Inhibiting extracellular vesicle release from human cardiosphere derived cells with lentiviral knockdown of nSMase2 differentially effects proliferation and apoptosis in cardiomyocytes, fibroblasts and endothelial cells in Vitro

PLoS ONE

Volumn 11, Issue 11, 2016, Pages

  Lang, Jennifer K ^a   Young, Rebeccah F ^a   Ashraf, Hashmat ^b   Canty, John M ^a,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b GATES VASCULAR INSTITUTE AT KALEIDA HEALTH   (United States)

^c VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD63 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYTOCHROME C; EARLY ENDOSOME ANTIGEN 1; HEAT SHOCK PROTEIN 90; MESSENGER RNA; SHORT HAIRPIN RNA; SMPD3 PROTEIN, HUMAN; SPHINGOMYELIN PHOSPHODIESTERASE;

ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CARDIOSPHERE DERIVED CELL; CASE REPORT; CELL COUNT; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURFACE; CELL VIABILITY; CELLULAR SECRETION; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXOSOME; GENE; GENE EXPRESSION; GENE SILENCING; HEART FIBROBLAST; HEART INFARCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LENTIVIRUS INFECTION; MOUSE; NEWBORN; NONHUMAN; NSMASE2 GENE; PARACRINE SIGNALING; PROTEIN EXPRESSION; RAT; CELL CULTURE; CYTOLOGY; FIBROBLAST; GENETICS; LENTIVIRINAE; METABOLISM; PROCEDURES; SECRETION (PROCESS);

APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; EXTRACELLULAR VESICLES; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HUMANS; IN VITRO TECHNIQUES; LENTIVIRUS; MYOCYTES, CARDIAC; PARACRINE COMMUNICATION; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84994593525     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0165926     Document Type: Article

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