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Volumn 27, Issue 5, 2008, Pages 675-683

CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-β signaling

Author keywords

Carcinoembryonic antigen; Gastric cancer; Smad3; TGF

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN CEACAM5; CARCINOEMBRYONIC ANTIGEN CEACAM6; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

EID: 38549143104     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210686     Document Type: Article
Times cited : (51)

References (33)
  • 1
    • 0024558306 scopus 로고
    • Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule
    • Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. (1989). Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334.
    • (1989) Cell , vol.57 , pp. 327-334
    • Benchimol, S.1    Fuks, A.2    Jothy, S.3    Beauchemin, N.4    Shirota, K.5    Stanners, C.P.6
  • 2
    • 0036202346 scopus 로고    scopus 로고
    • Leukocyte recruitment in colon cancer: Role of cell adhesion molecules, nitric oxide, and transforming growth factor β1
    • Bessa X, Elizalde JI, Mitjans F, Pinol V, Miquel R, Panes J et al. (2002). Leukocyte recruitment in colon cancer: role of cell adhesion molecules, nitric oxide, and transforming growth factor β1. Gastroenterology 122: 1122-1132.
    • (2002) Gastroenterology , vol.122 , pp. 1122-1132
    • Bessa, X.1    Elizalde, J.I.2    Mitjans, F.3    Pinol, V.4    Miquel, R.5    Panes, J.6
  • 3
    • 0023678699 scopus 로고    scopus 로고
    • Induction of carcinoembryonic antigen secretion and modulation of protein secretion/expression and fibronectin/laminin expression in human colon carcinoma cells by transforming growth factor-β
    • Chakrabarty S, Tobon A, Varani J, Brattain MG. (1998). Induction of carcinoembryonic antigen secretion and modulation of protein secretion/expression and fibronectin/laminin expression in human colon carcinoma cells by transforming growth factor-β. Cancer Res 48: 4059-4064.
    • (1998) Cancer Res , vol.48 , pp. 4059-4064
    • Chakrabarty, S.1    Tobon, A.2    Varani, J.3    Brattain, M.G.4
  • 4
    • 0030793369 scopus 로고    scopus 로고
    • Expression of transforming growth factor β type II receptor reduces tumorigenicity in human gastric cancer cells
    • Chang J, Park K, Bang YJ, Kim WS, Kim D, Kim SJ. (1997). Expression of transforming growth factor β type II receptor reduces tumorigenicity in human gastric cancer cells. Cancer Res 57: 2856-2859.
    • (1997) Cancer Res , vol.57 , pp. 2856-2859
    • Chang, J.1    Park, K.2    Bang, Y.J.3    Kim, W.S.4    Kim, D.5    Kim, S.J.6
  • 5
    • 0025911082 scopus 로고
    • CEA in tumors of other than colorectal origin
    • Chevinsky AH. (1991). CEA in tumors of other than colorectal origin. Semin Surg Oncol 7: 162-166.
    • (1991) Semin Surg Oncol , vol.7 , pp. 162-166
    • Chevinsky, A.H.1
  • 6
    • 0033868371 scopus 로고    scopus 로고
    • CEA-related cell adhesion molecule 1: A potent angiogenic factor and a major effector of vascular endothelial growth factor
    • Ergun S, Kilik N, Ziegeler G, Hansen A, Nollau P, Götze J et al. (2000). CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol Cell 5: 311-320.
    • (2000) Mol Cell , vol.5 , pp. 311-320
    • Ergun, S.1    Kilik, N.2    Ziegeler, G.3    Hansen, A.4    Nollau, P.5    Götze, J.6
  • 7
    • 0036159130 scopus 로고    scopus 로고
    • Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)
    • Feng XH, Liang YY, Liang M, Zhai W, Lin X. (2002). Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B). Mol Cell 9: 133-143.
    • (2002) Mol Cell , vol.9 , pp. 133-143
    • Feng, X.H.1    Liang, Y.Y.2    Liang, M.3    Zhai, W.4    Lin, X.5
  • 8
    • 0013797617 scopus 로고
    • Specific carcinoembryonic antigens of the human digestive system
    • Gold P, Freedman SO. (1965). Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122: 467-481.
    • (1965) J Exp Med , vol.122 , pp. 467-481
    • Gold, P.1    Freedman, S.O.2
  • 9
    • 0033057177 scopus 로고    scopus 로고
    • The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
    • Hammarström S. (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 9: 67-81.
    • (1999) Semin Cancer Biol , vol.9 , pp. 67-81
    • Hammarström, S.1
  • 10
    • 1442332673 scopus 로고    scopus 로고
    • Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer
    • Han SU, Kim HT, Seong DH, Kim YS, Park YS, Bang Y-J et al. (2004). Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene 23: 1333-1341.
    • (2004) Oncogene , vol.23 , pp. 1333-1341
    • Han, S.U.1    Kim, H.T.2    Seong, D.H.3    Kim, Y.S.4    Park, Y.S.5    Bang, Y.-J.6
  • 11
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P. (1997). TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 12
    • 0033491274 scopus 로고    scopus 로고
    • Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F
    • Huang J, Hardy JD, Sun Y, Shively JE. (1999). Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci 112: 4193-4205.
    • (1999) J Cell Sci , vol.112 , pp. 4193-4205
    • Huang, J.1    Hardy, J.D.2    Sun, Y.3    Shively, J.E.4
  • 13
    • 0023633741 scopus 로고
    • Cell adhesion protein receptors as targets for transforming growth factor-β action
    • Ignotz RA, Massague J. (1987). Cell adhesion protein receptors as targets for transforming growth factor-β action. Cell 51: 189-197.
    • (1987) Cell , vol.51 , pp. 189-197
    • Ignotz, R.A.1    Massague, J.2
  • 14
    • 0036118491 scopus 로고    scopus 로고
    • Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation
    • Ilantzis C, DeMarte L, Screaton RA, Stanners CP. (2002). Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia 4: 151-163.
    • (2002) Neoplasia , vol.4 , pp. 151-163
    • Ilantzis, C.1    DeMarte, L.2    Screaton, R.A.3    Stanners, C.P.4
  • 15
    • 0031772640 scopus 로고    scopus 로고
    • Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: Structure, expression and involvement in T cell activation
    • Kammerer R, Hahn S, Singer BB, Luo JS, von Kleist S. (1998). Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation. Eur J Immunol 28: 3664-3674.
    • (1998) Eur J Immunol , vol.28 , pp. 3664-3674
    • Kammerer, R.1    Hahn, S.2    Singer, B.B.3    Luo, J.S.4    von Kleist, S.5
  • 16
    • 0035337109 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation
    • Kammerer R, Stober D, Singer BB, brink B, Reimann J. (2001). Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation. J Immunol 166: 6537-6544.
    • (2001) J Immunol , vol.166 , pp. 6537-6544
    • Kammerer, R.1    Stober, D.2    Singer, B.B.3    brink, B.4    Reimann, J.5
  • 17
    • 0028339086 scopus 로고
    • The carcinoembryonic antigen (CEA) modulates effector-target cell interaction by binding to activated lymphocytes
    • Kammerer R, von Kleist S. (1994). The carcinoembryonic antigen (CEA) modulates effector-target cell interaction by binding to activated lymphocytes. Int J Cancer 57: 341-347.
    • (1994) Int J Cancer , vol.57 , pp. 341-347
    • Kammerer, R.1    von Kleist, S.2
  • 18
    • 0032588657 scopus 로고    scopus 로고
    • Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells
    • Kang SH, Bang YJ, Jong HS, Seo JY, Kim KN, Kim S-J. (1999). Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells. Br J Cancer 80: 1144-1149.
    • (1999) Br J Cancer , vol.80 , pp. 1144-1149
    • Kang, S.H.1    Bang, Y.J.2    Jong, H.S.3    Seo, J.Y.4    Kim, K.N.5    Kim, S.-J.6
  • 19
    • 0033900328 scopus 로고    scopus 로고
    • Significance of serum and tissue carcinoembryonic antigen for the prognosis of gastric carcinoma patients
    • Kim DY, Kim HR, Shim JH, Park CS, Kim SK, Kim YJ. (2000). Significance of serum and tissue carcinoembryonic antigen for the prognosis of gastric carcinoma patients. J Surg Oncol 74: 185-192.
    • (2000) J Surg Oncol , vol.74 , pp. 185-192
    • Kim, D.Y.1    Kim, H.R.2    Shim, J.H.3    Park, C.S.4    Kim, S.K.5    Kim, Y.J.6
  • 20
    • 0026492460 scopus 로고
    • Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers
    • Kim J, Kaye FJ, Henslee JG, Shively JE, Park JG, Lai SL et al. (1992). Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers. Int J Cancer 52: 718-725.
    • (1992) Int J Cancer , vol.52 , pp. 718-725
    • Kim, J.1    Kaye, F.J.2    Henslee, J.G.3    Shively, J.E.4    Park, J.G.5    Lai, S.L.6
  • 21
    • 0034027480 scopus 로고    scopus 로고
    • Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis
    • Kim S-J, Im Y-H, Markowitz SD, Bang Y-J. (2000). Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis. Cytokine Growth Factor Rev 11: 159-168.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 159-168
