메뉴 건너뛰기




Volumn 151, Issue 5, 2016, Pages 933-944.e3

Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon

Author keywords

Colonic Motility; IBD; Mucosal Drug Action; Wound Healing

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; ENEMA; SEROTONIN 4 RECEPTOR; TEGASEROD; DEXTRAN SULFATE; INDOLE DERIVATIVE; SEROTONIN 4 AGONIST; SEROTONIN 4 ANTAGONIST; SULFONAMIDE; TRINITROBENZENESULFONIC ACID;

EID: 84994853548     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.07.032     Document Type: Article
Times cited : (92)

References (50)
  • 1
    • 64549158645 scopus 로고    scopus 로고
    • The expanded biology of serotonin
    • 1 Berger, M., Gray, J.A., Roth, B.L., The expanded biology of serotonin. Annu Rev Med 60 (2009), 355–366.
    • (2009) Annu Rev Med , vol.60 , pp. 355-366
    • Berger, M.1    Gray, J.A.2    Roth, B.L.3
  • 2
    • 84881479285 scopus 로고    scopus 로고
    • Serotonin signalling in the gut–functions, dysfunctions and therapeutic targets
    • 2 Mawe, G.M., Hoffman, J.M., Serotonin signalling in the gut–functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol 10 (2013), 473–486.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 473-486
    • Mawe, G.M.1    Hoffman, J.M.2
  • 3
    • 68549123001 scopus 로고    scopus 로고
    • 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice
    • 3 Liu, M.T., Kuan, Y.H., Wang, J., et al. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci 29 (2009), 9683–9699.
    • (2009) J Neurosci , vol.29 , pp. 9683-9699
    • Liu, M.T.1    Kuan, Y.H.2    Wang, J.3
  • 4
    • 79951834274 scopus 로고    scopus 로고
    • Serotonin activates dendritic cell function in the context of gut inflammation
    • 4 Li, N., Ghia, J.E., Wang, H., et al. Serotonin activates dendritic cell function in the context of gut inflammation. Am J Pathol 178 (2011), 662–671.
    • (2011) Am J Pathol , vol.178 , pp. 662-671
    • Li, N.1    Ghia, J.E.2    Wang, H.3
  • 5
    • 84876800938 scopus 로고    scopus 로고
    • Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation
    • 5 Kim, J.J., Bridle, B.W., Ghia, J.E., et al. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J Immunol 190 (2013), 4795–4804.
    • (2013) J Immunol , vol.190 , pp. 4795-4804
    • Kim, J.J.1    Bridle, B.W.2    Ghia, J.E.3
  • 6
    • 0028210437 scopus 로고
    • 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons
    • 6 Pan, H., Galligan, J.J., 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 266 (1994), G230–G238.
    • (1994) Am J Physiol , vol.266 , pp. G230-G238
    • Pan, H.1    Galligan, J.J.2
  • 7
    • 0024511561 scopus 로고
    • Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum
    • 7 Tonini, M., Galligan, J.J., North, R.A., Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum. Gastroenterology 96 (1989), 1257–1264.
    • (1989) Gastroenterology , vol.96 , pp. 1257-1264
    • Tonini, M.1    Galligan, J.J.2    North, R.A.3
  • 8
    • 84859415106 scopus 로고    scopus 로고
    • Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity
    • 8 Hoffman, J.M., Tyler, K., MacEachern, S.J., et al. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology 142 (2012), 844–854 e4.
    • (2012) Gastroenterology , vol.142 , pp. 844-854 e4
    • Hoffman, J.M.1    Tyler, K.2    MacEachern, S.J.3
  • 9
    • 77949262990 scopus 로고    scopus 로고
    • The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage
    • 9 Fujisawa, M., Murata, T., Hori, M., et al. The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage. J Gastroenterol 45 (2010), 179–186.
