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Volumn 19, Issue 7, 2013, Pages 968-978

Histological healing in inflammatory bowel disease: A still unfulfilled promise

Author keywords

Crohn's disease; Healing; Histology; Inflammatory bowel diseases; Ulcerative colitis

Indexed keywords

AZATHIOPRINE; BALSALAZIDE; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; CYCLOSPORIN A; ETANERCEPT; HEPARIN; HYDROCORTISONE SODIUM SUCCINATE; IMMUNOMODULATING AGENT; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; METHYLPREDNISOLONE; OLSALAZINE; PLACEBO; PREDNISONE; SALAZOSULFAPYRIDINE;

EID: 84874379714     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i7.968     Document Type: Editorial
Times cited : (87)

References (90)
  • 1
    • 80051480268 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease (IBD)
    • [PMID: 21857074]
    • Pithadia AB, Jain S. Treatment of inflammatory bowel disease (IBD). Pharmacol Rep 2011; 63: 629-642 [PMID: 21857074]
    • (2011) Pharmacol Rep , vol.63 , pp. 629-642
    • Pithadia, A.B.1    Jain, S.2
  • 2
    • 80455122788 scopus 로고    scopus 로고
    • Optimization of conventional therapy in patients with IBD
    • [PMID: 21970871 DOI: 10.1038/nrgastro.2011.172]
    • Taylor KM, Irving PM. Optimization of conventional therapy in patients with IBD. Nat Rev Gastroenterol Hepatol 2011; 8: 646-656 [PMID: 21970871 DOI: 10.1038/nrgastro.2011.172]
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 646-656
    • Taylor, K.M.1    Irving, P.M.2
  • 5
    • 3843109109 scopus 로고    scopus 로고
    • Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee
    • [PMID: 15233681 DOI: 10.1111/ j.1572-0241.2004.40036.x]
    • Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 2004; 99: 1371-1385 [PMID: 15233681 DOI: 10.1111/ j.1572-0241.2004.40036.x]
    • (2004) Am J Gastroenterol , vol.99 , pp. 1371-1385
    • Kornbluth, A.1    Sachar, D.B.2
  • 6
    • 0036104086 scopus 로고    scopus 로고
    • Influence of treatment on morphological features of mucosal inflammation
    • [PMID: 11953331 DOI: 10.1136/gut.50.suppl_3. iii37]
    • Geboes K, Dalle I. Influence of treatment on morphological features of mucosal inflammation. Gut 2002; 50 Suppl 3: 337-342 [PMID: 11953331 DOI: 10.1136/gut.50.suppl_3. iii37]
    • (2002) Gut , vol.50 , Issue.SUPPL. 3 , pp. 337-342
    • Geboes, K.1    Dalle, I.2
  • 8
    • 79953205566 scopus 로고    scopus 로고
    • Chronic idiopathic inflammatory bowel diseases: The histology report
    • [, PMID: 21459335 DOI: 10.1016/S1590-8658(11)60585-9]
    • Cornaggia M, Leutner M, Mescoli C, Sturniolo GC, Gullotta R. Chronic idiopathic inflammatory bowel diseases: the histology report. Dig Liver Dis 2011; 43 Suppl 4: S293-S303 [PMID: 21459335 DOI: 10.1016/S1590-8658(11)60585-9]
    • (2011) Dig Liver Dis , vol.43 , Issue.SUPPL. 4
    • Cornaggia, M.1    Leutner, M.2    Mescoli, C.3    Sturniolo, G.C.4    Gullotta, R.5
  • 9
    • 75049086190 scopus 로고    scopus 로고
    • Clinical implications of mucosal healing for the management of IBD
    • [PMID: 19949430 DOI: 10.1038/nrgastro.2009.203]
    • Pineton de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel JF. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol 2010; 7: 15-29 [PMID: 19949430 DOI: 10.1038/nrgastro.2009.203]
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 15-29
    • de Chambrun, G.P.1    Peyrin-Biroulet, L.2    Lémann, M.3    Colombel, J.F.4
  • 10
    • 70449473949 scopus 로고    scopus 로고
    • Mucosal healing: Impact on the natural course or therapeutic strategies
    • [PMID:, 19897962 DOI: 10.1159/000233285]
    • Vatn MH. Mucosal healing: impact on the natural course or therapeutic strategies. Dig Dis 2009; 27: 470-475 [PMID: 19897962 DOI: 10.1159/000233285]
    • (2009) Dig Dis , vol.27 , pp. 470-475
    • Vatn, M.H.1
  • 11
    • 80054687451 scopus 로고    scopus 로고
    • Non-IBD colitides: Clinically useful histopathological clues
    • [PMID: 21770683 DOI: 10.4321/S1130-01082011000700006]
    • Villanacci V, Manenti S, Antonelli E, Chiudinelli M, Giuliano V, Bassotti G. Non-IBD colitides: clinically useful histopathological clues. Rev Esp Enferm Dig 2011; 103: 366-372 [PMID: 21770683 DOI: 10.4321/S1130-01082011000700006]
    • (2011) Rev Esp Enferm Dig , vol.103 , pp. 366-372
    • Villanacci, V.1    Manenti, S.2    Antonelli, E.3    Chiudinelli, M.4    Giuliano, V.5    Bassotti, G.6
  • 12
    • 0031043997 scopus 로고    scopus 로고
    • Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative
    • [PMID: 9155688 DOI: 10.1136/jcp.50.2.93]
    • Jenkins D, Balsitis M, Gallivan S, Dixon MF, Gilmour HM, Shepherd NA, Theodossi A, Williams GT. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol 1997; 50: 93-105 [PMID: 9155688 DOI: 10.1136/jcp.50.2.93]
    • (1997) J Clin Pathol , vol.50 , pp. 93-105
