Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis

European Journal of Pharmacology

Volumn 771, Issue , 2016, Pages 18-28

  Yang, Xue ^a   Yan, Jun ^a   Feng, Juan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Adhesion molecules; Blood brain barrier; Chemokines; Experimental autoimmune encephalomyelitis; Tanshinone IIA

Indexed keywords

ADAPTOR PROTEIN; CELL ADHESION MOLECULE; CHEMOKINE; CLAUDIN 5; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; IONIZED CALCIUM BINDING ADAPTER MOLECULE 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OCCLUDIN; PROTEIN ZO1; RANTES; TANSHINONE IIA; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ABIETANE DERIVATIVE; ACTIN BINDING PROTEIN; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; TANSHINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DEMYELINATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DEMYELINATING DISEASES; DOSE RESPONSE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENETICS; LEWIS RAT; METABOLISM; MOVEMENT DISORDERS; PATHOLOGY;

ANIMALS; BLOOD-BRAIN BARRIER; CALCIUM-BINDING PROTEINS; CELL ADHESION MOLECULES; CHEMOKINES; DEMYELINATING DISEASES; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROFILAMENT PROTEINS; MOVEMENT DISORDERS; RATS; RATS, INBRED LEW; TIGHT JUNCTION PROTEINS;

EID: 84954225656     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.12.014     Document Type: Article

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