    • (2010) J Gastroenterol , vol.45 , pp. 179-186
    • Fujisawa, M.1    Murata, T.2    Hori, M.3
  • 10
    • 84891713847 scopus 로고    scopus 로고
    • The 5-hydroxytryptamine 4 receptor agonist-induced actions and enteric neurogenesis in the gut
    • 10 Takaki, M., Goto, K., Kawahara, I., The 5-hydroxytryptamine 4 receptor agonist-induced actions and enteric neurogenesis in the gut. J Neurogastroenterol Motil 20 (2014), 17–30.
    • (2014) J Neurogastroenterol Motil , vol.20 , pp. 17-30
    • Takaki, M.1    Goto, K.2    Kawahara, I.3
  • 11
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • 11 Cooper, H.S., Murthy, S.N., Shah, R.S., et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69 (1993), 238–249.
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3
  • 12
    • 84874379714 scopus 로고    scopus 로고
    • Histological healing in inflammatory bowel disease: a still unfulfilled promise
    • 12 Villanacci, V., Antonelli, E., Geboes, K., et al. Histological healing in inflammatory bowel disease: a still unfulfilled promise. World J Gastroenterol 19 (2013), 968–978.
    • (2013) World J Gastroenterol , vol.19 , pp. 968-978
    • Villanacci, V.1    Antonelli, E.2    Geboes, K.3
  • 13
    • 34247183551 scopus 로고    scopus 로고
    • Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    • 13 Savidge, T.C., Newman, P., Pothoulakis, C., et al. Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology 132 (2007), 1344–1358.
    • (2007) Gastroenterology , vol.132 , pp. 1344-1358
    • Savidge, T.C.1    Newman, P.2    Pothoulakis, C.3
  • 14
    • 67650066789 scopus 로고    scopus 로고
    • Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome
    • 14 Joly, F., Mayeur, C., Messing, B., et al. Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. Am J Physiol Gastrointest Liver Physiol 297 (2009), G116–G123.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , pp. G116-G123
    • Joly, F.1    Mayeur, C.2    Messing, B.3
  • 15
    • 80355142423 scopus 로고    scopus 로고
    • Gastrointestinal motility monitor (GIMM)
    • 15 Hoffman, J.M., Brooks, E.M., Mawe, G.M., Gastrointestinal motility monitor (GIMM). J Vis Exp, 46, 2010, 2435.
    • (2010) J Vis Exp , vol.46 , pp. 2435
    • Hoffman, J.M.1    Brooks, E.M.2    Mawe, G.M.3
  • 16
    • 33751119918 scopus 로고    scopus 로고
    • Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function
    • 16 Nasser, Y., Fernandez, E., Keenan, C.M., et al. Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function. Am J Physiol Gastrointest Liver Physiol 291 (2006), G912–G927.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. G912-G927
    • Nasser, Y.1    Fernandez, E.2    Keenan, C.M.3
  • 17
    • 84881030107 scopus 로고    scopus 로고
    • Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon
    • 17 Roberts, J.A., Durnin, L., Sharkey, K.A., et al. Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon. J Physiol 591 (2013), 3725–3737.
    • (2013) J Physiol , vol.591 , pp. 3725-3737
    • Roberts, J.A.1    Durnin, L.2    Sharkey, K.A.3
  • 18
    • 77950522750 scopus 로고    scopus 로고
    • Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon
    • 18 Strong, D.S., Cornbrooks, C.F., Roberts, J.A., et al. Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon. J Physiol 588 (2010), 847–859.
    • (2010) J Physiol , vol.588 , pp. 847-859
    • Strong, D.S.1    Cornbrooks, C.F.2    Roberts, J.A.3
  • 19
    • 0032573495 scopus 로고    scopus 로고
    • Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu
    • 19 Clement, M.V., Ponton, A., Pervaiz, S., Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu. FEBS Lett 440 (1998), 13–18.
    • (1998) FEBS Lett , vol.440 , pp. 13-18
    • Clement, M.V.1    Ponton, A.2    Pervaiz, S.3
  • 20
    • 34347230544 scopus 로고    scopus 로고
    • Sulforhodamine B colorimetric assay for cytotoxicity screening
    • 20 Vichai, V., Kirtikara, K., Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc 1 (2006), 1112–1116.