    • Jenkins, D.1    Balsitis, M.2    Gallivan, S.3    Dixon, M.F.4    Gilmour, H.M.5    Shepherd, N.A.6    Theodossi, A.7    Williams, G.T.8
  • 13
    • 0028351635 scopus 로고
    • A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation
    • [PMID: 8047806 DOI: 10.3109/00365529409094843]
    • Schumacher G, Kollberg B, Sandstedt B. A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation. Scand J Gastroenterol 1994; 29: 318-332 [PMID: 8047806 DOI: 10.3109/00365529409094843]
    • (1994) Scand J Gastroenterol , vol.29 , pp. 318-332
    • Schumacher, G.1    Kollberg, B.2    Sandstedt, B.3
  • 15
    • 0020424548 scopus 로고
    • A quantitative method of estimating inflammation in the rectal mucosa. III. Chronic ulcerative colitis
    • [, PMID: 7167739]
    • Rubio CA, Johansson C, Kock Y. A quantitative method of estimating inflammation in the rectal mucosa. III. Chronic ulcerative colitis. Scand J Gastroenterol 1982; 17: 1083-1087 [PMID: 7167739]
    • (1982) Scand J Gastroenterol , vol.17 , pp. 1083-1087
    • Rubio, C.A.1    Johansson, C.2    Kock, Y.3
  • 16
    • 0021364710 scopus 로고
    • Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease
    • [PMID: 6689653]
    • Surawicz CM, Belic L. Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease. Gastroenterology 1984; 86: 104-113 [PMID: 6689653]
    • (1984) Gastroenterology , vol.86 , pp. 104-113
    • Surawicz, C.M.1    Belic, L.2
  • 17
    • 0025889013 scopus 로고
    • Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: Diagnostic implications
    • [PMID: 1773958 DOI: 10.1136/gut.32.12.1514]
    • Seldenrijk CA, Morson BC, Meuwissen SG, Schipper NW, Lindeman J, Meijer CJ. Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut 1991; 32: 1514-1520 [PMID: 1773958 DOI: 10.1136/gut.32.12.1514]
    • (1991) Gut , vol.32 , pp. 1514-1520
    • Seldenrijk, C.A.1    Morson, B.C.2    Meuwissen, S.G.3    Schipper, N.W.4    Lindeman, J.5    Meijer, C.J.6
  • 18
    • 0021256363 scopus 로고
    • A quantitative method of estimating inflammation in the rectal mucosa. IV. Ulcerative colitis in remission
    • [PMID: 6463576]
    • Rubio CA, Johansson C, Uribe A, Kock Y. A quantitative method of estimating inflammation in the rectal mucosa. IV. Ulcerative colitis in remission. Scand J Gastroenterol 1984; 19: 525-530 [PMID: 6463576]
    • (1984) Scand J Gastroenterol , vol.19 , pp. 525-530
    • Rubio, C.A.1    Johansson, C.2    Uribe, A.3    Kock, Y.4
  • 19
    • 0023931271 scopus 로고
    • What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens
    • [PMID: 3343381 DOI: 10.1136/jcp.41.1.72]
    • Jenkins D, Goodall A, Drew K, Scott BB. What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens. J Clin Pathol 1988; 41: 72-79 [PMID: 3343381 DOI: 10.1136/jcp.41.1.72]
    • (1988) J Clin Pathol , vol.41 , pp. 72-79
    • Jenkins, D.1    Goodall, A.2    Drew, K.3    Scott, B.B.4
  • 20
    • 0020539823 scopus 로고
    • Rectal mucosal plasma cells in inflammatory bowel disease
    • [PMID: 6852632 DOI: 10.1136/gut.24.6.519]
    • Scott BB, Goodall A, Stephenson P, Jenkins D. Rectal mucosal plasma cells in inflammatory bowel disease. Gut 1983; 24: 519-524 [PMID: 6852632 DOI: 10.1136/gut.24.6.519]
    • (1983) Gut , vol.24 , pp. 519-524
    • Scott, B.B.1    Goodall, A.2    Stephenson, P.3    Jenkins, D.4
  • 21
    • 36048995039 scopus 로고    scopus 로고
    • Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis
    • [PMID: 17293387 DOI: 10.1136/ jcp.2006.045336]
    • Rubio CA, Orrego A, Nesi G, Finkel Y. Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis. J Clin Pathol 2007; 60: 1268-1272 [PMID: 17293387 DOI: 10.1136/ jcp.2006.045336]
    • (2007) J Clin Pathol , vol.60 , pp. 1268-1272
    • Rubio, C.A.1    Orrego, A.2    Nesi, G.3    Finkel, Y.4
  • 22
    • 77949917037 scopus 로고    scopus 로고
    • Immunomodulation does not alter histology in resected Crohn's disease
    • [, PMID: 19774438 DOI: 10.1007/s10151-009-0538-7]
    • Frizelle FA, Ing A, Gearry RB, Whitehead M, Faragher IG, Dobbs B. Immunomodulation does not alter histology in resected Crohn's disease. Tech Coloproctol 2009; 13: 295-300 [PMID: 19774438 DOI: 10.1007/s10151-009-0538-7]
    • (2009) Tech Coloproctol , vol.13 , pp. 295-300
    • Frizelle, F.A.1    Ing, A.2    Gearry, R.B.3    Whitehead, M.4    Faragher, I.G.5    Dobbs, B.6
  • 23
    • 0001458414 scopus 로고
    • Biopsy studies in ulcerative colitis
    • [PMID: 13316140 DOI:, 10.1136/bmj.1.4979.1315]
    • Truelove SC, Richards WC. Biopsy studies in ulcerative colitis. Br Med J 1956; 1: 1315-1318 [PMID: 13316140 DOI: 10.1136/bmj.1.4979.1315]
    • (1956) Br Med J , vol.1 , pp. 1315-1318
    • Truelove, S.C.1    Richards, W.C.2
  • 24
    • 0020066727 scopus 로고
    • Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis
    • [PMID: 6979471 DOI: 10.1007/BF01296733]
    • Powell-Tuck J, Day DW, Buckell NA, Wadsworth J, Lennard-Jones JE. Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis. Dig Dis Sci 1982; 27: 533-537 [PMID: 6979471 DOI: 10.1007/BF01296733]
