Idazoxan reduces blood-brain barrier damage during experimental autoimmune encephalomyelitis in mouse

European Journal of Pharmacology

Volumn 736, Issue , 2014, Pages 70-76

  Wang, Xin Shi ^a   Fang, Hui Lin ^a   Chen, Yu ^a   Liang, Shan Shan ^a   Zhu, Zhen Guo ^a   Zeng, Qing Yi ^a   Li, Jia ^a   Xu, Hui Qin ^a   Shao, Bei ^a   He, Jin Cai ^a   Hou, Sheng Tao ^a,b   Zheng, Rong Yuan ^a  

^a THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^b SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Blood brain barrier; Experimental autoimmune encephalomyelitis; Idazoxan; JAM 1; MMP 9; Tight junction

Indexed keywords

CLAUDIN 5; GELATINASE B; IDAZOXAN; JUNCTIONAL ADHESION MOLECULE A; OCCLUDIN; PROTEIN ZO1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; ANTIINFLAMMATORY AGENT; MMP9 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; TIMP1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PROTECTION; CELL INFILTRATION; CONTROLLED STUDY; DEMYELINATION; DRUG MECHANISM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; INFLAMMATORY CELL; MEMBRANE DAMAGE; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD ATROPHY; TIGHT JUNCTION; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; METABOLISM; MULTIPLE SCLEROSIS; PATHOLOGY; PERMEABILITY; ULTRASTRUCTURE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IDAZOXAN; MATRIX METALLOPROTEINASE 9; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; NEUROPROTECTIVE AGENTS; PERMEABILITY; TIGHT JUNCTIONS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84900360392     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.04.034     Document Type: Article

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