    • (2006) Nat Protoc , vol.1 , pp. 1112-1116
    • Vichai, V.1    Kirtikara, K.2
  • 21
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ: 25 years of image analysis
    • 21 Schneider, C.A., Rasband, W.S., Eliceiri, K.W., NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9 (2012), 671–675.
    • (2012) Nat Methods , vol.9 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3
  • 22
    • 84938215537 scopus 로고    scopus 로고
    • Inhibiting inducible nitric oxide synthase in enteric glia restores electrogenic ion transport in mice with colitis
    • 22 MacEachern, S.J., Patel, B.A., Keenan, C.M., et al. Inhibiting inducible nitric oxide synthase in enteric glia restores electrogenic ion transport in mice with colitis. Gastroenterology 149 (2015), 445–455 e3.
    • (2015) Gastroenterology , vol.149 , pp. 445-455 e3
    • MacEachern, S.J.1    Patel, B.A.2    Keenan, C.M.3
  • 23
    • 0029940608 scopus 로고    scopus 로고
    • Epithelial cell migration in the intestine
    • 23 Heath, J.P., Epithelial cell migration in the intestine. Cell Biol Int 20 (1996), 139–146.
    • (1996) Cell Biol Int , vol.20 , pp. 139-146
    • Heath, J.P.1
  • 24
    • 0037164808 scopus 로고    scopus 로고
    • Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
    • 24 Denker, S.P., Barber, D.L., Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol 159 (2002), 1087–1096.
    • (2002) J Cell Biol , vol.159 , pp. 1087-1096
    • Denker, S.P.1    Barber, D.L.2
  • 25
    • 78650798979 scopus 로고    scopus 로고
    • Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis
    • 25 Shi, X.Z., Winston, J.H., Sarna, S.K., Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis. Am J Physiol Gastrointest Liver Physiol 300 (2011), G41–G51.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G41-G51
    • Shi, X.Z.1    Winston, J.H.2    Sarna, S.K.3
  • 26
    • 85053778295 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in inflammatory bowel disease
    • 26 Novak, E.A., Mollen, K.P., Mitochondrial dysfunction in inflammatory bowel disease. Front Cell Dev Biol, 3, 2015, 62.
    • (2015) Front Cell Dev Biol , vol.3 , pp. 62
    • Novak, E.A.1    Mollen, K.P.2
  • 27
    • 84881030277 scopus 로고    scopus 로고
    • Complex roles of caspases in the pathogenesis of inflammatory bowel disease
    • 27 Becker, C., Watson, A.J., Neurath, M.F., Complex roles of caspases in the pathogenesis of inflammatory bowel disease. Gastroenterology 144 (2013), 283–293.
    • (2013) Gastroenterology , vol.144 , pp. 283-293
    • Becker, C.1    Watson, A.J.2    Neurath, M.F.3
  • 28
    • 0026261530 scopus 로고
    • Colonic motility and transit in health and ulcerative colitis
    • 28 Reddy, S.N., Bazzocchi, G., Chan, S., et al. Colonic motility and transit in health and ulcerative colitis. Gastroenterology 101 (1991), 1289–1297.
    • (1991) Gastroenterology , vol.101 , pp. 1289-1297
    • Reddy, S.N.1    Bazzocchi, G.2    Chan, S.3
  • 29
    • 85027934479 scopus 로고    scopus 로고
    • Neuroplasticity and dysfunction after gastrointestinal inflammation
    • 29 Brierley, S.M., Linden, D.R., Neuroplasticity and dysfunction after gastrointestinal inflammation. Nat Rev Gastroenterol Hepatol 11 (2014), 611–627.
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 611-627
    • Brierley, S.M.1    Linden, D.R.2
  • 30
    • 2342613824 scopus 로고    scopus 로고
    • Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon
    • 30 Linden, D.R., Sharkey, K.A., Ho, W., et al. Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon. J Physiol 557 (2004), 191–205.