    • (1982) Dig Dis Sci , vol.27 , pp. 533-537
    • Powell-Tuck, J.1    Day, D.W.2    Buckell, N.A.3    Wadsworth, J.4    Lennard-Jones, J.E.5
  • 25
    • 0022622315 scopus 로고
    • Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease
    • [PMID: 3949241 DOI: 10.1136/ gut.27.1.92]
    • Gomes P, du Boulay C, Smith CL, Holdstock G. Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease. Gut 1986; 27: 92-95 [PMID: 3949241 DOI: 10.1136/ gut.27.1.92]
    • (1986) Gut , vol.27 , pp. 92-95
    • Gomes, P.1    du Boulay, C.2    Smith, C.L.3    Holdstock, G.4
  • 26
    • 0023226091 scopus 로고
    • Histologic and colonoscopic assessment of disease extension in ulcerative colitis
    • [PMID: 3602926 DOI: 10.3109, /00365528708991491]
    • Florén CH, Benoni C, Willén R. Histologic and colonoscopic assessment of disease extension in ulcerative colitis. Scand J Gastroenterol 1987; 22: 459-462 [PMID: 3602926 DOI: 10.3109 /00365528708991491]
    • (1987) Scand J Gastroenterol , vol.22 , pp. 459-462
    • Florén, C.H.1    Benoni, C.2    Willén, R.3
  • 28
    • 0023906720 scopus 로고
    • Comparison of delayed-release 5-aminosalicylic acid (mesalazine) and sulfasalazine as maintenance treatment for patients with ulcerative colitis
    • [PMID: 2896139]
    • Riley SA, Mani V, Goodman MJ, Herd ME, Dutt S, Turnberg LA. Comparison of delayed-release 5-aminosalicylic acid (mesalazine) and sulfasalazine as maintenance treatment for patients with ulcerative colitis. Gastroenterology 1988; 94: 1383-1389 [PMID: 2896139]
    • (1988) Gastroenterology , vol.94 , pp. 1383-1389
    • Riley, S.A.1    Mani, V.2    Goodman, M.J.3    Herd, M.E.4    Dutt, S.5    Turnberg, L.A.6
  • 29
    • 0026065160 scopus 로고
    • Microscopic activity in ulcerative colitis: What does it mean?
    • [PMID: 1864537 DOI: 10.1136/gut.32.2.174]
    • Riley SA, Mani V, Goodman MJ, Dutt S, Herd ME. Microscopic activity in ulcerative colitis: what does it mean? Gut 1991; 32: 174-178 [PMID: 1864537 DOI: 10.1136/gut.32.2.174]
    • (1991) Gut , vol.32 , pp. 174-178
    • Riley, S.A.1    Mani, V.2    Goodman, M.J.3    Dutt, S.4    Herd, M.E.5
  • 30
    • 0027301716 scopus 로고
    • Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis
    • [PMID: 8352372 DOI: 10.1097/ 00000478-199309000-00002]
    • Odze R, Antonioli D, Peppercorn M, Goldman H. Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. Am J Surg Pathol 1993; 17: 869-875 [PMID: 8352372 DOI: 10.1097/ 00000478-199309000-00002]
    • (1993) Am J Surg Pathol , vol.17 , pp. 869-875
    • Odze, R.1    Antonioli, D.2    Peppercorn, M.3    Goldman, H.4
  • 32
    • 0029901887 scopus 로고    scopus 로고
    • Beclomethasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus the combination of both (3 mg/2 g) as retention enemas in active ulcerative proctitis
    • [PMID: 8823568 DOI: 10.1097/00042737-199606000-00010]
    • Mulder CJ, Fockens P, Meijer JW, van der Heide H, Wiltink EH, Tytgat GN. Beclomethasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus the combination of both (3 mg/2 g) as retention enemas in active ulcerative proctitis. Eur J Gastroenterol Hepatol 1996; 8: 549-553 [PMID: 8823568 DOI: 10.1097/00042737-199606000-00010]
    • (1996) Eur J Gastroenterol Hepatol , vol.8 , pp. 549-553
    • Mulder, C.J.1    Fockens, P.2    Meijer, J.W.3    van der Heide, H.4    Wiltink, E.H.5    Tytgat, G.N.6
  • 33
    • 0033849872 scopus 로고    scopus 로고
    • A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
    • [, PMID: 10940279 DOI: 10.1136/gut.47.3.404]
    • Geboes K, Riddell R, Ost A, Jensfelt B, Persson T, Löfberg R. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 2000; 47: 404-409 [PMID: 10940279 DOI: 10.1136/gut.47.3.404]
    • (2000) Gut , vol.47 , pp. 404-409
    • Geboes, K.1    Riddell, R.2    Ost, A.3    Jensfelt, B.4    Persson, T.5    Löfberg, R.6
  • 34
    • 0035052090 scopus 로고    scopus 로고
    • Serum transglutaminase correlates with endoscopic and histopathologic grading in patients with ulcerative colitis
    • [PMID: 11318547]
    • D'Argenio G, Cosenza V, Riegler G, Della Valle N, Deritis F, Mazzacca G. Serum transglutaminase correlates with endoscopic and histopathologic grading in patients with ulcerative colitis. Dig Dis Sci 2001; 46: 649-657 [PMID: 11318547]
    • (2001) Dig Dis Sci , vol.46 , pp. 649-657
    • D'Argenio, G.1    Cosenza, V.2    Riegler, G.3    della Valle, N.4    Deritis, F.5    Mazzacca, G.6
  • 36
    • 0028884691 scopus 로고
    • The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease
    • [PMID: 8580276 DOI: 10.1111/j.1365-2036.1995. tb00419.x]
    • Breese EJ, Michie CA, Nicholls SW, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT. The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease. Aliment Pharmacol Ther 1995; 9: 547-552 [PMID: 8580276 DOI: 10.1111/j.1365-2036.1995. tb00419.x]
