731.
-
(2012)
Nat. Commun
, vol.3
, pp. 731
-
-
Shen, D.1
Wang, X.2
Li, X.3
Zhang, X.4
Yao, Z.5
Dibble, S.6
Dong, X.-P.7
Yu, T.8
Lieberman, A.P.9
Showalter, H.D.10
-
41
-
-
10744224318
-
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies
-
Sherer, N. M., Lehmann, M. J., Jimenez-Soto, L. F., Ingmundson, A., Horner, S. M., Cicchetti, G., Allen, P. G., Pypaert, M., Cunningham, J. M. and Mothes, W. (2003). Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic 4, 785-801.
-
(2003)
Traffic
, vol.4
, pp. 785-801
-
-
Sherer, N.M.1
Lehmann, M.J.2
Jimenez-Soto, L.F.3
Ingmundson, A.4
Horner, S.M.5
Cicchetti, G.6
Allen, P.G.7
Pypaert, M.8
Cunningham, J.M.9
Mothes, W.10
-
42
-
-
33745193718
-
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1
-
Venkatachalam, K., Hofmann, T. and Montell, C. (2006). Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J. Biol. Chem. 281, 17517-17527.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 17517-17527
-
-
Venkatachalam, K.1
Hofmann, T.2
Montell, C.3
-
43
-
-
33644655372
-
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes
-
Vergarajauregui, S. and Puertollano, R. (2006). Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes. Traffic 7, 337-353.
-
(2006)
Traffic
, vol.7
, pp. 337-353
-
-
Vergarajauregui, S.1
Puertollano, R.2
-
45
-
-
79959546648
-
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels
-
Yamaguchi, S., Jha, Y., Li, Q., Soyombo, A. A., Dickinson, G. D., Churamani, D., Brailoiu, E., Patel, S. and Muallem, S. (2011). Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J. Biol. Chem. 286, 22934-22942.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 22934-22942
-
-
Yamaguchi, S.1
Jha, Y.2
Li, Q.3
Soyombo, A.A.4
Dickinson, G.D.5
Churamani, D.6
Brailoiu, E.7
Patel, S.8
Muallem, S.9
-
46
-
-
79960989377
-
Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1-/-cells
-
Zhang, F., Xu, M., Han, W.-Q. and Li, P.-L. (2011). Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1-/-cells. Am. J. Physiol. Cell Physiol. 301, C421-C430.
-
(2011)
Am. J. Physiol. Cell Physiol
, vol.301
, pp. C421-C430
-
-
Zhang, F.1
Xu, M.2
Han, W.-Q.3
Li, P.-L.4
-
47
-
-
84863922724
-
Phosphoinositide isoforms determine compartment-specific ion channel activity
-
Zhang, X., Li, X. and Xu, H. (2012). Phosphoinositide isoforms determine compartment-specific ion channel activity. Proc. Natl. Acad. Sci. USA 109, 11384-11389.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 11384-11389
-
-
Zhang, X.1
Li, X.2
Xu, H.3
|