MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease

Circulation

Volumn 134, Issue 24, 2016, Pages 1973-1990

  Hartmann, Dorothee ^a   Fiedler, Jan ^a   Sonnenschein, Kristina ^a   Just, Annette ^a   Pfanne, Angelika ^a   Zimmer, Karina ^a   Remke, Janet ^a   Foinquinos, Ariana ^a   Butzlaff, Malte ^a   Schimmel, Katharina ^a   Maegdefessel, Lars ^b   Hilfiker Kleiner, Denise ^a   Lachmann, Nico ^a   Schober, Andreas ^c,d   Froese, Natali ^a   Heineke, Jörg ^a   Bauersachs, Johann ^a   Batkai, Sandor ^a   Thum, Thomas ^a,e  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

angiogenesis inducing agents; GATA2 transcription factor; microRNAs; MIRN126 microRNA, human; MIRN221 microRNA, human; reendothelialization

Indexed keywords

ACTIVIN A; ADAMTS1 PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BASIC HELIX LOOP-HELIX TRANSCRIPTION FACTOR ATONAL HOMOLOG 8; CRE RECOMBINASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR LIKE DOMAIN MULTIPLE 7 PROTEIN; FIBROBLAST GROWTH FACTOR 2; INTERCELLULAR ADHESION MOLECULE 1; MICRORNA 126; MICRORNA 221; PLACENTAL GROWTH FACTOR; SMALL INTERFERING RNA; SPROUTY PROTEIN; SPROUTY RELATED EVH1 DOMAIN CONTAINING 1 PROTEIN; TAMOXIFEN; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR GATA 2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; 3' UNTRANSLATED REGION; ANTAGOMIR; FOXO3 PROTEIN, HUMAN; GATA2 PROTEIN, HUMAN; ICAM1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MICRORNA; NANOPARTICLE; SIGNAL PEPTIDE; SPRED1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR FKHRL1;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY INJURY; CELL NUCLEUS; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; CYTOPLASM; DEMETHYLATION; DNA FLANKING REGION; DNA METHYLATION; DRUG ANTAGONISM; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETICS; GAIN OF FUNCTION MUTATION; GENE EXPRESSION PROFILING; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEFT COMMON CAROTID ARTERY; LENTIVIRINAE; LOSS OF FUNCTION MUTATION; LUCIFERASE ASSAY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CAROTID ARTERY DISEASES; CHEMISTRY; DISEASE MODEL; GENE VECTOR; GENETICS; KNOCKOUT MOUSE; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; RNA INTERFERENCE; SEQUENCE ALIGNMENT;

3' UNTRANSLATED REGIONS; ANIMALS; ANTAGOMIRS; BASE SEQUENCE; CAROTID ARTERY DISEASES; DISEASE MODELS, ANIMAL; FORKHEAD BOX PROTEIN O3; GATA2 TRANSCRIPTION FACTOR; GENETIC VECTORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LENTIVIRUS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; NANOPARTICLES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT;

EID: 84994614310     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.022478     Document Type: Article

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