    • (1995) Aliment Pharmacol Ther , vol.9 , pp. 547-552
    • Breese, E.J.1    Michie, C.A.2    Nicholls, S.W.3    Williams, C.B.4    Domizio, P.5    Walker-Smith, J.A.6    Macdonald, T.T.7
  • 37
    • 0031915148 scopus 로고    scopus 로고
    • Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum
    • [PMID: 9453485 DOI:, 10.1016/S0016-5085(98)70476-7]
    • D'Haens GR, Geboes K, Peeters M, Baert F, Penninckx F, Rutgeerts P. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 1998; 114: 262-267 [PMID: 9453485 DOI: 10.1016/S0016-5085(98)70476-7]
    • (1998) Gastroenterology , vol.114 , pp. 262-267
    • D'Haens, G.R.1    Geboes, K.2    Peeters, M.3    Baert, F.4    Penninckx, F.5    Rutgeerts, P.6
  • 41
    • 80053130162 scopus 로고    scopus 로고
    • Results of the 2nd part Scientific Workshop of the ECCO. II: Measures and markers of prediction to achieve, detect, and monitor intestinal healing in inflammatory bowel disease
    • [PMID: 21939926 DOI: 10.1016/j.crohns.2011.07.003]
    • Daperno M, Castiglione F, de Ridder L, Dotan I, Färkkilä M, Florholmen J, Fraser G, Fries W, Hebuterne X, Lakatos PL, Panés J, Rimola J, Louis E. Results of the 2nd part Scientific Workshop of the ECCO. II: Measures and markers of prediction to achieve, detect, and monitor intestinal healing in inflammatory bowel disease. J Crohns Colitis 2011; 5: 484-498 [PMID: 21939926 DOI: 10.1016/j.crohns.2011.07.003]
    • (2011) J Crohns Colitis , vol.5 , pp. 484-498
    • Daperno, M.1    Castiglione, F.2    de Ridder, L.3    Dotan, I.4    Färkkilä, M.5    Florholmen, J.6    Fraser, G.7    Fries, W.8    Hebuterne, X.9    Lakatos, P.L.10    Panés, J.11    Rimola, J.12    Louis, E.13
  • 42
    • 0032786709 scopus 로고    scopus 로고
    • Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease
    • [PMID: 10606313 DOI: 10.1111/j.1572-0241. 1999.01640.x]
    • Saitoh O, Kojima K, Sugi K, Matsuse R, Uchida K, Tabata K, Nakagawa K, Kayazawa M, Hirata I, Katsu K. Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease. Am J Gastroenterol 1999; 94: 3513-3520 [PMID: 10606313 DOI: 10.1111/j.1572-0241. 1999.01640.x]
    • (1999) Am J Gastroenterol , vol.94 , pp. 3513-3520
    • Saitoh, O.1    Kojima, K.2    Sugi, K.3    Matsuse, R.4    Uchida, K.5    Tabata, K.6    Nakagawa, K.7    Kayazawa, M.8    Hirata, I.9    Katsu, K.10
  • 44
    • 0031880601 scopus 로고    scopus 로고
    • Ulcerative colitis: Patterns of involvement in colorectal biopsies and changes with time
    • [PMID: 9706978 DOI:, 10.1097/00000478-199808000-00008]
    • Kleer CG, Appelman HD. Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time. Am J Surg Pathol 1998; 22: 983-989 [PMID: 9706978 DOI: 10.1097/00000478-199808000-00008]
    • (1998) Am J Surg Pathol , vol.22 , pp. 983-989
    • Kleer, C.G.1    Appelman, H.D.2
  • 45
    • 33749370428 scopus 로고    scopus 로고
    • Medical management of left-sided ulcerative colitis and ulcerative proctitis: Critical evaluation of therapeutic trials
    • [PMID: 17012969 DOI:, 10.1097/01.mib.0000231495.92013.5e]
    • Regueiro M, Loftus EV, Steinhart AH, Cohen RD. Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials. Inflamm Bowel Dis 2006; 12: 979-994 [PMID: 17012969 DOI: 10.1097/01.mib.0000231495.92013.5e]
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 979-994
    • Regueiro, M.1    Loftus, E.V.2    Steinhart, A.H.3    Cohen, R.D.4
  • 46
    • 0001099179 scopus 로고
    • Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium; a report on a controlled therapeutic trial
    • [PMID: 13584853 DOI: 10.1136/bmj.2.5104.1072]
    • TRUELOVE SC, HAMBLING MH. Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium; a report on a controlled therapeutic trial. Br Med J 1958; 2: 1072-1077 [PMID: 13584853 DOI: 10.1136/bmj.2.5104.1072]
    • (1958) Br Med J , vol.2 , pp. 1072-1077
    • Truelove, S.C.1    Hambling, M.H.2
  • 47
    • 0016641317 scopus 로고
    • Mucosal-cell counts in ulcerative and granulomatous colitis
    • [PMID: 234674]
    • Sommers SC, Korelitz BI. Mucosal-cell counts in ulcerative and granulomatous colitis. Am J Clin Pathol 1975; 63: 359-365 [PMID: 234674]
    • (1975) Am J Clin Pathol , vol.63 , pp. 359-365
    • Sommers, S.C.1    Korelitz, B.I.2
  • 48
    • 0019128167 scopus 로고
    • Treatment of distal ulcerative colitis (proctosigmoiditis) in relapse: Comparison of hydrocortisone enemas and rectal hydrocortisone foam
    • [PMID: 7002739 DOI:, 10.1136/gut.21.10.885]
    • Ruddell WS, Dickinson RJ, Dixon MF, Axon AT. Treatment of distal ulcerative colitis (proctosigmoiditis) in relapse: comparison of hydrocortisone enemas and rectal hydrocortisone foam. Gut 1980; 21: 885-889 [PMID: 7002739 DOI: 10.1136/gut.21.10.885]
    • (1980) Gut , vol.21 , pp. 885-889
    • Ruddell, W.S.1    Dickinson, R.J.2    Dixon, M.F.3    Axon, A.T.4
  • 49