    • Kim, S.-J.1    Im, Y.-H.2    Markowitz, S.D.3    Bang, Y.-J.4
  • 22
    • 0026654956 scopus 로고
    • CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells
    • Kuijpers TW, Hoogerwerf M, van der Laan LJ, Nagel G, van der Schoot CE, Grunert F et al. (1992). CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. J Cell Biol 118: 457-466.
    • (1992) J Cell Biol , vol.118 , pp. 457-466
    • Kuijpers, T.W.1    Hoogerwerf, M.2    van der Laan, L.J.3    Nagel, G.4    van der Schoot, C.E.5    Grunert, F.6
  • 23
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-β signaling
    • Massague J, Chen YG. (2000). Controlling TGF-β signaling. Genes Dev 14: 627-644.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 24
    • 0028785602 scopus 로고
    • A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability
    • Myeroff LL, Parsons R, Kim S-J, Hedrick L, Cho KR, Orth K et al. (1995). A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55: 5545-5547.
    • (1995) Cancer Res , vol.55 , pp. 5545-5547
    • Myeroff, L.L.1    Parsons, R.2    Kim, S.-J.3    Hedrick, L.4    Cho, K.R.5    Orth, K.6
  • 25
    • 0027482854 scopus 로고
    • Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas
    • Neumaier M, Paululat S, Chan A, Matthaes P, Wagener C. (1993). Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci USA 90: 10744-10748.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10744-10748
    • Neumaier, M.1    Paululat, S.2    Chan, A.3    Matthaes, P.4    Wagener, C.5
  • 26
    • 0034234257 scopus 로고    scopus 로고
    • Human carcinoembryonic antigen functions as a general inhibitor of anoikis
    • Ordonez C, Screaton RA, Ilantzis C, Stanners CP. (2000). Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res 60: 3419-3424.
    • (2000) Cancer Res , vol.60 , pp. 3419-3424
    • Ordonez, C.1    Screaton, R.A.2    Ilantzis, C.3    Stanners, C.P.4
  • 27
    • 0031038107 scopus 로고    scopus 로고
    • Establishment and characterization of human gastric carcinoma cell lines
    • Park JG, Yang HK, Kim WH, Chung JK, Kang MS, Lee JH et al. (1997). Establishment and characterization of human gastric carcinoma cell lines. Int J Cancer 70: 443-449.
    • (1997) Int J Cancer , vol.70 , pp. 443-449
    • Park, J.G.1    Yang, H.K.2    Kim, W.H.3    Chung, J.K.4    Kang, M.S.5    Lee, J.H.6
  • 28
    • 0028556486 scopus 로고
    • Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β
    • Park K, Kim S-J, Bang Y-J, Park J-G, Kim NK, Roberts AB et al. (1994). Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc Natl Acad Sci USA 91: 8772-8776.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8772-8776
    • Park, K.1    Kim, S.-J.2    Bang, Y.-J.3    Park, J.-G.4    Kim, N.K.5    Roberts, A.B.6
  • 29
    • 0034618075 scopus 로고    scopus 로고
    • The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor
    • Screaton RA, DeMarte L, Draber P, Stanners CP. (2000). The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor. J Cell Biol 150: 613-626.
    • (2000) J Cell Biol , vol.150 , pp. 613-626
    • Screaton, R.A.1    DeMarte, L.2    Draber, P.3    Stanners, C.P.4
  • 30
    • 0036467496 scopus 로고    scopus 로고
    • TGF-β signaling: Positive and negative effects on tumorigenesis
    • Wakefield LM, Roberts AB. (2002). TGF-β signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 12: 22-29.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 31
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H et al. (1999). Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J 18: 1280-1291.
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6
  • 33
    • 0003134451 scopus 로고    scopus 로고
    • The nature and expression of the rodent CEA families: Evolutionary considerations
    • Stanners CP ed, Harwood Academic Publishers: Amsterdam, The Netherlands. pp
    • Zimmermann W. (1998). The nature and expression of the rodent CEA families: evolutionary considerations. In: Stanners CP (ed). Cell Adhesion and Communication Mediated by the CEA Family. Harwood Academic Publishers: Amsterdam, The Netherlands. pp 31-55.
    • (1998) Cell Adhesion and Communication Mediated by the CEA Family , pp. 31-55
    • Zimmermann, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.