    • (2004) J Physiol , vol.557 , pp. 191-205
    • Linden, D.R.1    Sharkey, K.A.2    Ho, W.3
  • 31
    • 79959341247 scopus 로고    scopus 로고
    • The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon
    • 673-e279
    • 31 Hoffman, J.M., McKnight, N.D., Sharkey, K.A., et al. The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon. Neurogastroenterol Motil, 23, 2011 673-e279.
    • (2011) Neurogastroenterol Motil , vol.23
    • Hoffman, J.M.1    McKnight, N.D.2    Sharkey, K.A.3
  • 32
    • 0037335602 scopus 로고    scopus 로고
    • Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon
    • 32 Linden, D.R., Sharkey, K.A., Mawe, G.M., Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon. J Physiol 547 (2003), 589–601.
    • (2003) J Physiol , vol.547 , pp. 589-601
    • Linden, D.R.1    Sharkey, K.A.2    Mawe, G.M.3
  • 33
    • 0026610670 scopus 로고
    • A study of the relationship among survival, gut-origin sepsis, and bacterial translocation in a model of systemic inflammation
    • 33 Deitch, E.A., Kemper, A.C., Specian, R.D., et al. A study of the relationship among survival, gut-origin sepsis, and bacterial translocation in a model of systemic inflammation. J Trauma 32 (1992), 141–147.
    • (1992) J Trauma , vol.32 , pp. 141-147
    • Deitch, E.A.1    Kemper, A.C.2    Specian, R.D.3
  • 34
    • 84879485147 scopus 로고    scopus 로고
    • Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense
    • 34 Gershon, M.D., Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc 123 (2012), 268–280.
    • (2012) Trans Am Clin Climatol Assoc , vol.123 , pp. 268-280
    • Gershon, M.D.1
  • 35
    • 70350097269 scopus 로고    scopus 로고
    • Serotonin has a key role in pathogenesis of experimental colitis
    • 35 Ghia, J.E., Li, N., Wang, H., et al. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 137 (2009), 1649–1660.
    • (2009) Gastroenterology , vol.137 , pp. 1649-1660
    • Ghia, J.E.1    Li, N.2    Wang, H.3
  • 36
    • 65349092020 scopus 로고    scopus 로고
    • Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice
    • 36 Bischoff, S.C., Mailer, R., Pabst, O., et al. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol 296 (2009), G685–G695.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G685-G695
    • Bischoff, S.C.1    Mailer, R.2    Pabst, O.3
  • 37
    • 77953353237 scopus 로고    scopus 로고
    • A 5-HT(4)-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult
    • e226
    • 37 Matsuyoshi, H., Kuniyasu, H., Okumura, M., et al. A 5-HT(4)-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult. Neurogastroenterol Motil 22 (2010), 806–813 e226.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 806-813
    • Matsuyoshi, H.1    Kuniyasu, H.2    Okumura, M.3
  • 38
    • 84858189637 scopus 로고    scopus 로고
    • Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats
    • 38 Kawahara, I., Kuniyasu, H., Matsuyoshi, H., et al. Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats. Am J Physiol Gastrointest Liver Physiol 302 (2012), G588–G597.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G588-G597
    • Kawahara, I.1    Kuniyasu, H.2    Matsuyoshi, H.3
  • 39
    • 84925445744 scopus 로고    scopus 로고
    • Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism
    • 39 Belkind-Gerson, J., Hotta, R., Nagy, N., et al. Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism. Inflamm Bowel Dis 21 (2015), 870–878.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 870-878
    • Belkind-Gerson, J.1    Hotta, R.2    Nagy, N.3
  • 40
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    • 40 Van der Sluis, M., De Koning, B.A., De Bruijn, A.C., et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131 (2006), 117–129.
    • (2006) Gastroenterology , vol.131 , pp. 117-129
    • Van der Sluis, M.1    De Koning, B.A.2    De Bruijn, A.C.3
  • 41
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    • 41 Johansson, M.E., Gustafsson, J.K., Holmen-Larsson, J., et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63 (2014), 281–291.