    • 9044244136 scopus 로고    scopus 로고
    • A randomised trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis
    • [PMID: 8801202 DOI: 10.1136/gut.38.2.229]
    • Lee FI, Jewell DP, Mani V, Keighley MR, Kingston RD, Record CO, Grace RH, Daniels S, Patterson J, Smith K. A randomised trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis. Gut 1996; 38: 229-233 [PMID: 8801202 DOI: 10.1136/gut.38.2.229]
    • (1996) Gut , vol.38 , pp. 229-233
    • Lee, F.I.1    Jewell, D.P.2    Mani, V.3    Keighley, M.R.4    Kingston, R.D.5    Record, C.O.6    Grace, R.H.7    Daniels, S.8    Patterson, J.9    Smith, K.10
  • 50
    • 0031688477 scopus 로고    scopus 로고
    • Budesonide enema for the treatment of active, distal ulcerative colitis and proctitis: A dose-ranging study. U.S. Budesonide enema study group
    • [PMID: 9721148 DOI: 10.1016/S0016-5085(98)70131-3]
    • Hanauer SB, Robinson M, Pruitt R, Lazenby AJ, Persson T, Nilsson LG, Walton-Bowen K, Haskell LP, Levine JG. Budesonide enema for the treatment of active, distal ulcerative colitis and proctitis: a dose-ranging study. U.S. Budesonide enema study group. Gastroenterology 1998; 115: 525-532 [PMID: 9721148 DOI: 10.1016/S0016-5085(98)70131-3]
    • (1998) Gastroenterology , vol.115 , pp. 525-532
    • Hanauer, S.B.1    Robinson, M.2    Pruitt, R.3    Lazenby, A.J.4    Persson, T.5    Nilsson, L.G.6    Walton-Bowen, K.7    Haskell, L.P.8    Levine, J.G.9
  • 51
    • 0033852957 scopus 로고    scopus 로고
    • Randomized comparison of unfractionated heparin with corticosteroids in severe active inflammatory bowel disease
    • [PMID: 10930895 DOI: 10.1046/ j.1365-2036.2000.00802.x]
    • Ang YS, Mahmud N, White B, Byrne M, Kelly A, Lawler M, McDonald GS, Smith OP, Keeling PW. Randomized comparison of unfractionated heparin with corticosteroids in severe active inflammatory bowel disease. Aliment Pharmacol Ther 2000; 14: 1015-1022 [PMID: 10930895 DOI: 10.1046/ j.1365-2036.2000.00802.x]
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 1015-1022
    • Ang, Y.S.1    Mahmud, N.2    White, B.3    Byrne, M.4    Kelly, A.5    Lawler, M.6    McDonald, G.S.7    Smith, O.P.8    Keeling, P.W.9
  • 54
    • 0024359916 scopus 로고
    • Olsalazine or sulphasalazine in first attacks of ulcerative colitis? A double blind study
    • [PMID: 2567266 DOI: 10.1136/gut.30.5.675]
    • Rao SS, Dundas SA, Holdsworth CD, Cann PA, Palmer KR, Corbett CL. Olsalazine or sulphasalazine in first attacks of ulcerative colitis? A double blind study. Gut 1989; 30: 675-679 [PMID: 2567266 DOI: 10.1136/gut.30.5.675]
    • (1989) Gut , vol.30 , pp. 675-679
    • Rao, S.S.1    Dundas, S.A.2    Holdsworth, C.D.3    Cann, P.A.4    Palmer, K.R.5    Corbett, C.L.6
  • 55
    • 0036159152 scopus 로고    scopus 로고
    • A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis
    • [PMID: 11856079]
    • Green JR, Mansfield JC, Gibson JA, Kerr GD, Thornton PC. A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis. Aliment Pharmacol Ther 2002; 16: 61-68 [PMID: 11856079]
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 61-68
    • Green, J.R.1    Mansfield, J.C.2    Gibson, J.A.3    Kerr, G.D.4    Thornton, P.C.5
  • 56
    • 0036164249 scopus 로고    scopus 로고
    • A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis
    • [PMID: 11856080 DOI: 10.1046/ j.1365-2036.2002.01151.x]
    • Mansfield JC, Giaffer MH, Cann PA, McKenna D, Thornton PC, Holdsworth CD. A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis. Aliment Pharmacol Ther 2002; 16: 69-77 [PMID: 11856080 DOI: 10.1046/ j.1365-2036.2002.01151.x]
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 69-77
    • Mansfield, J.C.1    Giaffer, M.H.2    Cann, P.A.3    McKenna, D.4    Thornton, P.C.5    Holdsworth, C.D.6
  • 57
    • 0036191611 scopus 로고    scopus 로고
    • A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis
    • [PMID: 11876694 DOI: 10.1046/ j.1365-2036.2002.01199.x]
    • Malchow H, Gertz B. A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis. Aliment Pharmacol Ther 2002; 16: 415-423 [PMID: 11876694 DOI: 10.1046/ j.1365-2036.2002.01199.x]
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 415-423
    • Malchow, H.1    Gertz, B.2
  • 59
    • 18944363679 scopus 로고    scopus 로고
    • A new oral delivery system for 5-ASA: Preliminary clinical findings for MMx
    • [PMID: 15867580 DOI: 10.1097/01.MIB.0000158386. 25660.1e]
    • Prantera C, Viscido A, Biancone L, Francavilla A, Giglio L, Campieri M. A new oral delivery system for 5-ASA: preliminary clinical findings for MMx. Inflamm Bowel Dis 2005; 11: 421-427 [PMID: 15867580 DOI: 10.1097/01.MIB.0000158386. 25660.1e]
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 421-427
    • Prantera, C.1    Viscido, A.2    Biancone, L.3    Francavilla, A.4    Giglio, L.5    Campieri, M.6
  • 60
    • 58849136710 scopus 로고    scopus 로고
