The effect of (1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2- olide (LS-1) from Lobophyyum sp. On the apoptosis induction of SNU-C5 human colorectal cancer cells

Biomolecules and Therapeutics

Volumn 24, Issue 6, 2016, Pages 623-629

  Kim, Eun Ji ^a   Kang, Jung I I ^a   Tung, Nguyen Huu ^b   Kim, Young Ho ^b   Hyun, Jin Won ^a   Koh, Young Sang ^a   Chang, Weon Young ^a   Yoo, Eun Sook ^a   Kang, Hee Kyoung ^a  

^a Jeju National University School of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Apoptosis; LS 1; SNU C5; TGF pathway; Wnt catenin pathway

Indexed keywords

3,7,11,15 CEMBRATETRAEN 17,2 OLIDE; ANTINEOPLASTIC AGENT; BETA CATENIN; CARCINOEMBRYONIC ANTIGEN; GLYCOGEN SYNTHASE KINASE 3BETA; MYC PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL POPULATION; CELL VIABILITY ASSAY; COLORECTAL CANCER CELL LINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORAL; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LOBOPHYYUM; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84994908271     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2016.023     Document Type: Article

References (26)

1. Akiyama, T. (2000) Wnt/β-catenin signaling. Cytokine Growth Factor Rev. 11, 273-282.
2. Amado, N. G., Predes, D., Moreno, M. M., Carvalho, I. O., Mendes, F. A. and Abreu, J. G. (2014) Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies. Int. J. Mol. Sci. 15, 12094-12106.
3. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
4. Camacho-Leal, P. and Stanners, C. P. (2008) The human carcinoembryonic antigen (CEA) GPI anchor mediates anoikis inhibition by inactivation of the intrinsic death pathway. Oncogene 27, 1545-1553.
5. Chiarugi, V., Magnelli, L., Cinelli, M. and Basi, G. (1994) Apoptosis and the cell cycle. Cell. Mol. Biol. Res. 40, 603-612.
6. Constantinou, C., Papas, A. and Constantinou, A. I. (2008) Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs. Int. J. Cancer 123, 739-752.
7. Fried, J., Perez, A. G. and Clarkson, B. D. (1976) Flow cytofluorometric analysis of cell cycle distributions using propidium iodide. Properties of the method and mathematical analysis of the data. J. Cell Biol. 71, 172-181.
8. Han, S. U., Kwak, T. H., Her, K. H., Cho, Y. H., Choi, C., Lee, H. J., Hong, S., Park, Y. S., Kim, Y. S., Kim, T. A. and Kim, S. J. (2008) CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling. Oncogene 27, 675-683.
9. Hong, J. Y., Boo, H. J., Kang, J. I., Kim, M. K., Yoo, E. S., Hyun, J. W., Koh, Y. S., Kim, G. Y., Maeng, Y. H., Hyun, C. L., Chang, W. Y., Kim, Y. H., Kim, Y. R. and Kang, H. K. (2012) (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation. Biol. Pharm. Bull. 35, 1054-1063.
10. Hoosein, N. M., McKnight, M. K., Levine, A. E., Mulder, K. M., Childress, K. E., Brattain, D. E. and Brattain, M. G. (1989) Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-beta 1. Exp. Cell Res. 181, 442-453.
11. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Murray, T. and Thun, M. J. (2008) Cancer statistics, 2008. CA Cancer J. Clin. 58, 71-96.
12. Kim, E. J., Kang, J. I., Kwak, J. W., Jeon, C. H., Tung, N. H., Kim, Y. H., Choi, C. H., Hyun, J. W., Koh, Y. S., Yoo, E. S. and Kang, H. K. (2015) The anticancer effect of (1S,2S,3E,7E,11E)-3,7,11, 15-cembratetraen-17,2-olide(LS-1) through the activation of TGF-β signaling in SNU-C5/5-FU, fluorouracil-resistant human colon cancer cells. Mar. Drugs 13, 1340-1359.
13. Li, Y., Cao, H., Jiao, Z., Pakala, S. B., Sirigiri, D. N., Li, W., Kumar, R. and Mishra, L. (2010) Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers. Cancer Res. 70, 8159-8168.
14. Nguyen, H. T., Chau, V. M., Phan, V. K., Hoang, T. H., Nguyen, H. N., Nguyen, X. C., Tran, H. Q., Nguyen, X. N., Hyun, J. H., Kang, H. K. and Kim, Y. H. (2010) Chemical components from the Vietnamese soft coral Lobophytum sp. Arch. Pharm. Res. 33, 503-508.
15. Nicklas, D. and Saiz, L. (2013) Characterization of Negative Feedback Network Motifs in the TGF-β Signaling Pathway. PLoS ONE. 8, e83531.
16. Pendas-Franco, N., Aguilera, O., Pereira, F., Gonzalez-Sancho, J. M. and Munoz, A. (2008) Vitamin D and Wnt/β-catenin pathway in colon cancer: role and regulation of DICKKOPF genes. Anticancer Res. 28, 2613-2623.
17. Portella, G., Cumming, S. A., Liddell, J., Cui, W., Ireland, H., Akhurst, R. J. and Balmain, A. (1998) Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ. 9, 393-404.
18. Romano, S., Mallardo, M., Chiurazzi, F., Bisogni, R., D’Angelillo, A., Liuzzi, R., Compare, G. and Romano, M. F. (2008) The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells. Haematologica. 93, 1039-1048.
19. Samara, R. N., Laguinge, L. M. and Jessup, J. M. (2007) Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. Cancer Res. 67, 4774-4782.
20. Schneikert, J. and Behrens, J. (2007) The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut. 56, 417-425.
21. Scudiero, D. A., Shoemaker, R. H., Paull, K. D., Monks, A., Tierney, S., Nofziger, T. H., Currens, M. J., Seniff, D. and Boyd, M. R. (1988) Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48, 4827-4833.
22. Sheen, Y. Y., Kim, M. J., Park, S. A., Park, S. Y. and Nam, J. S. (2013) Targeting the transforming growth factor-β signaling in cancer therapy. Biomol. Ther. (Seoul) 21, 323-331.
23. Song, L., Li, Z. Y., Liu, W. P. and Zhao, M. R. (2015) Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biol. Ther. 16, 1-7.
24. Sun, L., Wu, G., Willson, J. K., Zborowska, E., Yang, J., Rajkarunanayake, I., Wang, J., Gentry, L. E., Wang, X. F. and Brattain, M. G. (1994) Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem. 269, 26449-26455.
25. Thuault, S., Valcourt, U., Petersen, M., Manfioletti, G., Heldin, C. H. and Moustakas, A. (2006) Transforming growth factor-β employs HMGA2 to elicit epithelial-mesenchymal transition. J. Cell Biol. 174, 175-183.
26. Xu, Y. and Pasche, B. (2007) TGF-β signaling alterations and susceptibility to colorectal cancer. Hum. Mol. Genet. 16 Spec No 1, R14-R20.