    • (2014) Gut , vol.63 , pp. 281-291
    • Johansson, M.E.1    Gustafsson, J.K.2    Holmen-Larsson, J.3
  • 42
    • 0005560921 scopus 로고
    • The peristaltic reflex: an analysis of the nerve pathways and their pharmacology
    • 42 Costa, M., Furness, J.B., The peristaltic reflex: an analysis of the nerve pathways and their pharmacology. Naunyn Schmiedebergs Arch Pharmacol 294 (1976), 47–60.
    • (1976) Naunyn Schmiedebergs Arch Pharmacol , vol.294 , pp. 47-60
    • Costa, M.1    Furness, J.B.2
  • 43
    • 0034756149 scopus 로고    scopus 로고
    • Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps
    • 43 D'Antona, G., Hennig, G.W., Costa, M., et al. Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps. Neurogastroenterol Motil 13 (2001), 483–492.
    • (2001) Neurogastroenterol Motil , vol.13 , pp. 483-492
    • D'Antona, G.1    Hennig, G.W.2    Costa, M.3
  • 44
    • 0038339428 scopus 로고    scopus 로고
    • Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
    • 44 Linden, D.R., Chen, J.X., Gershon, M.D., et al. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 285 (2003), G207–G216.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , pp. G207-G216
    • Linden, D.R.1    Chen, J.X.2    Gershon, M.D.3
  • 45
    • 8144228797 scopus 로고    scopus 로고
    • Real-time detection of serotonin release from enterochromaffin cells of the guinea-pig ileum
    • 45 Bertrand, P.P., Real-time detection of serotonin release from enterochromaffin cells of the guinea-pig ileum. Neurogastroenterol Motil 16 (2004), 511–514.
    • (2004) Neurogastroenterol Motil , vol.16 , pp. 511-514
    • Bertrand, P.P.1
  • 46
    • 33845704516 scopus 로고    scopus 로고
    • In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum
    • 46 Patel, B.A., Bian, X., Quaiserova-Mocko, V., et al. In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum. Analyst 132 (2007), 41–47.
    • (2007) Analyst , vol.132 , pp. 41-47
    • Patel, B.A.1    Bian, X.2    Quaiserova-Mocko, V.3
  • 47
    • 0035093669 scopus 로고    scopus 로고
    • Constitutively active mutants of 5-HT4 receptors are they in unique active states?
    • 47 Claeysen, S., Sebben, M., Becamel, C., et al. Constitutively active mutants of 5-HT4 receptors are they in unique active states?. EMBO Rep 2 (2001), 61–67.
    • (2001) EMBO Rep , vol.2 , pp. 61-67
    • Claeysen, S.1    Sebben, M.2    Becamel, C.3
  • 48
    • 0031593398 scopus 로고    scopus 로고
    • The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor
    • 48 Blondel, O., Gastineau, M., Langlois, M., et al. The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor. Br J Pharmacol 125 (1998), 595–597.
    • (1998) Br J Pharmacol , vol.125 , pp. 595-597
    • Blondel, O.1    Gastineau, M.2    Langlois, M.3
  • 49
    • 0033949566 scopus 로고    scopus 로고
    • Pharmacological properties of 5-hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors
    • 49 Claeysen, S., Sebben, M., Becamel, C., et al. Pharmacological properties of 5-hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors. Mol Pharmacol 58 (2000), 136–144.
    • (2000) Mol Pharmacol , vol.58 , pp. 136-144
    • Claeysen, S.1    Sebben, M.2    Becamel, C.3
  • 50
    • 24344442033 scopus 로고    scopus 로고
    • A high-affinity monoclonal antibody with functional activity against the 5-hydroxytryptaminergic (5-HT4) receptor
    • 50 Kamel, R., Eftekhari, P., Garcia, S., et al. A high-affinity monoclonal antibody with functional activity against the 5-hydroxytryptaminergic (5-HT4) receptor. Biochem Pharmacol 70 (2005), 1009–1018.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1009-1018
    • Kamel, R.1    Eftekhari, P.2    Garcia, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.