    • Once daily versus three times daily mesalazine granules in active ulcerative colitis: A double-blind, doubledummy, randomised, non-inferiority trial
    • [PMID: 18832520 DOI: 10.1136/gut.2008.154302]
    • Kruis W, Kiudelis G, Rácz I, Gorelov IA, Pokrotnieks J, Horynski M, Batovsky M, Kykal J, Boehm S, Greinwald R, Mueller R. Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, doubledummy, randomised, non-inferiority trial. Gut 2009; 58: 233-240 [PMID: 18832520 DOI: 10.1136/gut.2008.154302]
    • (2009) Gut , vol.58 , pp. 233-240
    • Kruis, W.1    Kiudelis, G.2    Rácz, I.3    Gorelov, I.A.4    Pokrotnieks, J.5    Horynski, M.6    Batovsky, M.7    Kykal, J.8    Boehm, S.9    Greinwald, R.10    Mueller, R.11
  • 61
    • 0036791285 scopus 로고    scopus 로고
    • Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: Results of an open-label study on efficacy and tolerability in inducing and maintaining remission
    • [, PMID: 12269968 DOI: 10.1046/j.1365-2036.2002.01340.x]
    • Paoluzi OA, Pica R, Marcheggiano A, Crispino P, Iacopini F, Iannoni C, Rivera M, Paoluzi P. Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: results of an open-label study on efficacy and tolerability in inducing and maintaining remission. Aliment Pharmacol Ther 2002; 16: 1751-1759 [PMID: 12269968 DOI: 10.1046/j.1365-2036.2002.01340.x]
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1751-1759
    • Paoluzi, O.A.1    Pica, R.2    Marcheggiano, A.3    Crispino, P.4    Iacopini, F.5    Iannoni, C.6    Rivera, M.7    Paoluzi, P.8
  • 63
    • 77957883550 scopus 로고    scopus 로고
    • The role of biologics in ulcerative colitis
    • [PMID: 20926878 DOI: 10.1159/000320408]
    • Hanauer SB. The role of biologics in ulcerative colitis. Dig Dis 2010; 28: 497-500 [PMID: 20926878 DOI: 10.1159/000320408]
    • (2010) Dig Dis , vol.28 , pp. 497-500
    • Hanauer, S.B.1
  • 65
    • 34547691199 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha down-regulation parallels inflammatory regression in ulcerative colitis patients treated with infliximab
    • [PMID: 17652038 DOI: 10.1016/ j.dld.2007.06.003]
    • Hassan C, Ierardi E, Burattini O, De Francesco V, Zullo A, Stoppino G, Panella C, Morini S. Tumour necrosis factor alpha down-regulation parallels inflammatory regression in ulcerative colitis patients treated with infliximab. Dig Liver Dis 2007; 39: 811-817 [PMID: 17652038 DOI: 10.1016/ j.dld.2007.06.003]
    • (2007) Dig Liver Dis , vol.39 , pp. 811-817
    • Hassan, C.1    Ierardi, E.2    Burattini, O.3    de Francesco, V.4    Zullo, A.5    Stoppino, G.6    Panella, C.7    Morini, S.8
  • 66
    • 77954662897 scopus 로고    scopus 로고
    • Ultrastructural evidence of mucosal healing after infliximab in patients with ulcerative colitis
    • [PMID: 20593047]
    • Fratila OC, Craciun C. Ultrastructural evidence of mucosal healing after infliximab in patients with ulcerative colitis. J Gastrointestin Liver Dis 2010; 19: 147-153 [PMID: 20593047]
    • (2010) J Gastrointestin Liver Dis , vol.19 , pp. 147-153
    • Fratil, O.C.1    Craciu, C.2
  • 67
    • 33748511451 scopus 로고    scopus 로고
    • Mucosal features and granulocytemonocyte-apheresis in steroid-dependent/refractory ulcerative colitis
    • [PMID: 16569521 DOI: 10.1016/j.dld.2005.12.005]
    • D'Ovidio V, Aratari A, Viscido A, Marcheggiano A, Papi C, Capurso L, Caprilli R. Mucosal features and granulocytemonocyte-apheresis in steroid-dependent/refractory ulcerative colitis. Dig Liver Dis 2006; 38: 389-394 [PMID: 16569521 DOI: 10.1016/j.dld.2005.12.005]
    • (2006) Dig Liver Dis , vol.38 , pp. 389-394
    • D'Ovidio, V.1    Aratari, A.2    Viscido, A.3    Marcheggiano, A.4    Papi, C.5    Capurso, L.6    Caprilli, R.7
  • 68
    • 0025219580 scopus 로고
    • Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Thérapeutique des Affections Inflammatoires Digestives
    • [PMID: 2179031 DOI: 10.1016/0016-5085(90)90002-I]
    • Modigliani R, Mary JY, Simon JF, Cortot A, Soule JC, Gendre JP, Rene E. Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Thérapeutique des Affections Inflammatoires Digestives. Gastroenterology 1990; 98: 811-818 [PMID: 2179031 DOI: 10.1016/0016-5085(90)90002-I]
    • (1990) Gastroenterology , vol.98 , pp. 811-818
    • Modigliani, R.1    Mary, J.Y.2    Simon, J.F.3    Cortot, A.4    Soule, J.C.5    Gendre, J.P.6    Rene, E.7
  • 69
    • 66149148366 scopus 로고    scopus 로고
    • Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn' s disease
    • [PMID: 19009634 DOI: 10.1002/ibd.20777]
    • Mantzaris GJ, Christidou A, Sfakianakis M, Roussos A, Koilakou S, Petraki K, Polyzou P. Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn' s disease. Inflamm Bowel Dis 2009; 15: 375-382 [PMID: 19009634 DOI: 10.1002/ibd.20777]
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 375-382
    • Mantzaris, G.J.1    Christidou, A.2    Sfakianakis, M.3    Roussos, A.4    Koilakou, S.5    Petraki, K.6    Polyzou, P.7
