A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring

Cell Reports

Volumn 17, Issue 4, 2016, Pages 1022-1036

  Yang, Guang ^a   Cancino, Gonzalo I ^a   Zahr, Siraj K ^a,b   Guskjolen, Axel ^a,b   Voronova, Anastassia ^a   Gallagher, Denis ^a   Frankland, Paul W ^a,b,c   Kaplan, David R ^a,b   Miller, Freda D ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

autism spectrum disorder; cortical development; Glyoxalase 1; maternal diabetes; methylglyoxal; neural stem cells; neurodevelopmental disorders; neurogenesis

Indexed keywords

CELL PROTEIN; EOMESODERMIN; GLO1 PROTEIN; MESSENGER RNA; METHYLGLYOXAL; NESTIN; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG; GLO1 PROTEIN, MOUSE; LACTOYLGLUTATHIONE LYASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; BRAIN DEVELOPMENT; CELL PROLIFERATION; CONTROLLED STUDY; DNA POLYMORPHISM; ELECTROPORATION; EMBRYO; EXPRESSION VECTOR; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE IN SITU HYBRIDIZATION; MATERNAL DIABETES MELLITUS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SUBVENTRICULAR ZONE; WESTERN BLOTTING; ADULT STEM CELL; ANIMAL; ANIMAL BEHAVIOR; BRAIN CORTEX; C57BL MOUSE; CYTOLOGY; EMBRYOLOGY; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENE SILENCING; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE EMBRYONIC STEM CELL; NERVE CELL; NEWBORN; PATHOLOGY; PREGNANCY; SIGNAL TRANSDUCTION;

ADULT STEM CELLS; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; DIABETES MELLITUS, EXPERIMENTAL; DIABETES, GESTATIONAL; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; LACTOYLGLUTATHIONE LYASE; MICE; MICE, INBRED C57BL; MOUSE EMBRYONIC STEM CELLS; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; PREGNANCY; PYRUVALDEHYDE; SIGNAL TRANSDUCTION;

EID: 84994884367     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.09.067     Document Type: Article

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