  • 70
    • 78649501725 scopus 로고    scopus 로고
    • A short course of corticosteroids prior to surveillance colonoscopy to decrease mucosal inflammation in inflammatory bowel disease patients: Results from a randomized controlled trial
    • [PMID: 21122577 DOI: 10.1016/j.crohns.2010.07.011]
    • Baars JE, Vogelaar L, Wolfhagen FH, Biermann K, Kuipers EJ, van der Woude CJ. A short course of corticosteroids prior to surveillance colonoscopy to decrease mucosal inflammation in inflammatory bowel disease patients: results from a randomized controlled trial. J Crohns Colitis 2010; 4: 661-668 [PMID: 21122577 DOI: 10.1016/j.crohns.2010.07.011]
    • (2010) J Crohns Colitis , vol.4 , pp. 661-668
    • Baars, J.E.1    Vogelaar, L.2    Wolfhagen, F.H.3    Biermann, K.4    Kuipers, E.J.5    van der Woude, C.J.6
  • 71
    • 0030888894 scopus 로고    scopus 로고
    • Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease
    • [PMID: 9136824]
    • D'Haens G, Geboes K, Ponette E, Penninckx F, Rutgeerts P. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease. Gastroenterology 1997; 112: 1475-1481 [PMID: 9136824]
    • (1997) Gastroenterology , vol.112 , pp. 1475-1481
    • D'Haens, G.1    Geboes, K.2    Ponette, E.3    Penninckx, F.4    Rutgeerts, P.5
  • 72
    • 0032723990 scopus 로고    scopus 로고
    • Endoscopic and histologic healing of Crohn's (ileo-) colitis with azathioprine
    • [PMID: 10536324 DOI:, 10.1016/S0016-5107(99)80017-0]
    • D'Haens G, Geboes K, Rutgeerts P. Endoscopic and histologic healing of Crohn's (ileo-) colitis with azathioprine. Gastrointest Endosc 1999; 50: 667-671 [PMID: 10536324 DOI: 10.1016/S0016-5107(99)80017-0]
    • (1999) Gastrointest Endosc , vol.50 , pp. 667-671
    • D'Haens, G.1    Geboes, K.2    Rutgeerts, P.3
  • 73
    • 0024517127 scopus 로고
    • Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease
    • [PMID: 2492786]
    • Kozarek RA, Patterson DJ, Gelfand MD, Botoman VA, Ball TJ, Wilske KR. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med 1989; 110: 353-356 [PMID: 2492786]
    • (1989) Ann Intern Med , vol.110 , pp. 353-356
    • Kozarek, R.A.1    Patterson, D.J.2    Gelfand, M.D.3    Botoman, V.A.4    Ball, T.J.5    Wilske, K.R.6
  • 74
    • 79951674459 scopus 로고    scopus 로고
    • Mucosal healing with methotrexate in Crohn's disease: A prospective comparative study with azathioprine and infliximab
    • [PMID: 21235604 DOI:, 10.1111/j.1365-2036.2010.04569.x]
    • Laharie D, Reffet A, Belleannée G, Chabrun E, Subtil C, Razaire S, Capdepont M, de Lédinghen V. Mucosal healing with methotrexate in Crohn's disease: a prospective comparative study with azathioprine and infliximab. Aliment Pharmacol Ther 2011; 33: 714-721 [PMID: 21235604 DOI: 10.1111/j.1365-2036.2010.04569.x]
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 714-721
    • Laharie, D.1    Reffet, A.2    Belleannée, G.3    Chabrun, E.4    Subtil, C.5    Razaire, S.6    Capdepont, M.7    de Lédinghen, V.8
  • 76
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly downregulates the inflammation in Crohn's ileocolitis
    • [PMID: 9869598 DOI: 10.1016/ S0016-5085(99)70224-6]
    • Baert FJ, D'Haens GR, Peeters M, Hiele MI, Schaible TF, Shealy D, Geboes K, Rutgeerts PJ. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly downregulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999; 116: 22-28 [PMID: 9869598 DOI: 10.1016/ S0016-5085(99)70224-6]
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3    Hiele, M.I.4    Schaible, T.F.5    Shealy, D.6    Geboes, K.7    Rutgeerts, P.J.8
  • 77
    • 27944453865 scopus 로고    scopus 로고
    • Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease
    • [PMID: 16307694 DOI: 10.1185/030079905X65457]
    • Geboes K, Rutgeerts P, Opdenakker G, Olson A, Patel K, Wagner CL, Marano CW. Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease. Curr Med Res Opin 2005; 21: 1741-1754 [PMID: 16307694 DOI: 10.1185/030079905X65457]
    • (2005) Curr Med Res Opin , vol.21 , pp. 1741-1754
    • Geboes, K.1    Rutgeerts, P.2    Opdenakker, G.3    Olson, A.4    Patel, K.5    Wagner, C.L.6    Marano, C.W.7
  • 78
    • 0034827790 scopus 로고    scopus 로고
    • Etanercept in the treatment of active refractory Crohn's disease: A single-center pilot trial
    • [PMID: 11569676 DOI: 10.1111/j.1572-0241.2001.04705.x]
    • D'Haens G, Swijsen C, Noman M, Lemmens L, Ceuppens J, Agbahiwe H, Geboes K, Rutgeerts P. Etanercept in the treatment of active refractory Crohn's disease: a single-center pilot trial. Am J Gastroenterol 2001; 96: 2564-2568 [PMID: 11569676 DOI: 10.1111/j.1572-0241.2001.04705.x]
    • (2001) Am J Gastroenterol , vol.96 , pp. 2564-2568
    • D'Haens, G.1    Swijsen, C.2    Noman, M.3    Lemmens, L.4    Ceuppens, J.5    Agbahiwe, H.6    Geboes, K.7    Rutgeerts, P.8
  • 79
    • 20444447446 scopus 로고    scopus 로고
    • Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: Cytokine production and endoscopic and histological findings
    • [PMID: 15905706 DOI:, 10.1097/01.MIB.0000161307.58327.96]
    • Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T, Matsumoto K. Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: cytokine production and endoscopic and histological findings. Inflamm Bowel Dis 2005; 11: 580-588 [PMID: 15905706 DOI: 10.1097/01.MIB.0000161307.58327.96]
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 580-588
    • Yamamoto, T.1    Nakahigashi, M.2    Umegae, S.3    Kitagawa, T.4    Matsumoto, K.5
  • 80
    • 0022621499 scopus 로고
    • Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion
    • [PMID: 3956932]
    • Saverymuttu SH, Camilleri M, Rees H, Lavender JP, Hodgson HJ, Chadwick VS. Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion. Gastroenterology 1986; 90: 1121-1128 [PMID: 3956932]
    • (1986) Gastroenterology , vol.90 , pp. 1121-1128
    • Saverymuttu, S.H.1    Camilleri, M.2    Rees, H.3    Lavender, J.P.4    Hodgson, H.J.5    Chadwick, V.S.6
  • 81
    • 33947718717 scopus 로고    scopus 로고
    • Anti-mycobacterial therapy in Crohn's disease heals mucosa with longitudinal scars
    • [PMID: 17369114 DOI: 10.1016/j.dld.2007.01.008]
    • Borody TJ, Bilkey S, Wettstein AR, Leis S, Pang G, Tye S. Anti-mycobacterial therapy in Crohn's disease heals mucosa with longitudinal scars. Dig Liver Dis 2007; 39: 438-444 [PMID: 17369114 DOI: 10.1016/j.dld.2007.01.008]
    • (2007) Dig Liver Dis , vol.39 , pp. 438-444
    • Borody, T.J.1    Bilkey, S.2    Wettstein, A.R.3    Leis, S.4    Pang, G.5    Tye, S.6
  • 82
    • 77953278068 scopus 로고    scopus 로고
    • Value of mucosal assessment and biomarkers in inflammatory bowel disease
    • [PMID: 20528116 DOI:, 10.1586/egh.10.22]
    • Stidham RW, Higgins PD. Value of mucosal assessment and biomarkers in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2010; 4: 285-291 [PMID: 20528116 DOI: 10.1586/egh.10.22]
    • (2010) Expert Rev Gastroenterol Hepatol , vol.4 , pp. 285-291
    • Stidham, R.W.1    Higgins, P.D.2
  • 83
    • 77950843951 scopus 로고    scopus 로고
    • Mucosal healing and anti TNFs in IBD
    • [, PMID: 20210770 DOI: 10.2174/138945010790309902]
    • van Assche G, Vermeire S, Rutgeerts P. Mucosal healing and anti TNFs in IBD. Curr Drug Targets 2010; 11: 227-233 [PMID: 20210770 DOI: 10.2174/138945010790309902]
    • (2010) Curr Drug Targets , vol.11 , pp. 227-233
    • van Assche, G.1    Vermeire, S.2    Rutgeerts, P.3
  • 84
    • 83555174451 scopus 로고    scopus 로고
    • Stopping immunomodulators and biologics in inflammatory bowel disease patients in remission
    • [PMID: 21674731 DOI: 10.1002/ibd.21792]
    • Clarke K, Regueiro M. Stopping immunomodulators and biologics in inflammatory bowel disease patients in remission. Inflamm Bowel Dis 2012; 18: 174-179 [PMID: 21674731 DOI: 10.1002/ibd.21792]
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 174-179
    • Clarke, K.1    Regueiro, M.2
  • 85
    • 79958136275 scopus 로고    scopus 로고
    • Review article: Causative factors and the clinical management of patients with Crohn' s disease who lose response to anti-TNF-α therapy
    • [PMID: 21539588 DOI:, 10.1111/j.1365-2036.2011.04679.x]
    • Danese S, Fiorino G, Reinisch W. Review article: Causative factors and the clinical management of patients with Crohn' s disease who lose response to anti-TNF-α therapy. Aliment Pharmacol Ther 2011; 34: 1-10 [PMID: 21539588 DOI: 10.1111/j.1365-2036.2011.04679.x]
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 1-10
    • Danese, S.1    Fiorino, G.2    Reinisch, W.3
  • 89
    • 80052547054 scopus 로고    scopus 로고
    • Biological and histological parameters as predictors of relapse in ulcerative colitis: A prospective study
    • [PMID: 21546723 DOI: 10.4103/1319-3767.80383]
    • Azad S, Sood N, Sood A. Biological and histological parameters as predictors of relapse in ulcerative colitis: a prospective study. Saudi J Gastroenterol 2011; 17: 194-198 [PMID: 21546723 DOI: 10.4103/1319-3767.80383]
    • (2011) Saudi J Gastroenterol , vol.17 , pp. 194-198
    • Azad, S.1    Sood, N.2    Sood, A.3
  • 90
    • 34848893583 scopus 로고    scopus 로고
    • Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: A cohort study
    • quiz 1340-1341, [PMID: 17919486 DOI: 10.1053/ j.gastro.2007.08.001]
    • Gupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, Ullman T. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 2007; 133: 1099-1105; quiz 1340-1341 [PMID: 17919486 DOI: 10.1053/ j.gastro.2007.08.001]
    • (2007) Gastroenterology , vol.133 , pp. 1099-1105
    • Gupta, R.B.1    Harpaz, N.2    Itzkowitz, S.3    Hossain, S.4    Matula, S.5    Kornbluth, A.6    Bodian, C.7    Ullman, T.8


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